Search Results - "Cool, M."

Concise Review: Multifaceted Characterization of Human Mesenchymal Stem Cells for Use in Regenerative Medicine by Samsonraj, Rebekah M., Raghunath, Michael, Nurcombe, Victor, Hui, James H., van Wijnen, Andre J., Cool, Simon M.

“…Mesenchymal stem cells (MSC) hold great potential for regenerative medicine because of their ability for self‐renewal and differentiation into tissue‐specific…”
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Wnt signaling controls the fate of mesenchymal stem cells by Ling, Ling, Nurcombe, Victor, Cool, Simon M.

“…Multipotential mesenchymal stem cells (MSCs) are able to differentiate along several known lineages and have been shown to be efficacious for in vivo wound…”
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Establishing Criteria for Human Mesenchymal Stem Cell Potency by Samsonraj, Rebekah M., Rai, Bina, Sathiyanathan, Padmapriya, Puan, Kia Joo, Rötzschke, Olaf, Hui, James H., Raghunath, Michael, Stanton, Lawrence W., Nurcombe, Victor, Cool, Simon M.

“…This study sought to identify critical determinants of mesenchymal stem cell (MSC) potency using in vitro and in vivo attributes of cells isolated from the…”
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The three-dimensional vascularization of growth factor-releasing hybrid scaffold of poly (ε-caprolactone)/collagen fibers and hyaluronic acid hydrogel by Ekaputra, Andrew K, Prestwich, Glenn D, Cool, Simon M, Hutmacher, Dietmar W

“…Abstract A significant stumbling block in the creation of functional three-dimensional (3D) engineered tissues is the proper vascularization of the constructs…”
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Human Mesenchymal Stem Cells Retain Multilineage Differentiation Capacity Including Neural Marker Expression after Extended In Vitro Expansion by Okolicsanyi, Rachel K, Camilleri, Emily T, Oikari, Lotta E, Yu, Chieh, Cool, Simon M, van Wijnen, Andre J, Griffiths, Lyn R, Haupt, Larisa M

“…The suitability of human mesenchymal stem cells (hMSCs) in regenerative medicine relies on retention of their proliferative expansion potential in conjunction…”
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New cataclysmic variables and other exotic binaries in the globular cluster 47 Tucanae by Rivera Sandoval, L E, van den Berg, M, Heinke, C O, Cohn, H N, Lugger, P M, Anderson, J, Cool, A M, Edmonds, P D, Wijnands, R, Ivanova, N, Grindlay, J E

“…Abstract We present 22 new (+3 confirmed) cataclysmic variables (CVs) in the non-core-collapsed globular cluster 47 Tucanae (47 Tuc). The total number of CVs…”
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Complexation and sequestration of BMP-2 from an ECM mimetic hyaluronan gel for improved bone formation by Kisiel, Marta, Klar, Agnieszka S, Ventura, Manuela, Buijs, Jos, Mafina, Marc-Krystelle, Cool, Simon M, Hilborn, Jöns

“…Bone morphogenetic protein-2 (BMP-2) is considered a promising adjuvant for the treatment of skeletal non-union and spinal fusion. However, BMP-2 delivery in a…”
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Vascular Endothelial Growth Factor 165-Binding Heparan Sulfate Promotes Functional Recovery From Cerebral Ischemia by Chan, Su Jing, Esposito, Elga, Hayakawa, Kazuhide, Mandaville, Emiri, Smith, Raymond A.A., Guo, Shuzhen, Niu, Wanting, Wong, Peter Tsun-Hong, Cool, Simon M., Lo, Eng H., Nurcombe, Victor

“…BACKGROUND AND PURPOSE:Although VEGF165 (vascular endothelial growth factor-165) is able to enhance both angiogenesis and neurogenesis, it also increases…”
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Controlled release of heparin from poly( ε-caprolactone) electrospun fibers by Luong-Van, Emma, Grøndahl, Lisbeth, Chua, Kian Ngiap, Leong, Kam W., Nurcombe, Victor, Cool, Simon M.

“…Sustained delivery of heparin to the localized adventitial surface of grafted blood vessels has been shown to prevent the vascular smooth muscle cell (VSMC)…”
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Retraction Note: Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes by Yan, Dongyao, Chen, Di, Cool, Simon M, van Wijnen, Andre J, Mikecz, Katalin, Murphy, Gillian, Im, Hee-Jeong

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Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis by Luo, Xiaoman, Lau, Chau Sang, Le, Bach Quang, Tan, Tuan Chun, Too, Jian Hui, Smith, Raymond Alexander Alfred, Yu, Na, Cool, Simon M.

“…It is challenging to regenerate periodontal tissues fully. We have previously reported a heparan sulfate variant with enhanced affinity for bone morphogenetic…”
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Differences between in vitro viability and differentiation and in vivo bone-forming efficacy of human mesenchymal stem cells cultured on PCL–TCP scaffolds by Rai, Bina, Lin, Jane L, Lim, Zophia X.H, Guldberg, Robert E, Hutmacher, Dietmar W, Cool, Simon M

“…Abstract Human mesenchymal stem cells (hMSCs) possess great therapeutic potential for the treatment of bone disease and fracture non-union. Too often however,…”
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The influence of collagen and hyaluronan matrices on the delivery and bioactivity of bone morphogenetic protein-2 and ectopic bone formation by Bhakta, Gajadhar, Lim, Zophia X.H., Rai, Bina, Lin, Tingxuan, Hui, James H., Prestwich, Glenn D., van Wijnen, Andre J., Nurcombe, Victor, Cool, Simon M.

“…Bone morphogenetic protein-2 (BMP-2) is known to enhance fracture healing when delivered via a bovine collagen sponge. However, collagen rapidly releases BMP-2…”
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Bone marrow-derived heparan sulfate potentiates the osteogenic activity of bone morphogenetic protein-2 (BMP-2) by Bramono, Diah S, Murali, Sadasivam, Rai, Bina, Ling, Ling, Poh, Wei Theng, Lim, Zophia Xuehui, Stein, Gary S, Nurcombe, Victor, van Wijnen, Andre J, Cool, Simon M

“…Abstract Lowering the efficacious dose of bone morphogenetic protein-2 (BMP-2) for the repair of critical-sized bone defects is highly desirable, as…”
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Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells by Ling, Ling, Camilleri, Emily T., Helledie, Torben, Samsonraj, Rebekah M., Titmarsh, Drew M., Chua, Ren Jie, Dreesen, Oliver, Dombrowski, Christian, Rider, David A., Galindo, Mario, Lee, Ian, Hong, Wanjin, Hui, James H., Nurcombe, Victor, van Wijnen, Andre J., Cool, Simon M.

“…Chronic use of heparin as an anti-coagulant for the treatment of thrombosis or embolism invokes many adverse systemic events including thrombocytopenia,…”
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The influence of fibrin based hydrogels on the chondrogenic differentiation of human bone marrow stromal cells by Ho, Saey T.B, Cool, Simon M, Hui, James H, Hutmacher, Dietmar W

“…Abstract Mesenchymal Stem Cells (MSC) are frequently incorporated into osteochondral implants and cell seeding is often facilitated with hydrogels which exert…”
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Application of a BMP2-binding heparan sulphate to promote periodontal regeneration by Le, B Q, Too, J H, Tan, T C, Smith, R Aa, Nurcombe, V, Cool, S M, Yu, N

“…Periodontitis is the most common inflammatory disease that leads to periodontal defects and tooth loss. Regeneration of alveolar bone and soft tissue in…”
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Heparan Sulfate Proteoglycans: Key Mediators of Stem Cell Function by Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Nurcombe, Victor, Cool, Simon M

“…Heparan sulfate proteoglycans (HSPGs) are an evolutionarily ancient subclass of glycoproteins with exquisite structural complexity. They are ubiquitously…”
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MicroRNA-34c Inversely Couples the Biological Functions of the Runt-related Transcription Factor RUNX2 and the Tumor Suppressor p53 in Osteosarcoma by van der Deen, Margaretha, Taipaleenmäki, Hanna, Zhang, Ying, Teplyuk, Nadiya M., Gupta, Anurag, Cinghu, Senthilkumar, Shogren, Kristen, Maran, Avudaiappan, Yaszemski, Michael J., Ling, Ling, Cool, Simon M., Leong, David T., Dierkes, Christian, Zustin, Jozef, Salto-Tellez, Manuel, Ito, Yoshiaki, Bae, Suk-Chul, Zielenska, Maria, Squire, Jeremy A., Lian, Jane B., Stein, Janet L., Zambetti, Gerard P., Jones, Stephen N., Galindo, Mario, Hesse, Eric, Stein, Gary S., van Wijnen, Andre J.

“…Osteosarcoma (OS) is a primary bone tumor that is most prevalent during adolescence. RUNX2, which stimulates differentiation and suppresses proliferation of…”
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Heparan Sulfate Proteoglycans and Human Breast Cancer Epithelial Cell Tumorigenicity by Okolicsanyi, Rachel K., van Wijnen, Andre J., Cool, Simon M., Stein, Gary S., Griffiths, Lyn R., Haupt, Larisa M.

“…ABSTRACT Heparan sulfate proteoglycans (HSPGs) are key components of the extracellular matrix that mediate cell proliferation, invasion, and cellular…”
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