Search Results - "Constancia, M"

Child Health, Developmental Plasticity, and Epigenetic Programming by Hochberg, Z, Feil, R, Constancia, M, Fraga, M, Junien, C, Carel, J.-C, Boileau, P, Le Bouc, Y, Deal, C. L, Lillycrop, K, Scharfmann, R, Sheppard, A, Skinner, M, Szyf, M, Waterland, R. A, Waxman, D. J, Whitelaw, E, Ong, K, Albertsson-Wikland, K

“…Plasticity in developmental programming has evolved to provide the best chances of survival and reproductive success to the organism under changing…”
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Placental efficiency and adaptation: endocrine regulation by Fowden, A. L., Sferruzzi‐Perri, A. N., Coan, P. M., Constancia, M., Burton, G. J.

“…Size at birth is critical in determining life expectancy and is dependent primarily on the placental supply of nutrients. However, the fetus is not just a…”
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Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice by Coan, P. M., Vaughan, O. R., Sekita, Y., Finn, S. L., Burton, G. J., Constancia, M., Fowden, A. L.

“…Undernutrition during pregnancy reduces birth weight and programmes adult phenotype with consequences for life expectancy, but its effects on the phenotype of…”
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Differential genomic imprinting regulates paracrine and autocrine roles of IGF2 in mouse adult neurogenesis by Ferrón, S. R., Radford, E. J., Domingo-Muelas, A., Kleine, I., Ramme, A., Gray, D., Sandovici, I., Constancia, M., Ward, A., Menheniott, T. R., Ferguson-Smith, A. C.

“…Genomic imprinting is implicated in the control of gene dosage in neurogenic niches. Here we address the importance of Igf2 imprinting for murine adult…”
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Programming placental nutrient transport capacity by Fowden, A. L., Ward, J. W., Wooding, F. P. B., Forhead, A. J., Constancia, M.

“…Many animal studies and human epidemiological findings have shown that impaired growth in utero is associated with physiological abnormalities in later life…”
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Imprinted genes, placental development and fetal growth by Fowden, A L, Sibley, C, Reik, W, Constancia, M

“…In mammals, imprinted genes have an important role in feto-placental development. They affect the growth, morphology and nutrient transfer capacity of the…”
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Imprinted genes and the epigenetic regulation of placental phenotype by Fowden, A.L., Coan, P.M., Angiolini, E., Burton, G.J., Constancia, M.

“…Imprinted genes are expressed in a parent-of-origin manner by epigenetic modifications that silence either the paternal or maternal allele. They are widely…”
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Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse by Coan, P. M., Fowden, A. L., Constancia, M., Ferguson‐Smith, A. C., Burton, G. J., Sibley, C. P.

“…Both complete knockout of the Igf2 gene ( Igf2 null +/− ) and knockout of its placental specific transcript alone ( Igf2 P0 +/− ) lead to fetal growth…”
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Regulation of supply and demand for maternal nutrients in mammals by imprinted genes by Reik, Wolf, Constância, Miguel, Fowden, Abigail, Anderson, Neil, Dean, Wendy, Ferguson-Smith, Anne, Tycko, Benjamin, Sibley, Colin

“…The placenta has evolved in eutherian mammals primarily to provide nutrients for the developing fetus. The genetic control of the regulation of supply and…”
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Placental-Specific Igf2 Deficiency Alters Developmental Adaptations to Undernutrition in Mice by Sferruzzi-Perri, A. N, Vaughan, O. R, Coan, P. M, Suciu, M. C, Darbyshire, R, Constancia, M, Burton, G. J, Fowden, A. L

“…The pattern of fetal growth is a major determinant of the subsequent health of the infant. We recently showed in undernourished (UN) mice that fetal growth is…”
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Maternal-fetal resource allocation by Fowden, A.L, Constancia, M

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Imprinting mechanisms by Constância, M, Pickard, B, Kelsey, G, Reik, W

“…A number of recent studies have provided new insights into mechanisms that regulate genomic imprinting in the mammalian genome. Regions of allele-specific…”
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Microsatellite instability at multiple loci in gastric carcinoma: Clinicopathologic implications and prognosis by dos Santos, NR, Seruca, R, Constancia, M, Seixas, M, Sobrinho-Simoes, M

“…BACKGROUND & AIMS: Microsatellite instability (replication error [RER]- positive phenotype) is a frequent genetic alteration in gastric carcinomas. The…”
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Multiple Imprinted Sense and Antisense Transcripts, Differential Methylation and Tandem Repeats in a Putative Imprinting Control Region Upstream of Mouse Igf2 by Moore, T., Constancia, M., Zubair, M., Bailleul, B., Feil, R., Sasaki, H., Reik, W.

“…The mouse insulin-like growth factor 2 (Igf2) locus is a complex genomic region that produces multiple transcripts from alternative promoters. Expression at…”
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Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions by Lopes, Susana, Lewis, Annabelle, Hajkova, Petra, Dean, Wendy, Oswald, Joachim, Forné, Thierry, Murrell, Adele, Constância, Miguel, Bartolomei, Marisa, Walter, Jörn, Reik, Wolf

“…Imprinted genes and their control elements occur in clusters in the mammalian genome and carry epigenetic modifications. Observations from imprinting disorders…”
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OR6-4: Sustained IGF-II production is necessary for adult neurogenesis by Ziegler, A.N, Testai, J, Constancia, M, Sandovici, I, Wood, T.L, Levison, S.W

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An intragenic methylated region in the imprinted Igf2 gene augments transcription by Murrell, Adele, Heeson, Sarah, Bowden, Lucy, Constância, Miguel, Dean, Wendy, Kelsey, Gavin, Reik, Wolf

“…DNA methylation is usually associated with transcriptional silencing, but in the imprinted mouse Igf2 gene, the paternally expressed copy is methylated in two…”
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OR11-3 IGF-II and neurogenesis: in vitro and in vivo analyses by Ziegler, A.N, Constancia, M, Sandovici, I, Wood, T.L, Levison, S.W

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Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice by Coan, P. M., Angiolini, E., Sandovici, I., Burton, G. J., Constância, M., Fowden, A. L.

“…Experimental reduction in placental growth often leads to increased placental efficiency measured as grams of fetus produced per gram of placenta, although…”
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Placental-Specific Igf2 Knockout Mice Exhibit Hypocalcemia and Adaptive Changes in Placental Calcium Transport by Dilworth, M. R., Kusinski, L. C., Cowley, E., Ward, B. S., Husain, S. M., Constância, M., Sibley, C. P., Glazier, J. D., Roberts, R. Michael

“…Evidence is emerging that the ability of the placenta to supply nutrients to the developing fetus adapts according to fetal demand. To examine this adaptation…”
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