Search Results - "Cooney, Gregory J."

Branched chain amino acids, aging and age-related health by Le Couteur, David G., Solon-Biet, Samantha M., Cogger, Victoria C., Ribeiro, Rosilene, de Cabo, Rafael, Raubenheimer, David, Cooney, Gregory J., Simpson, Stephen J.

“…•Branched chain amino acids influence aging, sarcopenia and cardiometabolic disease.•Branched chain amino acids regulate food intake, protein synthesis and…”
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The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice by Solon-Biet, Samantha M., McMahon, Aisling C., Ballard, J. William O., Ruohonen, Kari, Wu, Lindsay E., Cogger, Victoria C., Warren, Alessandra, Huang, Xin, Pichaud, Nicolas, Melvin, Richard G., Gokarn, Rahul, Khalil, Mamdouh, Turner, Nigel, Cooney, Gregory J., Sinclair, David A., Raubenheimer, David, Le Couteur, David G., Simpson, Stephen J.

“…The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the…”
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Modeling insulin resistance in rodents by alterations in diet: what have high-fat and high-calorie diets revealed? by Small, Lewin, Brandon, Amanda E, Turner, Nigel, Cooney, Gregory J

“…For over half a century, researchers have been feeding different diets to rodents to examine the effects of macronutrients on whole body and tissue insulin…”
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Fatty acid metabolism, energy expenditure and insulin resistance in muscle by Turner, Nigel, Cooney, Gregory J, Kraegen, Edward W, Bruce, Clinton R

“…Fatty acids (FAs) are essential elements of all cells and have significant roles as energy substrates, components of cellular structure and signalling…”
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Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice by Wahl, Devin, Solon-Biet, Samantha M., Wang, Qiao-Ping, Wali, Jibran A., Pulpitel, Tamara, Clark, Ximonie, Raubenheimer, David, Senior, Alistair M., Sinclair, David A., Cooney, Gregory J., de Cabo, Rafael, Cogger, Victoria C., Simpson, Stephen J., Le Couteur, David G.

“…Calorie restriction (CR) increases lifespan and improves brain health in mice. Ad libitum low-protein, high-carbohydrate (LPHC) diets also extend lifespan, but…”
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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism by Turner, Nigel, Lim, Xin Ying, Toop, Hamish D., Osborne, Brenna, Brandon, Amanda E., Taylor, Elysha N., Fiveash, Corrine E., Govindaraju, Hemna, Teo, Jonathan D., McEwen, Holly P., Couttas, Timothy A., Butler, Stephen M., Das, Abhirup, Kowalski, Greg M., Bruce, Clinton R., Hoehn, Kyle L., Fath, Thomas, Schmitz-Peiffer, Carsten, Cooney, Gregory J., Montgomery, Magdalene K., Morris, Jonathan C., Don, Anthony S.

“…Specific forms of the lipid ceramide, synthesized by the ceramide synthase enzyme family, are believed to regulate metabolic physiology. Genetic mouse models…”
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Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice by Alexopoulos, Stephanie J., Chen, Sing-Young, Brandon, Amanda E., Salamoun, Joseph M., Byrne, Frances L., Garcia, Christopher J., Beretta, Martina, Olzomer, Ellen M., Shah, Divya P., Philp, Ashleigh M., Hargett, Stefan R., Lawrence, Robert T., Lee, Brendan, Sligar, James, Carrive, Pascal, Tucker, Simon P., Philp, Andrew, Lackner, Carolin, Turner, Nigel, Cooney, Gregory J., Santos, Webster L., Hoehn, Kyle L.

“…Obesity is a health problem affecting more than 40% of US adults and 13% of the global population. Anti-obesity treatments including diet, exercise, surgery…”
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Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control by Solon-Biet, Samantha M., Cogger, Victoria C., Pulpitel, Tamara, Wahl, Devin, Clark, Ximonie, Bagley, Elena E., Gregoriou, Gabrielle C., Senior, Alistair M., Wang, Qiao-Ping, Brandon, Amanda E., Perks, Ruth, O’Sullivan, John, Koay, Yen Chin, Bell-Anderson, Kim, Kebede, Melkam, Yau, Belinda, Atkinson, Clare, Svineng, Gunbjorg, Dodgson, Tim, Wali, Jibran A., Piper, Matthew D. W., Juricic, Paula, Partridge, Linda, Rose, Adam J., Raubenheimer, David, Cooney, Gregory J., Le Couteur, David G., Simpson, Stephen J.

“…Elevated branched-chain amino acids (BCAAs) are associated with obesity and insulin resistance. How long-term dietary BCAAs impact late-life health and…”
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Effects of feeding time on daily rhythms of neuropeptide and clock gene expression in the rat hypothalamus by Wang, Dawei, Opperhuizen, Anne-Loes, Reznick, Jane, Turner, Nigel, Su, Yan, Cooney, Gregory J., Kalsbeek, Andries

“…•Feeding at an unnatural time-of-day induces desynchronization in SCN target areas.•Restricting feeding time affects rhythmicity of molecular clocks in…”
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Lactate production is a prioritized feature of adipocyte metabolism by Krycer, James R., Quek, Lake-Ee, Francis, Deanne, Fazakerley, Daniel J., Elkington, Sarah D., Diaz-Vegas, Alexis, Cooke, Kristen C., Weiss, Fiona C., Duan, Xiaowen, Kurdyukov, Sergey, Zhou, Ping-Xin, Tambar, Uttam K., Hirayama, Akiyoshi, Ikeda, Satsuki, Kamei, Yushi, Soga, Tomoyoshi, Cooney, Gregory J., James, David E.

“…Adipose tissue is essential for whole-body glucose homeostasis, with a primary role in lipid storage. It has been previously observed that lactate production…”
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Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance by BRUCE, Clinton R, HOY, Andrew J, TURNER, Nigel, WATT, Matthew J, ALLEN, Tamara L, CARPENTER, Kevin, COONEY, Gregory J, FEBBRAIO, Mark A, KRAEGEN, Edward W

“…Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin…”
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Contrasting metabolic effects of medium- versus long-chain fatty acids in skeletal muscle[S] by Montgomery, Magdalene K., Osborne, Brenna, Brown, Simon H.J., Small, Lewin, Mitchell, Todd W., Cooney, Gregory J., Turner, Nigel

“…Dietary intake of long-chain fatty acids (LCFAs) plays a causative role in insulin resistance and risk of diabetes. Whereas LCFAs promote lipid accumulation…”
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Regulation of mitochondrial metabolism in murine skeletal muscle by the medium‐chain fatty acid receptor Gpr84 by Montgomery, Magdalene K., Osborne, Brenna, Brandon, Amanda E., O'Reilly, Liam, Fiveash, Corrine E., Brown, Simon H. J., Wilkins, Brendan P., Samsudeen, Azrah, Yu, Josephine, Devanapalli, Beena, Hertzog, Ashley, Tolun, Adviye A., Kavanagh, Tomas, Cooper, Antony A., Mitchell, Todd W., Biden, Trevor J., Smith, Nicola J., Cooney, Gregory J., Turner, Nigel

“…Fatty acid receptors have been recognized as important players in glycaemic control. This study is the first to describe a role for the medium‐chain fatty acid…”
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Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival by Nelson, Marin E., Lahiri, Sujoy, Chow, Jenny D. Y., Byrne, Frances L., Hargett, Stefan R., Breen, David S., Olzomer, Ellen M., Wu, Lindsay E., Cooney, Gregory J., Turner, Nigel, James, David E., Slack-Davis, Jill K., Lackner, Carolin, Caldwell, Stephen H., Hoehn, Kyle L.

“…The metabolic pathway of de novo lipogenesis is frequently upregulated in human liver tumours, and its upregulation is associated with poor prognosis. Blocking…”
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Differing endoplasmic reticulum stress response to excess lipogenesis versus lipid oversupply in relation to hepatic steatosis and insulin resistance by Ren, Lu-Ping, Chan, Stanley M H, Zeng, Xiao-Yi, Laybutt, D Ross, Iseli, Tristan J, Sun, Ruo-Qiong, Kraegen, Edward W, Cooney, Gregory J, Turner, Nigel, Ye, Ji-Ming

“…Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been implicated in hepatic steatosis and insulin resistance. The present study…”
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A modified gas-trapping method for high-throughput metabolic experiments in Drosophila melanogaster by Francis, Deanne, Krycer, James R, Cooney, Gregory J, James, David E

“…Metabolism is often studied in animal models, with the fruit fly model offering ease of genetic manipulation and high-throughput studies. Fly metabolism is…”
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The RabGAP TBC1D1 plays a central role in exercise-regulated glucose metabolism in skeletal muscle by Stöckli, Jacqueline, Meoli, Christopher C, Hoffman, Nolan J, Fazakerley, Daniel J, Pant, Himani, Cleasby, Mark E, Ma, Xiuquan, Kleinert, Maximilian, Brandon, Amanda E, Lopez, Jamie A, Cooney, Gregory J, James, David E

“…Insulin and exercise stimulate glucose uptake into skeletal muscle via different pathways. Both stimuli converge on the translocation of the glucose…”
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Leveraging genetic diversity to identify small molecules that reverse mouse skeletal muscle insulin resistance by Masson, Stewart W C, Madsen, Søren, Cooke, Kristen C, Potter, Meg, Vegas, Alexis Diaz, Carroll, Luke, Thillainadesan, Senthil, Cutler, Harry B, Walder, Ken R, Cooney, Gregory J, Morahan, Grant, Stöckli, Jacqueline, James, David E

“…Systems genetics has begun to tackle the complexity of insulin resistance by capitalising on computational advances to study high-diversity populations…”
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Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice by Hocking, Samantha L., Stewart, Rebecca L., Brandon, Amanda E., Suryana, Eurwin, Stuart, Ella, Baldwin, Emily M., Kolumam, Ganesh A., Modrusan, Zora, Junutula, Jagath R., Gunton, Jenny E., Medynskyj, Michael, Blaber, Sinead P., Karsten, Elisabeth, Herbert, Benjamin R., James, David E., Cooney, Gregory J., Swarbrick, Michael M.

“…Aims/hypothesis Adipose tissue (AT) distribution is a major determinant of mortality and morbidity in obesity. In mice, intra-abdominal transplantation of…”
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Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism by Krycer, James R., Yugi, Katsuyuki, Hirayama, Akiyoshi, Fazakerley, Daniel J., Quek, Lake-Ee, Scalzo, Richard, Ohno, Satoshi, Hodson, Mark P., Ikeda, Satsuki, Shoji, Futaba, Suzuki, Kumi, Domanova, Westa, Parker, Benjamin L., Nelson, Marin E., Humphrey, Sean J., Turner, Nigel, Hoehn, Kyle L., Cooney, Gregory J., Soga, Tomoyoshi, Kuroda, Shinya, James, David E.

“…Insulin triggers an extensive signaling cascade to coordinate adipocyte glucose metabolism. It is considered that the major role of insulin is to provide…”
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