Search Results - "Cook, Darren A. N"

Autophagy regulates Wolbachia populations across diverse symbiotic associations by Voronin, Denis, Cook, Darren A. N, Steven, Andrew, Taylor, Mark J

“…Wolbachia are widespread and abundant intracellular symbionts of arthropods and filarial nematodes. Their symbiotic relationships encompass obligate mutualism,…”
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Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia by Turner, Joseph D, Pionnier, Nicolas, Furlong-Silva, Julio, Sjoberg, Hanna, Cross, Stephen, Halliday, Alice, Guimaraes, Ana F, Cook, Darren A N, Steven, Andrew, Van Rooijen, Nico, Allen, Judith E, Jenkins, Stephen J, Taylor, Mark J

“…Eosinophils are effectors in immunity to tissue helminths but also induce allergic immunopathology. Mechanisms of eosinophilia in non-mucosal tissues during…”
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Pre-clinical assays predict pan-African Echis viper efficacy for a species-specific antivenom by Casewell, Nicholas R, Cook, Darren A N, Wagstaff, Simon C, Nasidi, Abdulsalami, Durfa, Nandul, Wüster, Wolfgang, Harrison, Robert A

“…Snakebite is a significant cause of death and disability in subsistent farming populations of sub-Saharan Africa. Antivenom is the most effective treatment of…”
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Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms by Casewell, Nicholas R., Wagstaff, Simon C., Wüster, Wolfgang, Cook, Darren A. N., Bolton, Fiona M. S., King, Sarah I., Pla, Davinia, Sanz, Libia, Calvete, Juan J., Harrison, Robert A.

“…Variation in venom composition is a ubiquitous phenomenon in snakes and occurs both interspecifically and intraspecifically. Venom variation can have severe…”
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Analysis of camelid antibodies for antivenom development: Neutralisation of venom-induced pathology by Cook, Darren A.N., Owen, Timothy, Wagstaff, Simon C., Kinne, Joerg, Wernery, Ulrich, Harrison, Robert A.

“…Camelid IgG has been reported to be less immunogenic, less able to activate the complement cascade and more thermostable than IgG from other mammals, and has…”
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Preclinical development of an oral anti- Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis by Taylor, Mark J, von Geldern, Thomas W, Ford, Louise, Hübner, Marc P, Marsh, Kennan, Johnston, Kelly L, Sjoberg, Hanna T, Specht, Sabine, Pionnier, Nicolas, Tyrer, Hayley E, Clare, Rachel H, Cook, Darren A N, Murphy, Emma, Steven, Andrew, Archer, John, Bloemker, Dominique, Lenz, Franziska, Koschel, Marianne, Ehrens, Alexandra, Metuge, Haelly M, Chunda, Valerinne C, Ndongmo Chounna, Patrick W, Njouendou, Abdel J, Fombad, Fanny F, Carr, Robert, Morton, Howard E, Aljayyoussi, Ghaith, Hoerauf, Achim, Wanji, Samuel, Kempf, Dale J, Turner, Joseph D, Ward, Stephen A

“…There is an urgent global need for a safe macrofilaricide drug to accelerate elimination of the neglected tropical diseases onchocerciasis and lymphatic…”
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Analysis of camelid IgG for antivenom development: Serological responses of venom-immunised camels to prepare either monospecific or polyspecific antivenoms for West Africa by Cook, Darren A.N., Owen, Timothy, Wagstaff, Simon C., Kinne, Joerg, Wernery, Ulrich, Harrison, Robert A.

“…Snake envenoming is a significant cause of mortality and morbidity in sub-Saharan Africa. The only effective treatment, antivenom, has been in short supply…”
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Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides by Clare, Rachel H., Bardelle, Catherine, Harper, Paul, Hong, W. David, Börjesson, Ulf, Johnston, Kelly L., Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren, Plant, Helen, Clark, Roger, Cook, Darren A. N., Steven, Andrew, Archer, John, McGillan, Paul, Charoensutthivarakul, Sitthivut, Bibby, Jaclyn, Sharma, Raman, Nixon, Gemma L., Slatko, Barton E., Cantin, Lindsey, Wu, Bo, Turner, Joseph, Ford, Louise, Rich, Kirsty, Wigglesworth, Mark, Berry, Neil G., O’Neill, Paul M., Taylor, Mark J., Ward, Stephen A.

“…Nematodes causing lymphatic filariasis and onchocerciasis rely on their bacterial endosymbiont, Wolbachia , for survival and fecundity, making Wolbachia a…”
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Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis by Aljayyoussi, Ghaith, Tyrer, Hayley E., Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A. N., Steven, Andrew, Sharma, Raman, Guimaraes, Ana F., Clare, Rachel H., Cassidy, Andrew, Johnston, Kelly L., Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.

“…Lymphatic filariasis (LF) and onchocerciasis are priority neglected tropical diseases targeted for elimination. The only safe drug treatment with substantial…”
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Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis by Jacobs, Robert T, Lunde, Christopher S, Freund, Yvonne R, Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S, Berry, Pamela W, Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J, Ford, Louise, Johnston, Kelly L, Cook, Darren A. N, Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F, Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J, Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P, McNamara, Case W, Bakowski, Malina A, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A

“…A series of pleuromutilins modified by introduction of a boron-containing heterocycle on C(14) of the polycyclic core are described. These analogs were found…”
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Analysis of camelid IgG for antivenom development: Immunoreactivity and preclinical neutralisation of venom-induced pathology by IgG subclasses, and the effect of heat treatment by Cook, Darren A.N., Samarasekara, Chamali L., Wagstaff, Simon C., Kinne, Joerg, Wernery, Ulrich, Harrison, Robert A.

“…Antivenom is the most effective treatment of snake envenoming and is manufactured from the IgG of venom-immunised horses and sheep. Camelids have a unique IgG…”
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Development and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis by Clare, Rachel H, Cook, Darren A N, Johnston, Kelly L, Ford, Louise, Ward, Stephen A, Taylor, Mark J

“…There is an urgent need to develop new, safe, and affordable macrofilaricidal drugs for onchocerciasis and lymphatic filariasis treatment and control. The…”
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Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis by Aljayyoussi, Ghaith, Tyrer, Hayley E., Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne, Metuge, Haelly, Cook, Darren A. N., Steven, Andrew, Sharma, Raman, Guimaraes, Ana F., Clare, Rachel H., Cassidy, Andrew, Johnston, Kelly L., Myhill, Laura, Hayward, Laura, Wanji, Samuel, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A.

“…A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper…”
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Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment by Quek, Shannon, Cook, Darren A N, Wu, Yang, Marriott, Amy E, Steven, Andrew, Johnston, Kelly L, Ford, Louise, Archer, John, Hemingway, Janet, Ward, Stephen A, Wagstaff, Simon C, Turner, Joseph D, Taylor, Mark J

“…Lymphatic filariasis is a vector-borne neglected tropical disease prioritized for global elimination. The filarial nematodes that cause the disease host a…”
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AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis by Hong, W. David, Benayoud, Farid, Nixon, Gemma L., Ford, Louise, Johnston, Kelly L., Clare, Rachel H., Cassidy, Andrew, Cook, Darren A. N., Siu, Amy, Shiotani, Motohiro, Webborn, Peter J. H., Kavanagh, Stefan, Aljayyoussi, Ghaith, Murphy, Emma, Steven, Andrew, Archer, John, Struever, Dominique, Frohberger, Stefan J., Ehrens, Alexandra, Hübner, Marc P., Hoerauf, Achim, Roberts, Adam P., Hubbard, Alasdair T. M., Tate, Edward W., Serwa, Remigiusz A., Leung, Suet C., Qie, Li, Berry, Neil G., Gusovsky, Fabian, Hemingway, Janet, Turner, Joseph D., Taylor, Mark J., Ward, Stephen A., O’Neill, Paul M.

“…Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both…”
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Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis by Turner, Joseph D., Sharma, Raman, Al Jayoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Priestley, Richard S., Murphy, Emma A., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., McCall, John, Ford, Louise, Hemingway, Janet, Ward, Stephen A., Taylor, Mark J.

“…Elimination of filariasis requires a macrofilaricide treatment that can be delivered within a 7-day period. Here we have identified a synergy between the…”
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Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis by Sharma, Raman, Jayoussi, Ghaith Al, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Guimaraes, Ana F., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Myhill, Laura J., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., Ford, Louise, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J.

“…Lymphatic filariasis and onchocerciasis are parasitic helminth diseases, which cause severe morbidities such as elephantiasis, skin disease and blindness,…”
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Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis by Sharma, Raman, Aljayyoussi, Ghaith, Tyrer, Hayley E, Gamble, Joanne, Hayward, Laura, Guimaraes, Ana F, Davies, Jill, Waterhouse, David, Cook, Darren A N, Myhill, Laura J, Clare, Rachel H, Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L, Ford, Louise, Turner, Joseph D, Ward, Stephen A, Taylor, Mark J

“…This corrects the article DOI: 10.1038/srep23458…”
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Identification and prioritization of novel anti- Wolbachia chemotypes from screening a 10,000-compound diversity library by Johnston, Kelly L, Cook, Darren A N, Berry, Neil G, David Hong, W, Clare, Rachel H, Goddard, Megan, Ford, Louise, Nixon, Gemma L, O'Neill, Paul M, Ward, Stephen A, Taylor, Mark J

“…Lymphatic filariasis and onchocerciasis are two important neglected tropical diseases (NTDs) that cause severe disability. Control efforts are hindered by the…”
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Correction: Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis by Sharma, Raman, Aljayyoussi, Ghaith, Tyrer, Hayley E., Gamble, Joanne, Hayward, Laura, Guimaraes, Ana F., Davies, Jill, Waterhouse, David, Cook, Darren A. N., Myhill, Laura J., Clare, Rachel H., Cassidy, Andrew, Steven, Andrew, Johnston, Kelly L., Ford, Louise, Turner, Joseph D., Ward, Stephen A., Taylor, Mark J.

“…Scientific Reports 6: Article number: 23458; published online: 21 March 2016; updated: 08 January 2018 The original version of this Article contained a…”
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