Search Results - "Cool, Barbara"

AMP-activated Protein Kinase Inhibits Transforming Growth Factor-β-induced Smad3-dependent Transcription and Myofibroblast Transdifferentiation by Mishra, Rangnath, Cool, Barbara L., Laderoute, Keith R., Foretz, Marc, Viollet, Benoit, Simonson, Michael S.

“…In wound healing, myofibroblast transdifferentiation (MFT) is a metaplastic change in phenotype producing profibrotic effector cells that secrete and remodel…”
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Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression by Stewart, Andrew O, Bhatia, Pramila A, McCarty, Catherine M, Patel, Meena V, Staeger, Michael A, Arendsen, David L, Gunawardana, Indrani W, Melcher, Laura M, Zhu, Gui-Dong, Boyd, Steven A, Fry, Dennis G, Cool, Barbara L, Kifle, Lemma, Lartey, Kraig, Marsh, Kennan C, Kempf-Grote, Anita J, Kilgannon, Patrick, Wisdom, Wendy, Meyer, Joey, Gallatin, W. Michael, Okasinski, Gregory F

“…A critical early event in the inflammatory cascade is the induced expression of cell adhesion molecules on the lumenal surface of vascular endothelial cells…”
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Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3-c]pyridines with Fine-Tuning at C-2 Carbamides by Zhu, Gui-Dong, Arendsen, David L, Gunawardana, Indrani W, Boyd, Steven A, Stewart, Andrew O, Fry, Dennis G, Cool, Barbara L, Kifle, Lemma, Schaefer, Verlyn, Meuth, Joseph, Marsh, Kennan C, Kempf-Grote, Anita J, Kilgannon, Patrick, Gallatin, W. Michael, Okasinski, Gregory F

“…The elevated expression of cell adhesion molecules (CAMs) on the lumenal surface of vascular endothelial cells is a critical early event in the complex…”
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Microarrayed compound screening (microARCS) to identify activators and inhibitors of AMP-activated protein kinase by Anderson, Steven N, Cool, Barbara L, Kifle, Lemma, Chiou, William, Egan, David A, Barrett, Leo W, Richardson, Paul L, Frevert, Ernst U, Warrior, Usha, Kofron, James L, Burns, David J

“…A novel and innovative high-throughput screening assay was developed to identify both activators and inhibitors of AMP-activated protein kinase (AMPK) using…”
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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome by Cool, Barbara, Zinker, Bradley, Chiou, William, Kifle, Lemma, Cao, Ning, Perham, Matthew, Dickinson, Robert, Adler, Andrew, Gagne, Gerard, Iyengar, Rajesh, Zhao, Gang, Marsh, Kennan, Kym, Philip, Jung, Paul, Camp, Heidi S., Frevert, Ernst

“…AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and whole-body energy metabolism. We have identified a thienopyridone family…”
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Immunocytochemical localization of the base excision repair enzyme uracil DNA glycosylase in quiescent and proliferating normal human cells by COOL, B. L, SIROVER, M. A

“…The immunocytochemical localization of the base excision repair enzyme uracil DNA glycosylase was examined as a function of cell proliferation. Two…”
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Discovery and SAR development of thienopyridones: A class of small molecule AMPK activators by Zhao, Gang, Iyengar, Rajesh R., Judd, Andrew S., Cool, Barbara, Chiou, William, Kifle, Lemma, Frevert, Ernst, Sham, Hing, Kym, Philip R.

“…AMP-activated protein kinase (AMPK) is well established as a sensor and regulator of intracellular and whole-body energy metabolism. A high-throughput screen…”
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AMP-activated Protein Kinase Inhibits Transforming Growth Factor-β-induced Smad3-dependent Transcription and Myofibroblast Transdifferentiation by Rangnath Mishra, Barbara L. Cool, Keith R. Laderoute, Marc Foretz, Benoit Viollet, Michael S. Simonson

“…In wound healing, myofibroblast transdifferentiation (MFT) is a metaplastic change in phenotype producing profibrotic effector cells that secrete and remodel…”
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Immunological Lesions in Human Uracil DNA Glycosylase: Association with Bloom Syndrome by Seal, Gita, Brech, Kilian, Karp, Seth J., Cool, Barbara L., Sirover, Michael A.

“…Three monoclonal antibodies that react with uracil DNA glycosylase of normal human placenta were tested to determine whether one of the antibodies could be…”
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Isolation and Characterization of the Human Uracil DNA Glycosylase Gene by Vollberg, Thomas M., Siegler, Katherine M., Cool, Barbara L., Sirover, Michael A.

“…A series of anti-human placental uracil DNA glycosylase monoclonal antibodies was used to screen a human placental cDNA library in phage λ gt11. Twenty-seven…”
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PHOTO-INDUCED DNA DAMAGE, DNA REPAIR AND CELL LETHALITY by COOL, BARBARA LYNNE

“…While mid-ultraviolet, near-ultraviolet and visible light are ubiquitous factors in our environment, relatively little information concerning the molecular or…”
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Biosynthesis of the human base excision repair enzyme uracil-DNA glycosylase by VOLLBERG, T. M, COOL, B. L, SIROVER, M. A

“…The biosynthesis of the human DNA repair enzyme uracil-DNA glycosylase has been characterized by the reaction of in vitro- and in vivo-produced protein with an…”
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Proliferation-dependent regulation of DNA glycosylases in progeroid cells by Cool, B L, Sirover, M A

“…The regulation of the base excision repair enzymes uracil DNA glycosylase and hypoxanthine DNA glycosylase was examined in 2 different progeroid cell strains…”
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Removal of DNA from RNA by chromatography on acetylated N-[N'-(m-dihydroxylborylphenyl)succinamyl]aminoethyl cellulose by Ackerman, S, Cool, B, Furth, J J

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