Search Results - "Coonen, Maarten L.J."

Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity by Van den Hof, Wim F.P.M, Van Summeren, Anke, Lommen, Arjen, Coonen, Maarten L.J, Brauers, Karen, van Herwijnen, Marcel, Wodzig, Will K.W.H, Kleinjans, Jos C.S

“…Abstract The liver is responsible for drug metabolism and drug-induced hepatotoxicity is the most frequent reason for drug withdrawal, indicating that better…”
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Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro by Van den Hof, Wim F.P.M., Ruiz-Aracama, Ainhoa, Van Summeren, Anke, Jennen, Danyel G.J., Gaj, Stan, Coonen, Maarten L.J., Brauers, Karen, Wodzig, Will K.W.H., van Delft, Joost H.M., Kleinjans, Jos C.S.

“…•Integrated analyses of transcriptome and metabonome results in relevant pathways.•We could unravel mechanisms underlying Cyclosporin A-induced…”
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cBiT: A transcriptomics database for innovative biomaterial engineering by Hebels, Dennie G.A.J., Carlier, Aurélie, Coonen, Maarten L.J., Theunissen, Daniël H., de Boer, Jan

“…Creating biomaterials that are suited for clinical application is still hampered by a lack of understanding of the interaction between a cell and the…”
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Classification of Hepatotoxicants Using HepG2 Cells: A Proof of Principle Study by Van den Hof, Wim F. P. M, Coonen, Maarten L. J, van Herwijnen, Marcel, Brauers, Karen, Wodzig, Will K. W. H, van Delft, Joost H. M, Kleinjans, Jos C. S

“…With the number of new drug candidates increasing every year, there is a need for high-throughput human toxicity screenings. As the liver is the most important…”
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Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity by Rieswijk, Linda, Brauers, Karen J J, Coonen, Maarten L J, Jennen, Danyel G J, van Breda, Simone G J, Kleinjans, Jos C S

“…The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus…”
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Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes by Rieswijk, Linda, Brauers, Karen J J, Coonen, Maarten L J, van Breda, Simone G J, Jennen, Danyel G J, Kleinjans, Jos C S

“…Chemical carcinogenesis can be induced by genotoxic (GTX) or non-genotoxic (NGTX) carcinogens. GTX carcinogens have a well-described mode of action. However,…”
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Validation of gene expression profiles from cholestatic hepatotoxicants in vitro against human in vivo cholestasis by Van den Hof, Wim F.P.M., Coonen, Maarten L.J., van Herwijnen, Marcel, Brauers, Karen, Jennen, Danyel, Olde Damink, Steven W.M., Schaap, Frank G., Kleinjans, Jos C.S.

“…Drug-induced liver injury remains the most common cause of acute liver failure and a frequently indicated reason for withdrawal of drugs. For the purpose of…”
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Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes by Jetten, Marlon J. A., Ruiz-Aracama, Ainhoa, Coonen, Maarten L. J., Claessen, Sandra M., van Herwijnen, Marcel H. M., Lommen, Arjen, van Delft, Joost H. M., Peijnenburg, Ad A. C. M., Kleinjans, Jos C. S.

“…Acetaminophen (APAP) is a readily available over-the-counter drug and is one of the most commonly used analgesics/antipyretics worldwide. Large interindividual…”
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Extensive temporal transcriptome and microRNA analyses identify molecular mechanisms underlying mitochondrial dysfunction induced by multi-walled carbon nanotubes in human lung cells by Nymark, Penny, Wijshoff, Peter, Cavill, Rachel, van Herwijnen, Marcel, Coonen, Maarten L. J., Claessen, Sandra, Catalán, Julia, Norppa, Hannu, Kleinjans, Jos C. S., Briedé, Jacob J.

“…Understanding toxicity pathways of engineered nanomaterials (ENM) has recently been brought forward as a key step in twenty-first century ENM risk assessment…”
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MagiCMicroRna: a web implementation of AgiMicroRna using shiny by Coonen, Maarten Lj, Theunissen, Daniel Hj, Kleinjans, Jos Cs, Jennen, Danyel Gj

“…MicroRNA expression can be quantified using sequencing techniques or commercial microRNA-expression arrays. Recently, the AgiMicroRna R-package was published…”
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