Search Results - "Contessa, Joseph N"

STING enhances cell death through regulation of reactive oxygen species and DNA damage by Hayman, Thomas J., Baro, Marta, MacNeil, Tyler, Phoomak, Chatchai, Aung, Thazin Nwe, Cui, Wei, Leach, Kevin, Iyer, Radhakrishnan, Challa, Sreerupa, Sandoval-Schaefer, Teresa, Burtness, Barbara A., Rimm, David L., Contessa, Joseph N.

“…Resistance to DNA-damaging agents is a significant cause of treatment failure and poor outcomes in oncology. To identify unrecognized regulators of cell…”
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Management of Brain Metastases in Tyrosine Kinase Inhibitor-Naïve Epidermal Growth Factor Receptor-Mutant Non-Small-Cell Lung Cancer: A Retrospective Multi-Institutional Analysis by Magnuson, William J, Lester-Coll, Nataniel H, Wu, Abraham J, Yang, T Jonathan, Lockney, Natalie A, Gerber, Naamit K, Beal, Kathryn, Amini, Arya, Patil, Tejas, Kavanagh, Brian D, Camidge, D Ross, Braunstein, Steven E, Boreta, Lauren C, Balasubramanian, Suresh K, Ahluwalia, Manmeet S, Rana, Niteshkumar G, Attia, Albert, Gettinger, Scott N, Contessa, Joseph N, Yu, James B, Chiang, Veronica L

“…Purpose Stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are…”
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The prognostic value of extranodal extension in human papillomavirus‐associated oropharyngeal squamous cell carcinoma by An, Yi, Park, Henry S., Kelly, Jacqueline R., Stahl, John M., Yarbrough, Wendell G., Burtness, Barbara A., Contessa, Joseph N., Decker, Roy H., Koshy, Matthew, Husain, Zain A.

“…BACKGROUND Extranodal (or extracapsular) extension (ENE) is an adverse prognostic factor in patients with head and neck cancers who undergo primary surgery…”
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Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors by Lopez Sambrooks, Cecilia, Baro, Marta, Quijano, Amanda, Narayan, Azeet, Cui, Wei, Greninger, Patricia, Egan, Regina, Patel, Abhijit, Benes, Cyril H, Saltzman, W Mark, Contessa, Joseph N

“…Asparagine (N)-linked glycosylation is a posttranslational modification essential for the function of complex transmembrane proteins. However, targeting…”
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Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells by Lopez-Sambrooks, Cecilia, Shrimal, Shiteshu, Khodier, Carol, Flaherty, Daniel P, Rinis, Natalie, Charest, Jonathan C, Gao, Ningguo, Zhao, Peng, Wells, Lance, Lewis, Timothy A, Lehrman, Mark A, Gilmore, Reid, Golden, Jennifer E, Contessa, Joseph N

“…A high-throughput screen identifies NGI-1 as an inhibitor of oligosaccharyltransferase, preventing transfer of N-linked glycans to proteins. NGI-1 blocked EGFR…”
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A Small-Molecule Oligosaccharyltransferase Inhibitor with Pan-flaviviral Activity by Puschnik, Andreas S., Marceau, Caleb D., Ooi, Yaw Shin, Majzoub, Karim, Rinis, Natalie, Contessa, Joseph N., Carette, Jan E.

“…The mosquito-borne flaviviruses include important human pathogens such as dengue, Zika, West Nile, and yellow fever viruses, which pose a serious threat for…”
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Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells by Contessa, Joseph N, Bhojani, Mahaveer S, Freeze, Hudson H, Rehemtulla, Alnawaz, Lawrence, Theodore S

“…Receptor tyrosine kinases (RTK) are therapeutic targets for the treatment of malignancy. However, tumor cells develop resistance to targeted therapies through…”
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A Clinical Model for Identifying Radiosensitive Tumor Genotypes in Non―Small Cell Lung Cancer by JOHUNG, Kimberly L, XIAOPAN YAO, FANGYONG LI, YU, James B, GETTINGER, Scott N, GOLDBERG, Sarah, DECKER, Roy H, HESS, Judith A, CHIANG, Veronica L, CONTESSA, Joseph N

“…Non-small cell lung cancer (NSCLC) includes a spectrum of radiosensitive and radioresistant tumors. However, little is known about the molecular determinants…”
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CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma by Chen, William S, Bindra, Ranjit S, Mo, Allen, Hayman, Thomas, Husain, Zain, Contessa, Joseph N, Gaffney, Stephen G, Townsend, Jeffrey P, Yu, James B

“…HPV infection is associated with high p16 expression and good prognosis in head and neck squamous cell carcinomas (HNSCCs). Analysis of CDKN2A, the gene…”
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Aberrant Cellular Glycosylation May Increase the Ability of Influenza Viruses to Escape Host Immune Responses through Modification of the Viral Glycome by Alymova, Irina V, Cipollo, John F, Parsons, Lisa M, Music, Nedzad, Kamal, Ram P, Tzeng, Wen-Pin, Goldsmith, Cynthia S, Contessa, Joseph N, Hartshorn, Kevan L, Wilson, Jason R, Zeng, Hui, Gansebom, Shane, York, Ian A

“…Individuals with metabolic dysregulation of cellular glycosylation often experience severe influenza disease, with a poor immune response to the virus and low…”
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Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis Is a Novel Target for Cancer Therapy by CONTESSA, Joseph N, BHOJANI, Mahaveer S, FREEZE, Hudson H, ROSS, Brian D, REHEMTULLA, Alnawaz, LAWRENCE, Theodore S

“…Redundant receptor tyrosine kinase (RTK) signaling is a mechanism for therapeutic resistance to epidermal growth factor receptor (EGFR) inhibition. A strategy…”
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Quantitative Analysis of [11 C]-Erlotinib PET Demonstrates Specific Binding for Activating Mutations of the EGFR Kinase Domain by Petrulli, J. Ryan, Sullivan, Jenna M, Zheng, Ming-Qiang, Bennett, Daniel C, Charest, Jonathan, Huang, Yiyun, Morris, Evan D, Contessa, Joseph N

“…Abstract Activating mutations of the epidermal growth factor receptor (EGFR) occur in multiple tumor types, including non-small cell lung cancer (NSCLC) and…”
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Mannose phosphate isomerase regulates fibroblast growth factor receptor family signaling and glioma radiosensitivity by Cazet, Aurélie, Charest, Jonathan, Bennett, Daniel C, Sambrooks, Cecilia Lopez, Contessa, Joseph N

“…Asparagine-linked glycosylation is an endoplasmic reticulum co- and post-translational modification that enables the transit and function of receptor tyrosine…”
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Spatially resolved analysis of the T cell immune contexture in lung cancer-associated brain metastases by Lu, Benjamin Y, Gupta, Richa, Aguirre-Ducler, Adam, Gianino, Nicole, Wyatt, Hailey, Ribeiro, Matthew, Chiang, Veronica L, Contessa, Joseph N, Adeniran, Adebowale J, Jilaveanu, Lucia B, Kluger, Harriet M, Schalper, Kurt A, Goldberg, Sarah B

“…Despite unique genetic alterations within brain metastases (BrMs) and an immunologically distinct surrounding microenvironment, the composition and functional…”
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Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole Brain Radiation Therapy by Jairam, Vikram, Park, Henry S., Yu, James B., Bindra, Ranjit S., Contessa, Joseph N., Jethwa, Krishan R.

“…Whole brain radiation therapy (WBRT) is often used as an effective treatment for patients with brain metastasis, although it is also known to have deleterious…”
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A multi species evaluation of the radiation dosimetry of [11 C]erlotinib, the radiolabeled analog of a clinically utilized tyrosine kinase inhibitor by Petrulli, J. Ryan, Hansen, Søren B, Abourbeh, Galith, Yaqub, Maqsood, Bahce, Idris, Holden, Daniel, Huang, Yiyun, Nabulsi, Nabeel B, Contessa, Joseph N, Mishani, Eyal, Lammertsma, Adriaan A, Morris, Evan D

“…Abstract Introduction Erlotinib is a tyrosine kinase inhibitor prescribed for non-small cell lung cancer patients bearing epidermal growth factor receptor…”
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Radiotherapy for Pancreatic Neuroendocrine Tumors by Contessa, Joseph N., M.D., Ph.D, Griffith, Kent A., M.S, Wolff, Elizabeth, Ensminger, William, M.D, Zalupski, Mark, M.D, Lawrence, Theodore S., M.D., Ph.D, Ben-Josef, Edgar, M.D

“…Purpose Pancreatic neuroendocrine tumors (PNTs) are rare malignant neoplasms considered to be resistant to radiotherapy (RT), although data on efficacy are…”
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Extended Survival and Prognostic Factors for Patients With ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastasis by Johung, Kimberly L, Yeh, Norman, Desai, Neil B, Williams, Terence M, Lautenschlaeger, Tim, Arvold, Nils D, Ning, Matthew S, Attia, Albert, Lovly, Christine M, Goldberg, Sarah, Beal, Kathryn, Yu, James B, Kavanagh, Brian D, Chiang, Veronica L, Camidge, D Ross, Contessa, Joseph N

“…We performed a multi-institutional study to identify prognostic factors and determine outcomes for patients with ALK-rearranged non-small-cell lung cancer…”
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ERBB receptor tyrosine kinases and cellular radiation responses by Schmidt-Ullrich, Rupert K, Contessa, Joseph N, Lammering, Guido, Amorino, George, Lin, Peck-Sun

“…Ionizing radiation induces in autocrine growth-regulated carcinoma and malignant glioma cells powerful cytoprotective responses that confer relative resistance…”
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Initial SRS for Patients With 5 to 15 Brain Metastases: Results of a Multi-Institutional Experience by Hughes, Ryan T., Masters, Adrianna H., McTyre, Emory R., Farris, Michael K., Chung, Caroline, Page, Brandi R., Kleinberg, Lawrence R., Hepel, Jaroslaw, Contessa, Joseph N., Chiang, Veronica, Ruiz, Jimmy, Watabe, Kounosuke, Su, Jing, Fiveash, John B., Braunstein, Steve, Chao, Samuel, Attia, Albert, Ayala-Peacock, Diandra N., Chan, Michael D.

“…Several studies evaluating stereotactic radiosurgery (SRS) for patients with >4 brain metastases (BM) demonstrated similar outcomes after treatment of 1, 2 to…”
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