Search Results - "Cookson, William O. C. M."

Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study by Manousaki, Despoina, Paternoster, Lavinia, Standl, Marie, Moffatt, Miriam F, Farrall, Martin, Bouzigon, Emmanuelle, Strachan, David P, Demenais, Florence, Lathrop, Mark, Cookson, William O C M, Richards, J Brent

“…Low circulating vitamin D levels have been associated with risk of asthma, atopic dermatitis, and elevated total immunoglobulin E (IgE). These epidemiological…”
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An epigenome-wide association study of total serum immunoglobulin E concentration by Liang, Liming, Willis-Owen, Saffron A. G., Laprise, Catherine, Wong, Kenny C. C., Davies, Gwyneth A., Hudson, Thomas J., Binia, Aristea, Hopkin, Julian M., Yang, Ivana V., Grundberg, Elin, Busche, Stephan, Hudson, Marie, Rönnblom, Lars, Pastinen, Tomi M., Schwartz, David A., Lathrop, G. Mark, Moffatt, Miriam F., Cookson, William O. C. M.

“…A survey of epigenetic associations between serum immunoglobulin E concentrations indicating allergy and methylation at CpG islands in families and a…”
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Improved detection of bifidobacteria with optimised 16S rRNA-gene based pyrosequencing by Sim, Kathleen, Cox, Michael J, Wopereis, Harm, Martin, Rocio, Knol, Jan, Li, Ming-Shi, Cookson, William O C M, Moffatt, Miriam F, Kroll, J Simon

“…The 16S rRNA gene is conserved across all bacteria and as such is routinely targeted in PCR surveys of bacterial diversity. PCR primer design aims to amplify…”
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Late-Onset Bloodstream Infection and Perturbed Maturation of the Gastrointestinal Microbiota in Premature Infants by Shaw, Alexander G, Sim, Kathleen, Randell, Paul, Cox, Michael J, McClure, Zoë E, Li, Ming-Shi, Donaldson, Hugo, Langford, Paul R, Cookson, William O C M, Moffatt, Miriam F, Kroll, J Simon

“…Late-onset bloodstream infection (LO-BSI) is a common complication of prematurity, and lack of timely diagnosis and treatment can have life-threatening…”
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The impact of persistent bacterial bronchitis on the pulmonary microbiome of children by Cuthbertson, Leah, Craven, Vanessa, Bingle, Lynne, Cookson, William O C M, Everard, Mark L, Moffatt, Miriam F

“…Persistent bacterial bronchitis (PBB) is a leading cause of chronic wet cough in young children. This study aimed to characterise the respiratory bacterial…”
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Filaggrin Mutations in Children with Severe Atopic Dermatitis by Morar, Nilesh, Cookson, William O.C.M., Harper, John I., Moffatt, Miriam F.

“…Atopic dermatitis (AD) results from strong genetic and environmental interactions. AD shows genetic linkage to Chromosome 1q21. This region contains the…”
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Integrated genomics point to immune vulnerabilities in pleural mesothelioma by Nastase, Anca, Mandal, Amit, Lu, Shir Kiong, Anbunathan, Hima, Morris-Rosendahl, Deborah, Zhang, Yu Zhi, Sun, Xiao-Ming, Gennatas, Spyridon, Rintoul, Robert C., Edwards, Matthew, Bowman, Alex, Chernova, Tatyana, Benepal, Tim, Lim, Eric, Taylor, Anthony Newman, Nicholson, Andrew G., Popat, Sanjay, Willis, Anne E., MacFarlane, Marion, Lathrop, Mark, Bowcock, Anne M., Moffatt, Miriam F., Cookson, William O. C. M.

“…Pleural mesothelioma is an aggressive malignancy with limited effective therapies. In order to identify therapeutic targets, we integrated SNP genotyping,…”
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Metabolomic, transcriptomic and genetic integrative analysis reveals important roles of adenosine diphosphate in haemostasis and platelet activation in non‐small‐cell lung cancer by Hoang, Long T., Domingo‐Sabugo, Clara, Starren, Elizabeth S., Willis‐Owen, Saffron A.G., Morris‐Rosendahl, Deborah J., Nicholson, Andrew G., Cookson, William O. C. M., Moffatt, Miriam F.

“…Lung cancer is the leading cause of cancer‐related deaths in the world. The most prevalent subtype, accounting for 85% of cases, is non‐small‐cell lung cancer…”
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EGF receptor (EGFR) inhibition promotes a slow-twitch oxidative, over a fast-twitch, muscle phenotype by Ciano, Margherita, Mantellato, Giada, Connolly, Martin, Paul-Clark, Mark, Willis-Owen, Saffron, Moffatt, Miriam F., Cookson, William O. C. M., Mitchell, Jane A., Polkey, Michael I., Hughes, Simon M., Kemp, Paul R., Natanek, S. Amanda

“…A low quadriceps slow-twitch (ST), oxidative (relative to fast-twitch) fiber proportion is prevalent in chronic diseases such Chronic Obstructive Pulmonary…”
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Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes by Taylor, Jennifer M, Street, Teresa L, Hao, Lizhong, Copley, Richard, Taylor, Martin S, Hayden, Patrick J, Stolper, Gina, Mott, Richard, Hein, Jotun, Moffatt, Miriam F, Cookson, William O C M

“…The mammalian epidermis is a continually renewing structure that provides the interface between the organism and an innately hostile environment. The…”
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Author Correction: Integrated genomics point to immune vulnerabilities in pleural mesothelioma by Nastase, Anca, Mandal, Amit, Lu, Shir Kiong, Anbunathan, Hima, Morris‑Rosendahl, Deborah, Zhang, Yu Zhi, Sun, Xiao‑Ming, Gennatas, Spyridon, Rintoul, Robert C., Edwards, Matthew, Bowman, Alex, Chernova, Tatyana, Benepal, Tim, Lim, Eric, Taylor, Anthony Newman, Nicholson, Andrew G., Popat, Sanjay, Willis, Anne E., MacFarlane, Marion, Lathrop, Mark, Bowcock, Anne M., Moffatt, Miriam F., Cookson, William O. C. M.

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Exposure to Environmental Microorganisms and Childhood Asthma by Ege, Markus J, Mayer, Melanie, Normand, Anne-Cécile, Genuneit, Jon, Cookson, William O.C.M, Braun-Fahrländer, Charlotte, Heederik, Dick, Piarroux, Renaud, von Mutius, Erika

“…Growing up on a farm protects children from asthma. In this study, the investigators show that the diversity of microbial exposure of farm children as compared…”
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New opportunities for managing acute and chronic lung infections by Cookson, William O. C. M., Cox, Michael J., Moffatt, Miriam F.

“…Traditional strategies to treat lung infections are based on the premise that the lung is sterile; however, it is now thought that the lung contains a resident…”
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COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix by Willis-Owen, Saffron A. G., Thompson, Anna, Kemp, Paul R., Polkey, Michael I., Cookson, William O. C. M., Moffatt, Miriam F., Natanek, Samantha A.

“…Skeletal muscle dysfunction is a frequent extra-pulmonary manifestation of Chronic Obstructive Pulmonary Disease (COPD) with implications for both quality of…”
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The genetics of atopic dermatitis by Morar, Nilesh, Willis-Owen, Saffron A.G., Moffatt, Miriam F., Cookson, William O.C.M.

“…Atopic dermatitis (AD) is a chronic itching (pruritic) skin disease. It results from a complex interplay between strong genetic and environmental factors…”
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Gene-environment interaction for childhood asthma and exposure to farming in Central Europe by Ege, Markus J., MD, Strachan, David P., MD, Cookson, William O.C.M., MD, DPhil, Moffatt, Miriam F., MD, DPhil, Gut, Ivo, PhD, Lathrop, Mark, PhD, Kabesch, Michael, MD, Genuneit, Jon, MD, Büchele, Gisela, PhD, Sozanska, Barbara, MD, Boznanski, Andrzej, MD, PhD, Cullinan, Paul, MD, Horak, Elisabeth, MD, Bieli, Christian, MD, Braun-Fahrländer, Charlotte, MD, Heederik, Dick, PhD, von Mutius, Erika, MD

“…Background Asthma is a disease in which both genetic and environmental factors play important roles. The farming environment has consistently been associated…”
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Presence of pleomorphic features but not growth patterns improves prognostic stratification of epithelioid malignant pleural mesothelioma by 2‐tier nuclear grade by Zhang, Yu Z, Brambilla, Cecilia, Molyneaux, Philip L, Rice, Alexandra, Robertus, Jan L, Jordan, Simon, Lim, Eric, Lang‐Lazdunski, Loic, Begum, Sofina, Dusmet, Michael, Anikin, Vladimir, Beddow, Emma, Finch, Jonathan, Asadi, Nizar, Popat, Sanjay, Quesne, John L, Husain, Aliya N, Cookson, William O C M, Moffatt, Miriam F, Nicholson, Andrew G

“…Aims Nuclear grade has been recently validated as a powerful prognostic tool in epithelioid malignant pleural mesothelioma (E‐MPM). In other studies…”
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Genome‐wide interaction study of early‐life smoking exposure on time‐to‐asthma onset in childhood by Sugier, Pierre‐Emmanuel, Sarnowski, Chloé, Granell, Raquel, Laprise, Catherine, Ege, Markus J., Margaritte‐Jeannin, Patricia, Dizier, Marie‐Hélène, Minelli, Cosetta, Moffatt, Miriam F., Lathrop, Mark, Cookson, William O. C. M., Henderson, A. John, Mutius, Erika, Kogevinas, Manolis, Demenais, Florence, Bouzigon, Emmanuelle

“…Background Asthma, a heterogeneous disease with variable age of onset, results from the interplay between genetic and environmental factors. Early‐life tobacco…”
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Investigation of the Chromosome 17q25 PSORS2 Locus in Atopic Dermatitis by Morar, Nilesh, Bowcock, Anne M., Harper, John I., Cookson, William O.C.M., Moffatt, Miriam F.

“…Psoriasis and atopic dermatitis (AD) are strongly genetic and inherited as multi-factorial traits. In both diseases, linkage has been reported to chromosome…”
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The lung microbiome in health and disease by Moffatt, Miriam F, Cookson, William OCM

“…The Human Microbiome Project began 10 years ago, leading to a significant growth in understanding of the role the human microbiome plays in health and disease…”
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