Search Results - "Connors, Patrick J."

Synthesis and Structure–activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor by Tucci, Fabio C., Zhu, Yun-Fei, Guo, Zhiqiang, Gross, Timothy D., Connors, Patrick J., Struthers, R.Scott, Reinhart, Greg J., Saunders, John, Chen, Chen

“…A new class of small molecule GnRH antagonists, the 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils, was designed and a novel stereoselective…”
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Initial Structure–Activity Relationship Studies of a Novel Series of Pyrrolo[1,2- a]pyrimid-7-ones as GnRH Receptor Antagonists by Zhu, Yun-Fei, Struthers, R.Scott, Connors, Jr, Patrick J., Gao, Yinghong, Gross, Timothy D., Saunders, John, Wilcoxen, Keith, Reinhart, Greg J., Ling, Nicholas, Chen, Chen

“…Initial SAR studies on 1-aminomethyl-2-aryl-3-cyano-pyrrolo[1,2- a]pyrimid-7-one-6-carboxylates as human GnRH receptor antagonists were discussed…”
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Synthesis and Structure−Activity Relationships of 1-Arylmethyl-5-aryl-6-methyluracils as Potent Gonadotropin-Releasing Hormone Receptor Antagonists by Guo, Zhiqiang, Zhu, Yun-Fei, Gross, Timothy D, Tucci, Fabio C, Gao, Yinghong, Moorjani, Manisha, Connors, Patrick J, Rowbottom, Martin W, Chen, Yongsheng, Struthers, R. Scott, Xie, Qiu, Saunders, John, Reinhart, Greg, Chen, Ta Kung, Bonneville, Anne L. Killam, Chen

“…Based on the SAR from bicyclic gonadotropin-releasing hormone (GnRH) antagonists such as 6-aminomethyl-7-aryl-pyrrolo[1,2-a]pyrimid-4-ones (5) and…”
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A Novel Synthesis of 2-Arylpyrrolo[1,2- a]pyrimid-7-ones and Their Structure–Activity Relationships as Potent GnRH Receptor Antagonists by Zhu, Yun-Fei, Wilcoxen, Keith, Saunders, John, Guo, Zhiqiang, Gao, Yinghong, Connors, Jr, Patrick J., Gross, Timothy D., Tucci, Fabio C., Scott Struthers, R., Reinhart, Greg J., Xie, Qiu, Chen, Chen

“…In the process of developing GnRH receptor antagonists, a novel base-catalyzed cyclization of compounds 5a– b was discovered, which led to the formation of the…”
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Design and Structure−Activity Relationships of 2-Alkyl-3-aminomethyl-6-(3-methoxyphenyl)-7-methyl-8-(2-fluorobenzyl)imidazolo[1,2-a]pyrimid-5-ones as Potent GnRH Receptor Antagonists by Zhu, Yun-Fei, Guo, Zhiqiang, Gross, Timothy D, Gao, Yinghong, Connors, Patrick J, Struthers, R. Scott, Xie, Qiu, Tucci, Fabio C, Reinhart, Greg J, Wu, Dongpei, Saunders, John, Chen

“…SAR studies of 7-phenylpyrrolo[1,2-a]pyrimid-4-ones 1 and 2, and 2-phenylimidazolo[1,2-a]pyrimidines 3 and 4, as nonpeptide human GnRH receptor antagonists,…”
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3-(2-Aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl- uracils as Orally Bioavailable Antagonists of the Human Gonadotropin Releasing Hormone Receptor by Tucci, Fabio C, Zhu, Yun-Fei, Guo, Zhiqiang, Gross, Timothy D, Connors, Patrick J, Gao, Yinghong, Rowbottom, Martin W, Struthers, R. Scott, Reinhart, Greg J, Xie, Qiu, Chen, Ta Kung, Bozigian, Haig, Killam Bonneville, Anne L, Fisher, Andrew, Jin, Liping, Saunders, John, Chen

“…Uracils possessing N-3 side chains derived from various amino alcohols were designed and synthesized as potent human gonadotropin releasing hormone receptor…”
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Identification of 1-Arylmethyl-3- (2-aminoethyl)-5-aryluracil as Novel Gonadotropin-Releasing Hormone Receptor Antagonists by Zhu, Yun-Fei, Gross, Timothy D, Guo, Zhiqiang, Connors, Patrick J, Gao, Yinghong, Tucci, Fabio C, Struthers, R. Scott, Reinhart, Greg J, Saunders, John, Chen, Ta Kung, Killam Bonneville, Anne L, Chen

“…Based on SAR from bicyclic GnRH antagonists such as 6-aminomethyl-7-arylpyrrolo[1,2-a]pyrimid-4-ones (1) and 2-aryl-3-aminomethylimidazolo[1,2-a]pyrimid-5-ones…”
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A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2- a]pyrimid-4-ones as potent, stable GnRH receptor antagonists by Tucci, Fabio C., Zhu, Yun-Fei, Guo, Zhiqiang, Gross, Timothy D., Connors, Patrick J., Struthers, R.Scott, Reinhart, Greg J., Wang, Xiaochuan, Saunders, John, Chen, Chen

“…A new class of small molecule GnRH antagonists, the 7-aryl-8-fluoro-pyrrolo[1,2- a]pyrimid-4-ones, was designed and a novel synthesis for these compounds was…”
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Synthesis and structure–activity relationships of uracil derived human GnRH receptor antagonists: ( R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5 by Rowbottom, Martin W., Tucci, Fabio C., Connors, Patrick J., Gross, Timothy D., Zhu, Yun-Fei, Guo, Zhiqiang, Moorjani, Manisha, Acevedo, Oscar, Carter, Lee, Sullivan, Susan K., Xie, Qiu, Fisher, Andrew, Struthers, R. Scott, Saunders, John, Chen, Chen

“…The design and synthesis of a number of 5-thiazolyl and 5-thienyl substituted uracils is described and results from SAR studies are summarized. The best…”
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Design, synthesis and structure–Activity relationships of novel imidazolo[1,2- a]pyrimid-5-ones as potent GnRH receptor antagonists by Gross, Timothy D., Zhu, Yun-Fei, Saunders, John, Wilcoxen, Keith M., Gao, Yinghong, Connors, Patrick J., Guo, Zhiqiang, Struthers, R.Scott, Reinhart, Greg J., Chen, Chen

“…SAR studies of lead GnRH receptor antagonists 2a and 2b reported earlier resulted in the discovery of compound 10b which showed much higher potency ( K i=4.6…”
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Coordination Compounds as Building Blocks:  Single-Step Synthesis of Heteronuclear Multimetallic Complexes Containing RuII and OsII by Connors, Patrick J, Tzalis, Dimitrios, Dunnick, Alejandro L, Tor, Yitzhak

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Synthesis and initial structure–Activity relationships of a novel series of imidazolo[1,2- a]pyrimid-5-ones as potent GnRH receptor antagonists by Wilcoxen, Keith M., Zhu, Yun-Fei, Connors, Patrick J., Saunders, John, Gross, Timothy D., Gao, Yinghong, Reinhart, Greg J., Struthers, R.Scott, Chen, Chen

“…SAR studies of 2-arylimidazolo[1,2- a]pyrimid-5-ones 10a– m, which were derived from initial lead 3a, resulted in the discovery of a series of potent…”
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Coordination Compounds as Building Blocks:  Single-Step Synthesis of Heteronuclear Multimetallic Complexes Containing Ru II and Os II by Connors, Patrick J., Tzalis, Dimitrios, Dunnick, Alejandro L., Tor, Yitzhak

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3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyl-ur acils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor by TUCCI, Fabio C, ZHU, Yun-Fei, TA KUNG CHEN, BOZIGIAN, Haig, BONNEVILLE, Anne L, FISHER, Andrew, LIPING JIN, SAUNDERS, John, CHEN CHEN, ZHIQIANG GUO, GROSS, Timothy D, CONNORS, Patrick J, YINGHONG GAO, ROWBOTTOM, Martin W, STRUTHERS, R. Scott, REINHART, Greg J, QIU XIE

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