Search Results - "Connors, Lawreen H"

Blood Proteomic Profiling in Inherited (ATTRm) and Acquired (ATTRwt) Forms of Transthyretin-Associated Cardiac Amyloidosis by Chan, Gloria G, Koch, Clarissa M, Connors, Lawreen H

“…Transthyretin-associated forms of cardiac amyloidosis are fatal protein misfolding diseases that can be inherited (ATTRm) or acquired (ATTRwt). An accurate…”
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Monoclonal gammopathy of undetermined significance in systemic transthyretin amyloidosis (ATTR) by Phull, Pooja, Sanchorawala, Vaishali, Connors, Lawreen H., Doros, Gheorghe, Ruberg, Frederick L., Berk, John L., Sarosiek, Shayna

“…Objective: To identify the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in patients with transthyretin (ATTR) amyloidosis. Patients…”
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Marked progress in AL amyloidosis survival: a 40-year longitudinal natural history study by Staron, Andrew, Zheng, Luke, Doros, Gheorghe, Connors, Lawreen H., Mendelson, Lisa M., Joshi, Tracy, Sanchorawala, Vaishali

“…The recent decades have ushered in considerable advancements in the diagnosis and treatment of systemic light chain (AL) amyloidosis. As disease outcomes…”
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Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death, and early mortality in zebrafish by Mishra, Shikha, Guan, Jian, Plovie, Eva, Seldin, David C, Connors, Lawreen H, Merlini, Giampaolo, Falk, Rodney H, MacRae, Calum A, Liao, Ronglih

“…Systemic amyloid light-chain (AL) amyloidosis is associated with rapidly progressive and fatal cardiomyopathy resulting from the direct cardiotoxic effects of…”
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Features of atrial fibrillation in wild‐type transthyretin cardiac amyloidosis: a systematic review and clinical experience by Mints, Yuliya Y., Doros, Gheorghe, Berk, John L., Connors, Lawreen H., Ruberg, Frederick L.

“…Aims Wild‐type transthyretin (ATTRwt) cardiac amyloidosis has emerged as an important cause of heart failure in the elderly. Atrial fibrillation (AF) commonly…”
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Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis by Ward, Jennifer Ellis, Ren, Ruiyi, Toraldo, Gianluca, SooHoo, Pam, Guan, Jian, O'Hara, Carl, Jasuja, Ravi, Trinkaus-Randall, Vickery, Liao, Ronglih, Connors, Lawreen H., Seldin, David C.

“…Systemic AL amyloidosis results from the aggregation of an amyloidogenic immunoglobulin (Ig) light chain (LC) usually produced by a plasma cell clone in the…”
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Unusual duplication mutation in a surface loop of human transthyretin leads to an aggressive drug-resistant amyloid disease by Klimtchuk, Elena S., Prokaeva, Tatiana, Frame, Nicholas M., Abdullahi, Hassan A., Spencer, Brian, Dasari, Surendra, Cui, Haili, Berk, John L., Kurtin, Paul J., Connors, Lawreen H., Gursky, Olga

“…Transthyretin (TTR) is a globular tetrameric transport protein in plasma. Nearly 140 single amino acid substitutions in TTR cause life-threatening amyloid…”
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Cardiac amyloidosis in African Americans: Comparison of clinical and laboratory features of transthyretin V122I amyloidosis and immunoglobulin light chain amyloidosis by Connors, Lawreen H., PhD, Prokaeva, Tatiana, MD, PhD, Lim, Amareth, PhD, Théberge, Roger, PhD, Falk, Rodney H., MD, Doros, Gheorghe, PhD, Berg, Alan, MD, Costello, Catherine E., PhD, O'Hara, Carl, MD, Seldin, David C., MD, PhD, Skinner, Martha, MD

“…Background Transthyretin (TTR) mutations known to cause cardiac amyloidosis include V122I, found almost exclusively in African Americans at a prevalence of…”
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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain‐mediated cardiotoxicity by Guan, Jian, Mishra, Shikha, Qiu, Yiling, Shi, Jianru, Trudeau, Kyle, Las, Guy, Liesa, Marc, Shirihai, Orian S, Connors, Lawreen H, Seldin, David C, Falk, Rodney H, MacRae, Calum A, Liao, Ronglih

“…AL amyloidosis is the consequence of clonal production of amyloidogenic immunoglobulin light chain (LC) proteins, often resulting in a rapidly progressive and…”
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Design and Rationale the SCAN-MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study by Ruberg, Frederick L, Blaner, William S, Chiuzan, Codruta, Connors, Lawreen H, Einstein, Andrew J, Fine, Denise, Helmke, Stephen, Kurian, Damian, Pandey, Shivda, Raiszadeh, Farbod, Rodriguez, Carlos, Sabogal, Natalia, Teruya, Sergio, Winburn, Morgan, Chung, Wendy K, Cohn, Elizabeth, Miller, Edward J, Kelly, Jeffery W, Maurer, Mathew S

“…Background Transthyretin amyloid cardiomyopathy (ATTR-CM) is an important cause of heart failure in older individuals. Misfolding and deposition of…”
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Clinical Penetrance of the Transthyretin V122I Variant in Older Black Patients With Heart Failure: The SCAN-MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study by Madhani, Avni, Sabogal, Natalia, Massillon, Daniel, Paul, Ludwine D, Rodriguez, Carlos, Fine, Denise, Helmke, Stephen, Winburn, Morgan, Kurian, Damian, Raiszadeh, Farbod, Teruya, Sergio, Cohn, Elizabeth, Einstein, Andrew J, Miller, Edward J, Connors, Lawreen H, Maurer, Mathew S, Ruberg, Frederick L

“…Background Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed cause of heart failure (HF) among patients ≥60 years of age. Although the V122I…”
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Human Amyloidogenic Light Chains Directly Impair Cardiomyocyte Function Through an Increase in Cellular Oxidant Stress by Brenner, Daniel A, Jain, Mohit, Pimentel, David R, Wang, Bo, Connors, Lawreen H, Skinner, Martha, Apstein, Carl S, Liao, Ronglih

“…Primary amyloidosis is a systemic disorder characterized by the clonal production and tissue deposition of immunoglobulin light chain (LC) proteins. Congestive…”
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The Critical Role of the Constant Region in Thermal Stability and Aggregation of Amyloidogenic Immunoglobulin Light Chain by Klimtchuk, Elena S, Gursky, Olga, Patel, Rupesh S, Laporte, Kathryn L, Connors, Lawreen H, Skinner, Martha, Seldin, David C

“…Light chain (LC) amyloidosis (AL) is a fatal disease in which immunoglobulin LC deposit as fibrils. Although the LC amyloid-forming propensity is attributed…”
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Amyloidogenic and Associated Proteins in Systemic Amyloidosis Proteome of Adipose Tissue by Lavatelli, Francesca, Perlman, David H., Spencer, Brian, Prokaeva, Tatiana, McComb, Mark E., Théberge, Roger, Connors, Lawreen H., Bellotti, Vittorio, Seldin, David C., Merlini, Giampaolo, Skinner, Martha, Costello, Catherine E.

“…In systemic amyloidoses, widespread deposition of protein as amyloid causes severe organ dysfunction. It is necessary to discriminate among the different forms…”
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Cooperative Stabilization of Transthyretin by Clusterin and Diflunisal by Greene, Michael J, Klimtchuk, Elena S, Seldin, David C, Berk, John L, Connors, Lawreen H

“…The circulating protein transthyretin (TTR) can unfold, oligomerize, and form highly structured amyloid fibrils that are deposited in tissues, causing organ…”
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Evidence for a Functional Role of the Molecular Chaperone Clusterin in Amyloidotic Cardiomyopathy by Greene, Michael J, Sam, Flora, Soo Hoo, Pamela T, Patel, Rupesh S, Seldin, David C, Connors, Lawreen H

“…Molecular chaperones, including the extracellular protein clusterin (CLU), play a significant role in maintaining proteostasis; they have a unique capacity to…”
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Role of Glycosaminoglycan Sulfation in the Formation of Immunoglobulin Light Chain Amyloid Oligomers and Fibrils by Ren, Ruiyi, Hong, Zhenning, Gong, Haiyan, Laporte, Kate, Skinner, Martha, Seldin, David C., Costello, Catherine E., Connors, Lawreen H., Trinkaus-Randall, Vickery

“…Primary amyloidosis (AL) results from overproduction of unstable monoclonal immunoglobulin light chains (LCs) and the deposition of insoluble fibrils in…”
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Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model by Arvanitis, Marios, Koch, Clarissa M, Chan, Gloria G, Torres-Arancivia, Celia, LaValley, Michael P, Jacobson, Daniel R, Berk, John L, Connors, Lawreen H, Ruberg, Frederick L

“…Transthyretin cardiac amyloidosis (ATTR) is an underrecognized cause of heart failure (HF) in older individuals, owing in part to difficulty in diagnosis. ATTR…”
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Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain‐mediated cardiotoxicity by Guan, Jian, Mishra, Shikha, Qiu, Yiling, Shi, Jianru, Trudeau, Kyle, Las, Guy, Liesa, Marc, Shirihai, Orian S, Connors, Lawreen H, Seldin, David C, Falk, Rodney H, MacRae, Calum A, Liao, Ronglih

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AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences by Bodi, Kip, Prokaeva, Tatiana, Spencer, Brian, Eberhard, Maurya, Connors, Lawreen H., Seldin, David C.

“…AL-Base, a curated database of human immunoglobulin (Ig) light chain (LC) sequences derived from patients with AL amyloidosis and controls, is described, along…”
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