Search Results - "Connor, T.J."

Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor by Kerr, D.M, Burke, N.N, Ford, G.K, Connor, T.J, Harhen, B, Egan, L.J, Finn, D.P, Roche, M

“…Abstract The endocannabinoid system is an important regulator of the nervous, neuroendocrine, and immune systems, thus representing a novel therapeutic target…”
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Differential lipopolysaccharide-induced immune alterations in the hippocampus of two mouse strains: Effects of stress by Browne, C.A, O’Brien, F.E, Connor, T.J, Dinan, T.G, Cryan, J.F

“…Highlights ► Swim-stress attenuated LPS-induced increases in C57LB/6J hippocampal IL-1β mRNA. ► Hippocampal TNFα mRNA expression was significantly increased in…”
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81. IFN-alpha and IL-6 reduce glucocorticoid sensitivity in murine microglia: A role for FKBP5? by Fagan, E.M, Dempsey, C, Tallon, E, Connor, T.J

“…Dysregulation of the GC system permitting excessive inflammation in the presence of elevated GCs occurs in depression, and is thought to be due to impaired GC…”
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96. Anti-depressants and kynurenine pathway inhibition: A therapeutic strategy for neuroprotection in vitro ? by Fagan, E.M, Gibney, S.M, Connor, T.J

“…The kynurenine pathway (KP) is the main pathway by which tryptophan is metabolized. Its rate limiting enzyme indolamine 2, 3-dioxygenase (IDO) catalyses the…”
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P.1.002 Alterations of the kynurenine pathway in rat chronic mild stress model by Duda, W, Curzytek, K, Kubera, M, Fagan, E, Connor, T.J

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111. Childhood trauma and depression are associated with a dysregulated inflammatory profile by Hughes, M.M, Carballedo, A, McLoughlin, D.M, Frodl, T, Connor, T.J

“…Here, we assess the relationship between childhood trauma (CTQ), inflammatory markers using Paxgene blood mRNA and depression (HAM-D scores) in a…”
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S22-02 - The effect of antidepressants on inflammatory markers in animal models of depression by Harkin, A, Connor, T.J

“…Considering the evidence that pro-inflammatory cytokines play a causal role in depressive illness, the ability of antidepressants to induce anti-inflammatory…”
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164. The Beta2-adrenoceptor agonist, salbutamol, induces GDNF expression in glia and increases the viability of cortical neurons by Day, J.S, Kilroy, D, Gibney, S.M, Connor, T.J

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Immunomodulatory effects of the beta2-adrenoceptor agonist clenbuterol in an acute brain injury model by Griffin, É.W, Anthony, D.C, Connor, T.J

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Comparison of kynurenine pathway activation and tryptophan depletion induced by activation of human T-cells and innate immune cells by Hughes, M.M, McLoughlin, D.M, Harkin, A, Connor, T.J

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Interferon-gamma stimulated microglia induce neurotoxicity – A role for the kynurenine pathway? by Fagan, E.M, Gibney, S.M, Connor, T.J, Harkin, A

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154. The serotonin transporter and monoamine oxidase A as novel pharmacological targets to inhibit microglial activation by Fagan, E.M, Gibney, S.M, Connor, T.J, Harkin, A

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67. The beta2-adrenoceptor agonist salmeterol inhibits thrombin-induced inflammation in primary glial cells: A role for PKA and EPAC activation by camp by Kilroy, D, Connor, T.J

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149. Poly I:C-induced activation of the innate immune response is accompanied by symptoms of depression and anxiety by Gibney, S, McGuinness, B, Prendergast, C, Harkin, A, Connor, T.J

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Synergistic CNS anti-inflammatory actions of combined treatment with the beta2-adrenoceptor agonist clenbuterol and the glucocorticoid dexamethasone by Griffin, E.W, Ryan, K.J, Connor, T.J

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The beta2-adrenoceptor agonist clenbuterol attenuates kainic acid-induced neuroinflammation and apoptosis in the hippocampus which is coupled with increased expression of BDNF and NGF by Gleeson, L.C, Griffin, E.W, Connor, T.J, Harkin, A

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150. Stimulation of central β2 -adrenoceptors suppresses NF-κB activity in hippocampus and cortex: A role for IκB by Ryan, K.J, Griffin, É.W, Yssel, J.D, Ryan, K.M, Harkin, A, Connor, T.J

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Inflammatory gene expression profile in treatment resistant depression by Hughes, M.M, Dunne, R, Noone, M, McLoughlin, D.M, Connor, T.J

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Anxiety related behaviour in an animal model of experimental colitis is associated with a long-term systemic and central inflammatory response by Abautret-Daly, A, Medina, C, Connor, T.J, Harkin, A

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Behavioural disturbances observed in experimental colitis are associated with activation of the kynurenine pathway and expression of hepatic tryptophan 2,3-dioxygenase by Abautret-Daly, A, Medina, C, Connor, T.J, Harkin, A

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