Search Results - "Cook, Leah M."

Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer by McGuire, Jeremy J., Frieling, Jeremy S., Lo, Chen Hao, Li, Tao, Muhammad, Ayaz, Lawrence, Harshani R., Lawrence, Nicholas J., Cook, Leah M., Lynch, Conor C.

“…Bone metastatic prostate cancer (PCa) promotes mesenchymal stem cell (MSC) recruitment and their differentiation into osteoblasts. However, the effects of…”
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An Integrated Computational Model of the Bone Microenvironment in Bone-Metastatic Prostate Cancer by ARAUJO, Arturo, COOK, Leah M, LYNCH, Conor C, BASANTA, David

“…Bone metastasis will impact most men with advanced prostate cancer. The vicious cycle of bone degradation and formation driven by metastatic prostate cells in…”
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Osteoid cell-derived chemokines drive bone-metastatic prostate cancer by Johnson, Catherine S, Cook, Leah M

“…One of the greatest challenges in improving prostate cancer (PCa) survival is in designing new therapies to effectively target bone metastases. PCa regulation…”
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Beyond the horizon: Neutrophils leading the way in the evolution of immunotherapy by Rajgopal, Sanjana, Nakano, Kosuke, Cook, Leah M.

“…Cancer is a complex and dynamic disease, initiated by a multitude of intrinsic mutations and progressed with the assistance of the tissue microenvironment,…”
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GD2 and its biosynthetic enzyme GD3 synthase promote tumorigenesis in prostate cancer by regulating cancer stem cell behavior by Bhat, Aaqib M., Mohapatra, Bhopal C., Luan, Haitao, Mushtaq, Insha, Chakraborty, Sukanya, Kumar, Siddhartha, Wu, Wangbin, Nolan, Ben, Dutta, Samikshan, Storck, Matthew D., Schott, Micah, Meza, Jane L., Lele, Subodh M., Lin, Ming-Fong, Cook, Leah M., Corey, Eva, Morrissey, Colm, Coulter, Donald W., Rowley, M. Jordan, Natarajan, Amarnath, Datta, Kaustubh, Band, Vimla, Band, Hamid

“…While better management of loco-regional prostate cancer (PC) has greatly improved survival, advanced PC remains a major cause of cancer deaths. Identification…”
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Improving treatment strategies for patients with metastatic castrate resistant prostate cancer through personalized computational modeling by Gallaher, Jill, Cook, Leah M., Gupta, Shilpa, Araujo, Arturo, Dhillon, Jasreman, Park, Jong Y., Scott, Jacob G., Pow-Sang, Julio, Basanta, David, Lynch, Conor C.

“…Metastatic castrate resistant prostate cancer (mCRPC) is responsible for the majority of prostate cancer deaths with the median survival after diagnosis being…”
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Emerging roles for myeloid immune cells in bone metastasis by Alsamraae, Massar, Cook, Leah M.

“…Metastasis, especially bone metastasis, is a major cause of cancer-related deaths, which is associated with long-term pain due to skeletal-related events and…”
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Neutrophil signaling during myocardial infarction wound repair by Daseke, Michael J., Chalise, Upendra, Becirovic-Agic, Mediha, Salomon, Jeffrey D., Cook, Leah M., Case, Adam J., Lindsey, Merry L.

“…Neutrophils are key effector cells of the innate immune system, serving as a first line of defense in the response to injury and playing essential roles in the…”
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Integrating new discoveries into the “vicious cycle” paradigm of prostate to bone metastases by Cook, Leah M., Shay, Gemma, Aruajo, Arturo, Lynch, Conor C.

“…In prostate to bone metastases, the “vicious cycle” paradigm has been traditionally used to illustrate how metastases manipulate the bone forming osteoblasts…”
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Black voices in cancer research and oncology by Ashad-Bishop, Kilan C., Balogun, Onyinye D., Chidebe, Runcie C. W., Cook, Leah M., Towers, Christina

“…Over the past few years, there has been an increasing realization that we need a more equal, diverse and inclusive culture for truly successful cancer research…”
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Neutrophils are mediators of metastatic prostate cancer progression in bone by Costanzo-Garvey, Diane L., Keeley, Tyler, Case, Adam J., Watson, Gabrielle F., Alsamraae, Massar, Yu, Yangsheng, Su, Kaihong, Heim, Cortney E., Kielian, Tammy, Morrissey, Colm, Frieling, Jeremy S., Cook, Leah M.

“…Bone metastatic prostate cancer (BM-PCa) significantly reduces overall patient survival and is currently incurable. Current standard immunotherapy showed…”
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S100A9 is a functional effector of infarct wall thinning after myocardial infarction by Chalise, Upendra, Becirovic-Agic, Mediha, Daseke, 2nd, Michael J, Konfrst, Shelby R, Rodriguez-Paar, Jocelyn R, Feng, Dan, Salomon, Jeffrey D, Anderson, Daniel R, Cook, Leah M, Lindsey, Merry L

“…Neutrophils infiltrate into the left ventricle (LV) early after myocardial infarction (MI) and launch a proinflammatory response. Along with neutrophil…”
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The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response by Law, Henry C-H, Lagundžin, Dragana, Clement, Emalie J, Qiao, Fangfang, Wagner, Zachary S, Krieger, Kimiko L, Costanzo-Garvey, Diane, Caffrey, Thomas C, Grem, Jean L, DiMaio, Dominick J, Grandgenett, Paul M, Cook, Leah M, Fisher, Kurt W, Yu, Fang, Hollingsworth, Michael A, Woods, Nicholas T

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease that can be separated into distinct subtypes based on molecular signatures. Identifying…”
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Size Matters: Metastatic Cluster Size and Stromal Recruitment in the Establishment of Successful Prostate Cancer to Bone Metastases by Araujo, Arturo, Cook, Leah M., Lynch, Conor C., Basanta, David

“…Prostate cancer (PCa) impacts over 180,000 men every year in the USA alone, with 26,000 patients expected to succumb to the disease ( cancer.gov ). The primary…”
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Androgen receptor inhibition suppresses anti-tumor neutrophil response against bone metastatic prostate cancer via regulation of TβRI expression by Alsamraae, Massar, Costanzo-Garvey, Diane, Teply, Benjamin A., Boyle, Shawna, Sommerville, Gary, Herbert, Zachary T., Morrissey, Colm, Dafferner, Alicia J., Abdalla, Maher Y., Fallet, Rachel W., Kielian, Tammy, Jensen-Smith, Heather, deOliveira, Edson I., Chen, Keqiang, Bettencourt, Ian A., Wang, Ji Ming, McVicar, Daniel W., Keeley, Tyler, Yu, Fang, Cook, Leah M.

“…Bone metastatic disease of prostate cancer (PCa) is incurable and progression in bone is largely dictated by tumor-stromal interactions in the bone…”
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MMP-12 polarizes neutrophil signalome towards an apoptotic signature by Chalise, Upendra, Becirovic-Agic, Mediha, Konfrst, Shelby R., Rodriguez-Paar, Jocelyn R., Cook, Leah M., Lindsey, Merry L.

“…While macrophages are well-known to polarize across the inflammatory spectrum, neutrophils have only recently been found to activate in a similar fashion in…”
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Betaglycan drives the mesenchymal stromal cell osteogenic program and prostate cancer-induced osteogenesis by Cook, Leah M., Frieling, Jeremy S., Nerlakanti, Niveditha, McGuire, Jeremy J., Stewart, Paul A., Burger, Karen L., Cleveland, John L., Lynch, Conor C.

“…Bone metastatic prostate cancer provokes extensive osteogenesis by driving the recruitment and osteoblastic differentiation of mesenchymal stromal cells…”
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Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer by Cook, Leah M., Araujo, Arturo, Pow-Sang, Julio M., Budzevich, Mikalai M., Basanta, David, Lynch, Conor C.

“…The ability to rapidly assess the efficacy of therapeutic strategies for incurable bone metastatic prostate cancer is an urgent need. Pre-clinical in vivo…”
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Prostate cancer addiction to oxidative stress defines sensitivity to anti-tumor neutrophils by Costanzo-Garvey, Diane L., Case, Adam J., Watson, Gabrielle F., Alsamraae, Massar, Chatterjee, Arpita, Oberley-Deegan, Rebecca E., Dutta, Samikshan, Abdalla, Maher Y., Kielian, Tammy, Lindsey, Merry L., Cook, Leah M.

“…Bone metastatic prostate cancer (BM-PCa) remains one of the most difficult cancers to treat due to the complex interactions of cancer and stromal cells. We…”
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Metastasis suppressors and the tumor microenvironment by Cook, Leah M, Hurst, Douglas R, Welch, Danny R

“…Abstract The most lethal and debilitating attribute of cancer cells is their ability to metastasize. Throughout the process of metastasis, tumor cells interact…”
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