Search Results - "Connor, Mark"

Quantifying and Comparing the Match Demands of U18, U23, and 1ST Team English Professional Soccer Players by Reynolds, James, Connor, Mark, Jamil, Mikael, Beato, Marco

“…The aim of this study was to quantify and compare the match load demands of U18, U23, and 1ST team players during the official season. A total of 65 matches…”
Get full text

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5–/– or Mfge8–/– mouse retina by Ruggiero, Linda, Connor, Mark P, Chen, Jeannie, Langen, Ralf, Finnemann, Silvia C

“…In the mammalian retina, life-long renewal of light-sensitive photoreceptor outer segments (POS) involves circadian shedding of distal rod POS tips and their…”
Get full text

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity by Soethoudt, Marjolein, Grether, Uwe, Fingerle, Jürgen, Grim, Travis W., Fezza, Filomena, de Petrocellis, Luciano, Ullmer, Christoph, Rothenhäusler, Benno, Perret, Camille, van Gils, Noortje, Finlay, David, MacDonald, Christa, Chicca, Andrea, Gens, Marianela Dalghi, Stuart, Jordyn, de Vries, Henk, Mastrangelo, Nicolina, Xia, Lizi, Alachouzos, Georgios, Baggelaar, Marc P., Martella, Andrea, Mock, Elliot D., Deng, Hui, Heitman, Laura H., Connor, Mark, Di Marzo, Vincenzo, Gertsch, Jürg, Lichtman, Aron H., Maccarrone, Mauro, Pacher, Pal, Glass, Michelle, van der Stelt, Mario

“…The cannabinoid CB 2 receptor (CB 2 R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although…”
Get full text

Allopurinol for pain relief: more than just crystal clearance? by Connor, Mark

“…Gout and pain are synonymous, and a study in this issue of the BJP reports a novel anti‐nociceptive effect of allopurinol, the drug most commonly used to treat…”
Get full text

Accelerating the search for the missing proteins in the human proteome by Baker, Mark S., Ahn, Seong Beom, Mohamedali, Abidali, Islam, Mohammad T., Cantor, David, Verhaert, Peter D., Fanayan, Susan, Sharma, Samridhi, Nice, Edouard C., Connor, Mark, Ranganathan, Shoba

“…The Human Proteome Project (HPP) aims to discover high-stringency data for all proteins encoded by the human genome. Currently, ∼18% of the proteins in the…”
Get full text

Pharmacology of Indole and Indazole Synthetic Cannabinoid Designer Drugs AB-FUBINACA, ADB-FUBINACA, AB-PINACA, ADB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA, ADBICA, and 5F-ADBICA by Banister, Samuel D, Moir, Michael, Stuart, Jordyn, Kevin, Richard C, Wood, Katie E, Longworth, Mitchell, Wilkinson, Shane M, Beinat, Corinne, Buchanan, Alexandra S, Glass, Michelle, Connor, Mark, McGregor, Iain S, Kassiou, Michael

“…Synthetic cannabinoid (SC) designer drugs based on indole and indazole scaffolds and featuring l-valinamide or l-tert-leucinamide side chains are encountered…”
Get full text

Using multiple machine learning algorithms to classify elite and sub-elite goalkeepers in professional men’s football by Jamil, Mikael, Phatak, Ashwin, Mehta, Saumya, Beato, Marco, Memmert, Daniel, Connor, Mark

“…This study applied multiple machine learning algorithms to classify the performance levels of professional goalkeepers (GK). Technical performances of GK’s…”
Get full text

Monitoring Fatigue During Intermittent Exercise With Accelerometer-Derived Metrics by Beato, Marco, De Keijzer, Kevin L, Carty, Benjamin, Connor, Mark

“…The aim of this study was to assess the sensitivity of accelerometer-derived metrics for monitoring fatigue during an intermittent exercise protocol. Fifteen…”
Get full text

Real‐time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action by Cawston, Erin E, Redmond, William J, Breen, Courtney M, Grimsey, Natasha L, Connor, Mark, Glass, Michelle

“…Background and Purpose The cannabinoid receptor type 1 (CB1) has an allosteric binding site. The drugs ORG27569…”
Get full text

Context is key: normalization as a novel approach to sport specific preprocessing of KPI’s for match analysis in soccer by Phatak, Ashwin A., Mehta, Saumya, Wieland, Franz-Georg, Jamil, Mikael, Connor, Mark, Bassek, Manuel, Memmert, Daniel

“…Key Performance Indicators (KPIs) have been investigated, validated and applied in multitude of sports for recruiting, coaching, opponent, self-analysis etc…”
Get full text

Tapentadol shows lower intrinsic efficacy at µ receptor than morphine and oxycodone by Manandhar, Preeti, Connor, Mark, Santiago, Marina

“…Tapentadol is a centrally acting analgesic with a dual mechanism of action. It acts as an agonist at the µ receptor and inhibitor of noradrenaline reuptake…”
Get full text

N‐Acyl amino acids and N‐acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets by Connor, Mark, Vaughan, Chris W., Vandenberg, Robert J.

“…The myriad functions of lipids as signalling molecules is one of the most interesting fields in contemporary pharmacology, with a host of compounds recognized…”
Get full text

Opioids: cellular mechanisms of tolerance and physical dependence by Bailey, Chris P, Connor, Mark

“…Morphine and other opioids are used and abused for their analgesic and rewarding properties. Tolerance to these effects develops over hours/days to weeks, as…”
Get full text

Quantifying the Kinetics of Signaling and Arrestin Recruitment by Nervous System G-Protein Coupled Receptors by Hoare, Sam R J, Tewson, Paul H, Sachdev, Shivani, Connor, Mark, Hughes, Thomas E, Quinn, Anne Marie

“…Neurons integrate inputs over different time and space scales. Fast excitatory synapses at boutons (ms and μm), and slow modulation over entire dendritic…”
Get full text

CUMYL-4CN-BINACA Is an Efficacious and Potent Pro-Convulsant Synthetic Cannabinoid Receptor Agonist by Kevin, Richard C, Anderson, Lyndsey, McGregor, Iain S, Boyd, Rochelle, Manning, Jamie J, Glass, Michelle, Connor, Mark, Banister, Samuel D

“…Synthetic cannabinoid receptor agonists (SCRAs) are the largest class of new psychoactive substances (NPS). New examples are detected constantly, and some are…”
Get full text

Do gabapentin or pregabalin directly modulate the µ receptor? by Manandhar, Preeti, Murnion, Bridin Patricia, Grimsey, Natasha L, Connor, Mark, Santiago, Marina

“…Pregabalin and gabapentin improve neuropathic pain symptoms but there are emerging concerns regarding their misuse. This is more pronounced among patients with…”
Get full text

The potentiating effect of calcitonin gene-related peptide on transient receptor potential vanilloid-1 activity and the electrophysiological responses of rat trigeminal neurons to nociceptive stimuli by Chatchaisak, Duangthip, Connor, Mark, Srikiatkhachorn, Anan, Chetsawang, Banthit

“…Growing evidence suggests that calcitonin gene-related peptide (CGRP) participates in trigeminal nociceptive responses. However, the role of CGRP in…”
Get full text

New-generation azaindole-adamantyl-derived synthetic cannabinoids by Longworth, Mitchell, Reekie, Tristan A., Blakey, Karen, Boyd, Rochelle, Connor, Mark, Kassiou, Michael

“…Purpose This work reports the synthesis and pharmacological and analytical data for a new series of recently identified azaindole-adamantyl-derived synthetic…”
Get full text

Identification of N‐arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors by Redmond, William J., Cawston, Erin E., Grimsey, Natasha L., Stuart, Jordyn, Edington, Amelia R., Glass, Michelle, Connor, Mark

“…Background and Purpose N‐arachidonyl dopamine (NADA) has been identified as a putative endocannabinoid, but there is little information about which signalling…”
Get full text

The 2-alkyl-2H-indazole regioisomers of synthetic cannabinoids AB-CHMINACA, AB-FUBINACA, AB-PINACA, and 5F-AB-PINACA are possible manufacturing impurities with cannabimimetic activities by Longworth, Mitchell, Banister, Samuel D., Mack, James B. C., Glass, Michelle, Connor, Mark, Kassiou, Michael

“…Indazole-derived synthetic cannabinoids (SCs) featuring an alkyl substituent at the 1-position and l -valinamide at the 3-carboxamide position (e.g.,…”
Get full text