Search Results - "Conroy, Andrea L."

Acute kidney injury is associated with impaired cognition and chronic kidney disease in a prospective cohort of children with severe malaria by Conroy, Andrea L, Opoka, Robert O, Bangirana, Paul, Idro, Richard, Ssenkusu, John M, Datta, Dibyadyuti, Hodges, James S, Morgan, Catherine, John, Chandy C

“…Acute kidney injury (AKI) is a recognized complication of pediatric severe malaria, but its long-term consequences are unknown. Ugandan children with cerebral…”
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What causes severe malaria and its complications in children? Lessons learned over the past 15 years by Conroy, Andrea L, Datta, Dibyadyuti, John, Chandy C

“…Over the past 15 years, malaria mortality has reduced by approximately 50%. However, malaria still causes more than 400,000 deaths annually, most of which…”
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Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection by Leligdowicz, Aleksandra, Conroy, Andrea L, Hawkes, Michael, Zhong, Kathleen, Lebovic, Gerald, Matthay, Michael A, Kain, Kevin C

“…Biomarkers can prognosticate outcome and enable risk-stratification. In severe infection, focusing on multiple markers reflecting pathophysiological mechanisms…”
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Risk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test by Leligdowicz, Aleksandra, Conroy, Andrea L., Hawkes, Michael, Richard-Greenblatt, Melissa, Zhong, Kathleen, Opoka, Robert O., Namasopo, Sophie, Bell, David, Liles, W. Conrad, da Costa, Bruno R., Jüni, Peter, Kain, Kevin C.

“…Identifying febrile children at risk of sepsis in low-resource settings can improve survival, but recognition triage tools are lacking. Here we test the…”
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Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study by Elphinstone, Robyn E, Weckman, Andrea M, McDonald, Chloe R, Tran, Vanessa, Zhong, Kathleen, Madanitsa, Mwayiwawo, Kalilani-Phiri, Linda, Khairallah, Carole, Taylor, Steve M, Meshnick, Steven R, Mwapasa, Victor, Ter Kuile, Feiko O, Conroy, Andrea L, Kain, Kevin C

“…Malaria in pregnancy is associated with adverse birth outcomes. However, the underlying mechanisms remain poorly understood. Tight regulation of angiogenic,…”
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Acute kidney injury in Ugandan children with severe malaria is associated with long-term behavioral problems by Hickson, Meredith R, Conroy, Andrea L, Bangirana, Paul, Opoka, Robert O, Idro, Richard, Ssenkusu, John M, John, Chandy C

“…Acute kidney injury (AKI) is a risk factor for neurocognitive impairment in severe malaria (SM), but the impact of AKI on long-term behavioral outcomes…”
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Xanthine oxidase levels and immune dysregulation are independently associated with anemia in Plasmodium falciparum malaria by Vasquez, Marilyn, Sica, Margaux, Namazzi, Ruth, Opoka, Robert O., Sherman, Julian, Datta, Dibyadyuti, Duran-Frigola, Miquel, Ssenkusu, John M., John, Chandy C., Conroy, Andrea L., Rodriguez, Ana

“…Severe anemia is an important contributor to mortality in children with severe malaria. Anemia in malaria is a multi-factorial complication, since…”
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Complement Activation and the Resulting Placental Vascular Insufficiency Drives Fetal Growth Restriction Associated with Placental Malaria by Conroy, Andrea L., Silver, Karlee L., Zhong, Kathleen, Rennie, Monique, Ward, Peter, Sarma, J. Vidya, Molyneux, Malcolm E., Sled, John, Fletcher, Joseph F., Rogerson, Stephen, Kain, Kevin C.

“…Placental malaria (PM) is a major cause of fetal growth restriction, yet the underlying mechanism is unclear. Complement C5a and C5a receptor levels are…”
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Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis by Ricciuto, Daniel R, dos Santos, Claudia C, Hawkes, Michael, Toltl, Lisa J, Conroy, Andrea L, Rajwans, Nimerta, Lafferty, Erin I, Cook, Deborah J, Fox-Robichaud, Alison, Kahnamoui, Kamyar, Kain, Kevin C, Liaw, Patricia C, Liles, W. Conrad

“…OBJECTIVE:To determine the utility of angiopoietin-1 and angiopoietin-2 as potentially novel biomarkers of morbidity and mortality in patients with severe…”
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Immune and endothelial activation markers and risk stratification of childhood pneumonia in Uganda: A secondary analysis of a prospective cohort study by McDonald, Chloe R, Leligdowicz, Aleksandra, Conroy, Andrea L, Weckman, Andrea M, Richard-Greenblatt, Melissa, Ngai, Michelle, Erice, Clara, Zhong, Kathleen, Namasopo, Sophie, Opoka, Robert O, Hawkes, Michael T, Kain, Kevin C

“…Background Despite the global burden of pneumonia, reliable triage tools to identify children in low-resource settings at risk of severe and fatal respiratory…”
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Intestinal Injury Biomarkers Predict Mortality in Pediatric Severe Malaria by Sarangam, Maithri L, Namazzi, Ruth, Datta, Dibyadyuti, Bond, Caitlin, Vanderpool, Charles P B, Opoka, Robert O, John, Chandy C, Conroy, Andrea L

“…Severe malaria (SM) increases the risk of invasive bacterial infection, and there is evidence to suggest increased gastrointestinal permeability. Studies have…”
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Cerebrospinal fluid biomarkers provide evidence for kidney-brain axis involvement in cerebral malaria pathogenesis by Conroy, Andrea L, Datta, Dibyadyuti, Opoka, Robert O, Batte, Anthony, Bangirana, Paul, Gopinadhan, Adnan, Mellencamp, Kagan A, Akcan-Arikan, Ayse, Idro, Richard, John, Chandy C

“…Cerebral malaria is one of the most severe manifestations of malaria and is a leading cause of acquired neurodisability in African children. Recent studies…”
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Neurocognitive outcomes in Malawian children exposed to malaria during pregnancy: An observational birth cohort study by Weckman, Andrea M, Conroy, Andrea L, Madanitsa, Mwayiwawo, Gnaneswaran, Bruno, McDonald, Chloe R, Kalilani-Phiri, Linda, Chandna, Jaya, Ali, Doreen, Mwapasa, Victor, Khairallah, Carole, Thwai, Kyaw Lay, Meshnick, Steven R, Taylor, Steve M, Ter Kuile, Feiko O, Kain, Kevin C, Gladstone, Melissa

“…Annually 125 million pregnancies are at risk of malaria infection. However, the impact of exposure to malaria in pregnancy on neurodevelopment in children is…”
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Sex as a determinant of disease severity and clinical outcome in febrile children under five presenting to a regional referral hospital in Uganda by McDonald, Chloe R, Weckman, Andrea M, Richardson, Emma, Hawkes, Michael T, Leligdowicz, Aleksandra, Namasopo, Sophie, Opoka, Robert O, Conroy, Andrea L, Kain, Kevin C

“…Sex and gender are well-established determinants of health in adult and adolescent populations in low resource settings. There are limited data on sex as a…”
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miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria by Barker, Kevin Richard, Lu, Ziyue, Kim, Hani, Zheng, Ying, Chen, Junmei, Conroy, Andrea L, Hawkes, Michael, Cheng, Henry S, Njock, Makon-Sébastien, Fish, Jason E, Harlan, John M, López, Jose A, Liles, W Conrad, Kain, Kevin C

“…miR-155 has been shown to participate in host response to infection and neuro-inflammation via negative regulation of blood-brain-barrier (BBB) integrity and T…”
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Editorial: Models to study malaria parasite-host interactions and pathogenesis by Bernabeu, Maria, Conroy, Andrea L., Craig, Alister G., Renia, Laurent

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Blackwater fever and acute kidney injury in children hospitalized with an acute febrile illness: pathophysiology and prognostic significance by Conroy, Andrea L, Hawkes, Michael T, Leligdowicz, Aleksandra, Mufumba, Ivan, Starr, Michelle C, Zhong, Kathleen, Namasopo, Sophie, John, Chandy C, Opoka, Robert O, Kain, Kevin C

“…Abstract Background Acute kidney injury (AKI) and blackwater fever (BWF) are related but distinct renal complications of acute febrile illness in East Africa…”
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Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013 by Hawkes, Michael, Conroy, Andrea L, Opoka, Robert O, Namasopo, Sophie, Zhong, Kathleen, Liles, W Conrad, John, Chandy C, Kain, Kevin C

“…Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had…”
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Parenteral artemisinins are associated with reduced mortality and neurologic deficits and improved long-term behavioral outcomes in children with severe malaria by Conroy, Andrea L, Opoka, Robert O, Bangirana, Paul, Namazzi, Ruth, Okullo, Allen E, Georgieff, Michael K, Cusick, Sarah, Idro, Richard, Ssenkusu, John M, John, Chandy C

“…In 2011, the World Health Organization recommended injectable artesunate as the first-line therapy for severe malaria (SM) due to its superiority in reducing…”
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Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study by Conroy, Andrea L, Phiri, Happy, Hawkes, Michael, Glover, Simon, Mallewa, Mac, Seydel, Karl B, Taylor, Terrie E, Molyneux, Malcolm E, Kain, Kevin C

“…Differentiating cerebral malaria (CM) from other causes of serious illness in African children is problematic, owing to the non-specific nature of the clinical…”
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