Search Results - "Connor, Janice R."

Human Osteoclast Cathepsin K Is Processed Intracellularly Prior to Attachment and Bone Resorption by Dodds, Robert A., James, Ian E., Rieman, David, Ahern, Reina, Hwang, Shing Mei, Connor, Janice R., Thompson, Scott D., Veber, Daniel F., Drake, Fred H., Holmes, Stephen, Lark, Michael W., Gowen, Maxine

“…Cathepsin K is a member of the papain superfamily of cysteine proteases and has been proposed to play a pivotal role in osteoclast‐mediated bone resorption. We…”
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Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts (∗) by Drake, Fred H., Dodds, Robert A., James, Ian E., Connor, Janice R., Debouck, Christine, Richardson, Susan, Lee-Rykaczewski, Elizabeth, Coleman, Lindsay, Rieman, David, Barthlow, Ray, Hastings, Gregg, Gowen, Maxine

“…Random high throughput sequencing of a human osteoclast cDNA library was employed to identify novel osteoclast-expressed genes. Of the 5475 ESTs obtained,…”
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Peptide Aldehyde Inhibitors of Cathepsin K Inhibit Bone Resorption Both In Vitro and In Vivo by Votta, Bartholomew J., Levy, Mark A., Badger, Alison, Bradbeer, Jeremy, Dodds, Robert A., James, Ian E., Thompson, Scott, Bossard, Mary J., Carr, Thomas, Connor, Janice R., Tomaszek, Thaddeus A., Szewczuk, Lawrence, Drake, Fred H., Veber, Daniel F., Gowen, Maxine

“…We have shown previously that cathepsin K, a recently identified member of the papain superfamily of cysteine proteases, is expressed selectively in…”
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Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions by Kumar, S, Hand, A T, Connor, J R, Dodds, R A, Ryan, P J, Trill, J J, Fisher, S M, Nuttall, M E, Lipshutz, D B, Zou, C, Hwang, S M, Votta, B J, James, I E, Rieman, D J, Gowen, M, Lee, J C

“…We have identified and cloned a novel connective tissue growth factor-like (CTGF-L) cDNA from primary human osteoblast cells encoding a 250-amino acid single…”
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Activation of the IL-1 Gene in UV-Irradiated Mouse Skin: Association with Inflammatory Sequelae and Pharmacologic Intervention by Griswold, Don E, Connor, Janice R, Dalton, Barbara J, Lee, John C, Simon, Philip, Hillegass, Leonard, Sieg, David J, Hanna, Nabil

“…The relationship between ultraviolet irradiation, interleukin-1 production, and inflammatory sequelae and the pharmacologic inhibition of these events was…”
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Viruses and the versatile macrophage by Morahan, P S, Connor, J R, Leary, K R

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Human osteoclasts, not osteoblasts, deposit osteopontin onto resorption surfaces: An in vitro and ex vivo study of remodeling bone by Dodds, Robert A., Connor, Janice R., James, Ian E., Lee Rykaczewski, Elizabeth, Appelbaum, Edward, Dul, Edward, Gowen, Maxine

“…Osteopontin is a phosphorylated glycoprotein believed to be secreted by osteoblasts and deposited into the bone matrix to facilitate osteoclast adhesion or to…”
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Induction and Expression of Human Cartilage Glycoprotein 39 in Rheumatoid Inflammatory and Peripheral Blood Monocyte-Derived Macrophages by Kirkpatrick, Robert B., Emery, John G., Connor, Janice R., Dodds, Robert, Lysko, Paul G., Rosenberg, Martin

“…Human cartilage glycoprotein 39 (HC gp-39) has been described as a major secreted product of cultured articular chondrocytes, synovial fibroblasts, and the…”
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CKβ-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues by Votta, Bartholomew J., White, John R., Dodds, Robert A., James, Ian E., Connor, Janice R., Elizabeth, Lee-Rykaczewski, Eichman, Christopher F., Kumar, Sanjay, Lark, Michael W., Gowen, Maxine

“…We have previously demonstrated that a tartrate‐resistant acid phosphatase (TRAP)‐positive subpopulation of mononuclear cells isolated from collagenase digests…”
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Cloning and Characterization of a Novel Integrin β3Subunit by Kumar, Chandrika S., James, Ian E., Wong, Angela, Mwangi, Vincent, Feild, John A., Nuthulaganti, Parvathi, Connor, Janice R., Eichman, Christopher, Ali, Fadia, Hwang, Shing Mei, Rieman, David J., Drake, Fred H., Gowen, Maxine

“…We have identified a novel integrin β3 subunit, termed β3C, from a human osteoclast cDNA library. The COOH-terminal sequence and 3′-untranslated region of the…”
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Purification and characterization of fully functional human osteoclast precursors by James, Ian E., Dodds, Robert A., Lee‐Rykaczewski, Elizabeth, Eichman, Christopher F., Connor, Janice R., Hart, Timothy K., Maleeff, Beverly E., Lackman, Richard D., Gowen, Maxine

“…The identification and purification of human osteoclast precursors is essential to further our understanding of the mechanisms that control human osteoclast…”
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CK?-8 [CCL23], a novel CC chemokine, is chemotactic for human osteoclast precursors and is expressed in bone tissues by Votta, Bartholomew J., White, John R., Dodds, Robert A., James, Ian E., Connor, Janice R., Elizabeth, Lee-Rykaczewski, Eichman, Christopher F., Kumar, Sanjay, Lark, Michael W., Gowen, Maxine

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The soluble form of E-selectin is an asymmetric monomer. Expression, purification, and characterization of the recombinant protein by Hensley, P, McDevitt, P J, Brooks, I, Trill, J J, Feild, J A, McNulty, D E, Connor, J R, Griswold, D E, Kumar, N V, Kopple, K D

“…The gene coding for a soluble form of human E-selectin (sE-selectin) has been expressed in Chinese hamster ovary (CHO) cells. Cells seeded into a hollow fiber…”
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Osteopontin deposition in remodeling bone: An osteoclast mediated event by Dodds, Robert A., Connor, Janice R., James, Ian E., Gowen, Maxine

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Cloning and Characterization of a Novel Integrin β3Subunit by Chandrika S. Kumar, Ian E. James, Angela Wong, Vincent Mwangi, John A. Feild, Parvathi Nuthulaganti, Janice R. Connor, Christopher Eichman, Fadia Ali, Shing Mei Hwang, David J. Rieman, Fred H. Drake, Maxine Gowen

“…We have identified a novel integrin β 3 subunit, termed β 3C , from a human osteoclast cDNA library. The COOH-terminal sequence and 3′-untranslated region…”
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Comparison of Herpes Simplex Virus Type 1 DNA Replication and Virus Production in Murine Bone Marrow-derived and Resident Peritoneal Macrophages by Leary, Kathryn, Connor, Janice R, Morahan, Page S

“…Department of Microbiology and Immunology, Medical College of Pennsylvania, 3300 Henry Avenue, Philadelphia, Pennsylvania 19129, U.S.A. The mechanism of…”
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Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues by Dodds, Robert A., Connor, Janice R., Drake, Fred H., Gowen, Maxine

“…Objective To investigate the expression of cathepsin K messenger RNA (mRNA) in the giant cells found in human osteoarthritic (OA) synovium and associated…”
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Lyso(bis)phosphatidic acid: a novel source of arachidonic acid for oxidative metabolism by rabbit alveolar macrophages by Cochran, F R, Connor, J R, Roddick, V L, Waite, B M

“…To identify the source of arachidonic acid utilized for eicosanoid production, rabbit alveolar macrophages were challenged with 1.0 microM…”
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A study of atherosclerosis regression in Macaca mulatta: III. Chemical changes in arteries from animals with atherosclerosis induced for 19 months and regressed for 48 months at plasma cholesterol concentrations of 300 or 200 mg/dl by Wagner, W D, St Clair, R W, Clarkson, T B, Connor, J R

“…The influence of two levels of plasma cholesterol concentration on the long-term regression of atherosclerotic plaques in rhesus monkeys (Macaca mulatta) was…”
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High molecular weight proteoglycans biosynthesized in culture by pigeon aortas by Wagner, W D, Connor, J R, Muldoon, E

“…The properties of aortic proteoglycans synthesized in vitro were examined to demonstrate synthesis of intact proteoglycans by aortic tissue in culture and to…”
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