Search Results - "Connolly, Janet M"

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex by Adams, Jarrett J., Narayanan, Samanthi, Liu, Baoyu, Birnbaum, Michael E., Kruse, Andrew C., Bowerman, Natalie A., Chen, Wei, Levin, Aron M., Connolly, Janet M., Zhu, Cheng, Kranz, David M., Garcia, K. Christopher

“…T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is essential to adaptive immunity, but it is unknown whether TCR signaling…”
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Basic and translational applications of engineered MHC class I proteins by Hansen, Ted H, Connolly, Janet M, Gould, Keith G, Fremont, Daved H

“…Major histocompatibility complex (MHC) class I molecules can be engineered as single chain trimers (SCTs) that sequentially incorporate all three subunits of…”
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Disulfide Bond Engineering to Trap Peptides in the MHC Class I Binding Groove by Truscott, Steven M, Lybarger, Lonnie, Martinko, John M, Mitaksov, Vesselin E, Kranz, David M, Connolly, Janet M, Fremont, Daved H, Hansen, Ted H

“…Immunodominant peptides in CD8 T cell responses to pathogens and tumors are not always tight binders to MHC class I molecules. Furthermore, antigenic peptides…”
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Human Major Histocompatibility Complex (MHC) Class I Molecules with Disulfide Traps Secure Disease-related Antigenic Peptides and Exclude Competitor Peptides by Truscott, Steven M., Wang, Xiaoli, Lybarger, Lonnie, Biddison, William E., McBerry, Cortez, Martinko, John M., Connolly, Janet M., Linette, Gerald P., Fremont, Daved H., Hansen, Ted H., Carreno, Beatriz M.

“…The ongoing discovery of disease-associated epitopes detected by CD8 T cells greatly facilitates peptide-based vaccine approaches and the construction of…”
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Enhanced Immune Presentation of a Single-chain Major Histocompatibility Complex Class I Molecule Engineered to Optimize Linkage of a C-terminally Extended Peptide by Lybarger, Lonnie, Yu, Y.Y.Lawrence, Miley, Michael J., Fremont, Daved H., Myers, Nancy, Primeau, Tina, Truscott, Steven M., Connolly, Janet M., Hansen, Ted H.

“…Major histocompatibility complex class I molecules can be expressed as single polypeptides wherein the antigenic peptide, β2-microglobulin, and heavy chain are…”
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Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC by Hoerter, John A H, Brzostek, Joanna, Artyomov, Maxim N, Abel, Steven M, Casas, Javier, Rybakin, Vasily, Ampudia, Jeanette, Lotz, Carina, Connolly, Janet M, Chakraborty, Arup K, Gould, Keith G, Gascoigne, Nicholas R J

“…Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have…”
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Single Peptide-MHC Complex Positively Selects a Diverse and Specific CD8 T Cell Repertoire by Wang, Baomei, Primeau, Tina M, Myers, Nancy, Rohrs, Henry W, Gross, Michael L, Lybarger, Lonnie, Hansen, Ted H, Connolly, Janet M

“…Pathogen recognition by T cells is dependent on their exquisite specificity for self-major histocompatibility complex (MHC) molecules presenting a bound…”
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Applications of major histocompatibility complex class I molecules expressed as single chains by Primeau, Tina, Myers, Nancy B, Yu, Y Y Lawrence, Lybarger, Lonnie, Wang, Xiaoli, Truscott, Steven M, Hansen, Ted H, Connolly, Janet M

“…Generation of CD8 T-cell responses to pathogens and tumors requires optimal expression of class I major histocompatibility complex/peptide complexes, which, in…”
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Cutting Edge: Single-Chain Trimers of MHC Class I Molecules Form Stable Structures That Potently Stimulate Antigen-Specific T Cells and B Cells by Yu, Yik Y. L, Netuschil, Nikolai, Lybarger, Lonnie, Connolly, Janet M, Hansen, Ted H

“…We report in this work the expression and characterization of class I molecules expressed as single-chain trimers consisting of an antigenic…”
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Class I-restricted cytotoxic T cell recognition of split peptide ligands by Gillanders, W E, Hanson, H L, Rubocki, R J, Hansen, T H, Connolly, J M

“…We developed a novel approach to probe the molecular basis of TCR recognition of the MHC class I-peptide complex and to determine how constraints placed on…”
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Homology Between an Alloantigen and a Self MHC Allele Calibrates the Avidity of the Alloreactive T Cell Repertoire Independent of TCR Affinity by Hornell, Tara M. C, Myers, Nancy, Hansen, Ted H, Connolly, Janet M

“…The self-restricted T cell repertoire exhibits a high frequency of alloreactivity. Because these alloreactive T cells are derived from the pool of cells…”
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Peptide Ligand-Induced Conformation and Surface Expression of the L(d) Class I MHC Molecule by Lie, Wen-Rong, Myers, Nancy B, Gorka, John, Rubocki, Ronald J, Connolly, Janet M, Hansen, Ted H

“…Newly synthesized major histocompatibility complex (MHC) class I molecules in the endoplasmic reticulum are thought to bind peptides of foreign and endogenous…”
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Peptide Length Variants p2Ca and QL9 Present Distinct Conformations to Ld-Specific T Cells by Hornell, Tara M. C, Martin, Shiloh M, Myers, Nancy B, Connolly, Janet M

“…Recent advances have provided insights into how the TCR interacts with MHC/peptide complexes and a rationale to predict optimal epitopes for MHC binding and T…”
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Peptide ligand-induced conformation and surface expression of the Ld class I MHC molecule by LIE, W.-R, MYERS, N. B, GORKA, J, RUBOCKI, R. J, CONNOLLY, J. M, HANSEN, T. H

“…Newly synthesized major histocompatibility complex (MHC) class I molecules in the endoplasmic reticulum are thought to bind peptides of foreign and endogenous…”
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Kb, Kd, and Ld Molecules Share Common Tapasin Dependencies as Determined Using a Novel Epitope Tag by Myers, Nancy B, Harris, Michael R, Connolly, Janet M, Lybarger, Lonnie, Yu, Yik Y. L, Hansen, Ted H

“…The endoplasmic reticulum protein tapasin is considered to be a class I-dedicated chaperone because it facilitates peptide loading by proposed mechanisms such…”
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Structural Engineering of pMHC Reagents for T Cell Vaccines and Diagnostics by Mitaksov, Vesselin, Truscott, Steven M., Lybarger, Lonnie, Connolly, Janet M., Hansen, Ted H., Fremont, Daved H.

“…MHC class I peptide complexes (pMHC) are routinely used to enumerate T cell populations and are currently being evaluated as vaccines to tumors and specific…”
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Specific Prolongation of Allograft Survival by a T-Cell-Receptor-Derived Peptide by Goss, John A., Alexander-Miller, Martha A., Gorka, John, Flye, M. Wayne, Connolly, Janet M., Hansen, Ted H.

“…Allograft rejection results from the specific recognition by host CD8+T cells of allogeneic major histocompatibility complex (MHC) molecules on the tissue…”
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Translational and basic applications of peptide-MHCI single chain trimers by Hansen, Ted H., Connolly, Janet M., Gould, Keith G., Fremont, Daved H.

“…MHC class I molecules can be engineered as s ingle c hain t rimers (SCT) that sequentially incorporate all three subunits of the fully assembled proteins,…”
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In vivo positive selection determines the peptide and MHC specificity of the CD8 T cell repertoire by Wang, Baomei, Lybarger, Lonnie, Primeau, Tina, Hansen, Ted H., Connolly, Janet M.

“…Abstract only The nature of the peptides that drive positive selection of T cells in the thymus remains poorly defined. To examine the role of peptides during…”
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The peptide p2Ca is immunodominant in allorecognition of L(d) by (beta) chain variable region V(beta)8(positive) but not V(beta)8(negative) strains by Connolly, Janet M

“…It is reported that ptwoCa is immunodominant in allorecognition of the murine major histocompatibility complex (MHC) I molecule H-2Ld in mice. Data indicate…”
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