Search Results - "Cook, Lena"
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ADAM8-Dependent Extracellular Signaling in the Tumor Microenvironment Involves Regulated Release of Lipocalin 2 and MMP-9
Published in International journal of molecular sciences (10-02-2022)“…The metalloprotease-disintegrin ADAM8 is critically involved in the progression of pancreatic cancer. Under malignant conditions, ADAM8 is highly expressed and…”
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The Relationship between CrossFit® Performance and Laboratory-Based Measurements of Fitness
Published in Sports (Basel) (11-08-2020)“…To date, research has examined the physiological determinants of performance in standardized CrossFit® (CF) workouts but not without the influence of CF…”
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Expression of the Metalloproteinase ADAM8 Is Upregulated in Liver Inflammation Models and Enhances Cytokine Release In Vitro
Published in Mediators of inflammation (2021)“…Acute and chronic liver inflammation is driven by cytokine and chemokine release from various cell types in the liver. Here, we report that the induction of…”
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ADAM8 signaling drives neutrophil migration and ARDS severity
Published in JCI insight (08-02-2022)“…Acute respiratory distress syndrome (ARDS) results in catastrophic lung failure and has an urgent, unmet need for improved early recognition and therapeutic…”
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Extracellular Vesicle-Based Detection of Pancreatic Cancer
Published in Frontiers in cell and developmental biology (23-07-2021)“…Due to a grim prognosis, there is an urgent need to detect pancreatic ductal adenocarcinoma (PDAC) prior to metastasis. However, reliable diagnostic imaging…”
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A jack of all trades – ADAM8 as a signaling hub in inflammation and cancer
Published in The FEBS journal (01-09-2024)“…As a member of the family of A Disintegrin And Metalloproteinases (ADAM) ADAM8 is preferentially expressed in lymphatic organs, immune cells, and tumor cells…”
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Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors
Published in ACS medicinal chemistry letters (11-11-2021)“…The metalloproteinase ADAM8 is upregulated in several cancers but has a dispensable function under physiological conditions. In tumor cells, ADAM8 is involved…”
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The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axis
Published in Cellular oncology (Dordrecht) (16-10-2024)“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and several studies demonstrate that STAT3 has critical roles throughout the course…”
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Proteometabolomics of initial and recurrent glioblastoma highlights an increased immune cell signature with altered lipid metabolism
Published in Neuro-oncology (Charlottesville, Va.) (04-03-2024)“…Abstract Background There is an urgent need to better understand the mechanisms associated with the development, progression, and onset of recurrence after…”
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Cohort Analysis of ADAM8 Expression in the PDAC Tumor Stroma
Published in Journal of personalized medicine (10-02-2021)“…Pancreatic ductal adenocarcinoma (PDAC) is a cancer type with one of the highest mortalities. The metalloprotease-disintegrin ADAM8 is highly expressed in…”
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The communication skills approach to stuttering in adolescence
Published in Logopedics, phoniatrics, vocology (1998)“…This assessment and therapy approach has been developed for young adults (15-18 years). This age group is considered by many to be the most resistant to…”
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Identification and characterization of a new strain of the unicellular green alga Dunaliella salina (Teod.) from Korea
Published in Journal of microbiology and biotechnology (01-05-2008)“…The unicellular green alga Dunaliella salina is a halotolerant eukaryotic organism. Its halophytic properties provide an important advantage for open pond mass…”
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