Search Results - "Conrad, David M"

Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines by Mader, Jamie S, Salsman, Jayme, Conrad, David M, Hoskin, David W

“…Bovine lactoferricin (LfcinB) is a cationic, amphipathic peptide that is cytotoxic for human and rodent cancer cells. However, the mechanism by which LfcinB…”
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A circulating proplatelet identified in an iron‐deficient patient by Bedier, Helbies, Theriault, Jessica, Conrad, David M.

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Bone marrow necrosis and hyperinflammation after treatment with inotuzumab ozogamicin for B-cell acute lymphoblastic leukaemia by Marcoux, Curtis, Thakkar, Pinkesh, Conrad, David M, Shawwa, Allam A, Chen, Luke Y C

“…Laboratory investigations showed a white blood cell count of 2·37 × 109 per L (typical range 4·5–11·0), haemoglobin concentration was 93 g/L (typical range…”
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Rapid optimized flow cytometric crossmatch (FCXM) assays: The Halifax and Halifaster protocols by Liwski, Robert S., Greenshields, Anna L., Conrad, David M., Murphey, Cathi, Bray, Robert A., Neumann, Jorge, Gebel, Howard M.

“…The flow cytometric crossmatch (FCXM) assay, which detects the presence of donor specific HLA antibodies in patient sera, is a cornerstone of HLA compatibility…”
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Process mining is an underutilized clinical research tool in transfusion medicine by Quinn, Jason G., Conrad, David M., Cheng, Calvino K.

“…BACKGROUND To understand inventory performance, transfusion services commonly use key performance indicators (KPIs) as summary descriptors of inventory…”
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A re-examination of the role of the acute phase protein response in innate cancer defence by Conrad, David M, Hoskin, David W, Liwski, Robert, Naugler, Christopher

“…Abstract Anti-cancer host defense mechanisms are traditionally considered to consist of tumor suppressor genes and immune surveillance by cells of the innate…”
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Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review) by HOSKIN, David W, MADER, Jamie S, FURLONG, Suzanne J, CONRAD, David M, BLAY, Jonathan

“…The resistance of many human cancers to immune-based therapies, including adoptive immunotherapy and the administration of therapeutic cancer vaccines, has…”
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The Acute Phase Protein Hepcidin Is Cytotoxic to Human and Mouse Myeloma Cells by Conrad, David M, Hilchie, Ashley L, McMillan, Katelyn A M, Liwski, Robert S, Hoskin, David W, Power Coombs, Melanie R

“…Hepcidin is a cationic acute phase reactant synthesized by the liver. It has bactericidal properties and is a major regulator of iron homeostasis. Cationic…”
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Adenosine Acts through A2 Receptors to Inhibit IL-2-Induced Tyrosine Phosphorylation of STAT5 in T Lymphocytes: Role of Cyclic Adenosine 3',5'-Monophosphate and Phosphatases by Zhang, Hong, Conrad, David M, Butler, Jared J, Zhao, Chuanli, Blay, Jonathan, Hoskin, David W

“…Adenosine is a purine nucleoside with immunosuppressive activity that acts through cell surface receptors (A(1), A(2a), A(2b), A(3)) on responsive cells such…”
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Pleurocidin-family cationic antimicrobial peptides mediate lysis of multiple myeloma cells and impair the growth of multiple myeloma xenografts by Hilchie, Ashley L., Conrad, David M., Power Coombs, Melanie R., Zemlak, Tyler, Doucette, Carolyn D., Liwski, Robert S., Hoskin, David W.

“…Abstract Multiple myeloma is a common hematological malignancy that urgently requires new approaches to treatment, since the disease is not curable using…”
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Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase by Boudreau, Robert T.M., Conrad, David M., Hoskin, David W.

“…Serine/threonine phosphatase regulation of phosphorylation-mediated intracellular signaling controls a number of important processes in mammalian cells. In…”
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The hardscrabble hypothesis: A reduction in chronic tissue damage has increased the incidence of autoimmune disease by Naugler, Christopher, Conrad, David M

“…Summary The adaptive immune system, fine tuned through millions of years of vertebrate evolution, discriminates self from foreign antigens through the deletion…”
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Extensive Neurocristic Hamartoma With Bone Marrow Involvement by CONRAD, David M, CHAPLIN, Anna, WALSH, Noreen M, PASTERNAK, Sylvia

“…Cutaneous neurocristic hamartoma (NCH) is a rare, pigmented lesion consisting of cells that aberrantly develop from the neurocrest. In addition to a dermal…”
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Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling by Forward, Nicholas A., Conrad, David M., Power Coombs, Melanie R., Doucette, Carolyn D., Furlong, Suzanne J., Lin, Tong-Jun, Hoskin, David W.

“…► Curcumin inhibits CD4+ T-lymphocyte proliferation. ► Curcumin inhibits interleukin-2 (IL-2) synthesis and CD25 expression by CD4+ T-lymphocytes. ► Curcumin…”
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Mixed phenotype acute leukemia, B/myeloid, NOS with near-tetraploidy: a case report by Nix, Kimberley M, Harrison, Karen J, Shivakumar, Sudeep P, Shawwa, Allam A, Conrad, David M

“…Acute leukemia in adults is usually associated with a myeloid phenotype, and less commonly presents as an acute lymphocytic leukemia. Rarely, the leukemic…”
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Primary Cutaneous PEComa by CHAPLIN, Anna, CONRAD, David M, TATLIDIL, Cuneyt, JOLLIMORE, Jason, WALSH, Noreen, COVERT, Alan, PASTERNAK, Sylvia

“…A 48-year-old woman attended a physician because of a solitary cutaneous nodule on the left lower leg. Microscopic examination of the excisional specimen…”
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The Ca2+ channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells by Conrad, David M., Furlong, Suzanne J., Doucette, Carolyn D., West, Kenneth A., Hoskin, David W.

“…Flunarizine is a Ca 2+ channel blocker that can be either cytoprotective or cytotoxic, depending on the cell type that is being examined. We show here that…”
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The Ca(2+) channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells by Conrad, David M, Furlong, Suzanne J, Doucette, Carolyn D, West, Kenneth A, Hoskin, David W

“…Flunarizine is a Ca(2+) channel blocker that can be either cytoprotective or cytotoxic, depending on the cell type that is being examined. We show here that…”
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Role of mitogen-activated protein kinases in Thy-1-induced T-lymphocyte activation by Conrad, David M., Furlong, Suzanne J., Doucette, Carolyn D., Boudreau, Robert T.M., Hoskin, David W.

“…Thy-1 (CD90) crosslinking by monoclonal antibodies (mAb) in the context of costimulation causes the activation of mouse T-lymphocytes; however, the associated…”
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Induction of CD4 CD25 Foxp3 regulatory T cells by Thy-1 stimulation of CD4 T cells by Conrad, David M, Coombs, Melanie R Power, Furlong, Suzanne J, Forward, Nicholas A, Hoskin, David W

“…Thy‐1 (CD90) on mouse T cells has been reported to have both T‐cell activating and regulatory roles. In this study, we show that monoclonal antibody…”
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