Search Results - "Coole, Jackson"

Deep learning extended depth-of-field microscope for fast and slide-free histology by Jin, Lingbo, Tang, Yubo, Wu, Yicheng, Coole, Jackson B., Tan, Melody T., Zhao, Xuan, Badaoui, Hawraa, Robinson, Jacob T., Williams, Michelle D., Gillenwater, Ann M., Richards-Kortum, Rebecca R., Veeraraghavan, Ashok

“…Microscopic evaluation of resected tissue plays a central role in the surgical management of cancer. Because optical microscopes have a limited depth-of-field…”
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Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment by Coole, Jackson B., Brenes, David, Mitbander, Ruchika, Vohra, Imran, Hou, Huayu, Kortum, Alex, Tang, Yubo, Maker, Yajur, Schwarz, Richard A., Carns, Jennifer, Badaoui, Hawraa, Williams, Michelle, Vigneswaran, Nadarajah, Gillenwater, Ann, Richards-Kortum, Rebecca

“…Despite recent advances in multimodal optical imaging, oral imaging systems often do not provide real-time actionable guidance to the clinician who is making…”
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DeepDOF-SE: affordable deep-learning microscopy platform for slide-free histology by Jin, Lingbo, Tang, Yubo, Coole, Jackson B., Tan, Melody T., Zhao, Xuan, Badaoui, Hawraa, Robinson, Jacob T., Williams, Michelle D., Vigneswaran, Nadarajah, Gillenwater, Ann M., Richards-Kortum, Rebecca R., Veeraraghavan, Ashok

“…Histopathology plays a critical role in the diagnosis and surgical management of cancer. However, access to histopathology services, especially frozen section…”
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Allele-Specific Recombinase Polymerase Amplification to Detect Sickle Cell Disease in Low-Resource Settings by Natoli, Mary E, Chang, Megan M, Kundrod, Kathryn A, Coole, Jackson B, Airewele, Gladstone E, Tubman, Venée N, Richards-Kortum, Rebecca R

“…Sickle cell disease (SCD) is a group of common, life-threatening disorders caused by a point mutation in the β globin gene. Early diagnosis through newborn and…”
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An integrated isothermal nucleic acid amplification test to detect HPV16 and HPV18 DNA in resource-limited settings by Kundrod, Kathryn A, Barra, Maria, Wilkinson, Alexis, Smith, Chelsey A, Natoli, Mary E, Chang, Megan M, Coole, Jackson B, Santhanaraj, Akshaya, Lorenzoni, Cesaltina, Mavume, Celda, Atif, Hira, Montealegre, Jane Richards, Scheurer, Michael E, Castle, Philip E, Schmeler, Kathleen M, Richards-Kortum, Rebecca R

“…High-risk human papillomavirus (HPV) DNA testing is widely acknowledged as the most sensitive cervical cancer screening method but has limited availability in…”
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Deployment and assessment of a deep learning model for real-time detection of anal precancer with high frame rate high-resolution microendoscopy by Brenes, David, Kortum, Alex, Coole, Jackson, Carns, Jennifer, Schwarz, Richard, Vohra, Imran, Richards-Kortum, Rebecca, Liu, Yuxin, Cai, Zhenjian, Sigel, Keith, Anandasabapathy, Sharmila, Gaisa, Michael, Chiao, Elizabeth

“…Anal cancer incidence is significantly higher in people living with HIV as HIV increases the oncogenic potential of human papillomavirus. The incidence of anal…”
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Multiscale Optical Imaging Fusion for Cervical Precancer Diagnosis: Integrating Widefield Colposcopy and High-Resolution Endomicroscopy by Brenes, David, Salcedo, Mila P., Coole, Jackson B., Maker, Yajur, Kortum, Alex, Schwarz, Richard A., Carns, Jennifer, Vohra, Imran S., Possati-Resende, Julio C., Antoniazzi, Marcio, de Oliveira Fonseca, Bruno, Souza, Karen C. Borba, Santana, Iara V. Vidigal, Barbin, Flavia Fazzio, Kreitchmann, Regis, Ramanujam, Nirmala, Schmeler, Kathleen M., Richards-Kortum, Rebecca

“…Objective: Early detection and treatment of cervical precancers can prevent disease progression. However, in low-resource communities with a high incidence of…”
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Scanning darkfield high-resolution microendoscope for label-free microvascular imaging by Hou, Huayu, Tang, Yubo, Coole, Jackson B, Kortum, Alex, Schwarz, Richard A, Carns, Jennifer, Gillenwater, Ann M, Ramalingam, Preetha, Milbourne, Andrea, Salcedo, Mila P, Schmeler, Kathleen M, Richards-Kortum, Rebecca R

“…Characterization of microvascular changes during neoplastic progression has the potential to assist in discriminating precancer and early cancer from benign…”
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Development of a multimodal mobile colposcope for real-time cervical cancer detection by Coole, Jackson B, Brenes, David, Possati-Resende, Júlio César, Antoniazzi, Márcio, Fonseca, Bruno de Oliveira, Maker, Yajur, Kortum, Alex, Vohra, Imran S, Schwarz, Richard A, Carns, Jennifer, Borba Souza, Karen Cristina, Vidigal Santana, Iara Viana, Kreitchmann, Regis, Salcedo, Mila P, Ramanujam, Nirmala, Schmeler, Kathleen M, Richards-Kortum, Rebecca

“…Cervical cancer remains a leading cause of cancer death among women in low-and middle-income countries. Globally, cervical cancer prevention programs are…”
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Improving Performance of a SARS-CoV-2 RT-LAMP Assay for Use With a Portable Isothermal Fluorimeter: Towards a Point-of-Care Molecular Testing Strategy by Natoli, Mary E, Kundrod, Kathryn A, Chang, Megan M, Smith, Chelsey A, Paul, Sai, Coole, Jackson B, Butlin, Nathaniel G, Tanner, Nathan A, Baker, Ellen, Schmeler, Kathleen M, Richards-Kortum, Rebecca

“…Frequent and accessible testing is a critical tool to contain the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To develop low-cost…”
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Development of Low-Cost Point-of-Care Technologies for Cervical Cancer Prevention Based on a Single-Board Computer by Parra, Sonia, Carranza, Eduardo, Coole, Jackson, Hunt, Brady, Smith, Chelsey, Keahey, Pelham, Maza, Mauricio, Schmeler, Kathleen, Richards-Kortum, Rebecca

“…Cervical cancer disproportionally affects women in low- and middle-income countries, in part due to the difficulty of implementing existing cervical cancer…”
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Real-time isothermal nucleic acid amplification detection in resource-limited settings: a description of an open-source miniature fluorimeter by Coole, Jackson, Kortum, Alex, Tang, Yubo, Vohra, Imran, Natoli, Mary, Kundrod, Kathryn, Richards-Kortum, Rebecca

“…The detection and quantification of nucleic acids traditionally relies on PCR, which requires the use of expensive thermocyclers with integrated fluorescence…”
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Persistent organic pollutants (POPs) increase rage signaling to promote downstream cardiovascular remodeling by Coole, Jackson B., Burr, Stephanie S., Kay, Amber M., Singh, Jaime A., Kondakala, Sandeep, Yang, Eun‐Ju, Kaplan, Barbara L. F., Howell, George E., Stewart, James A.

“…Exposure to environmental contaminants and consumption of a high, saturated fatty diet has been demonstrated to promote precursors for metabolic syndrome…”
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Allele-specific recombinase polymerase amplification for real-time detection of sickle cell anaemia in low-resource settings: evaluation of an isothermal nucleic acid amplification test to detect the βS globin point mutation in paediatric patients by Natoli, Mary, Chang, Megan, Kundrod, Kathryn, Coole, Jackson, Airewele, Gladstone, Tubman, Venée N, Richards-Kortum, Rebecca

“…Sickle cell anaemia is a common, life-threatening disorder caused by a point mutation in the β globin gene. The high cost and complexity of conventional…”
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Identification of processing elements and interactors implicate SMN, coilin and the pseudogene-encoded coilp1 in telomerase and box C/D scaRNP biogenesis by Poole, Aaron R., Enwerem, Isioma I., Vicino, Ian A., Coole, Jackson B., Smith, Stanley V., Hebert, Michael D.

“…Many cellular functions, such as translation, require ribonucleoproteins (RNPs). The biogenesis of RNPs is a multi-step process that, depending on the RNP, can…”
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High frame rate video mosaicking microendoscope to image large regions of intact tissue with subcellular resolution by Hunt, Brady, Coole, Jackson, Brenes, David, Kortum, Alex, Mitbander, Ruchika, Vohra, Imran, Carns, Jennifer, Schwarz, Richard, Richards-Kortum, Rebecca

“…High-resolution microendoscopy (HRME) is a low-cost strategy to acquire images of intact tissue with subcellular resolution at frame rates ranging from 11 to…”
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Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings by Coole, Jackson, Kortum, Alex, Tang, Yubo, Vohra, Imran, Maker, Yajur, Kundrod, Kathryn, Natoli, Mary, Richards-Kortum, Rebecca

“…Traditional methods to detect and quantify nucleic acids rely on polymerase chain reaction (PCR) and require the use of expensive thermocyclers with integrated…”
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