Search Results - "Cookson, William. O. C."

Disordered microbial communities in asthmatic airways by Hilty, Markus, Burke, Conor, Pedro, Helder, Cardenas, Paul, Bush, Andy, Bossley, Cara, Davies, Jane, Ervine, Aaron, Poulter, Len, Pachter, Lior, Moffatt, Miriam F, Cookson, William O C

“…A rich microbial environment in infancy protects against asthma [1], [2] and infections precipitate asthma exacerbations [3]. We compared the airway microbiota…”
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Longitudinal assessment of sputum microbiome by sequencing of the 16S rRNA gene in non-cystic fibrosis bronchiectasis patients by Cox, Michael J, Turek, Elena M, Hennessy, Catherine, Mirza, Ghazala K, James, Phillip L, Coleman, Meg, Jones, Andrew, Wilson, Robert, Bilton, Diana, Cookson, William O C, Moffatt, Miriam F, Loebinger, Michael R

“…Bronchiectasis is accompanied by chronic bronchial infection that may drive disease progression. However, the evidence base for antibiotic therapy is limited…”
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Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis by Molyneaux, Philip L, Cox, Michael J, Wells, Athol U, Kim, Ho Cheol, Ji, Wonjun, Cookson, William O C, Moffatt, Miriam F, Kim, Dong Soon, Maher, Toby M

“…Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) have been defined as events of clinically significant respiratory deterioration with an…”
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Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study by Manousaki, Despoina, Paternoster, Lavinia, Standl, Marie, Moffatt, Miriam F, Farrall, Martin, Bouzigon, Emmanuelle, Strachan, David P, Demenais, Florence, Lathrop, Mark, Cookson, William O C M, Richards, J Brent

“…Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological…”
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An epigenome-wide association study of total serum immunoglobulin E concentration by Liang, Liming, Willis-Owen, Saffron A. G., Laprise, Catherine, Wong, Kenny C. C., Davies, Gwyneth A., Hudson, Thomas J., Binia, Aristea, Hopkin, Julian M., Yang, Ivana V., Grundberg, Elin, Busche, Stephan, Hudson, Marie, Rönnblom, Lars, Pastinen, Tomi M., Schwartz, David A., Lathrop, G. Mark, Moffatt, Miriam F., Cookson, William O. C. M.

“…A survey of epigenetic associations between serum immunoglobulin E concentrations indicating allergy and methylation at CpG islands in families and a…”
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Comparison of the upper and lower airway microbiota in children with chronic lung diseases by Ahmed, Bushra, Cox, Michael J, Cuthbertson, Leah, James, Phillip L, Cookson, William O C, Davies, Jane C, Moffatt, Miriam F, Bush, Andrew

“…The lower airway microbiota is important in normal immunological development and chronic lung diseases (CLDs). Young children cannot expectorate and because of…”
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Improved detection of bifidobacteria with optimised 16S rRNA-gene based pyrosequencing by Sim, Kathleen, Cox, Michael J, Wopereis, Harm, Martin, Rocio, Knol, Jan, Li, Ming-Shi, Cookson, William O C M, Moffatt, Miriam F, Kroll, J Simon

“…The 16S rRNA gene is conserved across all bacteria and as such is routinely targeted in PCR surveys of bacterial diversity. PCR primer design aims to amplify…”
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Profiling mycobacterial communities in pulmonary nontuberculous mycobacterial disease by Cowman, Steven A, James, Phillip, Wilson, Robert, Cookson, William O C, Moffatt, Miriam F, Loebinger, Michael R

“…The diagnosis of pulmonary non-tuberculous mycobacterial disease (pNTM) is dependent on the isolation of NTM in culture, which is prone to overgrowth and…”
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Late-Onset Bloodstream Infection and Perturbed Maturation of the Gastrointestinal Microbiota in Premature Infants by Shaw, Alexander G, Sim, Kathleen, Randell, Paul, Cox, Michael J, McClure, Zoë E, Li, Ming-Shi, Donaldson, Hugo, Langford, Paul R, Cookson, William O C M, Moffatt, Miriam F, Kroll, J Simon

“…Late-onset bloodstream infection (LO-BSI) is a common complication of prematurity, and lack of timely diagnosis and treatment can have life-threatening…”
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The impact of persistent bacterial bronchitis on the pulmonary microbiome of children by Cuthbertson, Leah, Craven, Vanessa, Bingle, Lynne, Cookson, William O C M, Everard, Mark L, Moffatt, Miriam F

“…Persistent bacterial bronchitis (PBB) is a leading cause of chronic wet cough in young children. This study aimed to characterise the respiratory bacterial…”
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Filaggrin Mutations in Children with Severe Atopic Dermatitis by Morar, Nilesh, Cookson, William O.C.M., Harper, John I., Moffatt, Miriam F.

“…Atopic dermatitis (AD) results from strong genetic and environmental interactions. AD shows genetic linkage to Chromosome 1q21. This region contains the…”
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Crosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells by Chrisochoidou, Yakinthi, Roy, Rajat, Farahmand, Pooyeh, Gonzalez, Guadalupe, Doig, Jennifer, Krasny, Lukas, Rimmer, Ella F., Willis, Anne E, MacFarlane, Marion, Huang, Paul H., Carragher, Neil O., Munro, Alison F., Murphy, Daniel J., Veselkov, Kirill, Seckl, Michael J., Moffatt, Miriam F., Cookson, William O. C., Pardo, Olivier E.

“…Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive fibrotic response. The latter is in large part mediated by…”
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Integrated genomics point to immune vulnerabilities in pleural mesothelioma by Nastase, Anca, Mandal, Amit, Lu, Shir Kiong, Anbunathan, Hima, Morris-Rosendahl, Deborah, Zhang, Yu Zhi, Sun, Xiao-Ming, Gennatas, Spyridon, Rintoul, Robert C., Edwards, Matthew, Bowman, Alex, Chernova, Tatyana, Benepal, Tim, Lim, Eric, Taylor, Anthony Newman, Nicholson, Andrew G., Popat, Sanjay, Willis, Anne E., MacFarlane, Marion, Lathrop, Mark, Bowcock, Anne M., Moffatt, Miriam F., Cookson, William O. C. M.

“…Pleural mesothelioma is an aggressive malignancy with limited effective therapies. In order to identify therapeutic targets, we integrated SNP genotyping,…”
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Metabolomic, transcriptomic and genetic integrative analysis reveals important roles of adenosine diphosphate in haemostasis and platelet activation in non‐small‐cell lung cancer by Hoang, Long T., Domingo‐Sabugo, Clara, Starren, Elizabeth S., Willis‐Owen, Saffron A.G., Morris‐Rosendahl, Deborah J., Nicholson, Andrew G., Cookson, William O. C. M., Moffatt, Miriam F.

“…Lung cancer is the leading cause of cancer‐related deaths in the world. The most prevalent subtype, accounting for 85% of cases, is non‐small‐cell lung cancer…”
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Exposure to Environmental Microorganisms and Childhood Asthma by Ege, Markus J, Mayer, Melanie, Normand, Anne-Cécile, Genuneit, Jon, Cookson, William O.C.M, Braun-Fahrländer, Charlotte, Heederik, Dick, Piarroux, Renaud, von Mutius, Erika

“…Growing up on a farm protects children from asthma. In this study, the investigators show that the diversity of microbial exposure of farm children as compared…”
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Author Correction: Integrated genomics point to immune vulnerabilities in pleural mesothelioma by Nastase, Anca, Mandal, Amit, Lu, Shir Kiong, Anbunathan, Hima, Morris‑Rosendahl, Deborah, Zhang, Yu Zhi, Sun, Xiao‑Ming, Gennatas, Spyridon, Rintoul, Robert C., Edwards, Matthew, Bowman, Alex, Chernova, Tatyana, Benepal, Tim, Lim, Eric, Taylor, Anthony Newman, Nicholson, Andrew G., Popat, Sanjay, Willis, Anne E., MacFarlane, Marion, Lathrop, Mark, Bowcock, Anne M., Moffatt, Miriam F., Cookson, William O. C. M.

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Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease by MOLYNEAUX, Philip L, MALLIA, Patrick, MOFFATT, Miriam F, JOHNSTON, Sebastian L, COX, Michael J, FOOTITT, Joseph, WILLIS-OWEN, Saffron A. G, HOMOLA, Daniel, TRUJILLO-TORRALBO, Maria-Belen, ELKIN, Sarah, ONN MIN KON, COOKSON, William O. C

“…Rhinovirus infection is followed by significantly increased frequencies of positive, potentially pathogenic sputum cultures in chronic obstructive pulmonary…”
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EGF receptor (EGFR) inhibition promotes a slow-twitch oxidative, over a fast-twitch, muscle phenotype by Ciano, Margherita, Mantellato, Giada, Connolly, Martin, Paul-Clark, Mark, Willis-Owen, Saffron, Moffatt, Miriam F., Cookson, William O. C. M., Mitchell, Jane A., Polkey, Michael I., Hughes, Simon M., Kemp, Paul R., Natanek, S. Amanda

“…A low quadriceps slow-twitch (ST), oxidative (relative to fast-twitch) fiber proportion is prevalent in chronic diseases such Chronic Obstructive Pulmonary…”
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The role of bacteria in the pathogenesis and progression of idiopathic pulmonary fibrosis by Molyneaux, Phillip L, Cox, Michael J, Willis-Owen, Saffron A G, Mallia, Patrick, Russell, Kirsty E, Russell, Anne-Marie, Murphy, Elissa, Johnston, Sebastian L, Schwartz, David A, Wells, Athol U, Cookson, William O C, Maher, Toby M, Moffatt, Miriam F

“…Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown cause that leads to respiratory failure and death within 5 years of diagnosis…”
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Host-Microbial Interactions in Idiopathic Pulmonary Fibrosis by Molyneaux, Philip L, Willis-Owen, Saffron A G, Cox, Michael J, James, Phillip, Cowman, Steven, Loebinger, Michael, Blanchard, Andrew, Edwards, Lindsay M, Stock, Carmel, Daccord, Cécile, Renzoni, Elisabetta A, Wells, Athol U, Moffatt, Miriam F, Cookson, William O C, Maher, Toby M

“…Changes in the respiratory microbiome are associated with disease progression in idiopathic pulmonary fibrosis (IPF). The role of the host response to the…”
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