Search Results - "Conover Talbot, C."
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Synthetic Circular RNA Functions as a miR-21 Sponge to Suppress Gastric Carcinoma Cell Proliferation
Published in Molecular therapy. Nucleic acids (07-12-2018)“…MicroRNA (miR) sponges containing miR binding sequences constitute a potentially powerful molecular therapeutic strategy. Recently, naturally occurring…”
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2
Short telomere syndromes cause a primary T cell immunodeficiency
Published in The Journal of clinical investigation (01-12-2018)“…The mechanisms that drive T cell aging are not understood. We report that children and adult telomerase mutation carriers with short telomere length (TL)…”
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3
ZCCHC8 , the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation
Published in Genes & development (01-10-2019)“…Short telomere syndromes manifest as familial idiopathic pulmonary fibrosis; they are the most common premature aging disorders. We used genome-wide linkage to…”
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4
The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype
Published in Science translational medicine (20-02-2019)“…Skin barrier dysfunction has been reported in both atopic dermatitis (AD) and food allergy (FA). However, only one-third of patients with AD have FA. The…”
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5
TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons
Published in Cell death & disease (05-03-2018)“…Astrocytes are known to be critical regulators of neuronal function. However, relatively few mediators of astrocyte to neuron communication have been…”
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6
Gene expression profiling suggests severe, extensive central centrifugal cicatricial alopecia may be both clinically and biologically distinct from limited disease subtypes
Published in Experimental dermatology (01-05-2022)“…The natural history of central centrifugal cicatricial alopecia (CCCA) is widely variable. Some patients experience rapid progression to extensive, end‐stage…”
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7
Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease
Published in Scientific reports (11-03-2021)“…Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic…”
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8
HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells
Published in PloS one (02-05-2013)“…Emerging evidence suggests that tumor cells metastasize by co-opting stem cell transcriptional networks, although the molecular underpinnings of this process…”
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9
Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response
Published in Molecular biology of the cell (15-06-2012)“…Apoptosis serves as a protective mechanism by eliminating damaged cells through programmed cell death. After apoptotic cells pass critical checkpoints,…”
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10
Transcriptome Profiling of Developing Murine Lens Through RNA Sequencing
Published in Investigative ophthalmology & visual science (01-07-2015)“…Transcriptome is the entire repertoire of transcripts present in a cell at any particular time. We undertook a next-generation whole transcriptome sequencing…”
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11
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
Published in Nature communications (26-05-2021)“…Antagonistic pleiotropy is a foundational theory that predicts aging-related diseases are the result of evolved genetic traits conferring advantages early in…”
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12
Stable intronic sequence RNA (sisRNA), a new class of noncoding RNA from the oocyte nucleus of Xenopus tropicalis
Published in Genes & development (15-11-2012)“…To compare nuclear and cytoplasmic RNA from a single cell type, free of cross-contamination, we studied the oocyte of the frog Xenopus tropicalis, a giant cell…”
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13
mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation
Published in The Journal of clinical investigation (01-12-2019)“…The microphthalmia family of transcription factors (MiT/TFEs) controls lysosomal biogenesis and is negatively regulated by the nutrient sensor mTORC1. However,…”
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14
Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia
Published in Journal of the American Academy of Dermatology (01-11-2018)“…Central centrifugal cicatricial alopecia (CCCA) is a primary cicatricial alopecia that most commonly affects women of African descent. Like CCCA,…”
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A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes
Published in Cancer discovery (01-05-2021)“…The existence of distinct breast microbiota has been recently established, but their biological impact in breast cancer remains elusive. Focusing on the shift…”
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16
Gene map of the extended human MHC
Published in Nature reviews. Genetics (01-12-2004)“…The major histocompatibility complex (MHC) is the most important region in the vertebrate genome with respect to infection and autoimmunity, and is crucial in…”
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17
Excessive O-GlcNAcylation Causes Heart Failure and Sudden Death
Published in Circulation (New York, N.Y.) (27-04-2021)“…Heart failure is a leading cause of death worldwide and is associated with the rising prevalence of obesity, hypertension, and diabetes. -GlcNAcylation (the…”
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Chlorovirus ATCV-1 is part of the human oropharyngeal virome and is associated with changes in cognitive functions in humans and mice
Published in Proceedings of the National Academy of Sciences - PNAS (11-11-2014)“…Significance Human mucosal surfaces contain a wide range of microorganisms. The biological effects of these organisms are largely unknown. Large-scale…”
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Chronic CD4+ T-Cell Activation and Depletion in Human Immunodeficiency Virus Type 1 Infection: Type I Interferon-Mediated Disruption of T-Cell Dynamics
Published in Journal of Virology (01-02-2008)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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20
Integrated Omic Analysis of a Guinea Pig Model of Heart Failure and Sudden Cardiac Death
Published in Journal of proteome research (02-09-2016)“…Here, we examine key regulatory pathways underlying the transition from compensated hypertrophy (HYP) to decompensated heart failure (HF) and sudden cardiac…”
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