Search Results - "Conroy, Melissa J"

Real-time ex vivo monitoring of NK cell migration toward obesity-associated oesophageal adenocarcinoma following modulation of CX3CR1 by Mylod, Eimear, O’Connell, Fiona, Donlon, Noel E., Davern, Maria, Marion, Caroline, Butler, Christine, Reynolds, John V., Lysaght, Joanne, Conroy, Melissa J.

“…Oesophagogastric adenocarcinomas (OAC) are poor prognosis, obesity-associated cancers which may benefit from natural killer (NK) cell-based immunotherapies…”
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Harnessing Natural Killer Cells in Non-Small Cell Lung Cancer by Russell, Éilis, Conroy, Melissa J, Barr, Martin P

“…Lung cancer is the leading cause of cancer-related deaths worldwide. There are two main subtypes: small cell lung cancer (SCLC), and non-small cell lung cancer…”
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Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma by Melo, Ashanty M, O'Brien, Aisling M, Phelan, James J, Kennedy, Susan A, Wood, Nicole A W, Veerapen, Natacha, Besra, Gurdyal S, Clarke, Niamh E, Foley, Emma K, Ravi, Akshaya, MacCarthy, Finbar, O'Toole, Dermot, Ravi, Narayamasami, Reynolds, John V, Conroy, Melissa J, Hogan, Andrew E, O'Sullivan, Jacintha, Dunne, Margaret R

“…Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated…”
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Visceral adipose tissue secretome from early and late-stage oesophageal cancer patients differentially affects effector and regulatory T cells by Davern, Maria, Bracken-Clarke, Dara, Donlon, Noel E., Sheppard, Andrew D., Connell, Fiona O’, Heeran, Aisling B., Majcher, Klaudia, Conroy, Melissa J., Mylod, Eimear, Butler, Christine, Donohoe, Claire, Donnell, Dearbhaile O’, Lowery, Maeve, Bhardwaj, Anshul, Ravi, Narayanasamy, Melo, Ashanty A., Sullivan, Jacintha O’, Reynolds, John V., Lysaght, Joanne

“…Aim Visceral obesity is a key risk factor in the development of oesophagogastric junctional adenocarcinoma (OGJ), predominantly via generation of systemic low…”
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Identifying a Novel Role for Fractalkine (CX3CL1) in Memory CD8 + T Cell Accumulation in the Omentum of Obesity-Associated Cancer Patients by Conroy, Melissa J, Maher, Stephen G, Melo, Ashanty M, Doyle, Suzanne L, Foley, Emma, Reynolds, John V, Long, Aideen, Lysaght, Joanne

“…The omentum is enriched with pro-inflammatory effector memory CD8 T cells in patients with the obesity-associated malignancy, esophagogastric adenocarcinoma…”
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The Impact of Esophageal Oncological Surgery on Perioperative Immune Function; Implications for Adjuvant Immune Checkpoint Inhibition by Donlon, Noel E, Davern, Maria, Sheppard, Andrew D, O'Connell, Fiona, Dunne, Margaret R, Hayes, Conall, Mylod, Eimear, Ramjit, Sinead, Temperley, Hugo, Mac Lean, Michael, Cotter, Gillian, Bhardwaj, Anshul, Butler, Christine, Conroy, Melissa J, O'Sullivan, Jacintha, Ravi, Narayanasamy, Donohoe, Claire L, Reynolds, John V, Lysaght, Joanne

“…Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The…”
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Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses by Moran, Jennifer, Mylod, Eimear, Kane, Laura E, Marion, Caroline, Keenan, Emily, Mekhaeil, Marianna, Lysaght, Joanne, Dev, Kumlesh K, O'Sullivan, Jacintha, Conroy, Melissa J

“…Glioblastoma multiforme (GBM) is the most common adult primary brain malignancy, with dismal survival rates of ~14.6 months. The current standard-of-care…”
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Cooperation between chemotherapy and immune checkpoint blockade to enhance anti-tumour T cell immunity in oesophageal adenocarcinoma by Davern, Maria, Donlon, Noel E., O’ Connell, Fiona, Sheppard, Andrew D., Hayes, Conall, King, Ross, Temperley, Hugo, Butler, Christine, Bhardwaj, Anshul, Moore, Jenny, Bracken-Clarke, Dara, Donohoe, Claire, Ravi, Narayanasamy, Reynolds, John V., Maher, Stephen G., Conroy, Melissa J., Lysaght, Joanne

“…•Immune checkpoints correlate with higher grade tumours and poor treatment response.•First-line chemotherapies stimulate anti-tumour T cell immunity.•Dual…”
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Natural killer cell therapy: A new frontier for obesity-associated cancer by Mylod, Eimear, Lysaght, Joanne, Conroy, Melissa J.

“…Natural killer (NK) cell infiltration of solid tumours is associated with better outcomes, placing augmentation of NK cell abundance in tumours as an…”
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Analysing the Combined Effects of Radiotherapy and Chemokine Receptor 5 Antagonism: Complementary Approaches to Promote T Cell Function and Migration in Oesophageal Adenocarcinoma by Davern, Maria, O' Donovan, Cillian, Donlon, Noel E, Mylod, Eimear, Gaughan, Caoimhe, Bhardwaj, Anshul, Sheppard, Andrew D, Bracken-Clarke, Dara, Butler, Christine, Ravi, Narayanasamy, Donohoe, Claire L, Reynolds, John V, Lysaght, Joanne, Conroy, Melissa J

“…The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment…”
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The multifactorial effect of obesity on the effectiveness and outcomes of cancer therapies by Lysaght, Joanne, Conroy, Melissa J.

“…Epidemiology studies have demonstrated a clear association between obesity and the development of several distinct malignancies, with excessive visceral…”
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Examination and characterisation of the effect of amitriptyline therapy for chronic neuropathic pain on neuropeptide and proteomic constituents of human cerebrospinal fluid by Royds, Jonathan, Cassidy, Hilary, Conroy, Melissa J., Dunne, Margaret R., Lysaght, Joanne, McCrory, Connail

“…Amitriptyline is prescribed to reduce the intensity of chronic neuropathic pain. There is a paucity of validated in vivo evidence in humans regarding…”
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Measuring Immune Cell Movement Toward the Soluble Microenvironment of Human Tissues Using a Boyden Chamber-Based Migration Assay by Mylod, Eimear, Lysaght, Joanne, Conroy, Melissa J

“…Migration assays are used to measure cell movement toward a variety of chemoattractants in a controlled environment. Here we describe a method for a Boyden…”
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CX3CL1 Signaling in the Tumor Microenvironment by Conroy, Melissa J, Lysaght, Joanne

“…CX3CL1 (Fractalkine) is a multifunctional inflammatory chemokine with a single receptor CX3CR1. The biological effects elicited by CX3CL1 on surrounding cells…”
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Characterisation of the effects of pulsed radio frequency treatment of the dorsal root ganglion on cerebrospinal fluid cellular and peptide constituents in patients with chronic radicular pain: A randomised, triple-blinded, controlled trial by Moore, David, Galvin, Deborah, Conroy, Melissa J., Das, Basabjit, Dunne, Margaret, Lysaght, Joanne, McCrory, Connail

“…Chronic radicular neuropathic pain is a major clinical problem with a life time prevalence of more than 50%. Pulsed radiofrequency (PRF) treatment is a…”
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Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study by Royds, Jonathan, Conroy, Melissa J., Dunne, Margaret R., Cassidy, Hilary, Matallanas, David, Lysaght, Joanne, McCrory, Connail

“…Patients with neuropathic pain have altered proteomic and neuropeptide constituents in cerebrospinal fluid (CSF) compared to controls. Tonic spinal cord…”
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Chemokine-targeted therapies: An opportunity to remodel immune profiles in gastro-oesophageal tumours by O’Donovan, Cillian, Davern, Maria, Donlon, Noel E., Lysaght, Joanne, Conroy, Melissa J.

“…Immunotherapies are transforming outcomes for many cancer patients and are quickly becoming the fourth pillar of cancer therapy. However, their efficacy of…”
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An investigation into the modulation of T cell phenotypes by amitriptyline and nortriptyline by Royds, Jonathan, Conroy, Melissa J., Dunne, Margaret R., McCrory, Connail, Lysaght, Joanne

“…Amitriptyline is prescribed for treating the symptoms of neuroinflammatory disorders including neuropathic pain and fibromyalgia. As amitriptyline has evidence…”
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Fractalkine Elicits Chemotactic, Phenotypic, and Functional Effects on CX3CR1+CD27− NK Cells in Obesity-Associated Cancer by Mylod, Eimear, Melo, Ashanty M., Donlon, Noel E., Davern, Maria, Bhardwaj, Anshul, Reynolds, John V., Lysaght, Joanne, Conroy, Melissa J.

“…Esophagogastric adenocarcinomas (EAC) are obesity-associated malignancies underpinned by severe immune dysregulation and inflammation. Our previous work…”
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A study of the immune infiltrate and patient outcomes in esophageal cancer by Conroy, Melissa J, Kennedy, Susan A, Doyle, Suzanne L, Hayes, Brian, Kavanagh, Maria, van der Stok, Eric P, O'Sullivan, Katie, Cathcart, Mary-Clare, Reynolds, John V, Lysaght, Joanne

“…Cancer patient outcomes and selection for novel therapies are heavily influenced by the immune contexture of the tumor microenvironment. Esophageal cancer is…”
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