Search Results - "Cooke, Vesselina G"

Origin and function of myofibroblasts in kidney fibrosis by LeBleu, Valerie S, Taduri, Gangadhar, O'Connell, Joyce, Teng, Yingqi, Cooke, Vesselina G, Woda, Craig, Sugimoto, Hikaru, Kalluri, Raghu

“…Myofibroblasts are associated with organ fibrosis, but their origin and functional role remain unknown. Using multiple genetically engineered mice, the authors…”
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Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway by Cooke, Vesselina G., LeBleu, Valerie S., Keskin, Doruk, Khan, Zainab, O'Connell, Joyce T., Teng, Yingqi, Duncan, Michael B., Xie, Liang, Maeda, Genta, Vong, Sylvia, Sugimoto, Hikaru, Rocha, Rafael M., Damascena, Aline, Brentani, Ricardo R., Kalluri, Raghu

“…The functional role of pericytes in cancer progression remains unknown. Clinical studies suggest that low numbers of vessel-associated pericytes correlated…”
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Targeting Vascular Pericytes in Hypoxic Tumors Increases Lung Metastasis via Angiopoietin-2 by Keskin, Doruk, Kim, Jiha, Cooke, Vesselina G., Wu, Chia-Chin, Sugimoto, Hikaru, Gu, Chenghua, De Palma, Michele, Kalluri, Raghu, LeBleu, Valerie S.

“…Strategies to target angiogenesis include inhibition of the vessel-stabilizing properties of vascular pericytes. Pericyte depletion in early-stage non-hypoxic…”
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Studying clonal dynamics in response to cancer therapy using high-complexity barcoding by Bhang, Hyo-eun C, Ruddy, David A, Krishnamurthy Radhakrishna, Viveksagar, Caushi, Justina X, Zhao, Rui, Hims, Matthew M, Singh, Angad P, Kao, Iris, Rakiec, Daniel, Shaw, Pamela, Balak, Marissa, Raza, Alina, Ackley, Elizabeth, Keen, Nicholas, Schlabach, Michael R, Palmer, Michael, Leary, Rebecca J, Chiang, Derek Y, Sellers, William R, Michor, Franziska, Cooke, Vesselina G, Korn, Joshua M, Stegmeier, Frank

“…The authors have developed a barcoded library that enables the high-throughput tracking of tumor cell dynamics and clonal evolution in response to therapy…”
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An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide) by Korpal, Manav, Korn, Joshua M, Gao, Xueliang, Rakiec, Daniel P, Ruddy, David A, Doshi, Shivang, Yuan, Jing, Kovats, Steve G, Kim, Sunkyu, Cooke, Vesselina G, Monahan, John E, Stegmeier, Frank, Roberts, Thomas M, Sellers, William R, Zhou, Wenlai, Zhu, Ping

“…Castration-resistant prostate cancer (CRPC) is the most aggressive, incurable form of prostate cancer. MDV3100 (enzalutamide), an antagonist of the androgen…”
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VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization by O'Connell, Joyce T, Sugimoto, Hikaru, Cooke, Vesselina G, MacDonald, Brian A, Mehta, Ankit I, LeBleu, Valerie S, Dewar, Rajan, Rocha, Rafael M, Brentani, Ricardo R, Resnick, Murray B, Neilson, Eric G, Zeisberg, Michael, Kalluri, Raghu

“…Increased numbers of S100A4+ cells are associated with poor prognosis in patients who have cancer. Although the metastatic capabilities of S100A4+ cancer cells…”
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Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia by Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank

“…Frank Stegmeier, Levi Garraway and colleagues apply a targeted mass spectrometry approach that measures level of histone modifications and identify a recurrent…”
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Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF by Shao, Wenlin, Mishina, Yuji M, Feng, Yun, Caponigro, Giordano, Cooke, Vesselina G, Rivera, Stacy, Wang, Yingyun, Shen, Fang, Korn, Joshua M, Mathews Griner, Lesley A, Nishiguchi, Gisele, Rico, Alice, Tellew, John, Haling, Jacob R, Aversa, Robert, Polyakov, Valery, Zang, Richard, Hekmat-Nejad, Mohammad, Amiri, Payman, Singh, Mallika, Keen, Nicholas, Dillon, Michael P, Lees, Emma, Ramurthy, Savithri, Sellers, William R, Stuart, Darrin D

“…Resistance to the RAF inhibitor vemurafenib arises commonly in melanomas driven by the activated BRAF oncogene. Here, we report antitumor properties of RAF709,…”
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Inhibition of Wild-Type p53-Expressing AML by the Novel Small Molecule HDM2 Inhibitor CGM097 by Weisberg, Ellen, Halilovic, Ensar, Cooke, Vesselina G, Nonami, Atsushi, Ren, Tao, Sanda, Takaomi, Simkin, Irene, Yuan, Jing, Antonakos, Brandon, Barys, Louise, Ito, Moriko, Stone, Richard, Galinsky, Ilene, Cowens, Kristen, Nelson, Erik, Sattler, Martin, Jeay, Sebastien, Wuerthner, Jens U, McDonough, Sean M, Wiesmann, Marion, Griffin, James D

“…The tumor suppressor p53 is a key regulator of apoptosis and functions upstream in the apoptotic cascade by both indirectly and directly regulating Bcl-2…”
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Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers by Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri

“…RAS oncogenes have been implicated in >30% of human cancers, all representing high unmet medical need. The exquisite dependency on CRAF kinase in KRAS mutant…”
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Fibroblast Growth Factor-2 Failed to Induce Angiogenesis in Junctional Adhesion Molecule-A–Deficient Mice by Cooke, Vesselina G, Naik, Meghna U, Naik, Ulhas P

“…OBJECTIVE—We have previously shown that JAM-A regulates fibroblast growth factor-2 (FGF-2)–induced endothelial cell morphology, proliferation, and migration…”
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Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity by Eikesdal, Hans Petter, Sugimoto, Hikaru, Birrane, Gabriel, Maeshima, Yohei, Cooke, Vesselina G, Kieran, Mark, Kalluri, Raghu

“…Tumstatin is an angiogenesis inhibitor that binds to αvβ3 integrin and suppresses tumor growth. Previous deletion mutagenesis studies identified a 25-aa…”
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Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma by Rahal, Rami, Frick, Mareike, Romero, Rodrigo, Korn, Joshua M, Kridel, Robert, Chun Chan, Fong, Meissner, Barbara, Bhang, Hyo-eun, Ruddy, Dave, Kauffmann, Audrey, Farsidjani, Ali, Derti, Adnan, Rakiec, Daniel, Naylor, Tara, Pfister, Estelle, Kovats, Steve, Kim, Sunkyu, Dietze, Kerstin, Dörken, Bernd, Steidl, Christian, Tzankov, Alexandar, Hummel, Michael, Monahan, John, Morrissey, Michael P, Fritsch, Christine, Sellers, William R, Cooke, Vesselina G, Gascoyne, Randy D, Lenz, Georg, Stegmeier, Frank

“…A screen for compounds that may inhibit the growth of hematological malignancies reveals the specific dependence of some mantle cell lymphoma (MCL) cell lines…”
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LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors by Monaco, Kelli-Ann, Delach, Scott, Yuan, Jing, Mishina, Yuji, Fordjour, Paul, Labrot, Emma, McKay, Daniel, Guo, Ribo, Higgins, Stacy, Wang, Hui Qin, Liang, Jinsheng, Bui, Karen, Green, John, Aspesi, Peter, Ambrose, Jessi, Mapa, Felipa, Griner, Lesley, Jaskelioff, Mariela, Fuller, John, Crawford, Kenneth, Pardee, Gwynn, Widger, Stephania, Hammerman, Peter S, Engelman, Jeffrey A, Stuart, Darrin D, Cooke, Vesselina G, Caponigro, Giordano

“…Targeting RAF for antitumor therapy in RAS-mutant tumors holds promise. Herein, we describe in detail novel properties of the type II RAF inhibitor, LXH254…”
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Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma by Visser, Michael, Papillon, Julien P. N., Luzzio, Michael, LaMarche, Matthew J., Fan, Jianmei, Michael, Walter, Wang, David, Zhang, Alan, Straub, Christopher, Mathieu, Simon, Kato, Mitsunori, Palermo, Mark, Chen, Christine, Ramsey, Timothy, Joud, Carol, Barrett, Rosemary, Vattay, Anthony, Guo, Ribo, Bric, Anka, Chung, Franklin, Liang, Guiqing, Romanowski, Michael J., Lam, Joni, Thohan, Sanjeev, Atassi, Faraj, Wylie, Andrew, Cooke, Vesselina G.

“…Uveal melanoma (UM) is the most common primary intraocular malignancy in the adult eye. Despite the aggressive local management of primary UM, the development…”
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Deletion of JAM-A causes morphological defects in the corneal epithelium by Kang, Liang I., Wang, Yan, Suckow, Arthur T., Czymmek, Kirk J., Cooke, Vesselina G., Naik, Ulhas P., Duncan, Melinda K.

“…Junctional adhesion molecule-A (JAM-A, JAM-1, F11R) is an Ig domain containing transmembrane protein that has been proposed to function in diverse processes…”
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Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic by Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D

“…Direct pharmacological inhibition of RAS has remained elusive, and efforts to target CRAF have been challenging due to the complex nature of RAF signaling,…”
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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice by Townsend, Elizabeth C., Murakami, Mark A., Christodoulou, Alexandra, Christie, Amanda L., Köster, Johannes, DeSouza, Tiffany A., Morgan, Elizabeth A., Kallgren, Scott P., Liu, Huiyun, Wu, Shuo-Chieh, Plana, Olivia, Montero, Joan, Stevenson, Kristen E., Rao, Prakash, Vadhi, Raga, Andreeff, Michael, Armand, Philippe, Ballen, Karen K., Barzaghi-Rinaudo, Patrizia, Cahill, Sarah, Clark, Rachael A., Cooke, Vesselina G., Davids, Matthew S., DeAngelo, Daniel J., Dorfman, David M., Eaton, Hilary, Ebert, Benjamin L., Etchin, Julia, Firestone, Brant, Fisher, David C., Freedman, Arnold S., Galinsky, Ilene A., Gao, Hui, Garcia, Jacqueline S., Garnache-Ottou, Francine, Graubert, Timothy A., Gutierrez, Alejandro, Halilovic, Ensar, Harris, Marian H., Herbert, Zachary T., Horwitz, Steven M., Inghirami, Giorgio, Intlekofer, Andrew M., Ito, Moriko, Izraeli, Shai, Jacobsen, Eric D., Jacobson, Caron A., Jeay, Sébastien, Jeremias, Irmela, Kelliher, Michelle A., Koch, Raphael, Konopleva, Marina, Kopp, Nadja, Kornblau, Steven M., Kung, Andrew L., Kupper, Thomas S., LeBoeuf, Nicole R., LaCasce, Ann S., Lees, Emma, Li, Loretta S., Look, A. Thomas, Murakami, Masato, Muschen, Markus, Neuberg, Donna, Ng, Samuel Y., Odejide, Oreofe O., Orkin, Stuart H., Paquette, Rachel R., Place, Andrew E., Roderick, Justine E., Ryan, Jeremy A., Sallan, Stephen E., Shoji, Brent, Silverman, Lewis B., Soiffer, Robert J., Steensma, David P., Stegmaier, Kimberly, Stone, Richard M., Tamburini, Jerome, Thorner, Aaron R., van Hummelen, Paul, Wadleigh, Martha, Wiesmann, Marion, Weng, Andrew P., Wuerthner, Jens U., Williams, David A., Wollison, Bruce M., Lane, Andrew A., Letai, Anthony, Bertagnolli, Monica M., Ritz, Jerome, Brown, Myles, Long, Henry, Aster, Jon C., Shipp, Margaret A., Griffin, James D., Weinstock, David M.

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Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling by SCHOUMACHER, Marie, HUROV, Kristen E, COOKE, Vesselina G, STEIGER, Janine, LEDELL, Jebediah, STUMP, Mark D, SELLERS, William R, DANIAL, Nika N, WENLIN SHAO, LEHAR, Joseph, YAN-NEALE, Yan, MISHINA, Yuji, SONKIN, Dmitriy, KORN, Joshua M, FLEMMING, Daisy, JONES, Michael D, ANTONAKOS, Brandon

“…Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis, and mitosis, offering attractive targets for anticancer treatment. Using unbiased…”
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JAM-A is present in mammalian spermatozoa where it is essential for normal motility by Shao, Minghai, Ghosh, Ananya, Cooke, Vesselina G., Naik, Ulhas P., Martin-DeLeon, Patricia A.

“…Junctional adhesion molecules (JAMs) that are expressed in endothelial and epithelial cells and function in tight junction assembly, also perform important…”
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