Search Results - "Cook, P F"

Using biological–physical modelling for informing sea lice dispersal in Loch Linnhe, Scotland by Salama, N K G, Dale, A C, Ivanov, V V, Cook, P F, Pert, C C, Collins, C M, Rabe, B

“…Sea lice are a constraint on the sustainable growth of Scottish marine salmonid aquaculture. As part of an integrated pest management approach, farms…”
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Pyridoxal 5‘-Phosphate-Dependent α,β-Elimination Reactions:  Mechanism of O-Acetylserine Sulfhydrylase by Tai, Chia-Hui, Cook, Paul F

“…O-Acetylserine sulfhydrylase catalyzes the replacement of the β-acetoxy group of O-acetyl-l-serine with sulfide to generate l-cysteine. The reaction represents…”
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Characterization of the Allosteric Anion-Binding Site of O-Acetylserine Sulfhydrylase by Tai, Chia-Hui, Burkhard, Peter, Gani, David, Jenn, Thierry, Johnson, Corey, Cook, Paul F

“…A new crystal structure of the A-isozyme of O-acetylserine sulfhydrylase-A (OASS) with chloride bound to an allosteric site located at the dimer interface has…”
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Lysine 199 Is the General Acid in the NAD-Malic Enzyme Reaction by Liu, Dali, Karsten, William E, Cook, Paul F

“…Site-directed mutagenesis was used to change K199 in the Ascaris suum NAD-malic enzyme to A and R and Y126 to F. The K199A mutant enzyme gives a 105-fold…”
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Rapid development of polyclonal antisera against infectious salmon anaemia virus and its optimization and application as a diagnostic tool by McBeath, S J, Ellis, L M, Cook, P F, Wilson, L, Urquhart, K L, Bricknell, I R

“…Infectious salmon anaemia is an important disease of Atlantic salmon. One of the current methods of diagnosis is the indirect fluorescent antibody test (IFAT),…”
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Structure and Mechanism of O-Acetylserine Sulfhydrylase by Rabeh, Wael M., Cook, Paul F.

“…The O-acetylserine sulfhydrylase (OASS) from Salmonella typhimurium catalyzes a β-replacement reaction in which the β-acetoxy group of O-acetyl-l-serine (OAS)…”
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Glutamate 325 Is a General Acid−Base Catalyst in the Reaction Catalyzed by Fructose-2,6-bisphosphatase by Sakurai, Masaharu, Cook, Paul F, Haseman, Charles A, Uyeda, Kosaku

“…A bifunctional enzyme, fructose-6-phosphate, 2-kinase:fructose-2,6-bisphosphatase, catalyzes synthesis and hydrolysis of fructose 2,6-bisphosphate. The…”
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Determining the age of individual Lepeophtheirus salmonis (Krøyer, 1837) copepodids by measuring stored lipid volume; proof of principle by COOK, P.F, MCBEATH, S.J, BRICKNELL, I.R, BRON, J.E

“…Confocal microscopy has facilitated measurement of stained lipid volume in Lepeophtheirus salmonis copepodid larvae. Quantity of lipid, location and morphology…”
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Kinetic mechanism of NAD:malic enzyme from Ascaris suum in the direction of reductive carboxylation by MALLICK, S, HARRIS, B. G, COOK, P. F

“…Initial velocity studies in the absence and presence of product and dead-end inhibitors suggest a steady-state random mechanism for malic enzyme in the…”
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Acid base catalytic mechanism of the dihydropyrimidine dehydrogenase from pH studies by PODSCHUN, B, JAHNKE, K, SCHNACKERZ, K. D, COOK, P. F

“…Primary deuterium (NADPH(D)), solvent deuterium, and multiple isotope effects and the pH dependence of kinetic parameters have been used to probe the mechanism…”
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Kinetic mechanism of dihydropyrimidine dehydrogenase from pig liver by PODSCHUN, B, COOK, P. F, SCHNACKERZ, K. D

“…Data on initial velocity and isotope exchange at equilibrium suggest a nonclassical ping-pong mechanism for the dihydropyrimidine dehydrogenase from pig liver…”
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An alkaline phosphatase-based method for the detection of infectious salmon anaemia virus (ISAV) in tissue culture and tissue imprints by Wilson, L, McBeath, S J, Adamson, K L, Cook, P F, Ellis, L M, Bricknell, I R

“…Currently, the presence of infectious salmon anaemia virus (ISAV) is often detected in Atlantic salmon by the use of an indirect fluorescent antibody test…”
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Stepwise versus Concerted Oxidative Decarboxylation Catalyzed by Malic Enzyme: A Reinvestigation by Karsten, William E, Cook, Paul F

“…The NAD-malic enzyme catalyzes the divalent metal-ion-dependent oxidative decarboxylation of L-malate to yield CO2, pyruvate, and the reduced dinucleotide…”
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Kinetic Analysis of YPD1-Dependent Phosphotransfer Reactions in the Yeast Osmoregulatory Phosphorelay System by Janiak-Spens, Fabiola, Cook, Paul F, West, Ann H

“…In Saccharomyces cerevisiae, the histidine-containing phosphotransfer (HPt) protein YPD1 transfers phosphoryl groups between the three different response…”
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Kinetic Mechanism of Serine Transacetylase from Salmonella typhimurium by Leu, Lee Shan, Cook, Paul F

“…Serine transacetylase from Salmonella typhimurium was purified to near homogeneity. A complete initial velocity study in both reaction directions suggests that…”
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Chemical mechanism of 6-phosphogluconate dehydrogenase from Candida utilis from pH studies by Berdis, Anthony J, Cook, Paul F

“…The pH dependence of kinetic parameters and dissociation constants for competitive inhibitors was determined in order to obtain information on the chemical…”
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Overall kinetic mechanism of 6-phosphogluconate dehydrogenase from Candida utilis by Berdis, Anthony J, Cook, Paul F

“…A complete initial velocity study of the 6-phosphogluconate dehydrogenase from Candida utilis at pH 7 and 25 degrees C in both reaction directions suggests a…”
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Evidence from nitrogen-15 and solvent deuterium isotope effects on the chemical mechanism of adenosine deaminase by Weiss, Paul M, Cook, P. F, Hermes, J. D, Cleland, W. W

“…We have determined 15N isotope effects and solvent deuterium isotope effects for adenosine deaminase using both adenosine and the slow alternate substrate…”
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Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium by Burkhard, Peter, Jagannatha Rao, G.S, Hohenester, Erhard, Schnackerz, Klaus D, Cook, Paul F, Jansonius, Johan N

“…The last step in cysteine biosynthesis in enteric bacteria is catalyzed by the pyridoxal 5′-phosphate-dependent enzyme O-acetylserine sulfhydrylase. Here we…”
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Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium by Burkhard, Peter, Tai, Chia-Hui, Ristroph, Camille M., Cook, Paul F., Jansonius, Johan N.

“…Covalent binding of l-methionine as an external aldimine to the pyridoxal 5′-phosphate-cofactor in the K41A mutant of O-acetylserine sulfhydrylase from…”
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