Search Results - "Connors, Thomas"

Human T Cell Development, Localization, and Function throughout Life by Kumar, Brahma V., Connors, Thomas J., Farber, Donna L.

“…Throughout life, T cells coordinate multiple aspects of adaptive immunity, including responses to pathogens, allergens, and tumors. In mouse models, the role…”
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Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC) by Sherif, Zaki A, Gomez, Christian R, Connors, Thomas J, Henrich, Timothy J, Reeves, William Brian

“…COVID-19, with persistent and new onset of symptoms such as fatigue, post-exertional malaise, and cognitive dysfunction that last for months and impact…”
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Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19 by Szabo, Peter A., Dogra, Pranay, Gray, Joshua I., Wells, Steven B., Connors, Thomas J., Weisberg, Stuart P., Krupska, Izabela, Matsumoto, Rei, Poon, Maya M.L., Idzikowski, Emma, Morris, Sinead E., Pasin, Chloé, Yates, Andrew J., Ku, Amy, Chait, Michael, Davis-Porada, Julia, Guo, Xinzheng V., Zhou, Jing, Steinle, Matthew, Mackay, Sean, Saqi, Anjali, Baldwin, Matthew R., Sims, Peter A., Farber, Donna L.

“…Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe manifestations have largely been studied in circulation. Here, we examined the…”
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Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life by Granot, Tomer, Senda, Takashi, Carpenter, Dustin J., Matsuoka, Nobuhide, Weiner, Joshua, Gordon, Claire L., Miron, Michelle, Kumar, Brahma V., Griesemer, Adam, Ho, Siu-Hong, Lerner, Harvey, Thome, Joseph J.C., Connors, Thomas, Reizis, Boris, Farber, Donna L.

“…Maturation and migration to lymph nodes (LNs) constitutes a central paradigm in conventional dendritic cell (cDC) biology but remains poorly defined in humans…”
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SARS-CoV-2 infection generates tissue-localized immunological memory in humans by Poon, Maya M L, Rybkina, Ksenia, Kato, Yu, Kubota, Masaru, Matsumoto, Rei, Bloom, Nathaniel I, Zhang, Zeli, Hastie, Kathryn M, Grifoni, Alba, Weiskopf, Daniela, Wells, Steven B, Ural, Basak B, Lam, Nora, Szabo, Peter A, Dogra, Pranay, Lee, Yoon S, Gray, Joshua I, Bradley, Marissa C, Brusko, Maigan A, Brusko, Todd M, Saphire, Erica O, Connors, Thomas J, Sette, Alessandro, Crotty, Shane, Farber, Donna L

“…Adaptive immune responses to SARS-CoV-2 infection have been extensively characterized in blood; however, most functions of protective immunity must be…”
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Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells by Verma, Shivali, Bradley, Marissa C, Gray, Joshua, Dogra, Pranay, Caron, Daniel P, Maurrasse, Sarah, Grunstein, Eli, Waldman, Erik, Jang, Minyoung, Pethe, Kalpana, Farber, Donna L, Connors, Thomas J

“…CD4+ regulatory T cells (Tregs) are key orchestrators of the immune system, fostering the establishment of protective immunity while preventing deleterious…”
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Site-specific development and progressive maturation of human tissue-resident memory T cells over infancy and childhood by Connors, Thomas J, Matsumoto, Rei, Verma, Shivali, Szabo, Peter A, Guyer, Rebecca, Gray, Joshua, Wang, Zicheng, Thapa, Puspa, Dogra, Pranay, Poon, Maya M L, Rybkina, Ksenia, Bradley, Marissa C, Idzikowski, Emma, McNichols, James, Kubota, Masaru, Pethe, Kalpana, Shen, Yufeng, Atkinson, Mark A, Brusko, Maigan, Brusko, Todd M, Yates, Andrew J, Sims, Peter A, Farber, Donna L

“…Infancy and childhood are critical life stages for generating immune memory to protect against pathogens; however, the timing, location, and pathways for…”
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Generation and persistence of human tissue-resident memory T cells in lung transplantation by Snyder, Mark E, Finlayson, Michael O, Connors, Thomas J, Dogra, Pranay, Senda, Takashi, Bush, Erin, Carpenter, Dustin, Marboe, Charles, Benvenuto, Luke, Shah, Lori, Robbins, Hilary, Hook, Jaime L, Sykes, Megan, D'Ovidio, Frank, Bacchetta, Matthew, Sonett, Joshua R, Lederer, David J, Arcasoy, Selim, Sims, Peter A, Farber, Donna L

“…Tissue-resident memory T cells (T ) maintain immunity in diverse sites as determined in mouse models, whereas their establishment and role in human tissues…”
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SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19 by Rybkina, Ksenia, Bell, Joseph N, Bradley, Marissa C, Wohlbold, Teddy, Scafuro, Marika, Meng, Wenzhao, Korenberg, Rebecca C, Davis-Porada, Julia, Anderson, Brett R, Weller, Rachel J, Milner, Joshua D, Moscona, Anne, Porotto, Matteo, Luning Prak, Eline T, Pethe, Kalpana, Connors, Thomas J, Farber, Donna L

“…SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare cases severe disease can develop, including a multisystem…”
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Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity by Matsumoto, Rei, Gray, Joshua, Rybkina, Ksenia, Oppenheimer, Hanna, Levy, Lior, Friedman, Lilach M., Khamaisi, Muhammad, Meng, Wenzhao, Rosenfeld, Aaron M., Guyer, Rebecca S., Bradley, Marissa C., Chen, David, Atkinson, Mark A., Brusko, Todd M., Brusko, Maigan, Connors, Thomas J., Luning Prak, Eline T., Hershberg, Uri, Sims, Peter A., Hertz, Tomer, Farber, Donna L.

“…Infants and young children are more susceptible to common respiratory pathogens than adults but can fare better against novel pathogens like severe acute…”
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Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage by Hegewisch-Solloa, Everardo, Seo, Seungmae, Mundy-Bosse, Bethany L, Mishra, Anjali, Waldman, Erik H, Maurrasse, Sarah, Grunstein, Eli, Connors, Thomas J, Freud, Aharon G, Mace, Emily M

“…NK cells are innate immune cells that reside within tissue and circulate in peripheral blood. They interact with a variety of microenvironments, yet how NK…”
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Impact and Clinical Implications of Prematurity on Adaptive Immune Development by Idzikowski, Emma, Connors, Thomas J.

“…Purpose of Review Detail normal adaptive immune maturation during fetal and neonatal life and review the clinical implications of arrested immune development…”
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Heterogeneity of human anti-viral immunity shaped by virus, tissue, age, and sex by Poon, Maya M L, Byington, Eve, Meng, Wenzhao, Kubota, Masaru, Matsumoto, Rei, Grifoni, Alba, Weiskopf, Daniela, Dogra, Pranay, Lam, Nora, Szabo, Peter A, Ural, Basak Burcu, Wells, Steven B, Rosenfeld, Aaron M, Brusko, Maigan A, Brusko, Todd M, Connors, Thomas J, Sette, Alessandro, Sims, Peter A, Luning Prak, Eline T, Shen, Yufeng, Farber, Donna L

“…The persistence of anti-viral immunity is essential for protection and exhibits profound heterogeneity across individuals. Here, we elucidate the factors that…”
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Airway CD8(+) T Cells Are Associated with Lung Injury during Infant Viral Respiratory Tract Infection by Connors, Thomas J, Ravindranath, Thyyar M, Bickham, Kara L, Gordon, Claire L, Zhang, Feifan, Levin, Bruce, Baird, John S, Farber, Donna L

“…Infants and young children are disproportionately susceptible to severe complications from respiratory viruses, although the underlying mechanisms remain…”
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Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection by Connors, Thomas J, Baird, J Scott, Yopes, Margot C, Zens, Kyra D, Pethe, Kalpana, Ravindranath, Thyyar M, Ho, Siu-Hong, Farber, Donna L

“…Viral respiratory tract infections (VRTI) remain a leading cause of morbidity and mortality among infants and young children. In mice, optimal protection to…”
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Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum by Weisberg, Stuart P., Connors, Thomas J., Zhu, Yun, Baldwin, Matthew R., Lin, Wen-Hsuan, Wontakal, Sandeep, Szabo, Peter A., Wells, Steven B., Dogra, Pranay, Gray, Joshua, Idzikowski, Emma, Stelitano, Debora, Bovier, Francesca T., Davis-Porada, Julia, Matsumoto, Rei, Poon, Maya Meimei Li, Chait, Michael, Mathieu, Cyrille, Horvat, Branka, Decimo, Didier, Hudson, Krystalyn E., Zotti, Flavia Dei, Bitan, Zachary C., La Carpia, Francesca, Ferrara, Stephen A., Mace, Emily, Milner, Joshua, Moscona, Anne, Hod, Eldad, Porotto, Matteo, Farber, Donna L.

“…Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age 1 , 2 . Adults develop respiratory symptoms, which can…”
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Ventricular function and tissue characterization by cardiac magnetic resonance imaging following hospitalization for multisystem inflammatory syndrome in children: a prospective study by DiLorenzo, Michael P., Farooqi, Kanwal M., Shah, Amee M., Channing, Alexandra, Harrington, Jamie K., Connors, Thomas J., Martirosyan, Karen, Krishnan, Usha S., Ferris, Anne, Weller, Rachel J., Farber, Donna L., Milner, Joshua D., Gorelik, Mark, Rosenzweig, Erika B., Anderson, Brett R.

“…Background Multisystem inflammatory syndrome in children (MIS-C) is a severe life-threatening manifestation of severe acute respiratory syndrome coronavirus 2…”
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Pediatric acute respiratory distress syndrome associated with human metapneumovirus and respiratory syncytial virus by Ravindranath, Thyyar M., Gomez, Amanda, Harwayne‐Gidansky, Ilana, Connors, Thomas J., Neill, Nathan, Levin, Bruce, Howell, Joy D., Saiman, Lisa, Baird, John S.

“…Objectives To study the incidence, risk factors, clinical course, and outcome of ARDS in children with HMP and RSV. Working Hypothesis We hypothesized that…”
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Case Report: Secondary Hemophagocytic Lymphohistiocytosis With Disseminated Infection in Chronic Granulomatous Disease-A Serious Cause of Mortality by Squire, Jacqueline D, Vazquez, Stephanie N, Chan, Angela, Smith, Michele E, Chellapandian, Deepak, Vose, Laura, Teppa, Beatriz, Hanson, I Celine, Chinn, Ivan K, Forbes-Satter, Lisa, Seeborg, Filiz O, Nicholas, Sarah K, Martinez, Caridad A, Allen, Carl E, Connors, Thomas J, Satwani, Prakash, Shtessel, Maria, Ale, Hanadys, Noroski, Lenora M, Rider, Nicholas L, Milner, Joshua D, Leiding, Jennifer W

“…Chronic granulomatous disease (CGD) is a primary immune deficiency due to defects in phagocyte respiratory burst leading to severe and life-threatening…”
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Infant T cells are developmentally adapted for robust lung immune responses through enhanced T cell receptor signaling by Thapa, Puspa, Guyer, Rebecca S, Yang, Alexander Y, Parks, Christopher A, Brusko, Todd M, Brusko, Maigan, Connors, Thomas J, Farber, Donna L

“…Infants require coordinated immune responses to prevent succumbing to multiple infectious challenges during early life, particularly in the respiratory tract…”
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