Search Results - "Cook, Chyung S"

PHARMACOKINETICS AND METABOLISM OF [14C]EPLERENONE AFTER ORAL ADMINISTRATION TO HUMANS by COOK, Chyung S, BERRY, Loren M, BIBLE, Roy H, HRIBAR, Jeremy D, HAJDU, Elisabeth, LIU, Norman W

“…A pharmacokinetics and metabolism study was conducted in eight healthy human volunteers. After oral administration of [ 14 C]eplerenone (EP) at a dose of 100…”
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Involvement of CYP3A in the Metabolism of Eplerenone in Humans and Dogs: Differential Metabolism by CYP3A4 and CYP3A5 by COOK, Chyung S, BERRY, Loren M, KIM, David H, BURTON, Earl G, HRIBAR, Jeremy D, ZHANG, Liming

“…In vitro studies were conducted to identify the major metabolites of eplerenone (EP) and the cytochrome P450 (P450) isozymes involved in its primary oxidative…”
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Involvement of Human UGT2B7 and 2B15 in Rofecoxib Metabolism by ZHANG, Ji Y, ZHAN, Jenny, COOK, Chyung S, INGS, Robert M, BREAU, Alan P

“…O -Glucuronidation of 5-hydroxyrofecoxib is the major biotransformation pathway of rofecoxib in human, rat, and dog. The glucuronide conjugate is also involved…”
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Daily peritoneal administration of sodium pyrophosphate in a dialysis solution prevents the development of vascular calcification in a mouse model of uraemia by RISER, Bruce L, BARRETO, Fellype Carvalho, HOLMES, Clifford J, MASSY, Ziad A, REZG, Raja, VALAITIS, Paul W, COOK, Chyung S, WHITE, Jeffrey A, GASS, Jerome H, MAIZEL, Julien, LOUVET, Loic, DRUEKE, Tilman B

“…The high rate of cardiovascular mortality in patients with end-stage renal disease (ESRD) is a significant barrier to improved life expectancy. Unique in this…”
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DIFFERENTIAL ENANTIOSELECTIVITY AND PRODUCT-DEPENDENT ACTIVATION AND INHIBITION IN METABOLISM OF VERAPAMIL BY HUMAN CYP3AS by LIXIN SHEN, FITZLOFF, John F, COOK, Chyung S

“…In vitro studies of enantioselective metabolism of R -(+)- and S -(-)verapamil (VER) were conducted using human cDNA-expressed CYP3A isoforms, CYP3A4, CYP3A5,…”
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Interconversion pharmacokinetics of eplerenone, a selective aldosterone blocker, and its lactone-ring open form by Cook, Chyung S, Zhang, Liming

“…The interconversion pharmacokinetics of eplerenone and its lactone-ring open form, SC-70303, were examined in dogs using a stable isotope method. [13CD3]EP and…”
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Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption by Paulson, S K, Vaughn, M B, Jessen, S M, Lawal, Y, Gresk, C J, Yan, B, Maziasz, T J, Cook, C S, Karim, A

“…Celecoxib pharmacokinetics was evaluated after single and multiple oral dosing; after dosing in a solution and as a solid; with and without food; and after…”
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Atypical dose-route-dependent food effects of eplerenone in the dog: presence of food effects following intravenous dosing and lack of food effects of following oral dosing by Cook, Chyung S, Zhang, Liming

“…This study was conducted to investigate why a food effect was observed following an intravenous dose of eplerenone (EP) in the dog, but not following oral…”
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Absorption and disposition of a selective aldosterone receptor antagonist, eplerenone, in the dog by COOK, Chyung S, LIMING ZHANG, FISCHER, Judee S

“…The present study was conducted to characterize the pharmacokinetics of eplerenone (EP), a selective aldosterone receptor antagonist, and its open lactone ring…”
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Eplerenone: a selective aldosterone receptor antagonist (SARA) by Delyani, J A, Rocha, R, Cook, C S, Tobert, D S, Levin, S, Roniker, B, Workman, D L, Sing, Y L, Whelihan, B

“…Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), is a mineralocorticoid hormone that classically acts, via the…”
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Mechanism of compound- and species-specific food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide by COOK, C. S, LIMING ZHANG, OSIS, J, SCHOENHARD, G. L, KARIM, A

“…To determine mechanism of food effects observed with bidisomide but not with the structurally similar drug, disopyramide. Food effect studies of bidisomide and…”
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Mechanisms of food effects of structurally related antiarrhythmic drugs, disopyramide and bidisomide in the rat by LEE, K.-H, XU, G.-X, SCHOENHARD, G. L, COOK, C. S

“…To determine whether the rat is a good animal model for the food effects observed with bidisomide but not with the structurally similar antiarrhythmic drug,…”
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Effects of SC-56525, a Potent, Orally Active Renin Inhibitor, in Salt-Depleted and Renal Hypertensive Dogs by McMahon, Ellen G, Yang, Po-Chang, Babler, Maribeth A, Bittner, Stephen E, Suleymanov, Osman D, Cain-Janicki, Kimberly J, Bedell, Louis J, Hanson, Gunnar J, Cook, Chyung S

“…SC-56525 is a nanomolar inhibitor of plasma renin activity in human, cynomolgus monkey, dog, guinea pig, Yucatan micropig, and rabbit but is less active in…”
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Progress in Drug Metabolism: Vol. 10 by Cook, Chyung S.

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Species dependent esterase activities for hydrolysis of an anti-HIV prodrug glycovir and bioavailability of active SC-48334 by COOK, C. S, KARABATSOS, P. J, SCHOENHARD, G. L, KARIM, A

“…The in vitro fate of an ester prodrug, glycovir, was studied to determine if the species differences in the bioavailability of pharmacologically active…”
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Life Sciences -- Progress in Drug Metabolism (Vol. 10) edited by J. W. Bridges, L. F. Chasseaud and G. G. Gibson by Cook, Chyung S

“…Review…”
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Effects of SC-52458, an Angiotensin AT 1 Receptor Antagonist, in the Dog by McMahon, Ellen G, Yang, Po-Chang, Babler, Maribeth A, Suleymanov, Osman D, Palomo, Maria A, Olins, Gillian M, Cook, Chyung S

“…We have previously reported on the basic pharmacologic properties of SC-52458…”
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Effect of salicylic acid on the plasma protein binding and pharmacokinetics of misoprostol acid by Cook, C S, Schoenhard, G L, Karim, A

“…The in vitro serum protein binding and erythrocyte uptake of [3H]misoprostol acid ([3H]MPA; SC-30695), an active metabolite of the prostaglandin E1 (PGE1)…”
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Pharmacokinetics of a novel antiarrhythmic drug, actisomide by COOK, C. S, ROZEK, L. F, STOLZENBACH, J, ANDERSON, S, SCHOENHARD, G. L, KARIM, A

“…The pharmacokinetics of a novel antiarrhythmic drug, actisomide, were examined in the rat, dog, monkey, and human. The terminal half-life of actisomide was…”
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Effects of SC-52458, an Angiotensin AT1 Receptor Antagonist, in the Dog by McMahon, Ellen G., Yang, Po-Chang, Babler, Maribeth A., Suleymanov, Osman D., Palomo, Maria A., Olins, Gillian M., Cook, Chyung S.

“…We have previously reported on the basic pharmacologic properties of SC-52458…”
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