Search Results - "Coonrod, Scott A"

Histone Hypercitrullination Mediates Chromatin Decondensation and Neutrophil Extracellular Trap Formation by Wang, Yanming, Li, Ming, Stadler, Sonja, Correll, Sarah, Li, Pingxin, Wang, Danchen, Hayama, Ryo, Leonelli, Lauriebeth, Han, Hyunsil, Grigoryev, Sergei A., Allis, C. David, Coonrod, Scott A.

“…Peripheral blood neutrophils form highly decondensed chromatin structures, termed neutrophil extracellular traps (NETs), that have been implicated in innate…”
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PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling by Qin, Hao, Liu, Xiaoqiu, Li, Fujun, Miao, Lixia, Li, Tingting, Xu, Boqun, An, Xiaofei, Muth, Aaron, Thompson, Paul R., Coonrod, Scott A., Zhang, Xuesen

“…Peptidylargininedeiminase 1 (PAD1) catalyzes protein for citrullination, and this activity has been linked to the epidermal cornification. However, a role for…”
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Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells by Horibata, Sachi, Vo, Tommy V, Subramanian, Venkataraman, Thompson, Paul R, Coonrod, Scott A

“…Given the inherent difficulties in investigating the mechanisms of tumor progression in vivo, cell-based assays such as the soft agar colony formation assay…”
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Potential role for PAD2 in gene regulation in breast cancer cells by Cherrington, Brian D, Zhang, Xuesen, McElwee, John L, Morency, Eric, Anguish, Lynne J, Coonrod, Scott A

“…The peptidylarginine deiminase (PAD) family of enzymes post-translationally convert positively charged arginine residues in substrate proteins to the neutral,…”
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Design, Synthesis, and Biological Evaluation of Tetrazole Analogs of Cl-Amidine as Protein Arginine Deiminase Inhibitors by Subramanian, Venkataraman, Knight, Jason S, Parelkar, Sangram, Anguish, Lynne, Coonrod, Scott A, Kaplan, Mariana J, Thompson, Paul R

“…Protein arginine deiminases (PADs) catalyze the post-translational hydrolysis of arginine residues to form citrulline. This once obscure modification is now…”
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Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation by Zhang, Xuesen, Bolt, Michael, Guertin, Michael J, Chen, Wei, Zhang, Sheng, Cherrington, Brian D, Slade, Daniel J, Dreyton, Christina J, Subramanian, Venkataraman, Bicker, Kevin L, Thompson, Paul R, Mancini, Michael A, Lis, John T, Coonrod, Scott A

“…Cofactors for estrogen receptor α (ERα) can modulate gene activity by posttranslationally modifying histone tails at target promoters. Here, we found that…”
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GDNF-RET signaling and EGR1 form a positive feedback loop that promotes tamoxifen resistance via cyclin D1 by Marks, Brooke A, Pipia, Ilissa M, Mukai, Chinatsu, Horibata, Sachi, Rice, Edward J, Danko, Charles G, Coonrod, Scott A

“…Rearranged during transfection (RET) tyrosine kinase signaling has been previously implicated in endocrine resistant breast cancer, however the mechanism by…”
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Transient Estrogen Receptor Binding and p300 Redistribution Support a Squelching Mechanism for Estradiol-Repressed Genes by Guertin, Michael J, Zhang, Xuesen, Coonrod, Scott A, Hager, Gordon L

“…Proper gene regulation is essential for proper organismal development and appropriate responses to external stimuli. Specialized factors, termed master…”
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Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells by Li, Fujun, Miao, Lixia, Xue, Teng, Qin, Hao, Mondal, Santanu, Thompson, Paul R, Coonrod, Scott A, Liu, Xiaoqiu, Zhang, Xuesen

“…Tamoxifen resistance presents a huge clinical challenge for breast cancer patients. An understanding of the mechanisms of tamoxifen resistance can guide…”
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Role for Peptidylarginine Deiminase Enzymes in Disease and Female Reproduction by HORIBATA, Sachi, COONROD, Scott A., CHERRINGTON, Brian D.

“…The peptidylarginine deiminases (PADs) are a family of calcium-dependent enzymes that post-translationally convert positively charged arginine residues to…”
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Targeted H3R26 deimination specifically facilitates estrogen receptor binding by modifying nucleosome structure by Guertin, Michael J, Zhang, Xuesen, Anguish, Lynne, Kim, Sohyoung, Varticovski, Lyuba, Lis, John T, Hager, Gordon L, Coonrod, Scott A

“…Transcription factor binding to DNA in vivo causes the recruitment of chromatin modifiers that can cause changes in chromatin structure, including the…”
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Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice by Sams, Kelly L, Mukai, Chinatsu, Marks, Brooke A, Mittal, Chitvan, Demeter, Elena Alina, Nelissen, Sophie, Grenier, Jennifer K, Tate, Ann E, Ahmed, Faraz, Coonrod, Scott A

“…Abstract Background Peptidylarginine deiminase enzymes (PADs) convert arginine residues to citrulline in a process called citrullination or deimination…”
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Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells by Stadler, Sonja C, Vincent, C Theresa, Fedorov, Victor D, Patsialou, Antonia, Cherrington, Brian D, Wakshlag, Joseph J, Mohanan, Sunish, Zee, Barry M, Zhang, Xuesen, Garcia, Benjamin A, Condeelis, John S, Brown, Anthony M C, Coonrod, Scott A, Allis, C David

“…Peptidylarginine deiminase 4 (PAD4) is a Ca ²⁺-dependent enzyme that converts arginine and methylarginine residues to citrulline, with histone proteins being…”
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Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development by Zhang, Xiaoqian, Liu, Xiaoqiu, Zhang, Mei, Li, Tingting, Muth, Aaron, Thompson, Paul R., Coonrod, Scott A., Zhang, Xuesen

“…Peptidylarginine deiminase (PADI) enzymes are increasingly being associated with the regulation of chromatin structure and gene activity via histone…”
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Identification of PADI2 as a potential breast cancer biomarker and therapeutic target by McElwee, John L, Mohanan, Sunish, Griffith, Obi L, Breuer, Heike C, Anguish, Lynne J, Cherrington, Brian D, Palmer, Ashley M, Howe, Louise R, Subramanian, Venkataraman, Causey, Corey P, Thompson, Paul R, Gray, Joe W, Coonrod, Scott A

“…We have recently reported that the expression of peptidylarginine deiminase 2 (PADI2) is regulated by EGF in mammary cancer cells and appears to play a role in…”
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Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices by Kan, Rui, Yurttas, Piraye, Kim, Boram, Jin, Mei, Wo, Luccie, Lee, Bora, Gosden, Roger, Coonrod, Scott A.

“…Organelle positioning and movement in oocytes is largely mediated by microtubules (MTs) and their associated motor proteins. While yet to be studied in germ…”
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Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration by Horibata, Sachi, Rogers, Katherine E, Sadegh, David, Anguish, Lynne J, McElwee, John L, Shah, Pragya, Thompson, Paul R, Coonrod, Scott A

“…Penetration of the mammary gland basement membrane by cancer cells is a crucial first step in tumor invasion. Using a mouse model of ductal carcinoma in situ,…”
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Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo by Yurttas, Piraye, Vitale, Alejandra M, Fitzhenry, Robert J, Cohen-Gould, Leona, Wu, Wenzhu, Gossen, Jan A, Coonrod, Scott A

“…The mechanisms that mediate the establishment of totipotency during the egg-to-embryo transition in mammals remain poorly understood. However, it is clear that…”
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Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination by Wang, Yanming, Wysocka, Joanna, Sayegh, Joyce, Lee, Young-Ho, Perlin, Julie R., Leonelli, Lauriebeth, Sonbuchner, Lakshmi S., McDonald, Charles H., Cook, Richard G., Dou, Yali, Roeder, Robert C., Clarke, Steven, Stallcup, Michael R., Allis, C. David, Coonrod, Scott A.

“…Methylation of arginine (Arg) and lysine residues in histones has been correlated with epigenetic forms of gene regulation. Although histone methyltransferases…”
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ER-positive breast cancer cells are poised for RET-mediated endocrine resistance by Horibata, Sachi, Rice, Edward J, Mukai, Chinatsu, Marks, Brooke A, Sams, Kelly, Zheng, Hui, Anguish, Lynne J, Coonrod, Scott A, Danko, Charles G

“…The RET tyrosine kinase signaling pathway is involved in the development of endocrine resistant ER+ breast cancer. However, we know little about how ER+ cells…”
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