Search Results - "Conrath, K"

Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis by Deckers, N., Saerens, D., Kanobana, K., Conrath, K., Victor, B., Wernery, U., Vercruysse, J., Muyldermans, S., Dorny, P.

“…Taenia solium cysticercosis is a major helminth zoonosis in developing countries. Pigs are the intermediate hosts mediating transmission of infection. Specific…”
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β-Lactamase Inhibitors Derived from Single-Domain Antibody Fragments Elicited in the Camelidae by CONRATH, Katja E, LAUWEREYS, Marc, GALLENI, Moreno, MATAGNE, André, FRERE, Jean-Marie, KINNE, Jörg, WYNS, Lode, MUYLDERMANS, Serge

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Emergence and evolution of functional heavy-chain antibodies in Camelidae by Conrath, K.E, Wernery, U, Muyldermans, S, Nguyen, V.K

“…Antibodies of jawed-vertebrates are composed of paired heavy (H) and light (L) polypeptide chains. Surprisingly, the sera of camelids, nurse shark and…”
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WS13.6 GLPG1837 in subjects with cystic fibrosis (CF) and the G551D mutation: results from a phase II study (SAPHIRA1) by Davies, J, Bell, S.C, Van Koningsbruggen-Rietschel, S, McKone, E.F, Macgregor, G, Drevinek, P, Conrath, K, de Kock, H, Gesson, C, Kanters, D, Van de Steen, O

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WS06.3 Evaluation of novel corrector–potentiator combinations for treating cystic fibrosis in various assays by Balut, C, Musch, S, Vortherms, T, Singh, A, Vandevelde, A, Swensen, A, Nelles, L, Tse, C, Conrath, K

“…Defects in CFTR that result in cystic fibrosis can be broadly categorized into three processes: translational, folding/maturation, and functional. To address…”
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Neutralisation of venom-induced haemorrhage by IgG from camels and llamas immunised with viper venom and also by endogenous, non-IgG components in camelid sera by Harrison, R.A., Hasson, S.S., Harmsen, M., Laing, G.D., Conrath, K., Theakston, R.D.G.

“…Envenoming by snakes results in severe systemic and local pathology. Intravenous administration of antivenom, prepared from IgG of venom immunised horses or…”
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Camel Single-domain Antibodies as Modular Building Units in Bispecific and Bivalent Antibody Constructs by Els Conrath, Katja, Lauwereys, Mark, Wyns, Lode, Muyldermans, Serge

“…Single-domain antibodies against various antigens are isolated from the unique heavy-chain antibodies of immunized camels and llamas. These minimal sized…”
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222 PHARMACOLOGICAL INVESTIGATION OF THE ROLE OF AGGRECANASES IN HUMAN CARTILAGE DEGRADATION by Nelles, L, Lepescheux, L, Musch, S, Marsais, F, Sanière, L, Sartori, E, Conrath, K, Deprez, P, Feyen, J.H, Brys, R

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Molecular Basis for the Preferential Cleft Recognition by Dromedary Heavy-Chain Antibodies by De Genst, Erwin, Silence, Karen, Decanniere, Klaas, Conrath, Katja, Loris, Remy, Kinne, Jörg, Muyldermans, Serge, Wyns, Lode

“…Clefts on protein surfaces are avoided by antigen-combining Sites of conventional antibodies, in contrast to heavy-chain antibodies (HCAbs) of camelids that…”
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Antibody repertoire development in camelids by De Genst, Erwin, Saerens, Dirk, Muyldermans, Serge, Conrath, Katja

“…The humoral immune response of the Camelidae is unique as these animals are the only known mammals that seem to possess functional homodimeric heavy-chain…”
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Single-domain antibody fragments with high conformational stability by Dumoulin, Mireille, Conrath, Katja, Van Meirhaeghe, Annemie, Meersman, Filip, Heremans, Karel, Frenken, Leon G J, Muyldermans, Serge, Wyns, Lode, Matagne, André

“…A variety of techniques, including high‐pressure unfolding monitored by Fourier transform infrared spectroscopy, fluorescence, circular dichroism, and surface…”
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Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies by Saerens, Dirk, Pellis, Mireille, Loris, Remy, Pardon, Els, Dumoulin, Mireille, Matagne, André, Wyns, Lode, Muyldermans, Serge, Conrath, Katja

“…Camel single-domain antibody fragments (VHHs) are promising tools in numerous biotechnological and medical applications. However, some conditions under which…”
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Efficient targeting of conserved cryptic epitopes of infectious agents by single domain antibodies. African trypanosomes as paradigm by Stijlemans, Benoit, Conrath, Katja, Cortez-Retamozo, Virna, Van Xong, Hoang, Wyns, Lode, Senter, Peter, Revets, Hilde, De Baetselier, Patrick, Muyldermans, Serge, Magez, Stefan

“…Antigen variation is a successful defense system adopted by several infectious agents to evade the host immune response. The principle of this defense strategy…”
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The topology of the S protein in the yeast-derived hepatitis B surface antigen particles by Sonveaux, N, Conrath, K, Capiau, C, Brasseur, R, Goormaghtigh, E, Ruysschaert, J M

“…Hepatitis B surface antigen particles are highly immunogenic and have been shown to provide a suitable support for the presentation of foreign epitopes. More…”
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EPS3.05 GLPG2222 in subjects with cystic fibrosis homozygous for F508del: results from a phase II study (FLAMINGO) by van der Ent, K.C., Minic, P., Verhulst, S., Van Braeckel, E., Flume, P., Boas, S., Geller, D., de Kock, H., Loyau, S., Muller, K., Kanters, D., Conrath, K., Van de Steen, O.

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WS01.4 GLPG2222 in subjects with cystic fibrosis and the F508del/Class III mutation on stable treatment with ivacaftor: results from a phase II study (ALBATROSS) by Bell, S., De Boeck, K., Drevinek, P., Plant, B., Barry, P., Elborn, S., de Kock, H., Loyau, S., Muller, K., Vandebriel, L., Kanters, D., Van de Steen, O., Conrath, K.

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Alpha subunit of mitochondrial F1-ATPase from the fission yeast. Deduced sequence of the wild type and identification of a mutation that alters apparent negative cooperativity by Falson, P, Maffey, L, Conrath, K, Boutry, M

“…The nuclear gene atp1 encoding the mitochondrial ATP synthase alpha subunit of the fission yeast Schizosaccharomyces pombe was sequenced. It contains a…”
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Efficient tumor targeting by single‐domain antibody fragments of camels by Cortez‐Retamozo, Virna, Lauwereys, Marc, Hassanzadeh Gh, Gholamreza, Gobert, Martine, Conrath, Katja, Muyldermans, Serge, De Baetselier, Patrick, Revets, Hilde

“…The variable domain of functional heavy chain antibodies (VHH) devoid of light chains, found in camels, constitute the smallest intact antigen‐binding domain…”
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Single Domain Antibodies Derived from Dromedary Lymph Node and Peripheral Blood Lymphocytes Sensing Conformational Variants of Prostate-specific Antigen by Saerens, Dirk, Kinne, Jörg, Bosmans, Eugène, Wernery, Ulrich, Muyldermans, Serge, Conrath, Katja

“…The importance of the lymphocyte source to generate hybridomas or to construct antibody gene libraries from which to identify potent monoclonal antibodies is…”
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Enzymatic hydrolysis of reconstituted dimyristoylphosphatidylcholine-apo A-I complexes by Lins, L, Piron, S, Conrath, K, Vanloo, B, Brasseur, R, Rosseneu, M, Baert, J, Ruysschaert, J M

“…Apolipoproteins share a common structural feature, their interaction with phospholipids. It is believed that amphipathic helical sequences enable…”
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