Search Results - "Cook, Erik C."

Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin by Cook, Erik C, Featherston, Emily R, Showalter, Scott A, Cotruvo, Joseph A

“…Lanmodulin (LanM) is a high-affinity lanthanide (Ln)-binding protein recently identified in Methylobacterium extorquens, a bacterium that requires Lns for the…”
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Application of NMR to studies of intrinsically disordered proteins by Gibbs, Eric B., Cook, Erik C., Showalter, Scott A.

“…The prevalence of intrinsically disordered protein regions, particularly in eukaryotic proteins, and their clear functional advantages for signaling and gene…”
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Stoichiometry of the Calcineurin Regulatory Domain–Calmodulin Complex by Dunlap, Tori B, Guo, Hou-Fu, Cook, Erik C, Holbrook, Emily, Rumi-Masante, Julie, Lester, Terrence E, Colbert, Christopher L, Vander Kooi, Craig W, Creamer, Trevor P

“…Calcineurin is an essential serine/threonine phosphatase that plays vital roles in neuronal development and function, heart growth, and immune system…”
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Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus by Juvvadi, Praveen R, Gehrke, Christopher, Fortwendel, Jarrod R, Lamoth, Frédéric, Soderblom, Erik J, Cook, Erik C, Hast, Michael A, Asfaw, Yohannes G, Moseley, M Arthur, Creamer, Trevor P, Steinbach, William J

“…The fungus Aspergillus fumigatus is a leading infectious killer in immunocompromised patients. Calcineurin, a calmodulin (CaM)-dependent protein phosphatase…”
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Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain by Gibbs, Eric B., Laremore, Tatiana N., Usher, Grace A., Portz, Bede, Cook, Erik C., Showalter, Scott A.

“…The positive transcription elongation factor b (P-TEFb) promotes transcription elongation through phosphorylation of the RNA polymerase II C-terminal domain…”
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The Distal Helix in the Regulatory Domain of Calcineurin Is Important for Domain Stability and Enzyme Function by Dunlap, Tori B, Cook, Erik C, Rumi-Masante, Julie, Arvin, Hannah G, Lester, Terrence E, Creamer, Trevor P

“…Calcineurin (CaN) is a calmodulin-activated, serine/threonine phosphatase that is necessary for cardiac, vasculature, and nervous system development, as well…”
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Influence of electrostatic forces on the association kinetics and conformational ensemble of an intrinsically disordered protein by Cook, Erik C., Creamer, Trevor P.

“…Recent work has revealed that the association of a disordered region of a protein with a folded binding partner can occur as rapidly as association between two…”
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Solution Ensemble of the C‑Terminal Domain from the Transcription Factor Pdx1 Resembles an Excluded Volume Polymer by Cook, Erik C, Sahu, Debashish, Bastidas, Monique, Showalter, Scott A

“…The pancreatic and duodenal homeobox 1 (Pdx1) is an essential pancreatic transcription factor. The C-terminal intrinsically disordered domain of Pdx1 (Pdx1-C)…”
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Ultrasound-Guided Cytosolic Protein Delivery via Transient Fluorous Masks by Sloand, Janna N, Nguyen, Theodore T, Zinck, Scott A, Cook, Erik C, Zimudzi, Tawanda J, Showalter, Scott A, Glick, Adam B, Simon, Julianna C, Medina, Scott H

“…The inability to spatiotemporally guide proteins in tissues and efficiently deliver them into cells remains a key barrier to realizing their full potential in…”
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Calcineurin in a Crowded World by Cook, Erik C, Creamer, Trevor P

“…Calcineurin is a Ser/Thr phosphatase that is important for key biological processes, including immune system activation. We previously identified a region in…”
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Elucidating the Role of Microprocessor Protein DGCR8 in Bending RNA Structures by Pabit, Suzette A., Chen, Yen-Lin, Usher, Emery T., Cook, Erik C., Pollack, Lois, Showalter, Scott A.

“…Although conformational dynamics of RNA molecules are potentially important in microRNA (miRNA) processing, the role of the protein binding partners in…”
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Electrostatic control of calcineurin's intrinsically-disordered regulatory domain binding to calmodulin by Sun, Bin, Cook, Erik C., Creamer, Trevor P., Kekenes-Huskey, Peter M.

“…Calcineurin (CaN) is a serine/threonine phosphatase that regulates a variety of physiological and pathophysiological processes in mammalian tissue. The…”
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Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression by Rydzanicz, Małgorzata, Wachowska, Małgorzata, Cook, Erik C, Lisowski, Paweł, Kuźniewska, Bożena, Szymańska, Krystyna, Diecke, Sebastian, Prigione, Alessandro, Szczałuba, Krzysztof, Szybińska, Aleksandra, Koppolu, Agnieszka, Murcia Pienkowski, Victor, Kosińska, Joanna, Wiweger, Małgorzata, Kostrzewa, Grażyna, Brzozowska, Małgorzata, Domańska-Pakieła, Dorota, Jurkiewicz, Elżbieta, Stawiński, Piotr, Gromadka, Agnieszka, Zielenkiewicz, Piotr, Demkow, Urszula, Dziembowska, Magdalena, Kuźnicki, Jacek, Creamer, Trevor P, Płoski, Rafał

“…PPP3CA encodes calmodulin-binding catalytic subunit of calcineurin, a ubiquitously expressed calcium/calmodulin-regulated protein phosphatase. Recently de novo…”
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Niemann-Pick Type C2 Deficiency in Human Fibroblasts Confers Robust and Selective Activation of Prostaglandin E2 Biosynthesis by Frolov, Andrey, Dong, Hua, Jiang, Min, Yang, Lihua, Cook, Erik C., Matnani, Rahul, Hammock, Bruce D., Crofford, Leslie J.

“…Activated fibroblasts, also known as myofibroblasts, are mediators of several major human pathologies including proliferative fibrotic disorders, invasive…”
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1H, 15N, and 13C chemical shift assignments of the regulatory domain of human calcineurin by Yadav, Dinesh K., Tata, Sri Ramya, Hunt, John, Cook, Erik C., Creamer, Trevor P., Fitzkee, Nicholas C.

“…Calcineurin (CaN) plays an important role in T-cell activation, cardiac system development and nervous system function. Previous studies have demonstrated that…”
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Electrostatic Contributions to Calmodulin Interactions with Calcineurin by Creamer, Trevor P., Cook, Erik C.

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Evidence that Primary Microrna Bends in the Presence of DGCR8 Seen using Both Saxs and FRET Measurements by Pabit, Suzette A., Chen, Yen-Lin, Usher, Grace A., Cook, Erik C., Pollack, Lois, Showalter, Scott A.

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Transitional Disorder: Calcineurin as an Example by Creamer, Trevor P., Cook, Erik C., Dunlap, Tori B.

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Transient Disorder: Calcineurin as an Example by Creamer, Trevor P., Dunlap, Tori B., Cook, Erik C.

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The Use of 13 C Direct-Detect NMR to Characterize Flexible and Disordered Proteins by Cook, Erik C, Usher, Grace A, Showalter, Scott A

“…NMR spectroscopy remains the only experimental technique that provides (near) atomistic structural information for intrinsically disordered proteins (IDPs),…”
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