Search Results - "Cooper, J Mark"

Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells by McNeill, Alisdair, Magalhaes, Joana, Shen, Chengguo, Chau, Kai-Yin, Hughes, Derralyn, Mehta, Atul, Foltynie, Tom, Cooper, J. Mark, Abramov, Andrey Y., Gegg, Matthew, Schapira, Anthony H.V.

“…Heterozygous GBA gene mutations are the most frequent Parkinson’s disease risk factor. Using Parkinson’s disease patient derived fibroblasts McNeill et al…”
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Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology by Izco, María, Blesa, Javier, Schleef, Martin, Schmeer, Marco, Porcari, Riccardo, Al-Shawi, Raya, Ellmerich, Stephan, de Toro, María, Gardiner, Chris, Seow, Yiqi, Reinares-Sebastian, Alejandro, Forcen, Raquel, Simons, J. Paul, Bellotti, Vittorio, Cooper, J. Mark, Alvarez-Erviti, Lydia

“…The development of new therapies to slow down or halt the progression of Parkinson’s disease is a health care priority. A key pathological feature is the…”
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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy by Gegg, Matthew E., Cooper, J. Mark, Chau, Kai-Yin, Rojo, Manuel, Schapira, Anthony H.V., Taanman, Jan-Willem

“…Mitochondrial dysfunction and perturbed degradation of proteins have been implicated in Parkinson's disease (PD) pathogenesis. Mutations in the Parkin and…”
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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission by Alvarez-Erviti, Lydia, Seow, Yiqi, Schapira, Anthony H, Gardiner, Chris, Sargent, Ian L, Wood, Matthew J.A, Cooper, J. Mark

“…Abstract Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected…”
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Glial activation precedes alpha-synuclein pathology in a mouse model of Parkinson’s disease by Izco, Maria, Blesa, Javier, Verona, Guglielmo, Cooper, J Mark, Alvarez-Erviti, Lydia

“…[Display omitted] •Microglial cell activation in SNpc precedes alpha-synuclein inclusion formation.•In striatum a significant astrogliosis was observed 90…”
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Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains by Gegg, Matthew E., Burke, Derek, Heales, Simon J. R., Cooper, J. Mark, Hardy, John, Wood, Nicholas W., Schapira, Anthony H. V.

“…Objective: Mutations in the glucocerebrosidase gene (GBA) represent a significant risk factor for developing Parkinson disease (PD). We investigated the…”
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Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage by Cleeter, Michael W.J., Chau, Kai-Yin, Gluck, Caroline, Mehta, Atul, Hughes, Derralynn A., Duchen, Michael, Wood, Nicholas William, Hardy, John, Mark Cooper, J., Schapira, Anthony Henry

“…► Glucocerebrosidase gene mutations are a risk factor for Parkinson’s disease. ► Glucocerebrosidase inhibition causes mitochondrial dysfunction & oxidative…”
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G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization by PAPKOVSKAIA, Tatiana D, CHAU, Kai-Yin, MARK COOPER, J, INESTA-VAQUERA, Francisco, PAPKOVSKY, Dmitri B, HEALY, Daniel G, NISHIO, Koji, STADDON, James, DUCHEN, Michael R, HARDY, John, SCHAPIRA, Anthony H. V

“…The G2019S leucine rich repeat kinase 2 (LRRK2) mutation is the most common genetic cause of Parkinson's disease (PD), clinically and pathologically…”
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Silencing of PINK1 expression affects mitochondrial DNA and oxidative phosphorylation in dopaminergic cells by Gegg, Matthew E, Cooper, J Mark, Schapira, Anthony H V, Taanman, Jan-Willem

“…Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson's disease (PD). Impairment of the mitochondrial electron transport chain (ETC)…”
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Intranasal Delivery of pGDNF DNA Nanoparticles Provides Neuroprotection in the Rat 6-Hydroxydopamine Model of Parkinson’s Disease by Aly, Amirah E.-E., Harmon, Brendan T., Padegimas, Linas, Sesenoglu-Laird, Ozge, Cooper, Mark J., Waszczak, Barbara L.

“…Glial cell line-derived neurotrophic factor (GDNF) gene therapy could offer a disease-modifying treatment for Parkinson’s disease (PD). Here, we report that…”
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Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson’s Disease Patients by Yakhine-Diop, Sokhna M. S., Niso-Santano, Mireia, Rodríguez-Arribas, Mario, Gómez-Sánchez, Rubén, Martínez-Chacón, Guadalupe, Uribe-Carretero, Elisabet, Navarro-García, José A., Ruiz-Hurtado, Gema, Aiastui, Ana, Cooper, J. Mark, López de Munaín, Adolfo, Bravo-San Pedro, José M., González-Polo, Rosa A., Fuentes, José M.

“…Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder. While most PD cases are idiopathic, the known genetic causes of PD are useful…”
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Efficient non-viral ocular gene transfer with compacted DNA nanoparticles by Farjo, Rafal, Skaggs, Jeff, Quiambao, Alexander B, Cooper, Mark J, Naash, Muna I

“…The eye is an excellent candidate for gene therapy as it is immune privileged and much of the disease-causing genetics are well understood. Towards this goal,…”
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Intranasal delivery of hGDNF plasmid DNA nanoparticles results in long-term and widespread transfection of perivascular cells in rat brain by Aly, Amirah E-E., Harmon, Brendan, Padegimas, Linas, Sesenoglu-Laird, Ozge, Cooper, Mark J., Yurek, David M., Waszczak, Barbara L.

“…The intranasal route of administration allows large therapeutics to circumvent the blood–brain barrier and be delivered directly to the CNS. Here we examined…”
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Comparative analysis of DNA nanoparticles and AAVs for ocular gene delivery by Han, Zongchao, Conley, Shannon M, Makkia, Rasha, Guo, Junjing, Cooper, Mark J, Naash, Muna I

“…Gene therapy is a critical tool for the treatment of monogenic retinal diseases. However, the limited vector capacity of the current benchmark delivery…”
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Cell Surface Nucleolin Serves as Receptor for DNA Nanoparticles Composed of Pegylated Polylysine and DNA by Chen, Xuguang, Kube, Dianne M, Cooper, Mark J, Davis, Pamela B

“…Compacted DNA nanoparticles deliver transgenes efficiently to the lung following intrapulmonary dosing. Here we show that nucleolin, a protein known to shuttle…”
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Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice by Cooper, J. Mark, Wiklander, P.B. Oscar, Nordin, Joel Z., Al-Shawi, Raya, Wood, Matthew J., Vithlani, Mansi, Schapira, Anthony H. V., Simons, J. Paul, El-Andaloussi, Samir, Alvarez-Erviti, Lydia

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A partial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles by Cai, Xue, Nash, Zack, Conley, Shannon M, Fliesler, Steven J, Cooper, Mark J, Naash, Muna I

“…Previously we have shown that compacted DNA nanoparticles can drive high levels of transgene expression after subretinal injection in the mouse eye. Here we…”
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Extensive Anti-CoA Immunostaining in Alzheimer's Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A by Lashley, Tammaryn, Tossounian, Maria-Armineh, Costello Heaven, Neve, Wallworth, Samantha, Peak-Chew, Sew, Bradshaw, Aaron, Cooper, J Mark, de Silva, Rohan, Srai, Surjit Kaila, Malanchuk, Oksana, Filonenko, Valeriy, Koopman, Margreet B, Rüdiger, Stefan G D, Skehel, Mark, Gout, Ivan

“…Alzheimer's disease (AD) is a neurodegenerative disorder, accounting for at least two-thirds of dementia cases. A combination of genetic, epigenetic and…”
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Relationship between alpha synuclein phosphorylation, proteasomal inhibition and cell death: relevance to Parkinson’s disease pathogenesis by Chau, Kai‐Yin, Ching, Hey Long, Schapira, Anthony H. V., Cooper, J. Mark

“…Alpha synuclein can be phosphorylated at serine129 (P‐S129), and the presence of highly phosphorylated α‐synuclein in Lewy bodies suggests changes to its…”
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Enhancement of airway gene transfer by DNA nanoparticles using a pH-responsive block copolymer of polyethylene glycol and poly- l -lysine by Boylan, Nicholas J, Kim, Anthony J, Suk, Jung Soo, Adstamongkonkul, Pichet, Simons, Brian W, Lai, Samuel K, Cooper, Mark J, Hanes, Justin

“…Abstract Highly compacted DNA nanoparticles, composed of single molecules of plasmid DNA compacted with block copolymers of polyethylene glycol and poly- l…”
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