Search Results - "Connor, Ashton A"

Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data by Connor, Ashton A., Gallinger, Steven

“…Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial malignancies, is rising in both incidence and contribution to overall cancer…”
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Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids by Huang, Ling, Holtzinger, Audrey, Jagan, Ishaan, BeGora, Michael, Lohse, Ines, Ngai, Nicholas, Nostro, Cristina, Wang, Rennian, Muthuswamy, Lakshmi B, Crawford, Howard C, Arrowsmith, Cheryl, Kalloger, Steve E, Renouf, Daniel J, Connor, Ashton A, Cleary, Sean, Schaeffer, David F, Roehrl, Michael, Tsao, Ming-Sound, Gallinger, Steven, Keller, Gordon, Muthuswamy, Senthil K

“…Human pluripotent stem cells can be differentiated into exocrine pancreas progenitor organoids, allowing studies of development and pancreatic cancer modeling…”
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Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial by Aung, Kyaw L, Fischer, Sandra E, Denroche, Robert E, Jang, Gun-Ho, Dodd, Anna, Creighton, Sean, Southwood, Bernadette, Liang, Sheng-Ben, Chadwick, Dianne, Zhang, Amy, O'Kane, Grainne M, Albaba, Hamzeh, Moura, Shari, Grant, Robert C, Miller, Jessica K, Mbabaali, Faridah, Pasternack, Danielle, Lungu, Ilinca M, Bartlett, John M S, Ghai, Sangeet, Lemire, Mathieu, Holter, Spring, Connor, Ashton A, Moffitt, Richard A, Yeh, Jen Jen, Timms, Lee, Krzyzanowski, Paul M, Dhani, Neesha, Hedley, David, Notta, Faiyaz, Wilson, Julie M, Moore, Malcolm J, Gallinger, Steven, Knox, Jennifer J

“…To perform real-time whole genome sequencing (WGS) and RNA sequencing (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive…”
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Intrahepatic cholangiocarcinoma: The role of liver transplantation, adjunctive treatments, and prognostic biomarkers by Connor, Ashton A, Kodali, Sudha, Abdelrahim, Maen, Javle, Milind M, Brombosz, Elizabeth W, Ghobrial, R Mark

“…Intrahepatic cholangiocarcinoma (iCCA) is a primary epithelial cell malignancy of the liver with rising incidence rate globally. Its insidious presentation,…”
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Molecular Events in the Natural History of Pancreatic Cancer by Oldfield, Leslie E, Connor, Ashton A, Gallinger, Steven

“…Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest epithelial malignancies. Improvements in our understanding of PDAC carcinogenesis will hopefully…”
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Immune Checkpoint Inhibitors for Solid Tumors in the Adjuvant Setting: Current Progress, Future Directions, and Role in Transplant Oncology by Abboud, Karen, Umoru, Godsfavour, Esmail, Abdullah, Abudayyeh, Ala, Murakami, Naoka, Al-Shamsi, Humaid O, Javle, Milind, Saharia, Ashish, Connor, Ashton A, Kodali, Sudha, Ghobrial, Rafik M, Abdelrahim, Maen

“…The rationale for administering immune checkpoint inhibitors (ICIs) in the adjuvant setting is to eradicate micro-metastases and, ultimately, prolong survival…”
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Hereditary Pancreatic Cancer Syndromes by Connor, Ashton A., MD, Gallinger, Steven, MD, MSc

“…Despite decades of scientific and clinical research, pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy. The clinical and pathologic features…”
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Spontaneous Ureterocolic Fistula between Nonfunctioning Kidney Transplant Ureter and Colon in Setting of Diverticulitis by Krischak, Madison K., Ord, Jeffrey R., Connor, Ashton A., Barbas, Andrew S.

“…Ureterocolic fistula is a rare condition that most commonly occurs in the setting of diverticular disease. The development of a ureterocolic fistula following…”
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Factors affecting survival after liver retransplantation: a systematic review and meta-analysis by Brombosz, Elizabeth W, Moore, Linda W, Mobley, Constance M, Kodali, Sudha, Saharia, Ashish, Hobeika, Mark J, Connor, Ashton A, Victor, 3rd, David W, Cheah, Yee Lee, Simon, Caroline J, Gaber, Ahmed Osama, Ghobrial, Rafik Mark

“…Liver retransplantation (reLT) has historically had inferior survival relative to primary liver transplant (LT). To improve outcomes after reLT, researchers…”
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Single-center Outcomes After Liver Transplantation With SARS-CoV-2-Positive Donors: An Argument for Increased Utilization by Connor, Ashton A, Adelman, Max W, Mobley, Constance M, Moaddab, Mozhgon, Erhardt, Alexandra J, Hsu, David E, Brombosz, Elizabeth W, Sanghvi, Mansi, Cheah, Yee Lee, Simon, Caroline J, Hobeika, Mark J, Saharia, Ashish S, Victor, 3rd, David W, Kodali, Sudha, Basra, Tamneet, Graviss, Edward A, Nguyen, Duc T, Elsaiey, Ahmed, Moore, Linda W, Nigo, Masayuki, Drews, Ashley L, Grimes, Kevin A, Arias, Cesar A, Li, Xian C, Gaber, A Osama, Ghobrial, R Mark

“…The COVID-19 pandemic has led to an increase in SARS-CoV-2-test positive potential organ donors. The benefits of life-saving liver transplantation (LT) must be…”
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Progress in Combined Liver–lung Transplantation at a Single Center by Connor, Ashton A., Huang, Howard J., Mobley, Constance M., Graviss, Edward A., Nguyen, Duc T., Goodarzi, Ahmad, Saharia, Ashish, Yau, Simon, Hobeika, Mark J., Suarez, Erik E., Moaddab, Mozhgon, Brombosz, Elizabeth W., Moore, Linda W., Yi, Stephanie G., Gaber, A. Osama, Ghobrial, Rafik Mark

“…Combined liver-lung transplantation is an uncommon, although vital, procedure for patients with simultaneous end-stage lung and liver disease. The utility of…”
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Prevalence of Germline Mutations in Cancer Predisposition Genes in Patients With Pancreatic Cancer by Grant, Robert C, Selander, Iris, Connor, Ashton A, Selvarajah, Shamini, Borgida, Ayelet, Briollais, Laurent, Petersen, Gloria M, Lerner-Ellis, Jordan, Holter, Spring, Gallinger, Steven

“…Background & Aims We investigated the prevalence of germline mutations in APC , ATM , BRCA1 , BRCA2 , CDKN2A , MLH1 , MSH2 , MSH6 , PALB2 , PMS2 , PRSS1 ,…”
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Characterization, Detection, and Treatment Approaches for Homologous Recombination Deficiency in Cancer by O’Kane, Grainne M., Connor, Ashton A., Gallinger, Steven

“…Investigations of carcinogenesis have evolved from the identification of clonal driver mutations in candidate genes to the integration of large volumes of…”
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Impact of Research Training on Performance in General Surgery Residency by Mikhail, Alexandre, Connor, Ashton A., Ahmed, Najma

“…It is common for North American surgical trainees to interrupt clinical training to complete 2 or more years of research training. The impact of this practice…”
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Metastatic Urothelial Carcinoma from Transplanted Kidney with Complete Response to an Immune Checkpoint Inhibitor by Harrison, Michael R., Rege, Aparna S., Madden, John F., Howell, David N., Foo, Wen-Chi, Inman, Brant A., Connor, Ashton A., Chiang, Ryan S., Ellis, Matthew J.

“…Background. Donor-derived malignancy is a rare complication in patients who undergo organ transplant. Approaches to treatment have largely been individualized…”
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Liver transplantation for Alcohol-associated liver disease by Simonetto, Douglas A, Winder, G Scott, Connor, Ashton A, Terrault, Norah A

“…Alcohol-associated liver disease (ALD) is a major cause of morbidity and mortality worldwide, and a leading indication for liver transplantation (LT) in many…”
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Molecular profiling in the management of hepatocellular carcinoma by Soliman, Nadine, Saharia, Ashish, Abdelrahim, Maen, Connor, Ashton A

“…The purpose of this review is to both summarize the current knowledge of hepatocellular carcinoma molecular biology and to suggest a framework in which to…”
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Liver transplantation as an alternative for the treatment of intrahepatic cholangiocarcinoma: Past, present, and future directions by Kodali, Sudha, Connor, Ashton A, Thabet, Souhail, Brombosz, Elizabeth W, Ghobrial, R Mark

“…Intrahepatic cholangiocarcinoma (iCCA) is a rare biliary tract cancer with high mortality rate. Complete resection of the iCCA lesion is the first choice of…”
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Update on the Screening, Diagnosis, and Management of Cholangiocarcinoma by Kodali, Sudha, Connor, Ashton A, Brombosz, Elizabeth W, Ghobrial, R Mark

“…Cholangiocarcinoma (CCA) is a neoplasm of the biliary tract that has become increasingly prevalent throughout the world. Common risk factors for developing CCA…”
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The learning curve for robotic living donor right hepatectomy: Analysis of outcomes in two specialized centers by Cheah, Yee L, Yang, Hye Yeon, Simon, Caroline J, Akoad, Mohamed E, Connor, Ashton A, Daskalaki, Despoina, Han, Dai Hoon, Brombosz, Elizabeth W, Kim, Jae K, Tellier, Maureen A, Ghobrial, R Mark, Gaber, A Osama, Choi, Gi Hong

“…Robotic surgery is an emerging minimally invasive option for living donor hepatectomy. Currently, there are no studies on the learning curve of robotic donor…”
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