Search Results - "Cooper, Alan B."

1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents by Cooper, Alan B., Ciblat, Stephane, Shipps, Gerald, Levine, Jedd, Kostura, Matthew, Oza, Vibha, Constantineau-Forget, Lea, Dery, Martin, Grand-Maitre, Chantal, Bruneau-Latour, Nicolas, Bellavance, Edith, Patane, Michael, Siddiqui, Arshad, Luther, Michael

“…[Display omitted] A class of substituted 1-thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives was found to have potent anti-proliferative…”
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Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology by Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Yao, Xin, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Hruza, Alan, Buevich, Alexei, Zhang, Li-Kang, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert

“…[Display omitted] •Discovery of potent, selective and orally bioavailable ERK inhibitor for oncology.•Synthesis of tert 3-(S)thiomethyl pyrrolidine based ERK…”
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MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology by Boga, Sobhana Babu, Deng, Yongqi, Zhu, Liang, Nan, Yang, Cooper, Alan B., Shipps, Gerald W., Doll, Ronald, Shih, Neng-Yang, Zhu, Hugh, Sun, Robert, Wang, Tong, Paliwal, Sunil, Tsui, Hon-Chung, Gao, Xiaolei, Yao, Xin, Desai, Jagdish, Wang, James, Alhassan, Abdul Basit, Kelly, Joseph, Patel, Mehul, Muppalla, Kiran, Gudipati, Subrahmanyam, Zhang, Li-Kang, Buevich, Alexei, Hesk, David, Carr, Donna, Dayananth, Priya, Black, Stuart, Mei, Hong, Cox, Kathleen, Sherborne, Bradley, Hruza, Alan W., Xiao, Li, Jin, Weihong, Long, Brian, Liu, Gongjie, Taylor, Stacey A., Kirschmeier, Paul, Windsor, William T., Bishop, Robert, Samatar, Ahmed A.

“…The emergence and evolution of new immunological cancer therapies has sparked a rapidly growing interest in discovering novel pathways to treat cancer. Toward…”
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Corrigendum to “1-Thiazol-2-yl-N-3-methyl-1H-pyrozole-5-carboxylic acid derivatives as antitumor agents” [Bioorg. Med. Chem. Lett. 27 (2017) 4471–4477] by Cooper, Alan B., Ciblat, Stephane, Shipps, Gerald, Levine, Jedd, Kostura, Matthew, Oza, Vibha, Constantineau-Forget, Lea, Dery, Martin, Grand-Maitre, Chantal, Bruneau-Latour, Nicolas, Bellavance, Edith, Patane, Michael, Siddiqui, Arshad, Luther, Michael

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New class of azaheptapyridine FPT inhibitors as potential cancer therapy agents by Zhu, Hugh Y, Desai, Jagdish, Cooper, Alan B, Wang, James, Rane, Dinananth F, Kirschmeier, Paul, Strickland, Corey, Liu, Ming, Nomeir, Amin A, Girijavallabhan, Viyyoor M

“…Tertiary hydroxyl class of C-imidazole bridgehead azaheptapyridine FPT inhibitors were prepared in an attempt to block in vivo oxidation of secondary hydroxyl…”
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Pyrazolo[1,5- a]pyrimidine-based inhibitors of HCV polymerase by Popovici-Muller, Janeta, Shipps, Gerald W., Rosner, Kristin E., Deng, Yongqi, Wang, Tong, Curran, Patrick J., Brown, Meredith A., Siddiqui, M. Arshad, Cooper, Alan B., Duca, José, Cable, Michael, Girijavallabhan, Viyyoor

“…Synthesis and optimization of novel pyrazolo[1,5- a]pyrimidine HCV polymerase inhibitors are described. The present paper describes a novel series of HCV RNA…”
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Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase by YONGQI DENG, SHIPPS, Gerald W, TONG WANG, POPOVICI-MULLER, Janeta, ROSNER, Kristin E, ARSHAD SIDDIQUI, M, DUCA, Jose, COOPER, Alan B, CABLE, Michael

“…A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase…”
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Discovery of C-imidazole azaheptapyridine FPT inhibitors by Zhu, Hugh Y., Cooper, Alan B., Desai, Jagdish, Njoroge, George, Kirschmeier, Paul, Bishop, W. Robert, Strickland, Corey, Hruza, Alan, Doll, Ronald J., Girijavallabhan, Viyyoor M.

“…The discovery of C-linked imidazole azaheptapyridine bridgehead FPT inhibitors is described. This novel class of compounds are sub nM FPT enzyme inhibitors…”
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Total synthesis of the antifungal cyclic depsipeptides Sch 57697 and aureobasidin A by Jao, Edwin, Cooper, Alan B, Rane, Dinanath F, Saksena, Anil K, Desai, Jagdish, Wang, James, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

“…A novel cyclic depsinonapeptide antifungal 1a (Sch 57697) and its isomer 1b were synthesized by a fragment coupling approach and this methodology was applied…”
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(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336):  A Very Potent Farnesyl Protein Transferase Inhibitor as a Novel Antitumor Agent by Njoroge, F. George, Taveras, Arthur G, Kelly, Joseph, Remiszewski, Stacy, Mallams, Alan K, Wolin, Ronald, Afonso, Adriano, Cooper, Alan B, Rane, Dinananth F, Liu, Yi-Tsung, Wong, Jesse, Vibulbhan, Bancha, Pinto, Patrick, Deskus, Jeffrey, Alvarez, Carmen S, del Rosario, Joycelyn, Connolly, Michael, Wang, James, Desai, Jagdish, Rossman, Randall R, Bishop, W. Robert, Patton, Robert, Wang, Lynn, Kirschmeier, Paul, Bryant, Mathew S, Nomeir, Amin A, Lin, C.-C, Liu, Ming, McPhail, Andrew T, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

“…We have previously shown that appropriate modification of the benzocycloheptapyridine tricyclic ring system can provide potent farnesyl protein transferase…”
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Guiding farnesyltransferase inhibitors from an ECLiPS ® library to the catalytic zinc by Huang, Chia-Yu, Stauffer, Tara M., Strickland, Corey L., Reader, John C., Huang, He, Li, Ge, Cooper, Alan B., Doll, Ronald J., Ganguly, Ashit K., Baldwin, John J., Rokosz, Laura L.

“…Compounds 8 and 41 are potent analogs of farnesyltransferase inhibitors that were identified from an ECLiPS ® library screen. X-ray crystallographic analyses…”
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Aminothiazole inhibitors of HCV RNA polymerase by Shipps, Gerald W., Deng, Yongqi, Wang, Tong, Popovici-Muller, Janeta, Curran, Patrick J., Rosner, Kristin E., Cooper, Alan B., Girijavallabhan, Viyyoor, Butkiewicz, Nancy, Cable, Michael

“…[Display omitted] Aminothiazole-based inhibitors designed for HCV polymerase display low micromolar potencies in biochemical assays. These compounds show a…”
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Transcription of Fragments of Lectures in 1948 by Harry Stack Sullivan by Cooper, Alan B., Guynn, Robert W.

“…Psychiatrist Harry Stack Sullivan, like virtually all psychiatrists of his era, was originally exposed to classic psychoanalytic theory and underwent some 200…”
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Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidine-N-cyanoguanidine derivatives as inhibitors of ras farnesyl protein transferase by Cooper, Alan B, Strickland, Corey L, Wang, James, Desai, Jagdish, Kirschmeier, Paul, Patton, Robert, Bishop, W Robert, Weber, Patricia C, Girijavallabhan, V

“…A series of novel N-cyanoguanidine tricyclic farnesyl protein transferase (FPT) inhibitors was prepared. Replacement of a piperidine amide-group with a…”
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Structure-based drug design of clinical compound MK-8353, a novel inhibitor of ERK by Hruza, Alan, Boga, Sobhana Babu, Alhassan, Abdul-Basit, Cooper, Alan B., Doll, Ronald, Shih, Neng-Yang, Shipps, Gerald, Deng, Yongqi, Zhu, Hugh, Nan, Yang, Sun, Robert, Zhu, Liang, Desai, Jagdish, Patel, Mehul, Muppalla, Kiran, Gao, Xiaolei, Wang, James, Kelly, Joseph, Gudipati, Subrahmanyam, Paliwal, Sunil, Tsui, Hon-Chung, Wang, Tong, Sherborne, Bradley, Xiao, Li, Buevich, Alexei, Hesk, David, Samatar, Ahmed A., Carr, Donna, Long, Brian, Black, Stuart, Dayananth, Priya, Windsor, William, Kirschmeier, Paul, Bishop, Robert

“…Abstract only…”
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[3+2] Cycloaddition-mediated synthesis of 3-methylsulfanyl-pyrrolidine-3-carboxylic acid methyl ester by Boga, Sobhana B., Alhassan, Abdul-Basit, Cooper, Alan B., Shih, Neng-Yang, Doll, Ronald J.

“…Montmorollonite K-10 was found to be an efficient catalyst for the [3+2] annulation of thiomethylacrylate 2 and azomethine ylide precursor 3 towards the…”
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Discovery of 4 H-pyrazolo[1,5- a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase by Deng, Yongqi, Shipps, Gerald W., Wang, Tong, Popovici-Muller, Janeta, Rosner, Kristin E., Siddiqui, M. Arshad, Duca, Jose, Cooper, Alan B., Cable, Michael

“…The design, synthesis and evaluation of a series of 4 H-Pyrazolo[1,5- a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase are described. A…”
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Transcription of fragments of lectures in 1948 by Harry Stack Sullivan. Commentary by COOPER, Alan B, GUYNN, Robert W, GAARDER, Kenneth R, SCHULZ, Clarence G, KAFKA, John S

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Synthesis of 5,6-dihydro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidine-N-cyano guanidine derivatives as inhibitors of ras farnesyl protein transferase by COOPER, Alan B, STRICKLAND, Corey L, WANG, James, DESAI, Jagdish, KIRSCHMEIER, Paul, PATTON, Robert, BISHOP, W. Robert, WEBER, Patricia C, GIRIJAVALLABHAN, V

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Synthesis of 5,6-Dihydro-11 H-benzo[5,6]-cyclohepta[1,2- b]pyridin-11-ylidene)-1-piperidine- N-cyanoguanidine Derivatives as Inhibitors of Ras Farnesyl Protein Transferase by Cooper, Alan B, Strickland, Corey L, Wang, James, Desai, Jagdish, Kirschmeier, Paul, Patton, Robert, Bishop, W.Robert, Weber, Patricia C, Girijavallabhan, V

“…A series of novel N-cyanoguanidine tricyclic farnesyl protein transferase (FPT) inhibitors was prepared. Replacement of a piperidine amide-group with a…”
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