Search Results - "Cools, A. R."

Spiraling dopaminergic circuitry from the ventral striatum to dorsal striatum is an effective feed-forward loop by Ikeda, H, Saigusa, T, Kamei, J, Koshikawa, N, Cools, A.R

“…Highlights • Telencephalic dopaminergic systems are also connected in series. • A dysfunctioning accumbens results at last in a dysfunctioning dorsal striatum…”
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A study in male and female 5-HT transporter knockout rats: An animal model for anxiety and depression disorders by Olivier, J.D.A, Van Der Hart, M.G.C, Van Swelm, R.P.L, Dederen, P.J, Homberg, J.R, Cremers, T, Deen, P.M.T, Cuppen, E, Cools, A.R, Ellenbroek, B.A

“…Abstract Human studies have shown that a reduction of 5-HT transporter (SERT) increases the vulnerability for anxiety and depression. Moreover, women are more…”
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Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system by Homberg, J.R, Olivier, J.D.A, Smits, B.M.G, Mul, J.D, Mudde, J, Verheul, M, Nieuwenhuizen, O.F.M, Cools, A.R, Ronken, E, Cremers, T, Schoffelmeer, A.N.M, Ellenbroek, B.A, Cuppen, E

“…Abstract Serotonergic signaling is involved in many neurobiological processes and disturbed 5-HT homeostasis is implicated in a variety of psychiatric and…”
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Accumbal core: Essential link in feed-forward spiraling striato-nigro-striatal in series connected loop by Ikeda, H, Koshikawa, N, Cools, A.R

“…Highlights • Role of the Nacc core in the feed-forward dopaminergic circuitry was studied. • Stimulation of μ-opioid receptors in the VTA-induced contraversive…”
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Differential role of GABAA and GABAB receptors in two distinct output stations of the rat striatum: studies on the substantia nigra pars reticulata and the globus pallidus by Ikeda, H, Kotani, A, Koshikawa, N, Cools, A.R

“…Abstract The role of GABAA and GABAB receptors in the substantia nigra pars reticulata and the globus pallidus in turning behaviour of rats was studied…”
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Somatostatin receptors in the nucleus accumbens modulate dopamine-dependent but not acetylcholine-dependent turning behaviour of rats by Ikeda, H, Kotani, A, Koshikawa, N, Cools, A.R

“…Abstract The role of somatostatin receptors in the nucleus accumbens shell in rat turning behaviour was studied. Unilateral injection of neither the…”
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Reliance on external cues for movement initiation in Parkinson's disease: Evidence from movement-related potentials by PRAAMSTRA, P, STEGEMAN, D. F, COOLS, A. R, HORSTINK, M. W. I. M

“…The aim of this study was to investigate the neurophysiological mechanisms underlying Parkinson's disease patients' increased reliance on external cues for the…”
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Differential progression of proprioceptive and visual information processing deficits in Parkinson's disease by Keijsers, N. L. W., Admiraal, M. A., Cools, A. R., Bloem, B. R., Gielen, C. C. A. M.

“…Indirect evidence suggests that patients with Parkinson's disease (PD) have deficits not only in motor performance, but also in the processing of sensory…”
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Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats by Olivier, J. D. A., Jans, L. A. W., Korte-Bouws, G. A. H., Korte, S. M., Deen, P. M. T., Cools, A. R., Ellenbroek, B. A., Blokland, A.

“…Rationale Acute tryptophan depletion (ATD) transiently lowers central serotonin levels and can induce depressive mood states and cognitive defects. Previous…”
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Serotonin transporter deficiency in rats contributes to impaired object memory by Olivier, J. D. A., Jans, L. A. W., Blokland, A., Broers, N. J., Homberg, J. R., Ellenbroek, B. A., Cools, A. R.

“…Serotonin is well known for its role in affection, but less known for its role in cognition. The serotonin transporter (SERT) has an essential role in…”
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Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens by HIROSE, N, MURAKAWA, K, TAKADA, K, OI, Y, SUZUKI, T, NAGASE, H, COOLS, A. R, KOSHIKAWA, N

“…The effect of interactions among mu- and delta-opioid receptors, especially the putative delta(1)- and delta(2)-opioid receptors, in the nucleus accumbens on…”
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The Long-Term Effects of Maternal Deprivation Depend on the Genetic Background by Ellenbroek, B.A, Cools, A.R

“…The neurodevelopmental hypothesis of schizophrenia has led to a series of new animal models in which the long term consequences of early manipulations are…”
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Differential contribution of storage pools to the extracellular amount of accumbal dopamine in high and low responders to novelty: effects of reserpine by Verheij, M.M.M, Cools, A.R

“…The present study examined the effects of reserpine on the extracellular concentration of accumbal dopamine in high responders (HR) and low responders (LR) to…”
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Prepulse inhibition and latent inhibition: the role of dopamine in the medial prefrontal cortex by Ellenbroek, B.A, Budde, S, Cools, A.R

“…The prefrontal cortex has often been implicated in the pathophysiology of schizophrenia. Schizophrenic patients are known to suffer from certain information…”
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Mesolimbic alpha-, but not beta-adrenoceptors control the accumbal release of dopamine that is derived from reserpine-sensitive storage vesicles by Verheij, M.M.M, Cools, A.R

“…Abstract Mesolimbic beta-, but not alpha-adrenoceptors control the accumbal release of dopamine that is derived from alpha-methyl-para-tyrosine-sensitive pools…”
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The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals by Fusa, K., Takahashi, I., Watanabe, S., Aono, Y., Ikeda, H., Saigusa, T., Nagase, H., Suzuki, T., Koshikawa, N., Cools, A.R.

“…The activation of the δ-opioid receptors in the nucleus accumbens is known to induce a large and rapid increase of accumbal dopamine efflux. (±)-TAN-67…”
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GABAA receptors in the mediodorsal thalamus play a crucial role in rat shell-specific acetylcholine-mediated, but not dopamine-mediated, turning behaviour by Ikeda, H, Kotani, A, Lee, J, Koshikawa, N, Cools, A.R

“…Abstract The role of GABAA receptors in the mediodorsal thalamus (mdT) in turning behaviour of rats was studied. Neither the GABAA receptor agonist muscimol…”
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High and low responders to novelty: effects of a catecholamine synthesis inhibitor on novelty-induced changes in behaviour and release of accumbal dopamine by Saigusa, T, Tuinstra, T, Koshikawa, N, Cools, A.R

“…The purpose of the present study was two-fold: (i) investigating to what extent novelty, i.e. a novel cage with slightly larger dimensions than the home cage…”
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Fentanyl increases dopamine release in rat nucleus accumbens: involvement of mesolimbic mu- and delta-2-opioid receptors by Yoshida, Y, Koide, S, Hirose, N, Takada, K, Tomiyama, K, Koshikawa, N, Cools, A.R

“…The effects of the μ-receptor agonist fentanyl on extracellular levels of dopamine in rat nucleus accumbens were studied in awake animals by in vivo brain…”
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Animal models for the negative symptoms of schizophrenia by Ellenbroek, B.A, Cools, A.R

“…Negative or defect symptoms refer to a reduction in normal functioning. In schizophrenia, negative symptoms encompass, among others, anhedonia, flat affect,…”
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