Search Results - "Constantinou, Angelos"

Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage by Alsafadi, Samar, Houy, Alexandre, Battistella, Aude, Popova, Tatiana, Wassef, Michel, Henry, Emilie, Tirode, Franck, Constantinou, Angelos, Piperno-Neumann, Sophie, Roman-Roman, Sergio, Dutertre, Martin, Stern, Marc-Henri

“…Hotspot mutations in the spliceosome gene SF3B1 are reported in ∼20% of uveal melanomas. SF3B1 is involved in 3′-splice site (3′ss) recognition during RNA…”
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Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing by Laguette, Nadine, Brégnard, Christelle, Hue, Pauline, Basbous, Jihane, Yatim, Ahmad, Larroque, Marion, Kirchhoff, Frank, Constantinou, Angelos, Sobhian, Bijan, Benkirane, Monsef

“…The HIV auxiliary protein Vpr potently blocks the cell cycle at the G2/M transition. Here, we show that G2/M arrest results from untimely activation of the…”
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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates by Egger, Tom, Morano, Laura, Blanchard, Marie-Pierre, Basbous, Jihane, Constantinou, Angelos

“…Assembly of TopBP1 biomolecular condensates triggers activation of the ataxia telangiectasia-mutated and Rad3-related (ATR)/Chk1 signaling pathway, which…”
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Remodeling of DNA replication structures by the branch point translocase FANCM by Gari, Kerstin, Décaillet, Chantal, Delannoy, Mathieu, Wu, Leonard, Constantinou, Angelos

“…Fanconi anemia (FA) is a genetically heterogeneous chromosome instability syndrome associated with congenital abnormalities, bone marrow failure, and cancer…”
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Replication gap suppression depends on the double-strand DNA binding activity of BRCA2 by Vugic, Domagoj, Dumoulin, Isaac, Martin, Charlotte, Minello, Anna, Alvaro-Aranda, Lucia, Gomez-Escudero, Jesus, Chaaban, Rady, Lebdy, Rana, von Nicolai, Catharina, Boucherit, Virginie, Ribeyre, Cyril, Constantinou, Angelos, Carreira, Aura

“…Replication stress (RS) is a major source of genomic instability and is intrinsic to cancer cells. RS is also the consequence of chemotherapeutic drugs for…”
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The Fanconi Anemia Protein FANCM Can Promote Branch Migration of Holliday Junctions and Replication Forks by Gari, Kerstin, Décaillet, Chantal, Stasiak, Alicja Z., Stasiak, Andrzej, Constantinou, Angelos

“…Fanconi anemia (FA) is a genetically heterogeneous cancer-prone disorder associated with chromosomal instability and cellular hypersensitivity to DNA…”
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Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites by Basbous, Jihane, Aze, Antoine, Chaloin, Laurent, Lebdy, Rana, Hodroj, Dana, Ribeyre, Cyril, Larroque, Marion, Shepard, Caitlin, Kim, Baek, Pruvost, Alain, Moreaux, Jérôme, Maiorano, Domenico, Mechali, Marcel, Constantinou, Angelos

“…Imbalance in the level of the pyrimidine degradation products dihydrouracil and dihydrothymine is associated with cellular transformation and cancer…”
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Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors by Moriel-Carretero, María, Ovejero, Sara, Gérus-Durand, Marie, Vryzas, Dimos, Constantinou, Angelos

“…Proteins disabled in the cancer-prone disorder Fanconi anemia (FA) ensure the maintenance of chromosomal stability during DNA replication. FA proteins regulate…”
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An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells by Alghoul, Emile, Basbous, Jihane, Constantinou, Angelos

“…Inducible biomolecular condensates play fundamental roles in cellular responses to intracellular and environmental cues. Knowledge about their composition is…”
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A cyclin-dependent kinase-mediated phosphorylation switch of disordered protein condensation by Valverde, Juan Manuel, Dubra, Geronimo, Phillips, Michael, Haider, Austin, Elena-Real, Carlos, Fournet, Aurélie, Alghoul, Emile, Chahar, Dhanvantri, Andrés-Sanchez, Nuria, Paloni, Matteo, Bernadó, Pau, van Mierlo, Guido, Vermeulen, Michiel, van den Toorn, Henk, Heck, Albert J. R., Constantinou, Angelos, Barducci, Alessandro, Ghosh, Kingshuk, Sibille, Nathalie, Knipscheer, Puck, Krasinska, Liliana, Fisher, Daniel, Altelaar, Maarten

“…Cell cycle transitions result from global changes in protein phosphorylation states triggered by cyclin-dependent kinases (CDKs). To understand how this…”
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Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks by Ribeyre, Cyril, Zellweger, Ralph, Chauvin, Maeva, Bec, Nicole, Larroque, Christian, Lopes, Massimo, Constantinou, Angelos

“…During transcription and DNA replication, the DNA template is overwound ahead of RNA and DNA polymerases and relaxed by DNA topoisomerases. Inhibitors of…”
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Preparation and purification of mono-ubiquitinated proteins using Avi-tagged ubiquitin by Tan, Winnie, Murphy, Vincent J, Charron, Aude, van Twest, Sylvie, Sharp, Michael, Constantinou, Angelos, Parker, Michael W, Crismani, Wayne, Bythell-Douglas, Rohan, Deans, Andrew J

“…Site-specific conjugation of ubiquitin onto a range of DNA repair proteins regulates their critical functions in the DNA damage response. Biochemical and…”
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The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance by Ovejero, Sara, Viziteu, Elena, Dutrieux, Laure, Devin, Julie, Lin, Yea-Lih, Alaterre, Elina, Jourdan, Michel, Basbous, Jihane, Requirand, Guilhem, Robert, Nicolas, de Boussac, Hugues, Seckinger, Anja, Hose, Dirk, Vincent, Laure, Herbaux, Charles, Constantinou, Angelos, Pasero, Philippe, Moreaux, Jérôme

“…Multiple myeloma (MM) is a hematologic cancer characterized by accumulation of malignant plasma cells in the bone marrow. To date, no definitive cure exists…”
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Identification and Characterization of the Human Mus81-Eme1 Endonuclease by Ciccia, Alberto, Constantinou, Angelos, West, Stephen C

“…The faithful and complete replication of DNA is necessary for the maintenance of genome stability. It is known, however, that replication forks stall at…”
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KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance by Gaillard, Solenne, Charasson, Virginie, Ribeyre, Cyril, Salifou, Kader, Pillaire, Marie-Jeanne, Hoffmann, Jean-Sebastien, Constantinou, Angelos, Trouche, Didier, Vandromme, Marie

“…KDM5A and KDM5B histone-demethylases are overexpressed in many cancers and have been involved in drug tolerance. Here, we describe that KDM5A, together with…”
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A DNA repair pathway score predicts survival in human multiple myeloma: the potential for therapeutic strategy by Kassambara, Alboukadel, Gourzones-Dmitriev, Claire, Sahota, Surinder, Rème, Thierry, Moreaux, Jérôme, Goldschmidt, Hartmut, Constantinou, Angelos, Pasero, Philippe, Hose, Dirk, Klein, Bernard

“…DNA repair is critical to resolve extrinsic or intrinsic DNA damage to ensure regulated gene transcription and DNA replication. These pathways control repair…”
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The Bloom's Syndrome Gene Product Promotes Branch Migration of Holliday Junctions by Karow, Julia K., Constantinou, Angelos, Li, Ji-Liang, West, Stephen C., Hickson, Ian D.

“…Bloom's syndrome (BS) is an autosomal recessive disorder associated with dwarfism, immunodeficiency, reduced fertility, and elevated levels of many types of…”
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MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair by Roques, Céline, Coulombe, Yan, Delannoy, Mathieu, Vignard, Julien, Grossi, Simona, Brodeur, Isabelle, Rodrigue, Amélie, Gautier, Jean, Stasiak, Alicja Z, Stasiak, Andrzej, Constantinou, Angelos, Masson, Jean-Yves

“…Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross‐links. It was reported earlier that FANCD2…”
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Branch Migration and Holliday Junction Resolution Catalyzed by Activities from Mammalian Cells by Constantinou, Angelos, Davies, Adelina A, West, Stephen C

“…During homologous recombination, DNA strand exchange leads to Holliday junction formation. The movement, or branch migration, of this junction along DNA…”
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Base Excision Repair of Oxidative DNA Damage Activated by XPG Protein by Klungland, Arne, Höss, Matthias, Gunz, Daniela, Constantinou, Angelos, Clarkson, Stuart G, Doetsch, Paul W, Bolton, Philip H, Wood, Richard D, Lindahl, Tomas

“…Oxidized pyrimidines in DNA are removed by a distinct base excision repair pathway initiated by the DNA glycosylase—AP lyase hNth1 in human cells. We have…”
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