Search Results - "Coons, Laurel"

Lavender Products Associated With Premature Thelarche and Prepubertal Gynecomastia: Case Reports and Endocrine-Disrupting Chemical Activities by Ramsey, J Tyler, Li, Yin, Arao, Yukitomo, Naidu, Ajanta, Coons, Laurel A, Diaz, Alejandro, Korach, Kenneth S

“…Abstract Context Previous case reports associated prepubertal gynecomastia with lavender-containing fragrances, but there appear to be no reports of premature…”
Get full text

Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand-ERα Complexes by Li, Yin, Perera, Lalith, Coons, Laurel A, Burns, Katherine A, Tyler Ramsey, J, Pelch, Katherine E, Houtman, René, van Beuningen, Rinie, Teng, Christina T, Korach, Kenneth S

“…Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that might be harmful to human health. Recently, there has been widespread usage of bisphenol…”
Get full text

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes by Xu, Beibei, Allard, Camille, Alvarez-Mercado, Ana I., Fuselier, Taylor, Kim, Jun Ho, Coons, Laurel A., Hewitt, Sylvia C., Urano, Fumihiko, Korach, Kenneth S., Levin, Ellis R., Arvan, Peter, Floyd, Z. Elizabeth, Mauvais-Jarvis, Franck

“…Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum…”
Get full text

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023 by Burris, Thomas P, de Vera, Ian Mitchelle S, Cote, Isabelle, Flaveny, Colin A, Wanninayake, Udayanga S, Chatterjee, Arindam, Walker, John K, Steinauer, Nickolas, Zhang, Jinsong, Coons, Laurel A, Korach, Kenneth S, Cain, Derek W, Hollenberg, Anthony N, Webb, Paul, Forrest, Douglas, Jetten, Anton M, Edwards, Dean P, Grimm, Sandra L, Hartig, Sean, Lange, Carol A, Richer, Jennifer K, Sartorius, Carol A, Tetel, Marc, Billon, Cyrielle, Elgendy, Bahaa, Hegazy, Lamees, Griffett, Kristine, Peinetti, Nahuel, Burnstein, Kerry L, Hughes, Travis S, Sitaula, Sadichha, Stayrook, Keitch R, Culver, Alexander, Murray, Meghan H, Finck, Brian N, Cidlowski, John A

“…The NR superfamily comprises 48 transcription factors in humans that control a plethora of gene network programs involved in a wide range of physiologic…”
Get full text

Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites by Perera, Lalith, Li, Yin, Coons, Laurel A., Houtman, Rene, van Beuningen, Rinie, Goodwin, Bonnie, Auerbach, Scott S., Teng, Christina T.

“…Bisphenol A (BPA), bisphenol AF (BPAF), and bisphenol S (BPS) are well known endocrine disruptors. Previous in vitro studies showed that these compounds…”
Get full text

Transactivation Function-2 of Estrogen Receptor α Contains Transactivation Function-1-regulating Element by Arao, Yukitomo, Coons, Laurel A., Zuercher, William J., Korach, Kenneth S.

“…ERα has a ligand-dependent transactivation function in the ligand binding domain of ERα C terminus (AF-2) and a ligand-independent activation function in the N…”
Get full text

DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin by Coons, Laurel A, Hewitt, Sylvia C, Burkholder, Adam B, McDonnell, Donald P, Korach, Kenneth S

“…Gene regulatory programs are encoded in the sequence of the DNA. Since the completion of the Human Genome Project, millions of gene regulatory elements have…”
Get full text

DNA methylation and transcriptome aberrations mediated by ERα in mouse seminal vesicles following developmental DES exposure by Li, Yin, Hamilton, Katherine J., Wang, Tianyuan, Coons, Laurel A., Jefferson, Wendy N., Li, Ruifang, Wang, Yu, Grimm, Sara A., Ramsey, J. Tyler, Liu, Liwen, Gerrish, Kevin E., Williams, Carmen J., Wade, Paul A., Korach, Kenneth S.

“…Early transient developmental exposure to an endocrine active compound, diethylstilbestrol (DES), a synthetic estrogen, causes late-stage effects in the…”
Get full text

Differential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs) by Donoghue, Lauren J, Neufeld, Thomas I, Li, Yin, Arao, Yukitomo, Coons, Laurel A, Korach, Kenneth S

“…Endocrine-disrupting chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects…”
Get full text

Estrogen Receptor α L543A,L544A Mutation Changes Antagonists to Agonists, Correlating with the Ligand Binding Domain Dimerization Associated with DNA Binding Activity by Arao, Yukitomo, Hamilton, Katherine J., Coons, Laurel A., Korach, Kenneth S.

“…A ligand-dependent nuclear transcription factor, ERα has two transactivating functional domains (AF), AF-1 and AF-2. AF-1 is localized in the N-terminal…”
Get full text

Long-Term Follow-Up and Treatment of a Female With Complete Estrogen Insensitivity by Brakta, Soumia, Chorich, Lynn P, Kim, Hyung-Goo, Coons, Laurel A, Katzenellenbogen, John A, Hall, Janet E, Korach, Kenneth S, Layman, Lawrence C

“…Abstract Context We previously reported the first female with a causative ESR1 gene variant, who exhibited absent puberty and high estrogens. At age 15 years,…”
Get full text

A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment by Li, Yin, Coons, Laurel A, Houtman, René, Carlson, Kathryn E, Martin, Teresa A, Mayne, Christopher G, Melchers, Diana, Jefferson, Tanner B, Ramsey, J Tyler, Katzenellenbogen, John A, Korach, Kenneth S

“…A homozygous missense mutation in the gene encoding the estrogen receptor α (ERα) was previously identified in a female patient with estrogen insensitivity…”
Get more information

Activation of hepatic estrogen receptor-α increases energy expenditure by stimulating the production of fibroblast growth factor 21 in female mice by Allard, Camille, Bonnet, Fabrice, Xu, Beibei, Coons, Laurel, Albarado, Diana, Hill, Cristal, Fagherazzi, Guy, Korach, Kenneth S., Levin, Ellis R., Lefante, John, Morrison, Christopher, Mauvais-Jarvis, Franck

“…The endogenous estrogen 17β-estradiol (E2) promotes metabolic homeostasis in premenopausal women. In a mouse model of post-menopausal metabolic syndrome, we…”
Get full text

Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome by Coons, Laurel A., Burkholder, Adam B., Hewitt, Sylvia C., McDonnell, Donald P., Korach, Kenneth S.

“…Understanding why a transcription factor (TF) binds to a specific DNA element in the genome and whether that binding event affects transcriptional output…”
Get full text

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Nuclear hormone receptors by Alexander, Stephen PH, Cidlowski, John A, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Coons, Laurel, Fuller, Peter J., Korach, Kenneth S., Young, Morag J.

“…The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
Get full text

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Nuclear hormone receptors by Alexander, Stephen PH, Cidlowski, John A, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A, Coons, Laurel, Fuller, Peter, Korach, Kenneth S, Young, Morag

“…The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key…”
Get full text

The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors by Alexander, Stephen P. H., Cidlowski, John A., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Coons, Laurel, Fuller, Peter J., Korach, Kenneth S., Young, Morag J.

“…The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
Get full text

Differential activation of a mouse estrogen receptor [beta] isoform by Donoghue, Lauren J, Neufeld, Thomas I, Li, Yin, Arao, Yukitomo, Coons, Laurel A, Korach, Kenneth S

“…BACKGROUND: Endocrine-disrupting chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) [alpha] or [beta] (mER[beta]1…”
Get full text

The Concise Guide to PHARMACOLOGY 2021/22 by Alexander, Stephen P H, Cidlowski, John A, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Coons, Laurel, Fuller, Peter J, Korach, Kenneth S, Young, Morag J

“…The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
Get full text

DNA methylation and transcriptome aberrations mediated by ERa in mouse seminal vesicles following developmental DES exposure by Li, Yin, Hamilton, Katherine J, Wang, Tianyuan, Coons, Laurel A, Jefferson, Wendy N, Li, Ruifang, Wang, Yu, Grimm, Sara A, Ramsey, J Tyler, Liu, Liwen, Gerrish, Kevin E, Williams, Carmen J, Wade, Paul A, Korach, Kenneth S

“…Early transient developmental exposure to an endocrine active compound, diethylstilbestrol (DES), a synthetic estrogen, causes late-stage effects in the…”
Get full text