Search Results - "Cook, Elina"

Clonal hematopoiesis and inflammation: Partners in leukemogenesis and comorbidity by Cook, Elina K., Luo, Michael, Rauh, Michael J.

“…•CH expansion and inflammation may support each other in a self-perpetuating cycle.•High levels of IL-6 and TNF-α promote the expansion of Tet2-deficient…”
Get full text

Association of Clonal Hematopoiesis of Indeterminate Potential with Worse Kidney Function and Anemia in Two Cohorts of Patients with Advanced Chronic Kidney Disease by Vlasschaert, Caitlyn, McNaughton, Amy J M, Chong, Michael, Cook, Elina K, Hopman, Wilma, Kestenbaum, Bryan, Robinson-Cohen, Cassianne, Garland, Jocelyn, Moran, Sarah M, Paré, Guillaume, Clase, Catherine M, Tang, Mila, Levin, Adeera, Holden, Rachel, Rauh, Michael J, Lanktree, Matthew B

“…Clonal hematopoiesis of indeterminate potential (CHIP) is an inflammatory premalignant disorder resulting from acquired genetic mutations in hematopoietic stem…”
Get full text

Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117 by Sekeres, Mikkael A, Othus, Megan, List, Alan F, Odenike, Olatoyosi, Stone, Richard M, Gore, Steven D, Litzow, Mark R, Buckstein, Rena, Fang, Min, Roulston, Diane, Bloomfield, Clara D, Moseley, Anna, Nazha, Aziz, Zhang, Yanming, Velasco, Mario R, Gaur, Rakesh, Atallah, Ehab, Attar, Eyal C, Cook, Elina K, Cull, Alyssa H, Rauh, Michael J, Appelbaum, Frederick R, Erba, Harry P

“…Purpose Azacitidine is standard, first-line therapy in higher-risk myelodysplastic syndromes (MDS). Whether azacitidine-based combinations with lenalidomide or…”
Get full text

Novel Mutations and Decreased Expression of the Epigenetic Regulator TET2 in Pulmonary Arterial Hypertension by Potus, François, Pauciulo, Michael W., Cook, Elina K., Zhu, Na, Hsieh, Alexander, Welch, Carrie L., Shen, Yufeng, Tian, Lian, Lima, Patricia, Mewburn, Jeffrey, D’Arsigny, Christine L., Lutz, Katie A., Coleman, Anna W., Damico, Rachel, Snetsinger, Brooke, Martin, Ashley Y., Hassoun, Paul M., Nichols, William C., Chung, Wendy K., Rauh, Michael J., Archer, Stephen L.

“…BACKGROUND:Pulmonary arterial hypertension (PAH) is a lethal vasculopathy. Hereditary cases are associated with germline mutations in BMPR2 and 16 other genes…”
Get full text

Infection risk associated with clonal hematopoiesis of indeterminate potential is partly mediated by hematologic cancer transformation in the UK Biobank by Vlasschaert, Caitlyn, Akwo, Elvis, Robinson-Cohen, Cassianne, Cook, Elina K., Lanktree, Matthew B., Rauh, Michael J., Bick, Alexander G.

Get full text

Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis by Cook, Elina K., Izukawa, Terumi, Young, Sherylan, Rosen, Gili, Jamali, Mina, Zhang, Liying, Johnson, Dylan, Bain, Eva, Hilland, Jamie, Ferrone, Christina K., Buckstein, Jonah, Francis, Janika, Momtaz, Bushra, McNaughton, Amy J.M., Liu, Xudong, Snetsinger, Brooke, Buckstein, Rena, Rauh, Michael J.

“…•CH may be associated with broader ill health (worse performance status, increased and potentially novel comorbidities).•Serum interleukin-6 is elevated in…”
Get full text

Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function by Quin, Candice, DeJong, Erica N, Cook, Elina K, Luo, Yi Zhen, Vlasschaert, Caitlyn, Sadh, Sanathan, McNaughton, Amy Jm, Buttigieg, Marco M, Breznik, Jessica A, Kennedy, Allison E, Zhao, Kevin, Mewburn, Jeffrey, Dunham-Snary, Kimberly J, Hindmarch, Charles Ct, Bick, Alexander G, Archer, Stephen L, Rauh, Michael J, Bowdish, Dawn Me

“…Individuals with clonal hematopoiesis of indeterminate potential (CHIP) are at increased risk of aging related health conditions and all-cause mortality, but…”
Get full text

International training considerations of Canadian Clinician-Scientist Trainees - A national survey by Pietrobon, Adam, Cook, Elina K, Yin, Charles, Chan, Derek C H, Marvasti, Tina B

“…Canadian clinician-scientist trainees enrolled in dual degree programs often pursue an extended training route following completion of MD and MSc or PhD…”
Get full text

Piloting a long distance clinician scientist trainee mentorship match in Canada by Mirali, Sara, Fan, Kevin, Cook, Elina K, Marvasti, Tina B

“…Clinician scientists are physicians who are uniquely trained to bridge the gap between scientific discovery and clinical practice. However, the challenges of…”
Get full text

Newsletter Fall 2019: Clinician Investigator Trainee Association of Canada (CITAC) by Castanov, Valera, Ma, Xiya, Pietrobon, Adam, Blayney, Alan, Levit, Alexander, Weber-Adrian, Danielle, Hutchinson, Nora, Binesh Marvasti, Tina, Cook, Elina K

“…A message from Elina Cook (President): Demystifying and promoting the MD-PhD/MSc world—our progress Clinician Investigator Trainee Association of Canada…”
Get full text

Overview of the Canadian Clinician Investigator Trainees’ research presented at the 2019 CSCI-CITAC Joint Meeting by Castanov, Valera, Zhou, Tianwei E., Balestrini, Christopher S., Lefebvre, Cory, Cook, Elina K., Whittaker, Heather T., Macklin, Jillian, Briard, Joel N., Lazarte, Julieta, Trinder, Mark, Ware, Matthaeus A., Hu, Sophie, Pietrobon, Adam, Marvasti, Tina B.

“…The 2019 Annual General Meeting and Young Investigators’ Forum of the Canadian Society for Clinical Investigation / Société Canadienne de Recherche Clinique…”
Get full text

Early biomarker for radiation-induced wounds: day one post-irradiation assessment using hemoglobin concentration measured from diffuse optical reflectance spectroscopy by Chin, Lee C L, Cook, Elina K, Yohan, Darren, Kim, Anthony, Niu, Carolyn, Wilson, Brian C, Liu, Stanley K

“…Normal tissue radiation toxicities are evaluated subjectively and cannot predict the development of severe side-effects. Using a hand-held diffuse reflectance…”
Get full text

Scientific overview on CSCI-CITAC Annual General Meeting and 2017 Young Investigators' Forum by Barton, Kristen I, Ma, Xiya, Babadagli, Mustafa Ege, Zhou, Ellen, Tonial, Nicholas, Newell, Christopher, Ishaque, Abdullah, Leduc-Pessah, Heather, Marvasti, Tina B, Mirali, Sara, Levit, Alexander, Kumar, Sachin, Steadman, Patrick E, Cook, Elina K, Abraham, Josh

“…The 2017 Annual General Meeting of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator Trainee Association of Canada/Association…”
Get full text

Impact of Tet2 Deficiency, and of TET2 Mutations in Clonal Hematopoiesis, on Neutrophil/Granulocyte Immune Function by Cook, Elina K, Luo, Michael, Mewburn, Jeffrey, Dunham-Snary, Kimberly J, Hindmarch, Charles, Archer, Stephen L, Rauh, Michael J

“…Neutrophils, the most abundant leukocytes and granulocytes, are important regulators of cardiovascular, inflammatory and infectious diseases, yet their role in…”
Get full text

Newsletter Spring 2019: Clinician Investigator Trainee Association of Canada (CITAC) by Cook, Elina, Ma, Xiya, Castanov, Valera, Hutchinson, Nora

“…Message from the President: Demystifying and promoting the MD-PhD/MD+ world Since its inception in 2006, the Clinician-Investigator Trainee Association of…”
Get full text

RNA-Seq Analysis of Clonal Hematopoiesis (CHIP) Blood Leukocytes Shows Dysregulation of Neutrophil / Innate Immunity-Related Genes by Cook, Elina K, Armstrong, Richard N, Sharma, Eshita, Snetsinger, Brooke, Boultwood, Jacqueline, Buckstein, Rena, Pellagatti, Andrea, Rauh, Michael J.

“…BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) involves the peripheral blood (PB) expansion of progeny of a hematopoietic stem or…”
Get full text

Abstract 17245: Deficiency of Tet Methylcytosine Dioxygenase 2 (tet2),A Key Enzyme in Cytosine Demethylation,Is an Epigenetic Driver of Inflammation and Disease Progression in Pulmonary Arterial Hypertension by Potus, Francois, cook, Elina K, Tian, Lian, Hindmarch, Charles C, Lima, Patricia, Michael, Rauh J, Archer, Stephen L

“…BackgroundPulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by remodelling of distal pulmonary arteries associated with…”
Get full text

INTERNATIONAL TRAINING CONSIDERATIONS OF CANADIAN CLINICIAN-SCIENTIST TRAINEES - A NATIONAL SURVEY by HBSc, Adam Pietrobon, Cook, Elina K, Yin, Charles, Chan, Derek C H, Marvasti, Tina B

“…Purpose: Canadian clinician-scientist trainees enrolled in dual degree programs often pursue an extended training route following completion of MD and MSc or…”
Get full text

Feeding the Fire: The Comorbid and Inflammatory Backdrop of Clonal Hematopoiesis of Indeterminate Potential (CHIP) By Mutation Subtype by Cook, Elina K, Izukawa, Terumi, Young, Sherylan, Rosen, Gili, Jamali, Mina, Snetsinger, Brooke, Johnson, Dylan, Bain, Eva, Hilland, Jamie, Buckstein, Jonah, Francis, Janika, Momtaz, Bushra, Buckstein, Rena, Rauh, Michael J.

“…Clonal hematopoiesis of indeterminate potential/aging (CHIP) is a potential precursor to MDS and myeloid cancer; it is also associated with comorbid…”
Get full text

Scientific Overview on CSCI-CITAC Annual General Meeting and 2018 Young Investigators’ Forum by Castanov, Valera, Ma, Xiya, Pietrobon, Adam, Levit, Alexander, Weber-Adrian, Danielle, Lazarte, Julieta, Man-Ger Sun, Margaret, Ware, Matthaeus A., Steadman, Patrick E., Mirali, Sara, Marvasti, Tina Binesh, Cook, Elina K.

“…The 2018 Annual General Meeting (AGM) and Young Investigators’ Forum (YIF) of the Canadian Society of Clinician Investigators (CSCI) and Clinician Investigator…”
Get full text