Search Results - "Connor, Thomas"

A structure-based nomenclature for Bacillus thuringiensis and other bacteria-derived pesticidal proteins by Crickmore, Neil, Berry, Colin, Panneerselvam, Suresh, Mishra, Ruchir, Connor, Thomas R., Bonning, Bryony C.

“…[Display omitted] •An updated nomenclature for the pesticidal proteins of Bacillus thuringiensis.•Proteins split into classes that reflect structural…”
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Rapid phylogenetic analysis of large samples of recombinant bacterial whole genome sequences using Gubbins by Croucher, Nicholas J, Page, Andrew J, Connor, Thomas R, Delaney, Aidan J, Keane, Jacqueline A, Bentley, Stephen D, Parkhill, Julian, Harris, Simon R

“…The emergence of new sequencing technologies has facilitated the use of bacterial whole genome alignments for evolutionary studies and outbreak analyses. These…”
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A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers by Quail, Michael A, Smith, Miriam, Coupland, Paul, Otto, Thomas D, Harris, Simon R, Connor, Thomas R, Bertoni, Anna, Swerdlow, Harold P, Gu, Yong

“…Next generation sequencing (NGS) technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new…”
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Shedding of SARS-CoV-2 in feces and urine and its potential role in person-to-person transmission and the environment-based spread of COVID-19 by Jones, David L., Baluja, Marcos Quintela, Graham, David W., Corbishley, Alexander, McDonald, James E., Malham, Shelagh K., Hillary, Luke S., Connor, Thomas R., Gaze, William H., Moura, Ines B., Wilcox, Mark H., Farkas, Kata

“…The recent detection of SARS-CoV-2 RNA in feces has led to speculation that it can be transmitted via the fecal-oral/ocular route. This review aims to…”
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Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic by Attwood, Stephen W., Hill, Sarah C., Aanensen, David M., Connor, Thomas R., Pybus, Oliver G.

“…Determining the transmissibility, prevalence and patterns of movement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is central to…”
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Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice by Lawley, Trevor D, Clare, Simon, Walker, Alan W, Stares, Mark D, Connor, Thomas R, Raisen, Claire, Goulding, David, Rad, Roland, Schreiber, Fernanda, Brandt, Cordelia, Deakin, Laura J, Pickard, Derek J, Duncan, Sylvia H, Flint, Harry J, Clark, Taane G, Parkhill, Julian, Dougan, Gordon

“…Relapsing C. difficile disease in humans is linked to a pathological imbalance within the intestinal microbiota, termed dysbiosis, which remains poorly…”
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Establishment and lineage dynamics of the SARS-CoV-2 epidemic in the UK by du Plessis, Louis, McCrone, John T, Zarebski, Alexander E, Hill, Verity, Ruis, Christopher, Gutierrez, Bernardo, Raghwani, Jayna, Ashworth, Jordan, Colquhoun, Rachel, Connor, Thomas R, Faria, Nuno R, Jackson, Ben, Loman, Nicholas J, O'Toole, Áine, Nicholls, Samuel M, Parag, Kris V, Scher, Emily, Vasylyeva, Tetyana I, Volz, Erik M, Watts, Alexander, Bogoch, Isaac I, Khan, Kamran, Aanensen, David M, Kraemer, Moritz U G, Rambaut, Andrew, Pybus, Oliver G

“…The United Kingdom's COVID-19 epidemic during early 2020 was one of world's largest and was unusually well represented by virus genomic sampling. We determined…”
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Evaluating the risk of SARS-CoV-2 reinfection with the Omicron or Delta variant in Wales, UK by Postans, Mark, Pacchiarini, Nicole, Song, Jiao, Cottrell, Simon, Williams, Catie, Beazer, Andrew, Moore, Catherine, Connor, Thomas R, Williams, Christopher

“…Recent studies suggest an increased risk of reinfection with the SARS-CoV-2 Omicron variant compared with previous variants, potentially due to an increased…”
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Monitoring SARS-CoV-2 in municipal wastewater to evaluate the success of lockdown measures for controlling COVID-19 in the UK by Hillary, Luke S., Farkas, Kata, Maher, Kathryn H., Lucaci, Anita, Thorpe, Jamie, Distaso, Marco A., Gaze, William H., Paterson, Steve, Burke, Terry, Connor, Thomas R., McDonald, James E., Malham, Shelagh K., Jones, David L.

“…•Wastewater was used to monitor SARS-CoV-2 prevalence and genetic diversity.•SARS-CoV-2 RNA abundance and diversity reflects clinical case load and…”
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Genomic analysis of diversity, population structure, virulence, and antimicrobial resistance in Klebsiella pneumoniae, an urgent threat to public health by Holt, Kathryn E, Wertheim, Heiman, Zadoks, Ruth N, Baker, Stephen, Whitehouse, Chris A, Dance, David, Jenney, Adam, Connor, Thomas R, Hsu, Li Yang, Severin, Juliëtte, Brisse, Sylvain, Cao, Hanwei, Wilksch, Jonathan, Gorrie, Claire, Schultz, Mark B, Edwards, David J, Nguyen, Kinh Van, Nguyen, Trung Vu, Dao, Trinh Tuyet, Mensink, Martijn, Minh, Vien Le, Nhu, Nguyen Thi Khanh, Schultsz, Constance, Kuntaman, Kuntaman, Newton, Paul N, Moore, Catrin E, Strugnell, Richard A, Thomson, Nicholas R

“…Klebsiella pneumoniae is now recognized as an urgent threat to human health because of the emergence of multidrug-resistant strains associated with hospital…”
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Impacts of irrigated agriculture on food–energy–water–CO2 nexus across metacoupled systems by Xu, Zhenci, Chen, Xiuzhi, Liu, Jianguo, Zhang, Yu, Chau, Sophia, Bhattarai, Nishan, Wang, Ye, Li, Yingjie, Connor, Thomas, Li, Yunkai

“…Irrigated agriculture has important implications for achieving the United Nations Sustainable Development Goals. However, there is a lack of systematic and…”
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Hierarchical and spatially explicit clustering of DNA sequences with BAPS software by Cheng, Lu, Connor, Thomas R, Sirén, Jukka, Aanensen, David M, Corander, Jukka

“…Phylogeographical analyses have become commonplace for a myriad of organisms with the advent of cheap DNA sequencing technologies. Bayesian model-based…”
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Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease by Collins, Louise M., Toulouse, André, Connor, Thomas J., Nolan, Yvonne M.

“…Idiopathic Parkinson's disease (PD) represents a complex interaction between the inherent vulnerability of the nigrostriatal dopaminergic system, a possible…”
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The immune theory of psychiatric diseases: a key role for activated microglia and circulating monocytes by Beumer, Wouter, Gibney, Sinead M., Drexhage, Roosmarijn C., Pont‐Lezica, Lorena, Doorduin, Janine, Klein, Hans C., Steiner, Johann, Connor, Thomas J., Harkin, Andrew, Versnel, Marjan A., Drexhage, Hemmo A.

“…Review on the key role for activated microglia and monocytes in the pathogenesis of bipolar disorder and schizophrenia. This review describes a key role for…”
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SARS-CoV-2 within-host diversity and transmission by Lythgoe, Katrina A, Hall, Matthew, Ferretti, Luca, de Cesare, Mariateresa, MacIntyre-Cockett, George, Trebes, Amy, Andersson, Monique, Otecko, Newton, Wise, Emma L, Moore, Nathan, Lynch, Jessica, Kidd, Stephen, Cortes, Nicholas, Mori, Matilde, Williams, Rebecca, Vernet, Gabrielle, Justice, Anita, Green, Angie, Nicholls, Samuel M, Ansari, M Azim, Abeler-Dörner, Lucie, Moore, Catrin E, Peto, Timothy E A, Eyre, David W, Shaw, Robert, Simmonds, Peter, Buck, David, Todd, John A, Connor, Thomas R, Ashraf, Shirin, da Silva Filipe, Ana, Shepherd, James, Thomson, Emma C, Bonsall, David, Fraser, Christophe, Golubchik, Tanya

“…Extensive global sampling and sequencing of the pandemic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have enabled researchers to monitor…”
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Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression by Gibney, Sinead M, McGuinness, Barry, Prendergast, Christine, Harkin, Andrew, Connor, Thomas J

“…Highlights ► Depressive and anxiety-like behaviours elicited by poly I:C are associated with a reduction in BDNF signalling, and activation of the kynurenine…”
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Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs by Roussel, Christine, Witt, Kristine L., Shaw, Peter B., Connor, Thomas H.

“…Many antineoplastic drugs used to treat cancer, particularly alkylating agents and topoisomerase inhibitors, are known to induce genetic damage in patients…”
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Reproductive Health Risks Associated With Occupational Exposures to Antineoplastic Drugs in Health Care Settings: A Review of the Evidence by Connor, Thomas H., Lawson, Christina C., Polovich, Martha, McDiarmid, Melissa A.

“…OBJECTIVES:Antineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health…”
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Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study by Baker, Kate S, PhD, Dallman, Timothy J, PhD, Ashton, Philip M, PhD, Day, Martin, BSc, Hughes, Gwenda, PhD, Crook, Paul D, MSc, Gilbart, Victoria L, MSc, Zittermann, Sandra, PhD, Allen, Vanessa G, MD, Howden, Benjamin P, Prof, Tomita, Takehiro, PhD, Valcanis, Mary, MPH, Harris, Simon R, PhD, Connor, Thomas R, PhD, Sintchenko, Vitali, PhD, Howard, Peter, BSc, Brown, Jeremy D, MBBS, Petty, Nicola K, PhD, Gouali, Malika, PharmD, Thanh, Duy Pham, MSc, Keddy, Karen H, BSc (Med), Smith, Anthony M, PhD, Talukder, Kaisar A, PhD, Faruque, Shah M, PhD, Parkhill, Julian, Prof, Baker, Stephen, Prof, Weill, François-Xavier, PhD, Jenkins, Claire, PhD, Thomson, Nicholas R, Prof

“…Summary Background Shigellosis is an acute, severe bacterial colitis that, in high-income countries, is typically associated with travel to high-risk regions…”
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Mining Retrospective Data for Virtual Prospective Drug Repurposing: L-DOPA and Age-related Macular Degeneration by Brilliant, Murray H., PhD, Vaziri, Kamyar, MD, Connor, Thomas B., MD, Schwartz, Stephen G., MD, MBA, Carroll, Joseph J., PhD, McCarty, Catherine A., PhD, MPH, Schrodi, Steven J., PhD, Hebbring, Scott J., PhD, Kishor, Krishna S., MD, Flynn, Harry W., MD, Moshfeghi, Andrew A., MD, Moshfeghi, Darius M., MD, Fini, M. Elizabeth, PhD, McKay, Brian S., PhD

“…Abstract Background Age-related macular degeneration (AMD) is a leading cause of visual loss among the elderly. A key cell type involved in AMD, the retinal…”
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