Search Results - "Consolin Chelucci, Rafael"

Structure‐Metabolism Relationships of Benzimidazole Derivatives with anti‐Trypanosoma cruzi Activity for Chagas Disease by Espinoza‐Chávez, Rocío Marisol, Oliveira Rezende Júnior, Celso, Laureano de Souza, Mariana, Consolin Chelucci, Rafael, Michelan‐Duarte, Simone, Krogh, Renata, Gomes Ferreira, Leonardo Luiz, Valli, Marilia, Sena de Oliveira, Aldo, Andricopulo, Adriano D., Carlos Dias, Luiz

“…This study introduces further insights from the hit‐to‐lead optimization process involving a series of benzimidazole derivatives acting as inhibitors of the…”
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Identification of natural cytochalasins as leads for neglected tropical diseases drug discovery by Valli, Marilia, Souza, Julia Medeiros, Chelucci, Rafael Consolin, Biasetto, Carolina Rabal, Araujo, Angela Regina, Bolzani, Vanderlan da Silva, Andricopulo, Adriano Defini

“…Investigating the chemical diversity of natural products from tropical environments is an inspiring approach to developing new drug candidates for neglected…”
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Discovery of Arylpiperazines with Broad-Spectrum Antimicrobial Activity and Favorable Pharmacokinetic Profiles by Oliveira, Douglas Davison da Silva, Silva, Nagela Bernadelli Sousa, Lapierre, Thibault Joseph William Jacques Dit, de Souza, Sara Lemes, Brito, Nícolas Peterson Ferreira, Martinho, Ana Clara Cassiano, Clemente Dias, Renieidy Flávia, Farago, Danilo Nascimento, Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Cruz, Mariza Gabriela Faleiro de Moura Lodi, de Melo Resende, Daniela, Andricopulo, Adriano D, Murta, Silvane Maria Fonseca, Ferreira, Leonardo L G, Gomes Martins, Carlos Henrique, de Oliveira Rezende Júnior, Celso

“…Microorganisms can induce diseases with significant clinical implications for human health. Multidrug-resistant microorganisms have been on the rise worldwide…”
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2-aminobenzimidazoles for leishmaniasis: From initial hit discovery to in vivo profiling by Ferreira, Rafael Augusto Alves, Junior, Celso de Oliveira Rezende, Martinez, Pablo David Grigol, Koovits, Paul John, Soares, Bruna Miranda, Ferreira, Leonardo L G, Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Andricopulo, Adriano D, Galuppo, Mariana K, Uliana, Silvia R B, Matheeussen, An, Caljon, Guy, Maes, Louis, Campbell, Simon, Kratz, Jadel M, Mowbray, Charles E, Dias, Luiz Carlos

“…Leishmaniasis is a major infectious disease with hundreds of thousands of new cases and over 20,000 deaths each year. The current drugs to treat this…”
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Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds to Treat Sickle Cell Disease Symptoms. Part II: Furoxan Derivatives by Dos Santos, Jean Leandro, Lanaro, Carolina, Chelucci, Rafael Consolin, Gambero, Sheley, Bosquesi, Priscila Longhin, Reis, Juliana Santana, Lima, Lídia Moreira, Cerecetto, Hugo, González, Mercedes, Costa, Fernando Ferreira, Chung, Man Chin

“…Phthalimide derivatives containing furoxanyl subunits as nitric oxide (NO)-donors (3a–g) were designed, synthesized, and evaluated in vitro and in vivo for…”
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Antiplatelet and antithrombotic activities of non-steroidal anti-inflammatory drugs containing an N-acyl hydrazone subunit by Chelucci, Rafael Consolin, Dutra, Luiz Antônio, Lopes Pires, Maria Elisa, de Melo, Thais Regina Ferreira, Bosquesi, Priscila Longhin, Chung, Man Chin, Dos Santos, Jean Leandro

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) 1-5 containing an N-acyl hydrazone subunit were prepared and their antiplatelet and antithrombotic activities…”
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Pharmacological evaluation and preparation of nonsteroidal anti-inflammatory drugs containing an N-acyl hydrazone subunit by de Melo, Thais Regina Ferreira, Chelucci, Rafael Consolin, Pires, Maria Elisa Lopes, Dutra, Luiz Antonio, Barbieri, Karina Pereira, Bosquesi, Priscila Longhin, Trossini, Gustavo Henrique Goulart, Chung, Man Chin, dos Santos, Jean Leandro

“…A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a-e) were synthesized and characterized. Docking studies were performed that…”
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Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect by Santos, Jean Leandro Dos, Moreira, Vanessa, Campos, Michel Leandro, Chelucci, Rafael Consolin, Barbieri, Karina Pereira, de Castro Souto, Pollyana Cristina Maggio, Matsubara, Márcio Hideki, Teixeira, Catarina, Bosquesi, Priscila Longhin, Peccinini, Rosângela Gonçalves, Chin, Chung Man

“…Long-term nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been associated with several adverse effects such as gastric ulceration and cardiovascular…”
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Current advances in drug discovery for Chagas disease by Scarim, Cauê Benito, Jornada, Daniela Hartmann, Chelucci, Rafael Consolin, de Almeida, Leticia, dos Santos, Jean Leandro, Chung, Man Chin

“…Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected tropical diseases (NTDs) according to World Health Organization. It is…”
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Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease by de Oliveira Rezende Júnior, Celso, Martinez, Pablo David Grigol, Ferreira, Rafael Augusto Alves, Koovits, Paul John, Miranda Soares, Bruna, Ferreira, Leonardo L.G., Michelan-Duarte, Simone, Chelucci, Rafael Consolin, Andricopulo, Adriano D., Matheeussen, An, Van Pelt, Natascha, Caljon, Guy, Maes, Louis, Campbell, Simon, Kratz, Jadel M., Mowbray, Charles E., Dias, Luiz Carlos

“…Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi. Because current treatments present several limitations, including long duration,…”
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Structure-activity relationships of novel N -imidazoylpiperazines with potent anti- Trypanosoma cruzi activity by Espinoza-Chávez, Rocío Marisol, Oliveira Rezende Júnior, Celso de, de Souza, Mariana Laureano, Pauli, Ivani, Valli, Marilia, Gomes Ferreira, Leonardo Luiz, Chelucci, Rafael Consolin, Michelan-Duarte, Simone, Krogh, Renata, Romualdo da Silva, Fernando Bezerra, Cruz, Fábio Cardoso, de Oliveira, Aldo Sena, Andricopulo, Adriano Defini, Dias, Luiz Carlos

“…Chagas disease is caused by the parasite , and the lack of effective and safe treatments makes identifying new classes of compounds with anti- activity of…”
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Synthesis and evaluation of resveratrol derivatives as fetal hemoglobin inducers by Bosquesi, Priscila Longhin, Melchior, Aylime Castanho Bolognesi, Pavan, Aline Renata, Lanaro, Carolina, de Souza, Cristiane Maria, Rusinova, Radda, Chelucci, Rafael Consolin, Barbieri, Karina Pereira, Fernandes, Guilherme Felipe dos Santos, Carlos, Iracilda Zepone, Andersen, Olaf Sparre, Costa, Fernando Ferreira, Dos Santos, Jean Leandro

“…[Display omitted] •New resveratrol derivatives (10a-i) with NO-donor properties.•All compounds exhibited in vivo analgesic effect.•All compounds did not induce…”
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Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by histone acetylation by Melo, Thais Regina Ferreira de, Kumkhaek, Chutima, Fernandes, Guilherme Felipe dos Santos, Lopes Pires, Maria Elisa, Chelucci, Rafael Consolin, Barbieri, Karina Pereira, Coelho, Fernanda, Capote, Ticiana Sidorenko de Oliveira, Lanaro, Carolina, Carlos, Iracilda Zeppone, Marcondes, Sisi, Chegaev, Konstantin, Guglielmo, Stefano, Fruttero, Roberta, Chung, Man Chin, Costa, Fernando Ferreira, Rodgers, Griffin P., dos Santos, Jean Leandro

“…N-oxide derivatives 5(a–b), 8(a–b), and 11(a–c) were designed, synthesized and evaluated in vitro and in vivo as potential drugs that are able to ameliorate…”
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Identification of natural cytochalasins as leads for neglected tropical diseases drug discovery by Marilia Valli, Julia Medeiros Souza, Rafael Consolin Chelucci, Carolina Rabal Biasetto, Angela Regina Araujo, Vanderlan da Silva Bolzani, Adriano Defini Andricopulo

“…Investigating the chemical diversity of natural products from tropical environments is an inspiring approach to developing new drug candidates for neglected…”
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Synthesis and evaluation of novel dapsone–thalidomide hybrids for the treatment of type 2 leprosy reactions by Yamasaki, Paulo Renato, do Nascimento, Dejair Caetano, Chelucci, Rafael Consolin, de Faria Fernandes Belone, Andréa, Rosa, Patrícia Sammarco, Diório, Suzana Madeira, de Melo, Thais Regina Ferreira, Barbieri, Karina Pereira, Placeres, Marisa Campos Polési, Carlos, Iracilda Zepone, Chung, Man Chin, dos Santos, Jean Leandro

“…[Display omitted] We synthesized a series of novel dapsone–thalidomide hybrids (3a–i) by molecular hybridization and evaluated their potential for the…”
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