Search Results - "Cooke, Sophie"

Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy by Grange, Laura J., Reynolds, John J., Ullah, Farid, Isidor, Bertrand, Shearer, Robert F., Latypova, Xenia, Baxley, Ryan M., Oliver, Antony W., Ganesh, Anil, Cooke, Sophie L., Jhujh, Satpal S., McNee, Gavin S., Hollingworth, Robert, Higgs, Martin R., Natsume, Toyoaki, Khan, Tahir, Martos-Moreno, Gabriel Á., Chupp, Sharon, Mathew, Christopher G., Parry, David, Simpson, Michael A., Nahavandi, Nahid, Yüksel, Zafer, Drasdo, Mojgan, Kron, Anja, Vogt, Petra, Jonasson, Annemarie, Seth, Saad Ahmed, Gonzaga-Jauregui, Claudia, Brigatti, Karlla W., Stegmann, Alexander P. A., Kanemaki, Masato, Josifova, Dragana, Uchiyama, Yuri, Oh, Yukiko, Morimoto, Akira, Osaka, Hitoshi, Ammous, Zineb, Argente, Jesús, Matsumoto, Naomichi, Stumpel, Constance T.R.M., Taylor, Alexander M. R., Jackson, Andrew P., Bielinsky, Anja-Katrin, Mailand, Niels, Le Caignec, Cedric, Davis, Erica E., Stewart, Grant S.

“…Embryonic development is dictated by tight regulation of DNA replication, cell division and differentiation. Mutations in DNA repair and replication genes…”
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Discovery and In Vivo Efficacy of AZ-PRMT5i-1, a Novel PRMT5 Inhibitor with High MTA Cooperativity by Smith, James M., Barlaam, Bernard, Beattie, David, Bradshaw, Lauren, Chan, Ho Man, Chiarparin, Elisabetta, Collingwood, Olga, Cooke, Sophie L., Cronin, Anna, Cumming, Iain, Dean, Emma, Debreczeni, Judit É., del Barco Barrantes, Iván, Diene, Coura, Gianni, Davide, Guerot, Carine, Guo, Xiaoxiao, Guven, Sinem, Hayhow, Thomas G., Hong, Ted, Kemmitt, Paul D., Lamont, Gillian M., Lamont, Scott, Lynch, James T., McWilliams, Lisa, Moore, Shaun, Raubo, Piotr, Robb, Graeme R., Robinson, James, Scott, James S., Srinivasan, Bharath, Steward, Oliver, Stubbs, Christopher J., Syson, Karl, Tan, Lixiang, Turner, Oliver, Underwood, Elizabeth, Urosevic, Jelena, Vazquez-Chantada, Mercedes, Whittaker, Amy L., Wilson, David M., Winter-Holt, Jon J.

“…PRMT5, a type 2 arginine methyltransferase, has a critical role in regulating cell growth and survival in cancer. With the aim of developing MTA-cooperative…”
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Tos4 mediates gene expression homeostasis through interaction with HDAC complexes independently of H3K56 acetylation by Cooke, Sophie L., Soares, Barbara L., Müller, Carolin A., Nieduszynski, Conrad A., Bastos de Oliveira, Francisco M., de Bruin, Robertus A.M.

“…Saccharomyces cerevisiae exhibits gene expression homeostasis, which is defined as the buffering of transcription levels against changes in DNA copy number…”
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RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1 by Abu-Libdeh, Bassam, Jhujh, Satpal S, Dhar, Srijita, Sommers, Joshua A, Datta, Arindam, Longo, Gabriel Mc, Grange, Laura J, Reynolds, John J, Cooke, Sophie L, McNee, Gavin S, Hollingworth, Robert, Woodward, Beth L, Ganesh, Anil N, Smerdon, Stephen J, Nicolae, Claudia M, Durlacher-Betzer, Karina, Molho-Pessach, Vered, Abu-Libdeh, Abdulsalam, Meiner, Vardiella, Moldovan, George-Lucian, Roukos, Vassilis, Harel, Tamar, Brosh, Jr, Robert M, Stewart, Grant S

“…Despite being the first homolog of the bacterial RecQ helicase to be identified in humans, the function of RECQL1 remains poorly characterized. Furthermore,…”
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Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase by Catania, Sandra, Dumesic, Phillip A., Pimentel, Harold, Nasif, Ammar, Stoddard, Caitlin I., Burke, Jordan E., Diedrich, Jolene K., Cooke, Sophie, Shea, Terrance, Gienger, Elizabeth, Lintner, Robert, Yates, John R., Hajkova, Petra, Narlikar, Geeta J., Cuomo, Christina A., Pritchard, Jonathan K., Madhani, Hiten D.

“…Cytosine methylation of DNA is a widespread modification of DNA that plays numerous critical roles. In the yeast Cryptococcus neoformans, CG methylation occurs…”
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Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase by Catania, Sandra, Dumesic, Phillip A., Pimentel, Harold, Nasif, Ammar, Stoddard, Caitlin I., Burke, Jordan E., Diedrich, Jolene K., Cooke, Sophie, Shea, Terrance, Gienger, Elizabeth, Lintner, Robert, Yates, John R., Hajkova, Petra, Narlikar, Geeta J., Cuomo, Christina A., Pritchard, Jonathan K., Madhani, Hiten D.

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Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Lossof a De Novo Methyltransferase by Catania, Sandra, Dumesic, Phillip A., Pimentel, Harold, Nasif, Ammar, Stoddard, Caitlin I., Burke, Jordan E., Diedrich, Jolene K., Cooke, Sophie, Shea, Terrance, Gienger, Elizabeth, Lintner, Robert, Yates, John R., Hajkova, Petra, Narlikar, Geeta J., Cuomo, Christina A., Pritchard, Jonathan K., Madhani, Hiten D.

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Transcriptional Control During the G1 and S Phases of the Cell Cycle in Yeast by Cooke, Sophie Louise

“…Cell division is a tightly coordinated process that involves doubling of the cellular content and its separation into two genetically identical daughter cells…”
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Abstract 6272: AZ-PRMT5i-1: A potent MTAP-selective PRMT5 inhibitor with pharmacodynamic and monotherapy anti-tumor activity in MTAP-deleted tumours by Lynch, James T., Moore, Shaun, Barrantes, Ivan Del Barco, Bradshaw, Lauren, Chambers, Chris, Hong, Ted, Cooke, Sophie, Urosevic, Jelena, Vazquez-Chantada, Mercedes, Smith, James M., Cronin, Anna, Recolin, Benedicte, Gill, Sonja, Critchlow, Susan, Chan, Ho Man, Dean, Emma

“…Background: PRMT5 is an epigenetic enzyme that catalyzes symmetric dimethylation of arginine substrates (SDMA), regulating multiple cell processes. The…”
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The effects of physical attractiveness and gender on the judgments of guilt by Cooke, Sophie Staehely

“…This study investigated the effects of physical attractiveness and gender on mock jurors' decisions regarding an alleged case of sexual harassment using a 3 x…”
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FIGHTING FIT by Cooke, Sophie

“…Lacking both the obsessive ego and the funds normally associated with record-breaking attempts, Keith Russell set a new time for circumnavigating Britain on a…”
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The Trunkmaker At The Corner by COOKE, SOPHIE

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Domestic Service by COOKE, SOPHIE

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