Search Results - "Cooke, M."

Ice sheet contributions to future sea-level rise from structured expert judgment by Bamber, Jonathan L., Oppenheimer, Michael, Kopp, Robert E., Aspinall, Willy P., Cooke, Roger M.

“…Despite considerable advances in process understanding, numerical modeling, and the observational record of ice sheet contributions to global mean sea-level…”
Get full text

Multifactorial assessment and targeted intervention for preventing falls and injuries among older people in community and emergency care settings: systematic review and meta-analysis by Gates, S, Fisher, J D, Cooke, M W, Carter, Y H, Lamb, S E

“…Objective To evaluate the effectiveness of multifactorial assessment and intervention programmes to prevent falls and injuries among older adults recruited to…”
Get full text

A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis-A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial by Edwards, Jr, John E, Schwartz, Michael M, Schmidt, Clint S, Sobel, Jack D, Nyirjesy, Paul, Schodel, Florian, Marchus, Erica, Lizakowski, Mary, DeMontigny, Elizabeth A, Hoeg, Jesse, Holmberg, Tuomas, Cooke, M Timothy, Hoover, Keila, Edwards, Lance, Jacobs, Mark, Sussman, Steven, Augenbraun, Michael, Drusano, Michael, Yeaman, Michael R, Ibrahim, Ashraf S, Filler, Scott G, Hennessey, Jr, John P

“…Recurrent vulvovaginal candidiasis (RVVC) is a problematic form of mucosal Candida infection, characterized by repeated episodes per year. Candida albicans is…”
Get full text

Repeated evolution of amphibious behavior in fish and its implications for the colonization of novel environments by Ord, Terry J., Cooke, Georgina M.

“…We know little about on how frequently transitions into new habitats occur, especially the colonization of novel environments that are the most likely to…”
Get full text

Structure of class B GPCR corticotropin-releasing factor receptor 1 by Hollenstein, Kaspar, Kean, James, Bortolato, Andrea, Cheng, Robert K. Y., Doré, Andrew S., Jazayeri, Ali, Cooke, Robert M., Weir, Malcolm, Marshall, Fiona H.

“…Structural analysis of class B G-protein-coupled receptors (GPCRs), cell-surface proteins that respond to peptide hormones, has been restricted to the…”
Get full text

Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727 by Robertson, Nathan, Rappas, Mathieu, Doré, Andrew S., Brown, Jason, Bottegoni, Giovanni, Koglin, Markus, Cansfield, Julie, Jazayeri, Ali, Cooke, Robert M., Marshall, Fiona H.

“…The crystal structure of the complement receptor C5aR1 bound to a small-molecule antagonist provides insights into this receptor class and how they could be…”
Get full text

Safety, immunogenicity, and efficacy of NDV-3A against Staphylococcus aureus colonization: A phase 2 vaccine trial among US Army Infantry trainees by Millar, Eugene V., Bennett, Jason W., Barin, Burc, Carey, Patrick M., Law, Natasha N., English, Caroline E., Schwartz, Michael M., Cochrane, Terrence, Ellis, Michael W., Tribble, David R., Timothy Cooke, M., Hennessey, John P.

“…Military trainees are at increased risk for Staphylococcus aureus colonization and infection. Disease prevention strategies are needed, but a S. aureus vaccine…”
Get full text

Managing fire regimes in north Australian savannas: applying Aboriginal approaches to contemporary global problems by Russell-Smith, Jeremy, Cook, Garry D, Cooke, Peter M, Edwards, Andrew C, Lendrum, Mitchell, Meyer, CP (Mick), Whitehead, Peter J

“…Savannas constitute the most fire-prone biome on Earth and annual emissions from savanna-burning activities are a globally important source of greenhouse-gas…”
Get full text

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain by Doré, Andrew S., Okrasa, Krzysztof, Patel, Jayesh C., Serrano-Vega, Maria, Bennett, Kirstie, Cooke, Robert M., Errey, James C., Jazayeri, Ali, Khan, Samir, Tehan, Ben, Weir, Malcolm, Wiggin, Giselle R., Marshall, Fiona H.

“…Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate. Structural studies have been…”
Get full text

Walk, swim or fly? Locomotor mode predicts genetic differentiation in vertebrates by Medina, Iliana, Cooke, Georgina M., Ord, Terry J., Gaillard, Jean‐Michel

“…Limited dispersal is commonly used to explain differences in diversification rates. An obvious but unexplored factor affecting dispersal is the mode of…”
Get full text

The role of competition on invader colonization along stress gradients in the Fuegian steppe by Cooke, M. Melisa, Martelli, Ana, Sleiman, Maximiliano, Cipriotti, Pablo A.

“…Competition exerted by native plant communities is an important component of biotic resistance against the spread and impact of non-indigenous plant species in…”
Get full text

Structures of G protein-coupled receptors reveal new opportunities for drug discovery by Cooke, Robert M., Brown, Alastair J.H., Marshall, Fiona H., Mason, Jonathan S.

“…•X-ray structures are now available for more than 60 ligands and 20 GPCRs.•Structures reveal details of ligand biding that could not be…”
Get full text

Vines: A New Graphical Model for Dependent Random Variables by Bedford, Tim, Cooke, Roger M.

“…A new graphical model, called a vine, for dependent random variables is introduced. Vines generalize the Markov trees often used in modelling high-dimensional…”
Get full text

Atom-Based RF Electric Field Metrology: From Self-Calibrated Measurements to Subwavelength and Near-Field Imaging by Holloway, Christopher L., Simons, Matthew T., Gordon, Joshua A., Wilson, Perry F., Cooke, Caitlyn M., Anderson, David A., Raithel, Georg

“…We discuss a fundamentally new method for electric (E) field strength (V/m) metrology applicable to the near-field. This new approach is significantly…”
Get full text

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons by Weinert, Tobias, Olieric, Natacha, Cheng, Robert, Brünle, Steffen, James, Daniel, Ozerov, Dmitry, Gashi, Dardan, Vera, Laura, Marsh, May, Jaeger, Kathrin, Dworkowski, Florian, Panepucci, Ezequiel, Basu, Shibom, Skopintsev, Petr, Doré, Andrew S., Geng, Tian, Cooke, Robert M., Liang, Mengning, Prota, Andrea E., Panneels, Valerie, Nogly, Przemyslaw, Ermler, Ulrich, Schertler, Gebhard, Hennig, Michael, Steinmetz, Michel O., Wang, Meitian, Standfuss, Jörg

“…Historically, room-temperature structure determination was succeeded by cryo-crystallography to mitigate radiation damage. Here, we demonstrate that serial…”
Get full text

It's not what you hear, it's the way you think about it: appraisals as determinants of affect and behaviour in voice hearers by Peters, E R, Williams, S L, Cooke, M A, Kuipers, E

“…Previous studies have suggested that beliefs about voices mediate the relationship between actual voice experience and behavioural and affective response. We…”
Get more information

Controlling the Dissociation of Ligands from the Adenosine A2A Receptor through Modulation of Salt Bridge Strength by Segala, Elena, Guo, Dong, Cheng, Robert K. Y, Bortolato, Andrea, Deflorian, Francesca, Doré, Andrew S, Errey, James C, Heitman, Laura H, IJzerman, Adriaan P, Marshall, Fiona H, Cooke, Robert M

“…The association and dissociation kinetics of ligands binding to proteins vary considerably, but the mechanisms behind this variability are poorly understood,…”
Get full text

Crystal structure of the GLP-1 receptor bound to a peptide agonist by Jazayeri, Ali, Rappas, Mathieu, Brown, Alastair J. H., Kean, James, Errey, James C., Robertson, Nathan J., Fiez-Vandal, Cédric, Andrews, Stephen P., Congreve, Miles, Bortolato, Andrea, Mason, Jonathan S., Baig, Asma H., Teobald, Iryna, Doré, Andrew S., Weir, Malcolm, Cooke, Robert M., Marshall, Fiona H.

“…Glucagon-like peptide 1 (GLP-1) regulates glucose homeostasis through the control of insulin release from the pancreas. GLP-1 peptide agonists are efficacious…”
Get full text

Extra-helical binding site of a glucagon receptor antagonist by Jazayeri, Ali, Doré, Andrew S., Lamb, Daniel, Krishnamurthy, Harini, Southall, Stacey M., Baig, Asma H., Bortolato, Andrea, Koglin, Markus, Robertson, Nathan J., Errey, James C., Andrews, Stephen P., Teobald, Iryna, Brown, Alastair J. H., Cooke, Robert M., Weir, Malcolm, Marshall, Fiona H.

“…The X-ray crystal structure of the transmembrane portion of the human glucagon receptor, a class B G-protein-coupled receptor (GPCR), is solved in the presence…”
Get full text

Mechanical supports for acute, severe ankle sprain: a pragmatic, multicentre, randomised controlled trial by Lamb, SE, Prof, Marsh, JL, PhD, Hutton, JL, Prof, Nakash, R, PhD, Cooke, MW, Prof

“…Summary Background Severe ankle sprains are a common presentation in emergency departments in the UK. We aimed to assess the effectiveness of three different…”
Get full text