Search Results - "Coombs, Robert"

A phase 2a clinical trial of molnupiravir in patients with COVID-19 shows accelerated SARS-CoV-2 RNA clearance and elimination of infectious virus by Fischer, 2nd, William A, Eron, Jr, Joseph J, Holman, Wayne, Cohen, Myron S, Fang, Lei, Szewczyk, Laura J, Sheahan, Timothy P, Baric, Ralph, Mollan, Katie R, Wolfe, Cameron R, Duke, Elizabeth R, Azizad, Masoud M, Borroto-Esoda, Katyna, Wohl, David A, Coombs, Robert W, James Loftis, Amy, Alabanza, Paul, Lipansky, Felicia, Painter, Wendy P

“…There is an urgent need for an effective, oral, direct-acting therapeutic to block transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Cells producing residual viremia during antiretroviral treatment appear to contribute to rebound viremia following interruption of treatment by Aamer, Hadega A, McClure, Jan, Ko, Daisy, Maenza, Janine, Collier, Ann C, Coombs, Robert W, Mullins, James I, Frenkel, Lisa M

“…During antiretroviral therapy (ART) that suppresses HIV replication to below the limit-of-quantification, virions produced during ART can be detected at low…”
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Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study by Heffron, Renee, MPH, Donnell, Deborah, PhD, Rees, Helen, Prof, Celum, Connie, Prof, Mugo, Nelly, MBChB, Were, Edwin, MBChB, de Bruyn, Guy, MBBCh, Nakku-Joloba, Edith, MBChB, Ngure, Kenneth, MPH, Kiarie, James, MBChB, Coombs, Robert W, Prof, Baeten, Jared M, MD

“…Summary Background Hormonal contraceptives are used widely but their effects on HIV-1 risk are unclear. We aimed to assess the association between hormonal…”
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Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico by Dunkle, Lisa M, Kotloff, Karen L, Gay, Cynthia L, Áñez, Germán, Adelglass, Jeffrey M, Barrat Hernández, Alejandro Q, Harper, Wayne L, Duncanson, Daniel M, McArthur, Monica A, Florescu, Diana F, McClelland, R. Scott, Garcia-Fragoso, Veronica, Riesenberg, Robert A, Musante, David B, Fried, David L, Safirstein, Beth E, McKenzie, Mark, Jeanfreau, Robert J, Kingsley, Jeffrey K, Henderson, Jeffrey A, Lane, Dakotah C, Ruíz-Palacios, Guillermo M, Corey, Lawrence, Neuzil, Kathleen M, Coombs, Robert W, Greninger, Alex L, Hutter, Julia, Ake, Julie A, Smith, Katherine, Woo, Wayne, Cho, Iksung, Glenn, Gregory M, Dubovsky, Filip

“…NVX-CoV2373 is a vaccine containing a full-length stabilized recombinant spike protein trimer that is administered in two doses 3 weeks apart along with a…”
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A Randomized, Placebo-Controlled Trial of the Quadrivalent Human Papillomavirus Vaccine in Human Immunodeficiency Virus-Infected Adults Aged 27 Years or Older: AIDS Clinical Trials Group Protocol A5298 by Wilkin, Timothy J, Chen, Huichao, Cespedes, Michelle S, Leon-Cruz, Jorge T, Godfrey, Catherine, Chiao, Elizabeth Y, Bastow, Barbara, Webster-Cyriaque, Jennifer, Feng, Qinghua, Dragavon, Joan, Coombs, Robert W, Presti, Rachel M, Saah, Alfred, Cranston, Ross D

“…Anal cancer is common in human immunodeficiency virus-infected adults. This randomized trial did not find a benefit from human papillomavirus (HPV) vaccination…”
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Validation and verification of the Abbott RealTime SARS-CoV-2 assay analytical and clinical performance by Degli-Angeli, Emily, Dragavon, Joan, Huang, Meei-Li, Lucic, Danijela, Cloherty, Gavin, Jerome, Keith R., Greninger, Alexander L., Coombs, Robert W.

“…•The expected 100 copies/mL LOD reported in the EUA Abbott RealTime SARS-CoV-2 assay product insert was exceeded.•All clinical samples positive for 24…”
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The effect of oral preexposure prophylaxis on the progression of HIV-1 seroconversion by Donnell, Deborah, Ramos, Eric, Celum, Connie, Baeten, Jared, Dragavon, Joan, Tappero, Jordan, Lingappa, Jairam R, Ronald, Allan, Fife, Kenneth, Coombs, Robert W

“…OBJECTIVE:To investigate whether oral preexposure prophylaxis (PrEP) alters timing and patterns of seroconversion when PrEP use continues after HIV-1…”
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Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19 by Chew, Kara W., Moser, Carlee, Daar, Eric S., Wohl, David A., Li, Jonathan Z., Coombs, Robert W., Ritz, Justin, Giganti, Mark, Javan, Arzhang Cyrus, Li, Yijia, Choudhary, Manish C., Deo, Rinki, Malvestutto, Carlos, Klekotka, Paul, Price, Karen, Nirula, Ajay, Fischer, William, Bala, Veenu, Ribeiro, Ruy M., Perelson, Alan S., Fletcher, Courtney V., Eron, Joseph J., Currier, Judith S., Hughes, Michael D., Smith, Davey M.

“…Anti-SARS-CoV-2 monoclonal antibodies are mainstay COVID-19 therapeutics. Safety, antiviral, and clinical efficacy of bamlanivimab were evaluated in the…”
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HIV Transmission Risk Persists During the First 6 Months of Antiretroviral Therapy by Mujugira, Andrew, Celum, Connie, Coombs, Robert W, Campbell, James D, Ndase, Patrick, Ronald, Allan, Were, Edwin, Bukusi, Elizabeth A, Mugo, Nelly, Kiarie, James, Baeten, Jared M

“…OBJECTIVE:Combination antiretroviral therapy (ART) decreases the risk of sexual HIV transmission by suppressing blood and genital HIV RNA concentrations. We…”
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One Week of Oral Camostat Versus Placebo in Nonhospitalized Adults With Mild-to-Moderate Coronavirus Disease 2019: A Randomized Controlled Phase 2 Trial by Jilg, Nikolaus, Chew, Kara W, Giganti, Mark J, Daar, Eric S, Wohl, David A, Javan, Arzhang Cyrus, Kantor, Amy, Moser, Carlee, Coombs, Robert W, Neytman, Gene, Hoover, Keila, Jana, Atasi, Hart, Phil A, Greninger, Alexander L, Szurgot, Bob, Eron, Joseph J, Currier, Judith S, Hughes, Michael D, Smith, Davey M, Li, Jonathan Z

“…Abstract Background Camostat inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in vitro. We studied the safety and efficacy of…”
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Viral Load Dynamics in Plasma and Semen When Antiretroviral Therapy Is Initiated During Early HIV-1 Infection by Gilada, Trupti, Ulrich, Angela K, Wang, Yixin, Lama, Javier R, Alfaro, Ricardo, Harb, Socorro, Daza, Glenda, Holte, Sarah, Pasalar, Siavash, Rios, Jessica, Ganoza, Carmela, Dasgupta, Sayan, Coombs, Robert W, Duerr, Ann

“…Abstract We assessed human immunodeficiency virus (HIV) load in plasma and semen during primary HIV infection using serial samples of semen and plasma during…”
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Novel assays to investigate the mechanisms of latent infection with HIV-2 by Lu, Michael D, Telwatte, Sushama, Kumar, Nitasha, Ferreira, Fernanda, Martin, Holly Anne, Kadiyala, Gayatri Nikhila, Wedrychowski, Adam, Moron-Lopez, Sara, Chen, Tsui-Hua, Goecker, Erin A, Coombs, Robert W, Lu, Chuanyi M, Wong, Joseph K, Tsibris, Athe, Yukl, Steven A

“…Although there have been great advancements in the field of HIV treatment and prevention, there is no cure. There are two types of HIV: HIV-1 and HIV-2. In…”
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Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission by Baeten, Jared M, Kahle, Erin, Lingappa, Jairam R, Coombs, Robert W, Delany-Moretlwe, Sinead, Nakku-Joloba, Edith, Mugo, Nelly R, Wald, Anna, Corey, Lawrence, Donnell, Deborah, Campbell, Mary S, Mullins, James I, Celum, Connie

“…High plasma HIV-1 RNA concentrations are associated with an increased risk of HIV-1 transmission. Although plasma and genital HIV-1 RNA concentrations are…”
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Anti-SARS-CoV-2 Antibody Levels Measured by the AdviseDx SARS-CoV-2 Assay Are Concordant with Previously Available Serologic Assays but Are Not Fully Predictive of Sterilizing Immunity by Bradley, Benjamin T, Bryan, Andrew, Fink, Susan L, Goecker, Erin A, Roychoudhury, Pavitra, Huang, Meei-Li, Zhu, Haiying, Chaudhary, Anu, Madarampalli, Bhanupriya, Lu, Joyce Y C, Strand, Kathy, Whimbey, Estella, Bryson-Cahn, Chloe, Schippers, Adrienne, Mani, Nandita S, Pepper, Gregory, Jerome, Keith R, Morishima, Chihiro, Coombs, Robert W, Wener, Mark, Cohen, Seth, Greninger, Alexander L

“…With the availability of widespread SARS-CoV-2 vaccination, high-throughput quantitative anti-spike protein serological testing will likely become increasingly…”
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HIV DNA levels and decay in a cohort of 111 long-term virally suppressed patients by Golob, Jonathan L, Stern, Joshua, Holte, Sarah, Kitahata, Mari M, Crane, Heidi M, Coombs, Robert W, Goecker, Erin, Woolfrey, Ann E, Harrington, Robert D

“…ABSTRACTWe examined specimens from 111 HIV-infected participants virally suppressed on ART for a minimum of 5 years who had donated serial peripheral blood…”
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Time to Viral Rebound After Interruption of Modern Antiretroviral Therapies by Li, Jonathan Z, Aga, Evgenia, Bosch, Ronald J, Pilkinton, Mark, Kroon, Eugène, MacLaren, Lynsay, Keefer, Michael, Fox, Lawrence, Barr, Liz, Acosta, Edward, Ananworanich, Jintanat, Coombs, Robert, Mellors, John W, Landay, Alan L, Macatangay, Bernard, Deeks, Steven, Gandhi, Rajesh T, Smith, Davey M

“…Abstract Background Development of human immunodeficiency virus (HIV) remission strategies requires precise information on time to HIV rebound after treatment…”
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Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial by Baeten, Jared M, Prof, Donnell, Deborah, PhD, Mugo, Nelly R, MBChB, Ndase, Patrick, MBChB, Thomas, Katherine K, MS, Campbell, James D, MD, Wangisi, Jonathan, MBChB, Tappero, Jordan W, MD, Bukusi, Elizabeth A, MBChB, Cohen, Craig R, Prof, Katabira, Elly, Prof, Ronald, Allan, Prof, Tumwesigye, Elioda, MBChB, Were, Edwin, MBChB, Fife, Kenneth H, Prof, Kiarie, James, MBChB, Farquhar, Carey, Prof, John-Stewart, Grace, Prof, Kidoguchi, Lara, MPH, Coombs, Robert W, Prof, Hendrix, Craig, Prof, Marzinke, Mark A, PhD, Frenkel, Lisa, Prof, Haberer, Jessica E, MD, Bangsberg, David, Prof, Celum, Connie, Prof

“…Summary Background Antiretroviral pre-exposure prophylaxis (PrEP), with daily oral tenofovir disoproxil fumarate or tenofovir disoproxil fumarate in…”
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Estimating the impact of plasma HIV-1 RNA reductions on heterosexual HIV-1 transmission risk by Lingappa, Jairam R, Hughes, James P, Wang, Richard S, Baeten, Jared M, Celum, Connie, Gray, Glenda E, Stevens, Wendy S, Donnell, Deborah, Campbell, Mary S, Farquhar, Carey, Essex, M, Mullins, James I, Coombs, Robert W, Rees, Helen, Corey, Lawrence, Wald, Anna

“…The risk of sexual transmission of HIV-1 is strongly associated with the level of HIV-1 RNA in plasma making reduction in HIV-1 plasma levels an important…”
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Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study) by Duerr, Ann, Huang, Yunda, Buchbinder, Susan, Coombs, Robert W., Sanchez, Jorge, del Rio, Carlos, Casapia, Martin, Santiago, Steven, Gilbert, Peter, Corey, Lawrence, Robertson, Michael N.

“…Background. The Step Study tested whether an adenovirus serotype 5 (Ad5)-vectored human immunodeficiency virus (HIV) vaccine could prevent HIV acquisition…”
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Exploring the anatomical HIV reservoirs: role of the testicular tissue by Darcis, Gilles, Coombs, Robert W, Van Lint, Carine

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