Search Results - "Coombes, A.G.A."

Precipitation casting of polycaprolactone for applications in tissue engineering and drug delivery by Coombes, A.G.A., Rizzi, S.C., Williamson, M., Barralet, J.E., Downes, S., Wallace, W.A.

“…Microporous materials have been produced by gradual precipitation from solutions of poly( ε-caprolactone) (PCL) in acetone induced by solvent extraction across…”
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Biocomposites of non-crosslinked natural and synthetic polymers by Coombes, A.G.A, Verderio, E, Shaw, B, Li, X, Griffin, M, Downes, S

“…Biocomposite films comprising a non-crosslinked, natural polymer (collagen) and a synthetic polymer, poly( ε-caprolactone) (PCL), have been produced by…”
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The control of protein release from poly( dl-lactide co-glycolide) microparticles by variation of the external aqueous phase surfactant in the water-in oil-in water method by Coombes, A.G.A, Yeh, Ming-Kung, Lavelle, E.C, Davis, S.S

“…Poly( dl-lactide co-glycolide) microparticles below 5 μm in size and containing ovalbumin (OVA), were prepared using the water-in oil-in water (w/o/w)…”
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A new treatment based classification system for fractures of the bony orbit by Parbhoo, Alan Vijay, Antscherl, J.J, Coombes, A.G.A, Holmes, S.B

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A novel emulsification-solvent extraction technique for production of protein loaded biodegradable microparticles for vaccine and drug delivery by Yeh, Ming-Kung, Coombes, A.G.A., Jenkins, P.G., Davis, S.S.

“…This paper describes the preparation of poly(lactide-co-glycolide) (PLG) microparticles containing ovalbumin (OVA) as a model antigen, using three different…”
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Liposome formulation of poorly water soluble drugs: optimisation of drug loading and ESEM analysis of stability by Mohammed, A.R., Weston, N., Coombes, A.G.A., Fitzgerald, M., Perrie, Y.

“…Liposomes due to their biphasic characteristic and diversity in design, composition and construction, offer a dynamic and adaptable technology for enhancing…”
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Composite cell support membranes based on collagen and polycaprolactone for tissue engineering of skin by Dai, N.-T., Williamson, M.R., Khammo, N., Adams, E.F., Coombes, A.G.A.

“…The preparation and characterisation of collagen:PCL composites for manufacture of tissue engineered skin substitutes and models are reported. Films having…”
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Delivery of the antibiotic gentamicin sulphate from precipitation cast matrices of polycaprolactone by Chang, H.-I., Perrie, Y., Coombes, A.G.A.

“…Microporous, poly(ε-caprolactone) (PCL) matrices were loaded with the aminoglycoside antibiotic, gentamicin sulphate (GS) using the precipitation casting…”
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The potential for production of freeze-dried oral vaccines using alginate hydrogel microspheres as protein carriers by Hariyadi, D.M., Ma, Y., Wang, Y., Bostrom, T., Malouf, J., Turner, M.S., Bhandari, B., Coombes, A.G.A.

“…Oral administration of dry vaccine formulations is acknowledged to offer major clinical and logistical benefits by eliminating the cold chain required for…”
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Controlled release of an antibiotic, gentamicin sulphate, from gravity spun polycaprolactone fibers by Chang, H.-I., Lau, Y.-C., Yan, C., Coombes, A.G.A.

“…The antibiotic, gentamicin sulphate (GS), was incorporated in gravity‐spun polycaprolactone (PCL) fibers by spinning from particulate suspensions of the drug…”
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Biodegradable polymer/hydroxyapatite composites: Surface analysis and initial attachment of human osteoblasts by Rizzi, S.C., Heath, D.J., Coombes, A.G.A., Bock, N., Textor, M., Downes, S.

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Protein-loaded poly( dl-lactide-co-glycolide) microparticles for oral administration: formulation, structural and release characteristics by Rafati, H, Coombes, A.G.A, Adler, J, Holland, J, Davis, S.S

“…FITC-labelled bovine serum albumin has been entrapped in sub-5 micron particles of poly( dl-lactide-co-glycolide copolymer) (PLG) using a water-in-oil-in-water…”
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Direct encapsulation of small molecule hydrophilic and hydrophobic actives in alginate microspheres using a novel impinging aerosols method by Sohail, A., Bhandari, B., Turner, M.S., Coombes, A.G.A.

“…The hydrophilic antibacterial (metronidazole, MZ) and a hydrophobic non-steroidal anti-inflammatory drug (ketoprofen, KET) were directly encapsulated in…”
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Precipitation casting of drug-loaded microporous PCL matrices: Incorporation of progesterone by co-dissolution by Chang, H.-I., Williamson, M.R., Perrie, Y., Coombes, A.G.A.

“…Microporous, poly(ε-caprolactone) (PCL) matrices were loaded with progesterone by precipitation casting using co-solutions of PCL and progesterone in acetone…”
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Improving peptide-based assays to differentiate between vaccination and Mycobacterium bovis infection in cattle using nanoparticle carriers for adsorbed antigens by Saleem, I.Y., Vordermeier, M., Barralet, J.E., Coombes, A.G.A.

“…The development of diagnostic tests to differentiate between vaccinated animals and those infected with Mycobacterium bovis is required so that test and…”
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Detection and determination of surface levels of poloxamer and PVA surfactant on biodegradable nanospheres using SSIMS and XPS by Scholes, P.D, Coombes, A.G.A, Illum, L, Davis, S.S, Watts, J.F, Ustariz, C, Vert, M, Davies, M.C

“…The surface chemical characterisation of sub-200 nm poly( DL-lactide co-glycolide) nanospheres has been carried out using the complementary analytical…”
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Microporous polycaprolactone matrices for drug delivery and tissue engineering: the release behaviour of bioactives having extremes of aqueous solubility by Chang, H.-I., Wang, Y., Perrie, Y., Coombes, A.G.A.

“…Microporous polycaprolactone (PCL) matrices loaded with hydrophobic steroidal drugs or a hydrophilic drug – pilocarpine hydrochloride – were produced by…”
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A co-cultured skin model based on cell support membranes by Dai, Niann-Tzyy, Yeh, Ming-Kung, Liu, Demeral David, Adams, E.F., Chiang, Chiao-Hsi, Yen, Chung-Yang, Shih, Chien-Ming, Sytwu, Huey-Kang, Chen, Tim-Mo, Wang, Hsian-Jenn, Williamson, M.R., Coombes, A.G.A.

“…Tissue engineering of skin based on collagen:PCL biocomposites using a designed co-culture system is reported. The collagen:PCL biocomposites having…”
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Measuring the heterogeneity of protein loading in PLG microspheres using flow cytometry by Turner, P, Coombes, A.G.A, Al-Rubeai, M

“…Poly ( dl-lactide co-glycolide) (PLG) microspheres with mean sizes up to 1 μm containing Fluorescein Isothiocyanate labelled Bovine Serum Albumin (FITC-BSA)…”
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The stability and immunogenicity of a protein antigen encapsulated in biodegradable microparticles based on blends of lactide polymers and polyethylene glycol by Lavelle, E.C, Yeh, M.-K, Coombes, A.G.A, Davis, S.S

“…Protein-loaded microparticles were produced from blends of poly(ethylene glycol) (PEG) with poly( l-lactide) (PLA) homopolymer or poly( dl-lactide…”
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