Search Results - "Conrad, Jay C."

A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir by Peifer, Manuel, Berger, Raphaëlle, Shurtleff, Valerie W, Conrad, Jay C, MacMillan, David W. C

“…An efficient route towards biologically relevant pentose derivatives is described. The de novo synthetic strategy features an enantioselective α-oxidation…”
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Mechanistic Complexity in Organo-SOMO Activation by Devery, James J. III, Conrad, Jay C, MacMillan, David W.C, Flowers, Robert A. II

“…Wet chemistry: Organo‐SOMO activation is an intricate process. The catalyst is deactivated in the absence of H2O and its concentration is maintained with 2…”
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Highly Efficient Ru−Pseudohalide Catalysts for Olefin Metathesis by Conrad, Jay C, Parnas, Henrietta H, Snelgrove, Jennifer L, Fogg, Deryn E

“…Ruthenium alkylidene complexes containing one aryloxide “pseudohalide” ligand catalyze ring-closing metathesis of diene and ene-yne substrates with…”
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Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes by Welin, Eric R., Warkentin, Alexander A., Conrad, Jay C., MacMillan, David W. C.

“…The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective α‐cyanoalkylation of aldehydes. This…”
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Enantioselective Organocatalytic α-Fluorination of Cyclic Ketones by Kwiatkowski, Piotr, Beeson, Teresa D., Conrad, Jay C., MacMillan, David W. C.

“…The first highly enantioselective α-fluorination of ketones using organocatalysis has been accomplished. The long-standing problem of enantioselective ketone…”
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Enantioselective α-Arylation of Aldehydes via Organo-SOMO Catalysis. An Ortho-Selective Arylation Reaction Based on an Open-Shell Pathway by Conrad, Jay C, Kong, Jongrock, Laforteza, Brian N, MacMillan, David W. C

“…The intramolecular α-arylation of aldehydes has been accomplished using singly occupied molecular orbital (SOMO) catalysis. Selective oxidation of chiral…”
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Oligomers as Intermediates in Ring-Closing Metathesis by Conrad, Jay C, Eelman, Melanie D, Silva, João A. Duarte, Monfette, Sebastien, Parnas, Henrietta H, Snelgrove, Jennifer L, Fogg, Deryn E

“…Oligomerization is kinetically favored in RCM reactions catalyzed by RuCl2(PCy3)(IMes)(CHPh), for a range of unhindered α,ω-dienes leading to large or…”
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The First Highly Active, Halide-Free Ruthenium Catalyst for Olefin Metathesis by Conrad, Jay C, Amoroso, Dino, Czechura, Pawel, Yap, Glenn P. A, Fogg, Deryn E

“…New ruthenium alkylidyne and alkylidene complexes are prepared, in which aryloxide groups function as pseudohalide ligands. The selectivity for alkylidene or…”
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Geometric and Electronic Structure of a C 1-Symmetric Ruthenium-Aryloxide Metathesis Catalyst: An Experimental and Computational Study by Kotyk, Matthew W, Gorelsky, Serge I, Conrad, Jay C, Carra, Claudio, Fogg, Deryn E

“…Spectroscopic and computational methods were employed to establish the geometric and electronic structure of the Ru-pseudohalide metathesis catalyst…”
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Enantioselective α-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes by Welin, Eric R., Warkentin, Alexander A., Conrad, Jay C., MacMillan, David W. C.

“…The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective α‐cyanoalkylation of aldehydes. This…”
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Concise Route to Highly Reactive Ruthenium Metathesis Catalysts Containing a Labile Donor and an N-Heterocyclic Carbene (NHC) Ligand by Conrad, Jay C, Yap, Glenn P. A, Fogg, Deryn E

“…Complex 1a, containing two labile phosphine ligands, is a versatile precursor to the important class of olefin metathesis catalysts containing an activating…”
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An Attractive Route to Olefin Metathesis Catalysts: Facile Synthesis of a Ruthenium Alkylidene Complex Containing Labile Phosphane Donors by Amoroso, Dino, Snelgrove, Jennifer L., Conrad, Jay C., Drouin, Samantha D., Yap, Glenn P. A., Fogg, Deryn E.

“…Reaction of RuHCl(PPh3)3 4 with 3‐chloro‐3‐methyl‐1‐butyne effects transformation into RuCl2(PPh3)2(CHCHCMe2) 1c. Starting 4 is available commercially, or…”
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Inhibiting σ → π Isomerization of Aryloxide Ligands in Late Transition-Metal Complexes by Snelgrove, Jennifer L, Conrad, Jay C, Eelman, Melanie D, Moriarty, Maeve M, Yap, Glenn P. A, Fogg, Deryn E

“…The room-temperature reaction of thallium perfluorophenoxide with RuHCl(PPh3)3 (4a) yields RuH(σ-OC6X5)(PPh3)3 (X = F, 5 F ), the structure of which was…”
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Enantioselective [alpha]-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from [beta]-Cyanoaldehydes by Welin, Eric R, Warkentin, Alexander A, Conrad, Jay C, MacMillan, David W C

“…The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective [alpha]-cyanoalkylation of aldehydes. This…”
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Enantioselective α-Alkylation of Aldehydes via Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β-Cyanoaldehydes by Welin, Eric R., Warkentin, Alexander A., Conrad, Jay C., MacMillan, David W. C.

“…The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective α-cyanoalkylation of aldehydes. This…”
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Enantioselective [alpha]-Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from [beta]-Cyanoaldehydes by Welin, Eric R, Warkentin, Alexander A, Conrad, Jay C, MacMillan, David W C

“…The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective [alpha]-cyanoalkylation of aldehydes. This…”
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Ru-aryloxide metathesis catalysts with enhanced lability: Assessing the efficiency and homogeneity of initiation via ring-opening metathesis polymerization studies by Conrad, Jay C., Camm, Kenneth D., Fogg, Deryn E.

“…New Ru-aryloxide catalysts for olefin metathesis, bearing the substitutionally labile 3-bromopyridine ligand, are accessible in high yields. Improved…”
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X-ray absorption methods for the determination of Ru–Cl bond covalency in olefin metathesis catalysts: On the normalization of chlorine K-edges in ruthenium complexes by Delgado-Jaime, Mario Ulises, Conrad, Jay C., Fogg, Deryn E., Kennepohl, Pierre

“…An approach to the quantitative normalization of Cl K-edge data in ruthenium complexes is developed to allow for the determination of Ru–Cl covalency in olefin…”
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Mechanistic Complexity in Organo-SOMO Activation by Devery III, James J., Conrad, Jay C., MacMillan, David W. C., Flowers II, Robert A.

“…Nasse Chemie: „Organo‐SOMO‐Aktivierung“ ist ein komplizierter Prozess. Der Katalysator ist ohne H2O desaktiviert, und seine Konzentration wird durch 2 Äquiv…”
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Design of ruthenium-pseudohalide catalysts for olefin metathesis by Conrad, Jay C

“…Ruthenium-catalyzed olefin metathesis is an exceptionally powerful method for the catalytic formation of new C=C bonds, recognized last year with the Nobel…”
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