Search Results - "Cooper, Antony A."

Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology by Guennewig, Boris, Lim, Julia, Marshall, Lee, McCorkindale, Andrew N., Paasila, Patrick J., Patrick, Ellis, Kril, Jillian J., Halliday, Glenda M., Cooper, Antony A., Sutherland, Greg T.

“…Tau pathology in Alzheimer’s disease (AD) spreads in a predictable pattern that corresponds with disease symptoms and severity. At post-mortem there are…”
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Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84 by Montgomery, Magdalene K., Osborne, Brenna, Brandon, Amanda E., O'Reilly, Liam, Fiveash, Corrine E., Brown, Simon H. J., Wilkins, Brendan P., Samsudeen, Azrah, Yu, Josephine, Devanapalli, Beena, Hertzog, Ashley, Tolun, Adviye A., Kavanagh, Tomas, Cooper, Antony A., Mitchell, Todd W., Biden, Trevor J., Smith, Nicola J., Cooney, Gregory J., Turner, Nigel

“…Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid…”
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The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast by Chesi, Alessandra, Kilaru, Austin, Fang, Xiaodong, Cooper, Antony A, Gitler, Aaron D

“…YPK9 (Yeast PARK9; also known as YOR291W) is a non-essential yeast gene predicted by sequence to encode a transmembrane P-type transport ATPase. However, its…”
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Author Correction: Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology by Guennewig, Boris, Lim, Julia, Marshall, Lee, McCorkindale, Andrew N., Paasila, Patrick J., Patrick, Ellis, Kril, Jillian J., Halliday, Glenda M., Cooper, Antony A., Sutherland, Greg T.

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Misfolded proteins traffic from the endoplasmic reticulum (ER) due to ER export signals by Kincaid, Margaret M, Cooper, Antony A

“…Most misfolded secretory proteins remain in the endoplasmic reticulum (ER) and are degraded by ER-associated degradation (ERAD). However, some misfolded…”
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Author Correction: Defining early changes in Alzheimer’s disease from RNA sequencing of brain regions differentially affected by pathology by Guennewig, Boris, Lim, Julia, Marshall, Lee, McCorkindale, Andrew N., Paasila, Patrick J., Patrick, Ellis, Kril, Jillian J., Halliday, Glenda M., Cooper, Antony A., Sutherland, Greg T.

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Machine Learning Identifies Six Genetic Variants and Alterations in the Heart Atrial Appendage as Key Contributors to PD Risk Predictivity by Ho, Daniel, Schierding, William, Farrow, Sophie L, Cooper, Antony A, Kempa-Liehr, Andreas W, O'Sullivan, Justin M

“…Parkinson's disease (PD) is a complex neurodegenerative disease with a range of causes and clinical presentations. Over 76 genetic loci (comprising 90 SNPs)…”
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Redefining the hypotheses driving Parkinson’s diseases research by Farrow, Sophie L., Cooper, Antony A., O’Sullivan, Justin M.

“…Parkinson’s disease (PD) research has largely focused on the disease as a single entity centred on the development of neuronal pathology within the central…”
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Identification of 27 allele-specific regulatory variants in Parkinson’s disease using a massively parallel reporter assay by Farrow, Sophie L., Gokuladhas, Sreemol, Schierding, William, Pudjihartono, Michael, Perry, Jo K., Cooper, Antony A., O’Sullivan, Justin M.

“…Genome wide association studies (GWAS) have identified a number of genomic loci that are associated with Parkinson’s disease (PD) risk. However, the majority…”
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αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson's Disease? by Protter, David, Cooper, Antony A., Lang, Charmaine

“…Parkinson’s Disease (PD) is a complex, chronic, progressive, and debilitating neurodegenerative disorder. Neither a cure nor effective long-term therapy exist…”
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An HRD/DER-Independent ER Quality Control Mechanism Involves Rsp5p-Dependent Ubiquitination and ER-Golgi Transport by Haynes, Cole M., Caldwell, Sabrina, Cooper, Antony A.

“…We have identified a new pathway of ER-associated degradation in Saccharomyces cerevisiae that functions separately from the HRD/DER pathway comprised of…”
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The central role of noncoding RNA in the brain by Guennewig, Boris, Cooper, Antony A

“…Less than 3% of the human genome generates protein-coding transcripts; the majority, far from being strewn with evolutionary "junk," is dynamically transcribed…”
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Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes by Kong, Stephanie M.Y., Chan, Brian K.K., Park, Jin-Sung, Hill, Kathryn J., Aitken, Jade B., Cottle, Louise, Farghaian, Hovik, Cole, Adam R., Lay, Peter A., Sue, Carolyn M., Cooper, Antony A.

“…α-Synuclein plays a central causative role in Parkinson's disease (PD). Increased expression of the P-type ATPase ion pump PARK9/ATP13A2 suppresses α-Synuclein…”
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Establishing gene regulatory networks from Parkinson's disease risk loci by Farrow, Sophie L, Schierding, William, Gokuladhas, Sreemol, Golovina, Evgeniia, Fadason, Tayaza, Cooper, Antony A, O'Sullivan, Justin M

“…The latest meta-analysis of genome-wide association studies identified 90 independent variants across 78 genomic regions associated with Parkinson's disease,…”
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α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity by Gitler, Aaron D, Cooper, Antony A, Rochet, Jean-Christophe, Strathearn, Katherine E, Hill, Kathryn J, Chesi, Alessandra, Geddie, Melissa L, Caldwell, Kim A, Lindquist, Susan, Hamamichi, Shusei, Caldwell, Guy A

“…Susan Lindquist and colleagues report a genetic interaction between α-synuclein and the ortholog of human ATP13A2 (PARK9) in yeast, two genes that when mutated…”
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Enhancers active in dopamine neurons are a primary link between genetic variation and neuropsychiatric disease by Dong, Xianjun, Liao, Zhixiang, Gritsch, David, Hadzhiev, Yavor, Bai, Yunfei, Locascio, Joseph J., Guennewig, Boris, Liu, Ganqiang, Blauwendraat, Cornelis, Wang, Tao, Adler, Charles H., Hedreen, John C., Faull, Richard L. M., Frosch, Matthew P., Nelson, Peter T., Rizzu, Patrizia, Cooper, Antony A., Heutink, Peter, Beach, Thomas G., Mattick, John S., Müller, Ferenc, Scherzer, Clemens R.

“…Enhancers function as DNA logic gates and may control specialized functions of billions of neurons. Here we show a tailored program of noncoding genome…”
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α-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models by Cooper, Antony A, Gitler, Aaron D, Cashikar, Anil, Haynes, Cole M, Hill, Kathryn J, Bhullar, Bhupinder, Liu, Kangning, Xu, Kexiang, Strathearn, Katherine E, Liu, Fang, Cao, Songsong, Caldwell, Kim A, Caldwell, Guy A, Marsischky, Gerald, Kolodner, Richard D, LaBaer, Joshua, Rochet, Jean-Christophe, Bonini, Nancy M, Lindquist, Susan

“…Alpha-synuclein (αSyn) misfolding is associated with several devastating neurodegenerative disorders, including Parkinson's disease (PD). In yeast cells and in…”
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Degradation of Misfolded Proteins Prevents ER-Derived Oxidative Stress and Cell Death by Haynes, Cole M., Titus, Eric A., Cooper, Antony A.

“…A variety of debilitating diseases including diabetes, Alzheimer's, Huntington's, Parkinson's, and prion-based diseases are linked to stress within the…”
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ERADicate ER stress or die trying by Kincaid, Margaret M, Cooper, Antony A

“…Stress within the endoplasmic reticulum (ER) induces a sophisticated network of pathways termed the unfolded protein response (UPR), which is mediated through…”
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Intronic Haplotypes in GBA Modify Age at Diagnosis of Parkinson's: Replication in a Subgroup by O'Sullivan, Justin M., Heijer, Jonas M., Groeneveld, Geert J., Cooper, Antony A.

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