Search Results - "Contel, Maria"

Metal-based antibody drug conjugates. Potential and challenges in their application as targeted therapies in cancer by del Solar, Virginia, Contel, María

“…Antibody drug conjugates have emerged as a very attractive type of targeted therapy in cancer. They combine the antigen-targeting specificity of monoclonal…”
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Encapsulation of Gold-Based Anticancer Agents in Protease-Degradable Peptide Nanofilaments Enhances Their Potency by Marciano, Yaron, del Solar, Virginia, Nayeem, Nazia, Dave, Dhwanit, Son, Jiye, Contel, María, Ulijn, Rein V.

“…We investigated the use of amphiphilic, protease-cleavable peptides as encapsulation moieties for hydrophobic metallodrugs, in order to enhance their…”
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Preclinical evaluation of an unconventional ruthenium‐gold‐based chemotherapeutic: RANCE‐1, in clear cell renal cell carcinoma by Elie, Benelita T., Hubbard, Karen, Pechenyy, Yuriy, Layek, Buddhadev, Prabha, Swayam, Contel, Maria

“…Background There are few effective treatments for patients with advanced clear cell renal cell carcinoma (CCRCC). Recent findings indicate that ruthenium‐gold…”
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Exploring the Potential of Metallodrugs as Chemotherapeutics for Triple Negative Breast Cancer by Nayeem, Nazia, Contel, Maria

“…This review focuses on studies of coordination and organometallic compounds as potential chemotherapeutics against triple negative breast cancer (TNBC) which…”
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Customizing Morphology, Size, and Response Kinetics of Matrix Metalloproteinase-Responsive Nanostructures by Systematic Peptide Design by Son, Jiye, Kalafatovic, Daniela, Kumar, Mohit, Yoo, Barney, Cornejo, Mike A, Contel, María, Ulijn, Rein V

“…Overexpression and activation of matrix metalloproteinase-9 (MMP-9) is associated with multiple diseases and can serve as a stimulus to activate nanomaterials…”
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Potential Anticancer Heterometallic Fe–Au and Fe–Pd Agents: Initial Mechanistic Insights by Lease, Nicholas, Vasilevski, Vadim, Carreira, Monica, de Almeida, Andreia, Sanaú, Mercedes, Hirva, Pipsa, Casini, Angela, Contel, María

“…A series of gold(III) and palladium(II) heterometallic complexes with new iminophosphorane ligands derived from ferrocenylphosphanes [{Cp-P(Ph2)N-Ph}2Fe] (1),…”
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Titanocene–Gold Complexes Containing N‑Heterocyclic Carbene Ligands Inhibit Growth of Prostate, Renal, and Colon Cancers in Vitro by Mui, Yiu Fung, Fernández-Gallardo, Jacob, Elie, Benelita T, Gubran, Ahmed, Maluenda, Irene, Sanaú, Mercedes, Navarro, Oscar, Contel, Marı́a

“…We report on the synthesis, characterization, and stability studies of new titanocene complexes containing a methyl group and a carboxylate ligand (mba =…”
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Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer Properties by Frik, Malgorzata, Fernández-Gallardo, Jacob, Gonzalo, Oscar, Mangas-Sanjuan, Víctor, González-Alvarez, Marta, Serrano del Valle, Alfonso, Hu, Chunhua, González-Alvarez, Isabel, Bermejo, Marival, Marzo, Isabel, Contel, María

“…New organometallic gold­(III) and platinum­(II) complexes containing iminophosphorane ligands are described. Most of them are more cytotoxic to a number of…”
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Unconventional Anticancer Metallodrugs and Strategies to Improve Their Pharmacological Profile by Contel, María

“…For the past 41 years, metal-based drugs have been widely used for the treatment of cancer [...]…”
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Versatile synthesis of cationic N-heterocyclic carbene-gold(i) complexes containing a second ancillary ligand. Design of heterobimetallic ruthenium-gold anticancer agents by Fernández-Gallardo, Jacob, Elie, Benelita T, Sanaú, Mercedes, Contel, María

“…We describe a versatile and quick route to cationic gold(i) complexes containing N-heterocyclic carbenes and a second ancillary ligand (such as phosphanes,…”
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Frontispiece: Exploring the Potential of Metallodrugs as Chemotherapeutics for Triple Negative Breast Cancer by Nayeem, Nazia, Contel, Maria

“…Triple negative breast cancer (TNBC) has one of the poorest prognoses and worst survival rates for patients, with chemotherapy still the gold standard for…”
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In Vitro and in Vivo Evaluation of Water-Soluble Iminophosphorane Ruthenium(II) Compounds. A Potential Chemotherapeutic Agent for Triple Negative Breast Cancer by Frik, Malgorzata, Martínez, Alberto, Elie, Benelita T, Gonzalo, Oscar, Ramírez de Mingo, Daniel, Sanaú, Mercedes, Sánchez-Delgado, Roberto, Sadhukha, Tanmoy, Prabha, Swayam, Ramos, Joe W, Marzo, Isabel, Contel, María

“…A series of organometallic ruthenium­(II) complexes containing iminophosphorane ligands have been synthesized and characterized. Cationic compounds with…”
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Bimetallic titanocene-gold phosphane complexes inhibit invasion, metastasis, and angiogenesis-associated signaling molecules in renal cancer by Elie, Benelita T., Fernández-Gallardo, Jacob, Curado, Natalia, Cornejo, Mike A., Ramos, Joe W., Contel, María

“…Following promising recent in vitro and in vivo studies of the anticancer efficacies of heterometallic titanocene–gold chemotherapeutic candidates against…”
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Organometallic Titanocene–Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties by Fernández-Gallardo, Jacob, Elie, Benelita T, Sulzmaier, Florian J, Sanaú, Mercedes, Ramos, Joe W, Contel, María

“…Early–late transition metal TiAu2 compounds [(η-C5H5)2Ti­{OC­(O)­CH2PPh2AuCl}2] (3) and new [(η-C5H5)2Ti­{OC­(O)-4-C6H4­PPh2AuCl}2] (5) were evaluated as…”
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Organometallic Palladium Complexes with a Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents by Carreira, Monica, Calvo-Sanjuán, Rubén, Sanaú, Mercedes, Marzo, Isabel, Contel, María

“…The synthesis and characterization of a new water-soluble iminophosphorane ligand TPAN-C(O)-2BrC6H4 (1, C,N-IM; TPA = 1,3,5-triaza-7-phosphaadamantane) is…”
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Design, synthesis and characterisation of new chimeric ruthenium(II)-gold(I) complexes as improved cytotoxic agents by Massai, Lara, Fernández-Gallardo, Jacob, Guerri, Annalisa, Arcangeli, Annarosa, Pillozzi, Serena, Contel, María, Messori, Luigi

“…Two heterobimetallic complexes, i.e. [RuCl2(p-cymene)(μ-dppm)AuC] (1) and [RuCl2(p-cymene)(μ-dppm)Au(S-thiazoline)] (3), based on known cytotoxic…”
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A heterometallic ruthenium–gold complex displays antiproliferative, antimigratory, and antiangiogenic properties and inhibits metastasis and angiogenesis-associated proteases in renal cancer by Elie, Benelita T., Pechenyy, Yuriy, Uddin, Fathema, Contel, María

“…Heterobimetallic compounds are designed to harness chemotherapeutic traits of distinct metal species into a single molecule. The ruthenium–gold (Ru–Au) family…”
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A Bis(ortho-amine)aryl−Gold(I) Compound as an Efficient, Nontoxic, Arylating Reagent by Contel, Maria, Stol, Marianne, Casado, Miguel A, van Klink, Gerard P. M, Ellis, Dianne D, Spek, Anthony L, van Koten, Gerard

“…A novel strategy for the synthesis of bis(ortho-amine)chelated monoanionic bisaminoaryl−metal complexes is presented. This method constitutes the exchange of a…”
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Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo by Fernández-Gallardo, Jacob, Elie, Benelita T, Sadhukha, Tanmoy, Prabha, Swayam, Sanaú, Mercedes, Rotenberg, Susan A, Ramos, Joe W, Contel, María

“…Following recent work on heterometallic titanocene-gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis,…”
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Titanocene–Phosphine Derivatives as Precursors to Cytotoxic Heterometallic TiAu2 and TiM (M = Pd, Pt) Compounds. Studies of Their Interactions with DNA by González-Pantoja, Jose F, Stern, Michael, Jarzecki, Andrzej A, Royo, Eva, Robles-Escajeda, Elisa, Varela-Ramírez, Armando, Aguilera, Renato J, Contel, María

“…A series of tri- and bimetallic titanium–gold, titanium–palladium, and titanium–platinum derivatives of the general formulas [Ti{η5-C5H4(CH2) n…”
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