Search Results - "Connolly, James P.R."

Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens by Turner, Natasha C A, Connolly, James P R, Roe, Andrew J

“…Enterohaemorrhagic (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly…”
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Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli by Ormsby, Michael J., Johnson, Síle A., Carpena, Nuria, Meikle, Lynsey M., Goldstone, Robert J., McIntosh, Anne, Wessel, Hannah M., Hulme, Heather E., McConnachie, Ceilidh C., Connolly, James P.R., Roe, Andrew J., Hasson, Conor, Boyd, Joseph, Fitzgerald, Eamonn, Gerasimidis, Konstantinos, Morrison, Douglas, Hold, Georgina L., Hansen, Richard, Walker, Daniel, Smith, David G.E., Wall, Daniel M.

“…Propionic acid (PA) is a bacterium-derived intestinal antimicrobial and immune modulator used widely in food production and agriculture. Passage of Crohn’s…”
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A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage by Fox, Stephen, Goswami, Cosmika, Holden, Matthew, Connolly, James P. R., Mordue, James, O’Boyle, Nicky, Roe, Andrew, Connor, Martin, Leanord, Alistair, Evans, Tom J.

“…Bacterial type III secretion systems (T3SSs) play an important role in pathogenesis of Gram-negative infections. Enteropathogenic and enterohemorrhagic…”
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Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis by Scott, Nicholas A, Andrusaite, Anna, Andersen, Peter, Lawson, Melissa, Alcon-Giner, Cristina, Leclaire, Charlotte, Caim, Shabhonam, Le Gall, Gwenaelle, Shaw, Tovah, Connolly, James P R, Roe, Andrew J, Wessel, Hannah, Bravo-Blas, Alberto, Thomson, Carolyn A, Kästele, Verena, Wang, Ping, Peterson, Daniel A, Bancroft, Allison, Li, Xuhang, Grencis, Richard, Mowat, Allan McI, Hall, Lindsay J, Travis, Mark A, Milling, Simon W F, Mann, Elizabeth R

“…Macrophages in the healthy intestine are highly specialized and usually respond to the gut microbiota without provoking an inflammatory response. A breakdown…”
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A new family of bacterial ribosome hibernation factors by Helena-Bueno, Karla, Rybak, Mariia Yu, Ekemezie, Chinenye L., Sullivan, Rudi, Brown, Charlotte R., Dingwall, Charlotte, Baslé, Arnaud, Schneider, Claudia, Connolly, James P. R., Blaza, James N., Csörgő, Bálint, Moynihan, Patrick J., Gagnon, Matthieu G., Hill, Chris H., Melnikov, Sergey V.

“…To conserve energy during starvation and stress, many organisms use hibernation factor proteins to inhibit protein synthesis and protect their ribosomes from…”
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Distinct intraspecies virulence mechanisms regulated by a conserved transcription factor by Connolly, James P. R., O’Boyle, Nicky, Turner, Natasha C. A., Browning, Douglas F., Roe, Andrew J.

“…Tailoring transcriptional regulation to coordinate the expression of virulence factors in tandem with the core genome is a hallmark of bacterial pathogen…”
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The novel anti-phage system Shield co-opts an RmuC domain to mediate phage defense across Pseudomonas species by Macdonald, Elliot, Wright, Rosanna, Connolly, James P R, Strahl, Henrik, Brockhurst, Michael, van Houte, Stineke, Blower, Tim R, Palmer, Tracy, Mariano, Giuseppina

“…Competitive bacteria-bacteriophage interactions have resulted in the evolution of a plethora of bacterial defense systems preventing phage propagation. In…”
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Genomic plasticity of pathogenic Escherichia coli mediates D-serine tolerance via multiple adaptive mechanisms by O’Boyle, Nicky, Connolly, James P. R., Tucker, Nicholas P., Roe, Andrew J.

“…The molecular environment of the host can have profound effects on the behavior of resident bacterial species. We recently established how the sensing and…”
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Control of resistance against bacteriophage killing by a metabolic regulator in meningitis-associated Escherichia coli by Connolly, James P R, Turner, Natasha C A, Serrano, Ester, Rimbi, Patricia T, Browning, Douglas F, O'Boyle, Nicky, Roe, Andrew J

“…Ecologically beneficial traits in bacteria are encoded by intrinsic and horizontally acquired genes. However, such traits are not universal, and the highly…”
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Distinct ecological fitness factors coordinated by a conserved Escherichia coli regulator during systemic bloodstream infection by O'Boyle, Nicky, Douce, Gillian R, Farrell, Gillian, Rattray, Nicholas J W, Schembri, Mark A, Roe, Andrew J, Connolly, James P R

“…The ability of bacterial pathogens to adapt to host niches is driven by the carriage and regulation of genes that benefit pathogenic lifestyles. Genes that…”
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Host-associated niche metabolism controls enteric infection through fine-tuning the regulation of type 3 secretion by Connolly, James P. R., Slater, Sabrina L., O’Boyle, Nicky, Goldstone, Robert J., Crepin, Valerie F., Ruano-Gallego, David, Herzyk, Pawel, Smith, David G. E., Douce, Gillian R., Frankel, Gad, Roe, Andrew J.

“…Niche-adaptation of a bacterial pathogen hinges on the ability to recognize the complexity of signals from the environment and integrate that information with…”
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Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis by McHugh, Rebecca E, O'Boyle, Nicky, Connolly, James P R, Hoskisson, Paul A, Roe, Andrew J

“…Recent work has demonstrated that the polyketide natural product Aurodox from is able to block the pathogenesis of the murine pathogen In this work, we aimed…”
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Going virtual: a report from the sixth Young Microbiologists Symposium on 'Microbe Signalling, Organisation and Pathogenesis' by An, Shi-Qi, Lopes, Bruno Silvester, Connolly, James P R, Sharp, Connor, Nguyen, Thi Kim Loan, Kirkpatrick, Clare Louise

“…The sixth Young Microbiologists Symposium on 'Microbe Signalling, Organisation and Pathogenesis' was scheduled to be held at the University of Southampton, UK,…”
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d-Serine induces distinct transcriptomes in diverse Escherichia coli pathotypes by Connolly, James P R, Turner, Natasha C A, Hallam, Jennifer C, Rimbi, Patricia T, Flett, Tom, McCormack, Mhairi J, Roe, Andrew J, O'Boyle, Nicky

“…Appropriate interpretation of environmental signals facilitates niche specificity in pathogenic bacteria. However, the responses of niche-specific pathogens to…”
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Prokaryotic life finds a way: insights from evolutionary experimentation in bacteria by Connolly, James P R, Roe, Andrew J, O'Boyle, Nicky

“…While evolution proceeds through the generation of random variant alleles, the application of selective pressures can select for subsets of mutations that…”
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Novel compounds targeting the enterohemorrhagic Escherichia coli type three secretion system reveal insights into mechanisms of secretion inhibition by Zambelloni, Riccardo, Connolly, James P.R., Huerta Uribe, Alejandro, Burgess, Karl, Marquez, Rodolfo, Roe, Andrew J.

“…Summary Anti‐virulence (AV) compounds are a promising alternative to traditional antibiotics for fighting bacterial infections. The Type Three Secretion System…”
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From ingestion to colonization: the influence of the host environment on regulation of the LEE encoded type III secretion system in enterohaemorrhagic Escherichia coli by Connolly, James P R, Finlay, B Brett, Roe, Andrew J

“…Enterohaemorrhagic Escherichia coli (EHEC) binds to host tissue and intimately attaches to intestinal cells using a dedicated type III secretion system (T3SS)…”
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Plastic Circuits: Regulatory Flexibility in Fine Tuning Pathogen Success by O’Boyle, Nicky, Turner, Natasha C.A., Roe, Andrew J., Connolly, James P.R.

“…Bacterial pathogens employ diverse fitness and virulence mechanisms to gain an advantage in competitive niches. These lifestyle-specific traits require…”
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Postgenomics Characterization of an Essential Genetic Determinant of Mammary Pathogenic Escherichia coli by Blum, Shlomo E, Goldstone, Robert J, Connolly, James P R, Répérant-Ferter, Maryline, Germon, Pierre, Inglis, Neil F, Krifucks, Oleg, Mathur, Shubham, Manson, Erin, Mclean, Kevin, Rainard, Pascal, Roe, Andrew J, Leitner, Gabriel, Smith, David G E

“…are major bacterial pathogens causing bovine mastitis, a disease of great economic impact on dairy production worldwide. This work aimed to study the virulence…”
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Intracellular d-Serine Accumulation Promotes Genetic Diversity via Modulated Induction of RecA in Enterohemorrhagic Escherichia coli by Connolly, James P R, Roe, Andrew J

“…We recently discovered that exposure of enterohemorrhagic Escherichia coli (EHEC) to d-serine resulted in accumulation of this unusual amino acid, induction of…”
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