Search Results - "Cook, David N."

SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial by McGovern, Barbara H, Ford, Christopher B, Henn, Matthew R, Pardi, Darrell S, Khanna, Sahil, Hohmann, Elizabeth L, O’Brien, Edward J, Desjardins, Christopher A, Bernardo, Patricia, Wortman, Jennifer R, Lombardo, Mary-Jane, Litcofsky, Kevin D, Winkler, Jonathan A, McChalicher, Christopher W J, Li, Sunny S, Tomlinson, Amelia D, Nandakumar, Madhumitha, Cook, David N, Pomerantz, Roger J, Auninš, John G, Trucksis, Michele

“…Abstract Background Recurrent Clostridioides difficile infection (rCDI) is associated with loss of microbial diversity and microbe-derived secondary bile…”
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A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis by Henn, Matthew R., O’Brien, Edward J., Diao, Liyang, Feagan, Brian G., Sandborn, William J., Huttenhower, Curtis, Wortman, Jennifer R., McGovern, Barbara H., Wang-Weigand, Sherry, Lichter, David I., Chafee, Meghan, Ford, Christopher B., Bernardo, Patricia, Zhao, Peng, Simmons, Sheri, Tomlinson, Amelia D., Cook, David N., Pomerantz, Roger J., Misra, Bharat K., Auninš, John G., Trucksis, Michele

“…Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of…”
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Dosing a synbiotic of human milk oligosaccharides and B. infantis leads to reversible engraftment in healthy adult microbiomes without antibiotics by Button, Julie E., Autran, Chloe A., Reens, Abigail L., Cosetta, Casey M., Smriga, Steven, Ericson, Megan, Pierce, Jessica V., Cook, David N., Lee, Martin L., Sun, Adam K., Alousi, Amin M., Koh, Andrew Y., Rechtman, David J., Jenq, Robert R., McKenzie, Gregory J.

“…Predictable and sustainable engraftment of live biotherapeutic products into the human gut microbiome is being explored as a promising way to modulate the…”
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Listeria-Based Cancer Vaccines That Segregate Immunogenicity from Toxicity by Brockstedt, Dirk G., Giedlin, Martin A., Leong, Meredith L., Bahjat, Keith S., Gao, Yi, Luckett, William, Liu, Weiqun, Cook, David N., Portnoy, Daniel A., Dubensky, Thomas W., Allison, James P.

“…The facultative intracellular bacterium Listeria monocytogenes is being developed as a cancer vaccine platform because of its ability to induce potent innate…”
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A Novel Microbiome Therapeutic Increases Gut Microbial Diversity and Prevents Recurrent Clostridium difficile Infection by Khanna, Sahil, Pardi, Darrell S., Kelly, Colleen R., Kraft, Colleen S., Dhere, Tanvi, Henn, Matthew R., Lombardo, Mary-Jane, Vulic, Marin, Ohsumi, Toshiro, Winkler, Jonathan, Pindar, Christina, McGovern, Barbara H., Pomerantz, Roger J., Aunins, John G., Cook, David N., Hohmann, Elizabeth L.

“…Background. Patients with recurrent Clostridium difficile infection (CDI) have a > 60% risk of relapse, as conventional therapies do not address the underlying…”
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Reply to Lagier et al by Khanna, Sahil, Button, Julie E., Lombardo, Mary-Jane, Vulic, Marin, Henn, Matthew R., Cook, David N., Pomerantz, Roger J., Hohmann, Elizabeth L.

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Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli by Ma, D, Cook, D N, Alberti, M, Pon, N G, Nikaido, H, Hearst, J E

“…Defined mutations of acrA or acrB (formerly acrE) genes increased the susceptibility of Escherichia coli to a range of small inhibitor molecules. Deletion of…”
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Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes by YOSHIMURA, Kiyoshi, JAIN, Ajay, SLANSKY, Jill E, COOK, David N, DUBENSKY, Thomas W, PARDOLL, Drew M, SCHULICK, Richard D, ALLEN, Heather E, LAIRD, Lindsay S, CHIA, Christina Y, RAVI, Sowmya, BROCKSTEDT, Dirk G, GIEDLIN, Martin A, BAHJAT, Keith S, LEONG, Meredith L

“…Improved immunization and ex vivo T-cell culture strategies can generate larger numbers and more potent tumor-specific effector cells than previously possible…”
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Torsional Rigidity of Positively and Negatively Supercoiled DNA by Selvin, Paul R., Cook, David N., Pon, Ning G., Bauer, William R., Klein, Melvin P., Hearst, John E.

“…Time-correlated single-photon counting of intercalated ethidium bromide was used to measure the torsion constants of positively supercoiled, relaxed, and…”
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Vesicular stomatitis virus: An exciting new therapeutic oncolytic virus candidate for cancer or just another chapter from Field's Virology? by Giedlin, Martin A, Cook, David N, Dubensky, Thomas W

“…Selected mutant strains of vesicular stomatitis virus (VSV) are described that are unable to combat endogenous IFN-β signaling within infected normal cells and…”
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Dynamics of DNA Supercoiling by Transcription in Escherichia coli by Cook, David N., Ma, Dzwokai, Pon, Ning G., Hearst, John E.

“…The relative rotation between RNA polymerase and DNA during transcription elongation can lead to supercoiling of the DNA template. However, the variables that…”
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1641. Treatment of Recurrent Clostridium difficile Infection With SER-109 Reduces Gastrointestinal Carriage of Antimicrobial Resistance Genes by Ford, Christopher, Henn, Matthew, Bryant, Jessica, Diao, Liyang, Wortman, Jennifer, Tomlinson, Amelia, Litcofsky, Kevin, Bernardo, Patricia, McGovern, Barbara, Aunins, John G, Cook, David N, Trucksis, Michele

“…Abstract Background A healthy gut microbiome is associated with colonization resistance against C. difficile and other pathogens, including bacteria carrying…”
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621. Treatment of Recurrent Clostridium difficile Infection with SER-109 Increases the Concentration of Secondary Bile Acids in a Dose-Dependent Manner by Henn, Matthew, Ford, Christopher, O’Brien, Edward, Wortman, Jennifer, Diao, Liyang, Desjardins, Christopher, Tomlinson, Amelia, Litcofsky, Kevin, Wilcox, Mark, Buckley, Anthony, Bernardo, Patricia, McGovern, Barbara, Aunins, John G, Cook, David N, Trucksis, Michele

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Efflux pumps and drug resistance in gram-negative bacteria by Ma, D, Cook, D N, Hearst, J E, Nikaido, H

“…The outer membrane of Gram-negative bacteria can only slow down the influx of lipophilic inhibitors, and so these bacteria need active efflux pumps of broad…”
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Molecular cloning and characterization of acrA and acrE genes of Escherichia coli by MA, D, COOK, D. N, ALBERTI, M, PON, N. G, NIKAIDO, H, HEARST, J. E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Vesicular stomatitis virus by Giedlin, Martin A, Cook, David N, Dubensky, Thomas W

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[Urban Scales and Functions in Spanish America toward the Year 1600: First Conclusions]: Commentaries by Rolando Mellafe R., Scobie, James R., Cook, N. David

“…Util y amena ha sido la lectura del trabajo de Jorge E. Hardoy y Carmen Aranovich, “Escalas y funciones urbanas de América Hispánica hacia 1600, Un ensayo…”
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Analysis of the promoter and regulatory sequences of an oxygen-regulated bch operon in Rhodobacter capsulatus by site-directed mutagenesis by Ma, D, Cook, D N, O'Brien, D A, Hearst, J E

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Efficient anchoring of RNA polymerase in Escherichia coli during coupled transcription-translation of genes encoding integral inner membrane polypeptides by MA, D, COOK, D. N, PON, N. G, HEARST, J. E

“…While it has been known that supercoiling of the DNA template can be induced by transcription, the mechanism and the efficiency of this process in vivo is not…”
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New Research Possibilities in Los Collaguas, Peru by Cook, N. David, Pease, Franklin

“…The recent discovery in Lima's National Museum of History of a sixteenth-century inspection of the royal repartimiento of Yanque Collaguas in the district of…”
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