Search Results - "Constâncio, Vera"

DNA Methylation-Based Testing in Liquid Biopsies as Detection and Prognostic Biomarkers for the Four Major Cancer Types by Constâncio, Vera, Nunes, Sandra P, Henrique, Rui, Jerónimo, Carmen

“…Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal population-based cancer screening methods remain an unmet need, since…”
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Shifting the Cancer Screening Paradigm: The Rising Potential of Blood-Based Multi-Cancer Early Detection Tests by Brito-Rocha, Tiago, Constâncio, Vera, Henrique, Rui, Jerónimo, Carmen

“…Cancer remains a leading cause of death worldwide, partly owing to late detection which entails limited and often ineffective therapeutic options. Most cancers…”
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Circulating MicroRNAs as Biomarkers for Prostate Cancer Detection and Metastasis Development Prediction by Bidarra, David, Constâncio, Vera, Barros-Silva, Daniela, Ramalho-Carvalho, João, Moreira-Barbosa, Catarina, Antunes, Luís, Maurício, Joaquina, Oliveira, Jorge, Henrique, Rui, Jerónimo, Carmen

“…Prostate Cancer (PCa) overdiagnosis and overtreatment, as a consequence of the limited specificity of current detection and prognostication methods, remains a…”
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Circulating miR-99a-5p Expression in Plasma: A Potential Biomarker for Early Diagnosis of Breast Cancer by Garrido-Cano, Iris, Constâncio, Vera, Adam-Artigues, Anna, Lameirinhas, Ana, Simón, Soraya, Ortega, Belen, Martínez, María Teresa, Hernando, Cristina, Bermejo, Begoña, Lluch, Ana, Lopes, Paula, Henrique, Rui, Jerónimo, Carmen, Cejalvo, Juan Miguel, Eroles, Pilar

“…MicroRNAs have emerged as new diagnostic and therapeutic biomarkers for breast cancer. Herein, we analysed miR-99a-5p expression levels in primary tumours and…”
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MiRNA biomarkers in cancers of the male reproductive system: Are we approaching clinical application? by Constâncio, Vera, Tavares, Nuno Tiago, Henrique, Rui, Jerónimo, Carmen, Lobo, João

“…Background Specific cancer types face specific clinical management challenges. Owing to their stability, robustness and fast, easy and cost‐effective…”
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Improved recovery of urinary small extracellular vesicles by differential ultracentrifugation by Teixeira-Marques, Ana, Monteiro-Reis, Sara, Montezuma, Diana, Lourenço, Catarina, Oliveira, Miguel Carlos, Constâncio, Vera, Sequeira, José Pedro, Carvalho-Maia, Carina, Freitas, Rui, Martens-Uzunova, Elena S., Vasconcelos, M. Helena, Henrique, Rui, Jerónimo, Carmen

“…Extracellular vesicles (EVs) are lipid-membrane enclosed structures that are associated with several diseases, including those of genitourinary tract. Urine…”
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Urinary Extracellular Vesicles as Potential Biomarkers for Urologic Cancers: An Overview of Current Methods and Advances by Lourenço, Catarina, Constâncio, Vera, Henrique, Rui, Carvalho, Ângela, Jerónimo, Carmen

“…Urologic cancers are a heterogeneous group of tumors, some of which have poor prognosis. This is partly due to the unavailability of specific and sensitive…”
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DigiMir Test: Establishing a Novel Pipeline for MiR-371a Quantification Using Droplet Digital PCR in Liquid Biopsies From Testicular Germ Cell Tumor Patients by Sequeira, José Pedro, Lobo, João, Constâncio, Vera, Brito-Rocha, Tiago, Carvalho-Maia, Carina, Braga, Isaac, Maurício, Joaquina, Henrique, Rui, Jerónimo, Carmen

“…Testicular germ cell tumors (TGCTs) are the most common cancers in young-adult male patients aged between 15 and 39 years. Hsa-miR-371a-3p is currently the…”
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PROSTAGLANDIN E2 stimulates cancer‐related phenotypes in prostate cancer PC3 cells through cyclooxygenase‐2 by Madrigal‐Martínez, Antonio, Constâncio, Vera, Lucio‐Cazaña, Francisco J., Fernández‐Martínez, Ana B.

“…Cyclooxygenase (COX)‐derived prostaglandin E2 (PGE2) affects many mechanisms that have been shown to play roles in carcinogenesis. Recently, we found that, in…”
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Known epigenetic biomarkers for prostate cancer detection and management: exploring the potential of blood-based liquid biopsies by Constâncio, Vera, Barros-Silva, Daniela, Jerónimo, Carmen, Henrique, Rui

“…Although prostate cancer (PCa) stands as an important cause of cancer-related deaths, a sizeable proportion of diagnosed cases are clinically insignificant…”
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Early detection of the major male cancer types in blood-based liquid biopsies using a DNA methylation panel by Constâncio, Vera, Nunes, Sandra P, Moreira-Barbosa, Catarina, Freitas, Rui, Oliveira, Jorge, Pousa, Inês, Oliveira, Júlio, Soares, Marta, Dias, Carlos Gonçalves, Dias, Teresa, Antunes, Luís, Henrique, Rui, Jerónimo, Carmen

“…Lung (LC), prostate (PCa) and colorectal (CRC) cancers are the most incident in males worldwide. Despite recent advances, optimal population-based cancer…”
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Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors by Lobo, João, Constâncio, Vera, Guimarães‐Teixeira, Catarina, Leite‐Silva, Pedro, Miranda‐Gonçalves, Vera, Sequeira, José Pedro, Pistoni, Laura, Guimarães, Rita, Cantante, Mariana, Braga, Isaac, Maurício, Joaquina, Looijenga, Leendert H. J., Henrique, Rui, Jerónimo, Carmen

“…Testicular germ cell tumors (TGCTs) are the most common cancers in men aged 15–39 years and are divided into two major groups, seminomas and nonseminomas…”
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LiKidMiRs: A ddPCR-Based Panel of 4 Circulating miRNAs for Detection of Renal Cell Carcinoma by Sequeira, José Pedro, Constâncio, Vera, Salta, Sofia, Lobo, João, Barros-Silva, Daniela, Carvalho-Maia, Carina, Rodrigues, Jéssica, Braga, Isaac, Henrique, Rui, Jerónimo, Carmen

“…Decreased renal cell cancer-related mortality is an important societal goal, embodied by efforts to develop effective biomarkers enabling early detection and…”
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The Evidence Base for Circulating Tumor DNA-Methylation in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis by Maffeo, Debora, Rina, Angela, Serio, Viola Bianca, Markou, Athina, Powrózek, Tomasz, Constâncio, Vera, Nunes, Sandra P, Jerónimo, Carmen, Calvo, Alfonso, Mari, Francesca, Frullanti, Elisa, Rosati, Diletta, Palmieri, Maria

“…Background: Non-Small Cell Lung Cancer (NSCLC) remains a challenging disease to manage with effectiveness. Early detection and precise monitoring are crucial…”
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Unveiling the World of Circulating and Exosomal microRNAs in Renal Cell Carcinoma by Sequeira, José Pedro, Constâncio, Vera, Lobo, João, Henrique, Rui, Jerónimo, Carmen

“…Renal cell carcinoma is the third most common urological cancer. Despite recent advances, late diagnosis and poor prognosis of advanced-stage disease remain a…”
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Inflammatory infiltration is associated with AR expression and poor prognosis in hormone naïve prostate cancer by McAllister, Milly, Constâncio, Vera, Patek, Samantha, Gan, Hao, Bailey, Peter, Wheadon, Helen, Underwood, Mark, Leung, Hing, Edwards, Joanne

“…Background Tumor microenvironment inflammatory infiltration is proposed as a protumorigenic mechanism for prostate cancer with proinflammatory cytokines…”
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Redefining prostate cancer risk stratification: a pioneering strategy to estimate outcome based on Ki67 immunoscoring by Albuquerque-Castro, Ângela, Macedo-Silva, Catarina, Oliveira-Sousa, Rúben, Constâncio, Vera, Lobo, João, Carneiro, Isa, Henrique, Rui, Jerónimo, Carmen

“…Accurate prostate cancer (PCa) patient diagnosis and risk assessment are key to ensure the best outcome. Currently, low- and favorable intermediate-risk PCa…”
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DNA methylation biomarkers accurately detect esophageal cancer prior and post neoadjuvant chemoradiation by Macedo‐Silva, Catarina, Constâncio, Vera, Miranda‐Gonçalves, Vera, Leite‐Silva, Pedro, Salta, Sofia, Lobo, João, Guimarães, Rita, Carvalho‐Maia, Carina, Gigliano, Davide, Farinha, Mónica, Sousa, Olga, Henrique, Rui, Jerónimo, Carmen

“…Background Esophageal cancer (ECa) is associated with high mortality, mostly due to late diagnosis, precluding curativeintent surgery. Hence, neoadjuvant…”
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Comparing diagnostic and prognostic performance of two-gene promoter methylation panels in tissue biopsies and urines of prostate cancer patients by Moreira-Barbosa, Catarina, Barros-Silva, Daniela, Costa-Pinheiro, Pedro, Torres-Ferreira, Jorge, Constâncio, Vera, Freitas, Rui, Oliveira, Jorge, Antunes, Luís, Henrique, Rui, Jerónimo, Carmen

“…Prostate cancer (PCa) is one of the most common cancers among men worldwide. Current screening methods for PCa display limited sensitivity and specificity, not…”
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Identification of a Two-MicroRNA Signature in Plasma as a Novel Biomarker for Very Early Diagnosis of Breast Cancer by Adam-Artigues, Anna, Garrido-Cano, Iris, Carbonell-Asins, Juan Antonio, Lameirinhas, Ana, Simón, Soraya, Ortega-Morillo, Belén, Martínez, María Teresa, Hernando, Cristina, Constâncio, Vera, Burgues, Octavio, Bermejo, Begoña, Henrique, Rui, Lluch, Ana, Jerónimo, Carmen, Eroles, Pilar, Cejalvo, Juan Miguel

“…The early diagnosis of breast cancer is essential to improve patients’ survival rate. In this context, microRNAs have been described as potential diagnostic…”
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