Search Results - "Conrey, Peyton"

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 by Vella, Laura A, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Diorio, Caroline, Kuri-Cervantes, Leticia, Alanio, Cécile, Pampena, M Betina, Wu, Jennifer E, Chen, Zeyu, Huang, Yinghui Jane, Anderson, Elizabeth M, Gouma, Sigrid, McNerney, Kevin O, Chase, Julie, Burudpakdee, Chakkapong, Lee, Jessica H, Apostolidis, Sokratis A, Huang, Alexander C, Mathew, Divij, Kuthuru, Oliva, Goodwin, Eileen C, Weirick, Madison E, Bolton, Marcus J, Arevalo, Claudia P, Ramos, Andre, Jasen, C J, Conrey, Peyton E, Sayed, Samir, Giannini, Heather M, D'Andrea, Kurt, Meyer, Nuala J, Behrens, Edward M, Bassiri, Hamid, Hensley, Scott E, Henrickson, Sarah E, Teachey, David T, Betts, Michael R, Wherry, E John

“…Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children,…”
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IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation by Conrey, Peyton E, Denu, Lidiya, O'Boyle, Kaitlin C, Rozich, Isaiah, Green, Jamal, Maslanka, Jeffrey, Lubin, Jean-Bernard, Duranova, Tereza, Haltzman, Brittany L, Gianchetti, Lauren, Oldridge, Derek A, De Luna, Nina, Vella, Laura A, Allman, David, Spergel, Jonathan M, Tanes, Ceylan, Bittinger, Kyle, Henrickson, Sarah E, Silverman, Michael A

“…The ability of most patients with selective immunoglobulin A (IgA) deficiency (SIgAD) to remain apparently healthy has been a persistent clinical conundrum…”
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Activated PI3 kinase delta syndrome alters CD4 and CD8 T cell activation and is only partially corrected by targeted therapy by Conrey, Peyton, Sayed, Samir, Espinoza, Diego, Rao, V. Koneti, Henrickson, Sarah

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Interrogating mechanisms of CD8 T cell dysfunction in obese asthma by Hay, Ceire, Sayed, Samir, Conrey, Peyton, Campos, Jose, Pastore, Christopher F., Sengupta, Shaon, Herbert, De'Broski, Henrickson, Sarah E.

“…Abstract Pediatric obese atopic asthma (OA) is a complex and poorly understood disease at the intersection of two of the most common chronic inflammatory…”
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Amplified STAT3 increases expression of the CD39 ectoenzyme and impairs function of CD8+ T cells by Campos Duran, Jose, Sayed, Samir, Knight, Montana, Dalalo, Megan, Conrey, Peyton, Hay, Ceire, Schmitt, Erica, Thelin, Martin, Mauracher, Andrea, Forbes, Lisa, Holland, Steven, Bergerson, Jenna, Su, Helen, Romberg, Neil, Freeman, Alexandra, Leiding, Jennifer, Anderson, Mark

“…Abstract Regulation of T cell signaling is paramount to mount an appropriate immune response and protect the host from pathophysiology. Here, we study the…”
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Alterations in STAT Signaling Dysregulate CD8 T Cell Activation by Campos, Jose, Conrey, Peyton, Sayed, Samir, Vogel, Tiphanie, Leiding, Jennifer, Satter, Lisa Forbes, Holland, Steven, Freeman, Alexandra

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IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulation by Silverman, Michael A, Conrey, Peyton E., Denu, Lidiya, O’Boyle, Kaitlin C, Tanes, Ceylan, Green, Jamal, Bittinger, Kyle, Allman, David, Lubin, Jean-Bernard, Duranova, Tereza, Oldridge, Derek, Henrickson, Sarah

“…Abstract Mammals produce large quantities of mucosal and systemic antibodies that maintain the intestinal barrier, shape the intestinal microbiome and promote…”
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Primary Immune Regulatory Disorders (PIRDs) That Amplify mTOR Signaling Share a T Cell Exhaustion-like Process by Conrey, Peyton E, Campos, Jose, Mauracher, Andrea, Sayed, Samir, Walter, Jolan E., Su, Helen, Barmettler, Sara, Leiding, Jennifer W, Cooper, Megan, MacFarland, Suzanne P, Ruffner, Melanie A, Farmer, Jocelyn R, Rao, V. Koneti, Henrickson, Sarah E

“…Background: Primary Immune Regulatory Disorders (PIRDs) are a complex and challenging-to-treat subset of Inborn Errors of Immunity (IEI), which are…”
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Elevated CD38 expression on STAT1 GOF CD8+T cells – a potential driver of CD8+ T cell dysregulation? by Mauracher, Andrea, Conrey, Peyton, Sayed, Samir, Bergerson, Jenna, Vanderver, Adeline, Leiding, Jennifer, Satter, Lisa Forbes, Holland, Steven, Freeman, Alexandra, Henrickson, Sarah

“…STAT1 has a central role in relaying signals from type I, II and III interferons (IFN), thus contributing to the antiviral immune response. Working in tandem,…”
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Selective IgA deficiency alters systemic immune response to commensal gut microbiome by Conrey, Peyton, Denu, Lidiya, O, Kaitlin, Lubin, Jean-Bernard, Duranova, Tereza, Vella, Laura, Wherry, E. John, Spergel, Jonathan, Silverman, Michael

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Dysregulation of CD8+ T cell function in the setting of altered cytokine signaling due to inborn errors of immunity by Campos Duran, Jose S., Conrey, Peyton E., Sayed, Samir, Di, Chao, Gonzalez, Elena N., Romberg, Neil D., Bergerson, Jenna R.E., Holland, Steve M., Freeman, Alexandra F., Su, Helen C., Leiding, Jennifer W., Forbes, Lisa R., Vogel, Tiphanie P., Henrickson, Sarah E.

“…Abstract A key outcome of chronic antigenic stimulation in the setting of sustained inflammation is the development of CD8+ T cell exhaustion. However, the…”
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Amplified STAT3 signaling alters expression of CD39 in STAT3 gain-of-function (STAT3 GOF) and in healthy donor CD8 +T cells by Campos Duran, Jose S., Sayed, Samir, Conrey, Peyton E., Hay, Ceire A., Dalalo, Megan C., Schmitt, Erica G., Mauracher, Andrea A., Romberg, Neil D., Holland, Steven M., Freeman, Alexandra F., Bergerson, Jenna R.E., Su, Helen C., Leiding, Jennifer W., Forbes, Lisa R., Cooper, Megan A., Vogel, Tiphanie P., Henrickson, Sarah E.

“…Abstract It is still unknown whether primary immune regulatory disorders (PIRD) due to genetic variants that amplify T cell receptor and/or inflammatory…”
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IgA deficiency Alters Systemic Immune Response to Commensal Gut Microbes by Conrey, Peyton, O'Boyle, Kaitlin, Denu, Lidiya, Lubin, Jean-Bernard, Duranova, Tereza, Gianchetti, Lauren, Haltzman, Brittany, Vella, Laura, Spergel, Jonathan, Wherry, E. John, Henrickson, Sarah, Silverman, Michael

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The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants by Materna, Marie, Delmonte, Ottavia M, Bosticardo, Marita, Momenilandi, Mana, Conrey, Peyton E, Charmeteau-De Muylder, Bénédicte, Bravetti, Clotilde, Bellworthy, Rebecca, Cederholm, Axel, Staels, Frederik, Ganoza, Christian A, Darko, Samuel, Sayed, Samir, Le Floc'h, Corentin, Ogishi, Masato, Rinchai, Darawan, Guenoun, Andrea, Bolze, Alexandre, Khan, Taushif, Gervais, Adrian, Krüger, Renate, Völler, Mirjam, Palterer, Boaz, Sadeghi-Shabestari, Mahnaz, Langlois de Septenville, Anne, Schramm, Chaim A, Shah, Sanjana, Tello-Cajiao, John J, Pala, Francesca, Amini, Kayla, Campos, Jose S, Lima, Noemia Santana, Eriksson, Daniel, Lévy, Romain, Seeleuthner, Yoann, Jyonouchi, Soma, Ata, Manar, Al Ali, Fatima, Stittrich, Anna, Deswarte, Caroline, Pereira, Anaïs, Mégret, Jérôme, Le Voyer, Tom, Bastard, Paul, Berteloot, Laureline, Dussiot, Michaël, Vladikine, Natasha, Cardenas, Paula P, Jouanguy, Emmanuelle, Alqahtani, Mashael, Hasan, Amal, Thanaraj, Thangavel Alphonse, Rosain, Jérémie, Al Qureshah, Fahd, Sabato, Vito, Alyanakian, Marie Alexandra, Leruez-Ville, Marianne, Rozenberg, Flore, Haddad, Elie, Regueiro, Jose R, Toribio, Maria L, Kelsen, Judith R, Salehi, Mansoor, Nasiri, Shahram, Torabizadeh, Mehdi, Rokni-Zadeh, Hassan, Changi-Ashtiani, Majid, Vatandoost, Nasimeh, Moravej, Hossein, Akrami, Seyed Mohammad, Mazloomrezaei, Mohsen, Cobat, Aurélie, Meyts, Isabelle, Toyofuku, Etsushi, Nishimura, Madoka, Moriya, Kunihiko, Mizukami, Tomoyuki, Imai, Kohsuke, Abel, Laurent, Malissen, Bernard, Al-Mulla, Fahd, Alkuraya, Fowzan Sami, Parvaneh, Nima, von Bernuth, Horst, Beetz, Christian, Davi, Frédéric, Douek, Daniel C, Cheynier, Rémi, Langlais, David, Landegren, Nils, Marr, Nico, Morio, Tomohiro, Shahrooei, Mohammad, Schrijvers, Rik, Henrickson, Sarah E, Luche, Hervé, Notarangelo, Luigi D, Casanova, Jean-Laurent, Béziat, Vivien

“…We describe humans with rare biallelic loss-of-function variants impairing pre-α T cell receptor (pre-TCRα) expression. Low circulating naive αβ T cell counts…”
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Mechanisms by which Obesity Dysregulates Immunometabolic State in Asthma by Henrickson, Sarah, O'Boyle, Kaitlin, Conrey, Peyton, Manne, Sasikanth, Bengsch, Bertram, Mentch, Frank, Herati, Ramin, Qian, Ting, Vella, Laura, Pastore, Christopher, Hung, Li-Yin, Sayed, Samir, Herbert, De'Broski, Masino, Aaron, Hensley, Scott, Hakonarson, Hakon, Rabinowitz, Joshua, Coffin, Susan, Wherry, E. John

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