Search Results - "Constance, Jonathan E."

Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically‐Based Pharmacokinetic Modeling by Yellepeddi, Venkata K., Parashar, Kaustubh, Dean, Spencer M., Watt, Kevin M., Constance, Jonathan E., Baker, Olga J.

“…Sjögren’s syndrome (SS) is an autoimmune disease with no effective treatment options. Resolvin D1 (RvD1) belongs to a class of lipid‐based specialized…”
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Mapping the Evidence for Opioid-Mediated Changes in Malignancy and Chemotherapeutic Efficacy: Protocol for a Scoping Review by Constance, Jonathan E, McFarland, Mary M, Casucci, Tallie, Deininger, Michael W, Enioutina, Elena Y, Job, Kathleen, Lemons, Richard S, Lim, Carol S, Ward, Robert M, Yellepeddi, Venkata, Watt, Kevin M

“…Numerous reports contend opioids can augment or inhibit malignancy. At present, there is no consensus on the risk or benefit posed by opioids on malignancy or…”
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Selective Targeting of c-Abl via a Cryptic Mitochondrial Targeting Signal Activated by Cellular Redox Status in Leukemic and Breast Cancer Cells by Constance, Jonathan E., Despres, Samuel D., Nishida, Akemi, Lim, Carol S.

“…Purpose The tyrosine kinase c-Abl localizes to the mitochondria under cell stress conditions and promotes apoptosis. However, c-Abl has not been directly…”
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Controlling subcellular localization to alter function: Sending oncogenic Bcr– Abl to the nucleus causes apoptosis by Dixon, Andrew S., Kakar, Mudit, Schneider, Korbinian M.H., Constance, Jonathan E., Paullin, Blake C., Lim, Carol S.

“…Altering the subcellular localization of signal transducing proteins is a novel approach for therapeutic intervention. Mislocalization of tumor suppressors,…”
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Effectiveness of atropine in managing sialorrhea: A systematic review and meta-analysis by Yellepeddi, Venkata K, Race, Jonathan A, McFarland, Mary M, Constance, Jonathan E, Fanaeian, Elika, Murphy, Nancy A

“…To describe the efficacy of atropine in controlling salivary flow in patients with sialorrhea or drooling. We included randomized controlled studies,…”
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Xenobiotic metabolism of plant secondary compounds in juniper ( Juniperus monosperma) by specialist and generalist woodrat herbivores, genus Neotoma by Haley, Shannon L., Lamb, John G., Franklin, Michael R., Constance, Jonathan E., Denise Dearing, M.

“…Mammalian herbivores routinely consume diets laden with often-toxic xenobiotics, yet the manner in which mammalian herbivores detoxify these plant secondary…”
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“Pharm‐Ecology” of Diet Shifting: Biotransformation of Plant Secondary Compounds in Creosote (Larrea tridentata) by a Woodrat Herbivore,Neotoma lepida by Haley, Shannon L., Lamb, John G., Franklin, Michael R., Constance, Jonathan E., Dearing, M. Denise

“…Diet switching in mammalian herbivores may necessitate a change in the biotransformation enzymes used to process plant secondary compounds (PSCs). We…”
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A propensity-matched cohort study of vancomycin-associated nephrotoxicity in neonates by Constance, Jonathan E, Balch, Alfred H, Stockmann, Chris, Linakis, Matthew W, Korgenski, E Kent, Roberts, Jessica K, Ward, Robert M, Sherwin, Catherine M T, Spigarelli, Michael G

“…The incidence of nephrotoxicity among vancomycin-treated neonates has been reported to range from 2% to 20%. These widely varying estimates have led to…”
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Supportive care medications coinciding with chemotherapy among children with hematologic malignancy by Biltaji, Eman, Enioutina, Elena Y., Yellepeddi, Venkata, Rower, Joseph E., Sherwin, Catherine M. T., Ward, Robert M., Lemons, Richard S., Constance, Jonathan E.

“…Pharmacokinetic (PK) conflicts can arise between supportive care medications (SCM) and chemotherapy in children with hematologic malignancy (HM). In this…”
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Pharmacokinetics and Pharmacodynamics of Antifungals in Children and their Clinical Implications by Stockmann, Chris, Constance, Jonathan E., Roberts, Jessica K., Olson, Jared, Doby, Elizabeth H., Ampofo, Krow, Stiers, Justin, Spigarelli, Michael G., Sherwin, Catherine M. T.

“…Invasive fungal infections are a significant cause of morbidity and mortality in children. Successful management of these systemic infections requires…”
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Pharmacokinetics and Pharmacodynamics of Antibacterials, Antifungals, and Antivirals Used Most Frequently in Neonates and Infants by Roberts, Jessica K., Stockmann, Chris, Constance, Jonathan E., Stiers, Justin, Spigarelli, Michael G., Ward, Robert M., Sherwin, Catherine M. T.

“…Antimicrobials and antivirals are widely used in young infants and neonates. These patients have historically been largely excluded from clinical trials and,…”
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Herbal medicines: challenges in the modern world. Part 4. Canada and United States by Job, Kathleen M, Kiang, Tony K L, Constance, Jonathan E, Sherwin, Catherine M T, Enioutina, Elena Yu

“…Similar to other nations North American people used herbs for thousands of years to treat diseases and purify their spirits. By the middle of the 1900s,…”
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Direct Induction of Apoptosis Using an Optimal Mitochondrially Targeted p53 by Mossalam, Mohanad, Matissek, Karina J, Okal, Abood, Constance, Jonathan E, Lim, Carol S

“…Targeting the tumor suppressor p53 to the mitochondria triggers a rapid apoptotic response as efficiently as transcription-dependent p53. , p53 forms a complex…”
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Targeting malignant mitochondria with therapeutic peptides by Constance, Jonathan E, Lim, Carol S

“…The current status of peptides that target the mitochondria in the context of cancer is the focus of this review. Chemotherapy and radiotherapy used to kill…”
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Pharmacodynamic studies of voriconazole: informing the clinical management of invasive fungal infections by Job, Kathleen M, Olson, Jared, Stockmann, Chris, Constance, Jonathan E, Enioutina, Elena Y, Rower, Joseph E, Linakis, Matthew W, Balch, Alfred H, Yu, Tian, Liu, Xiaoxi, Thorell, Emily A, Sherwin, Catherine M T

“…Voriconazole is a broad-spectrum antifungal agent commonly used to treat invasive fungal infections (IFI), including aspergillosis, candidiasis, Scedosporium…”
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Renal Function Descriptors in Neonates: Which Creatinine-Based Formula Best Describes Vancomycin Clearance? by Bhongsatiern, Jiraganya, Stockmann, Chris, Yu, Tian, Constance, Jonathan E., Moorthy, Ganesh, Spigarelli, Michael G., Desai, Pankaj B., Sherwin, Catherine M. T.

“…Growth and maturational changes have been identified as significant covariates in describing variability in clearance of renally excreted drugs such as…”
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Dronabinol Prescribing and Exposure Among Children and Young Adults Diagnosed with Cancer by Rower, Joseph E, King, Amber D, Wilkins, Diana, Wilkes, Jacob, Yellepeddi, Venkata, Maese, Luke, Lemons, Richard S, Constance, Jonathan E

“…The therapeutic utility of in cancer is a topic of intense interest. Dronabinol is synthetic Δ -tetrahydrocannabinol (THC), the primary psychoactive component…”
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Unanswered Questions Regarding Optimal Pediatric Vancomycin Use by Stockmann, Chris, Sammons, Helen, Starkey, Elizabeth, Constance, Jonathan E, Sherwin, Catherine M T

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Pediatric vancomycin dosing: Trends over time and the impact of therapeutic drug monitoring by Balch, Alfred H., Constance, Jonathan E., Thorell, Emily A., Stockmann, Chris, Korgenski, Ernest K., Campbell, Sarah C., Spigarelli, Michael G., Sherwin, Catherine M.T.

“…Monitoring of vancomycin trough concentrations is recommended for pediatric patients in the product label and by several professional societies. However, among…”
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Pharmacokinetics, pharmacodynamics and pharmacogenetics associated with nonsteroidal anti-inflammatory drugs and opioids in pediatric cancer patients by Constance, Jonathan E, Campbell, Sarah C, Somani, Amit A, Yellepeddi, Venkata, Owens, Katie H, Sherwin, Catherine M T

“…Advancing appropriate and adequate analgesic pharmacotherapy in pediatric patients with cancer is an area of clinical need. Few studies have been performed to…”
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